CN103463395A - Pharmaceutical formulation for treating respiratory disease of chickens - Google Patents
Pharmaceutical formulation for treating respiratory disease of chickens Download PDFInfo
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- CN103463395A CN103463395A CN 201310448790 CN201310448790A CN103463395A CN 103463395 A CN103463395 A CN 103463395A CN 201310448790 CN201310448790 CN 201310448790 CN 201310448790 A CN201310448790 A CN 201310448790A CN 103463395 A CN103463395 A CN 103463395A
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Abstract
The invention discloses a pharmaceutical formulation and a preparing method for preventing the respiratory disease of chickens. Chinese pulsatilla roots, ephedra, selfheal, andrographis paniculata, honeysuckle, garlic, houttuynia cordata, liquorice and isatis roots are made into the pharmaceutical formulation according to a certain weight component. The pharmaceutical formulation is suitable for preventing and treating the espiratory disease of the chickens, and has the effect of clearing away heat and toxic materials and eliminating dampness and eliminating phlegm. In addition, the pharmaceutical formulation also has the effects of microbial resisting, dysentery stopping, virus resisting, spleen tonifying, vital energy regulating and immunity improving. The pharmaceutical formulation is made of pure Chinese herbal medicine preparations, is easy to use and free of the toxic and side effect, and has the obvious effect of preventing and treating the respiratory disease of the chickens.
Description
Technical field
The present invention relates to a kind of pharmaceutical formulation of relevant chicken disease, especially a kind of pharmaceutical formulation for the treatment of respiratory disease of chicken.
Background technology
Respiratory disease of chicken is one of several frequently seen disease of fowl disease, mostly occurs in cold season.Be the principal disease that affects the chicken aquaculture development, caused huge loss to the aquaculture of chicken.Chicken infects bronchitis or the infectious laryngotracheitis mortality rate is 10%-20%, the main antibiotics that adopts prevents and treats at present, but easily produces drug resistance and drug residue, and the kidney of chicken is also had to certain infringement, the long-time use, therapeutic effect can descend gradually.
Summary of the invention
Based on above-mentioned situation, the invention provides the pure Chinese medicinal preparation for the treatment of respiratory disease of chicken.The present invention have toxic and side effects little, do not produce drug resistance, there are the characteristics of obvious therapeutic action.
Technical solution of the present invention realizes by following manner: a kind of pharmaceutical formulation for the treatment of respiratory disease of chicken, described pharmaceutical formulation is comprised of the crude drug of following weight portion: Radix Pulsatillae 10-100g, Herba Ephedrae 10-100g, Spica Prunellae 10-200g, Herba Andrographis 20-100g, Flos Lonicerae 10-100g, Bulbus Allii 5-100g, Herba Houttuyniae 10-200g, Radix Glycyrrhizae 20-100g, Radix Isatidis 10-200g.
Specific features is: Radix Pulsatillae 30g, Herba Ephedrae 60g, Spica Prunellae 60g, Herba Andrographis 50g, Flos Lonicerae 30g, Bulbus Allii 30g, Herba Houttuyniae 60g, Radix Glycyrrhizae 60g, Radix Isatidis 60g.
The specific embodiment
Below in conjunction with embodiment, embodiment of the present invention are described in detail.
the preparation of medicine of the present invention
embodiment 1:
Take by weight various crude drug and mix, pulverize, cross 40 mesh sieves, in the ratio of 1:1, add water, 40min at a simmer, filter the residue obtained water that adds 5 times of weight, and 30min is boiled in heating, filters; Residue adds the water of 2 times of weight, and 30min is boiled in heating, filters merging filtrate.Add deionized water after filtration to 0.25g/ml, 4 ℃ of refrigerators are standby.
embodiment 2:
Take by weight various crude drug and mix, pulverize, cross 40 mesh sieves, in the ratio of 1:1, add water, 40min at a simmer, filter the residue obtained water that adds 5 times of weight, and 30min is boiled in heating, filters; Residue adds the water of 2 times of weight, and 30min is boiled in heating, filters merging filtrate.Add deionized water after filtration to 0.5g/ml, 4 ℃ of refrigerators are standby.
embodiment 3:
Take by weight various crude drug and mix, pulverize, cross 40 mesh sieves, in the ratio of 1:1, add water, 40min at a simmer, filter the residue obtained water that adds 5 times of weight, and 30min is boiled in heating, filters; Residue adds the water of 2 times of weight, and 30min is boiled in heating, filters merging filtrate.Add deionized water after filtration to 1g/ml, 4 ℃ of refrigerators are standby.
using method:
During use, medicine is joined to mix homogeneously in the normal drinking-water of chicken, chicken freely drinks water.
supply the reagent product:
the Radix Pulsatillae, Herba Ephedrae, Spica Prunellae, Herba Andrographis, Flos Lonicerae, Bulbus Allii, Herba Houttuyniae, Radix Glycyrrhizae, Radix Isatidis is all purchased from Jinan City medical material company.
the experiment strain:iLTV standard poison checks institute purchased from Chinese veterinary drug
laboratory animal:
Get 60 of 60 age in days chickens, be divided at random 5 groups, 12 every group.A group: Normal group; B group: normal saline group; C group: 0.25mg/kg group of the present invention; D group: 0.25mg/kg group; E group: 1mg/kg group.
experimental technique:
Get 60 of 60 age in days chickens, be divided at random 5 groups, 12 every group, each organizes isolated rearing.The A group does not deal with; The B group is with 10
-5/ 0.2mlILTV standard poisons larynx tracheal instillation connects poison, all not administrations after reaching before counteracting toxic substances; The C group is with 10
-5/ 0.2mlILTV standard poisons larynx tracheal instillation connects poison, and the medicine of the present invention that the rear 24h of counteracting toxic substances success gives 0.25mg/kg is treated; D group C group is with 10
-5/ 0.2mlILTV standard poisons larynx tracheal instillation connects poison, and the medicine of the present invention that the rear 24h of counteracting toxic substances success gives 0.5mg/kg is treated; E group C group is with 10
-5/ 0.2mlILTV standard poisons larynx tracheal instillation connects poison, and the medicine of the present invention that the rear 24h of counteracting toxic substances success gives 1mg/kg is treated; Successive administration 5 days, the active state of observing chicken every day changes, and records death toll.
results and analysis:
Table 1:
| Numbering | Group | Administration | Morbidity chicken quantity | Sickness rate | Dead chicken quantity | Mortality rate | Survival chicken number | Survival rate |
| A | Normal group | Normal diet | 0 | 0 | 0 | 0 | 12 | 100% |
| B | Model group | Normal diet | 12 | 100% | 11 | 91.7% | 1 | 8.3% |
| C | 0.25mg/kg | Low dosage | 12 | 100% | 8 | 66.7% | 4 | 33.3% |
| D | 0.5mg/kg | Middle dosage | 11 | 91.7% | 5 | 45.5% | 6 | 54.5% |
| E | 1mg/kg | High dose | 12 | 100% | 2 | 16.7% | 10 | 83.3% |
Table 2:
| Numbering | Group | Administration | 3 days cure rates | 4 days cure rates | 5 days cure rates | Total cure rate |
| A | Normal group | Normal diet | 100% | 100% | 100% | 100% |
| B | Model group | Normal diet | 0 | 0 | 8.3% | 8.3% |
| C | 0.25mg/kg | Low dosage | 8.3% | 16.7% | 25% | 33.3% |
| D | 0.5mg/kg | Middle dosage | 8.3% | 36.4% | 45.5% | 54.5% |
| E | 1mg/kg | High dose | 25% | 41.7% | 66.7% | 75% |
By table one data, can be found out, pharmaceutical formulation of the present invention can reduce the mortality rate of chicken to a certain extent, has improved the survival rate of chicken, and especially, after the medicine of the present invention to middle dosage and high dose, its survival rate obviously improves.Give with the respiratory tract disease modeling after, the medicine of high dose of the present invention has reached 66.7% at the 5th day cure rate, final total cure rate has reached 75%, illustrate that pharmaceutical formulation of the present invention has certain therapeutical effect to reaching respiratory tract disease.The present invention adopts pure Chinese medicine formula, and the drug resistance of having avoided the Western medicine such as application antibiotic to produce, also can reduce drug residue, for the clinical treatment respiratory disease of chicken provides certain treatment foundation.
Claims (3)
1. a pharmaceutical formulation for the treatment of respiratory disease of chicken, it is characterized in that: described Chinese medicine is comprised of the material of following weight portion: Radix Pulsatillae 10-100g, Herba Ephedrae 10-100g, Spica Prunellae 10-200g, Herba Andrographis 20-100g, Flos Lonicerae 10-100g, Bulbus Allii 5-100g, Herba Houttuyniae 10-200g, Radix Glycyrrhizae 20-100g, Radix Isatidis 10-200g.
2. a kind of pharmaceutical formulation for the treatment of respiratory disease of chicken according to claim 1, it is characterized in that: described Chinese medicine is comprised of the material of following weight portion: Radix Pulsatillae 20-50g, Herba Ephedrae 20-60g, Spica Prunellae 30-100g, Herba Andrographis 20-50g, Flos Lonicerae 20-100g, Bulbus Allii 10-50g, Herba Houttuyniae 50-100g, Radix Glycyrrhizae 20-60g, Radix Isatidis 20-100g.
3. be a kind of pharmaceutical formulation for the treatment of respiratory disease of chicken according to claim 2, it is characterized in that: described Chinese medicine is comprised of the material of following weight portion: Radix Pulsatillae 30g, Herba Ephedrae 60g, Spica Prunellae 60g, Herba Andrographis 50g, Flos Lonicerae 30g, Bulbus Allii 30g, Herba Houttuyniae 60g, Radix Glycyrrhizae 60g, Radix Isatidis 60g.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201310448790 CN103463395A (en) | 2013-09-28 | 2013-09-28 | Pharmaceutical formulation for treating respiratory disease of chickens |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201310448790 CN103463395A (en) | 2013-09-28 | 2013-09-28 | Pharmaceutical formulation for treating respiratory disease of chickens |
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| CN103463395A true CN103463395A (en) | 2013-12-25 |
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| CN 201310448790 Pending CN103463395A (en) | 2013-09-28 | 2013-09-28 | Pharmaceutical formulation for treating respiratory disease of chickens |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104666791A (en) * | 2014-12-06 | 2015-06-03 | 湖北文理学院 | Compound water aqua for preventing and treating upper respiratory infection of cats and preparation method of compound water aqua |
| CN104825951A (en) * | 2015-05-22 | 2015-08-12 | 陶建壮 | Medicine for treating respiratory diseases of chicken |
| CN105362868A (en) * | 2015-12-09 | 2016-03-02 | 湖北武当动物药业有限责任公司 | Drug for preventing and treating animal respiratory syndrome |
-
2013
- 2013-09-28 CN CN 201310448790 patent/CN103463395A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104666791A (en) * | 2014-12-06 | 2015-06-03 | 湖北文理学院 | Compound water aqua for preventing and treating upper respiratory infection of cats and preparation method of compound water aqua |
| CN104825951A (en) * | 2015-05-22 | 2015-08-12 | 陶建壮 | Medicine for treating respiratory diseases of chicken |
| CN105362868A (en) * | 2015-12-09 | 2016-03-02 | 湖北武当动物药业有限责任公司 | Drug for preventing and treating animal respiratory syndrome |
| CN105362868B (en) * | 2015-12-09 | 2019-08-20 | 湖北武当动物药业有限责任公司 | One kind is for preventing and treating animal breath syndrome drug |
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| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20131225 |
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| WD01 | Invention patent application deemed withdrawn after publication |