CN101637519A - Traditional Chinese veterinary medicine for reinforcing detoxifying function of liver and kidney of livestock and poultry - Google Patents
Traditional Chinese veterinary medicine for reinforcing detoxifying function of liver and kidney of livestock and poultry Download PDFInfo
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- CN101637519A CN101637519A CN200910101870A CN200910101870A CN101637519A CN 101637519 A CN101637519 A CN 101637519A CN 200910101870 A CN200910101870 A CN 200910101870A CN 200910101870 A CN200910101870 A CN 200910101870A CN 101637519 A CN101637519 A CN 101637519A
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Abstract
The invention relates to a veterinary medicine, in particular to a traditional Chinese veterinary medicine for reinforcing the detoxifying function of the liver and the kidney of livestock and poultry. The invention provides a traditional Chinese veterinary medicine for reinforcing the detoxifying function of the liver and the kidney of livestock and poultry, which has less toxic and side effect,is difficult to generate medicine resistance, is safe and efficient and has controllable quality by aiming at current various factors causing the toxicity of the liver and the kidney of the livestockand the poultry. The traditional Chinese medicine for treating diseases of the liver and the kidney of the livestock and the poultry is characterized by comprising the following prescription components based on parts by weight: 18-36 parts of oriental wormwood, 9-18 parts of cape jasmine, 10-20 parts of giant knotweed, 9-18 parts of scutellaria baicalensis and 1-20 parts of uncaria. The inventioncan be made into various preparations, such as particles, oral liquid, injection, tablets, powder, and the like.
Description
Technical field
The present invention relates to a kind of veterinary drug, particularly a kind of Chinese medicine veterinary drug that strengthens detoxifying function of liver and kidney of livestock and poultry.
Technical background
At present, poultry (especially pig and chicken) the breed scale is increasing, the intensification degree is more and more higher.And the various handicapped factor ubiquities of liver and kidney of livestock and poultry that cause, as global warming, viral disease such as pig blue-ear disease, high fever syndrome, bird flu etc. popular, the frequent use of medicine and vaccine; Environmental pollution, mycotoxins in feed etc. produce serious toxic and side effects to the animal liver and kidney function.In swinery, long-term, overdose is united and is used antibiotic and the liver of chemical synthetic drug deposits yields, the toxic reaction that the kidney dysbolismus causes; The liver that mycete and mycotoxin cause, renal failure; Pig hyperpyrexia syndrome, prdc etc. cause liver, renal failure; In the chicken and duck group, duckling viral hepatitis, chicken inclusion body hepatitis etc. cause hepatorenal disease.Various hepatic renal dysfunctions bring enormous economic loss for the production of poultry.But,,, still do not have a kind of Chinese medicine veterinary drug product of special enhancing detoxifying function of liver and kidney of livestock and poultry except replenishing some vitamin, the electrolyte at present at the various hepatic renal dysfunctions of poultry with suiting the medicine to the illness property.
Summary of the invention
The present invention is directed to the deficiencies in the prior art, the Chinese medicine veterinary drug that a kind of toxic and side effects is little, be difficult for producing chemical sproof enhancing detoxifying function of liver and kidney of livestock and poultry is provided, and safe, efficient, quality controllable.
The technical solution adopted in the present invention is: a kind of Chinese medicine veterinary drug that strengthens detoxifying function of liver and kidney of livestock and poultry, it is characterized in that its recipe ingredient (by weight) is: 18～36 parts of Herba Artemisiae Scopariaes, 9～18 parts of Fructus Gardeniaes, 10～20 parts of Rhizoma Polygoni Cuspidati, 9～18 parts of Radix Scutellariaes, 10～20 parts of Ramulus Uncariae Cum Uncis.
The present invention can be made into various dosage forms such as granule, oral liquid, injection, tablet, powder.
The present invention controls method according to Basic Theories of Chinese Medicine and dialectical opinion, in conjunction with the current toxic factor of liver and kidney of livestock and poultry that causes, select Herba Artemisiae Scopariae, Fructus Gardeniae, Rhizoma Polygoni Cuspidati, Radix Scutellariae, Ramulus Uncariae Cum Uncis to carry out prescription, have significant clearing away heat-damp and promoting diuresis, eliminating fire and detoxication, detoxifcation hepatoprotective, the effect of kidney tonifying toxin expelling.
Compared with prior art, the present invention has following advantage:
1. the Herba Artemisiae Scopariae among safe the present invention, Fructus Gardeniae, Rhizoma Polygoni Cuspidati, Radix Scutellariae, the Ramulus Uncariae Cum Uncis natural Chinese medicine of all originating, toxic and side effects is little, and noresidue, and these natural raw material of Chinese medicine and product thereof all can degrade in natural environment unlikelyly causes environmental pollution.
2. efficient the present invention, carries out the differential diagnosis in tcm opinion and controls prescription in conjunction with the research that causes the liver and kidney of livestock and poultry toxicity considerations will according to Basic Theories of Chinese Medicine, more meets the Chinese medicine feature, and product is through test, and effect is remarkable.
3. quality controllable product of the present invention is formulated quality standard, with jasminoidin, baicalin, Herba Artemisiae Scopariae control medicinal material and Rhizoma Polygoni Cuspidati control medicinal material as thin layer chromatography, with chlorogenic acid (C
16H
18O
9) meter, survey finished product Herba Artemisiae Scopariae content, steady quality, controlled.
The specific embodiment
Embodiment 1: a kind of Chinese medicine veterinary drug that strengthens detoxifying function of liver and kidney of livestock and poultry takes by weighing raw material (kg) by following proportioning: Herba Artemisiae Scopariae 36, Fructus Gardeniae 18, Rhizoma Polygoni Cuspidati 20, Radix Scutellariae 18, Ramulus Uncariae Cum Uncis 20, make granule through extraction.
Preparation method: with above Chinese medicine of the five flavours, decoct with water secondary jointly, each 1.0 hours, collecting decoction filters, filtrate is concentrated into 1: 1 (medical material: medicinal liquid), add 2 times of amount ethanol, left standstill (4 ℃) 24 hours, and filtered, being concentrated into relative density behind the filtrate recycling ethanol is the extractum of 1.30～1.35 (80 ℃); Get extractum, an amount of with sucrose, dextrin, mixing is granulated, cold drying, promptly.
This product contains Herba Artemisiae Scopariae with chlorogenic acid (C
16H
18O
9) meter, every 1g must not be less than 0.35mg.
Every 100g is equivalent to crude drug in whole 160g.
Embodiment 2: a kind of Chinese medicine veterinary drug that strengthens detoxifying function of liver and kidney of livestock and poultry takes by weighing raw material (kg) by following proportioning: Herba Artemisiae Scopariae 36, Fructus Gardeniae 18, Rhizoma Polygoni Cuspidati 20, Radix Scutellariae 18, Ramulus Uncariae Cum Uncis 20, make oral liquid through extraction.
Preparation method: with above Chinese medicine of the five flavours, decoct with water secondary jointly, each 1.0 hours, collecting decoction filters, filtrate is concentrated into 1: 1 (medical material: medicinal liquid), add 2 times of amount ethanol, left standstill (4 ℃) 24 hours, filter, filtrate recycling ethanol, medicinal liquid add the purified water dilution, transfer PH to 5.0-7.0, add an amount of antiseptic, add purified water and be adjusted to every 1ml and be equivalent to crude drug in whole 1.6g, fill, sterilization, promptly.
This product contains Herba Artemisiae Scopariae with chlorogenic acid (C
16H
18O
9) meter, every 1ml must not be less than 0.35mg.
Every 100ml is equivalent to crude drug in whole 160g.
Embodiment 3: a kind of Chinese medicine veterinary drug that strengthens detoxifying function of liver and kidney of livestock and poultry takes by weighing raw material (kg) by following proportioning: Herba Artemisiae Scopariae 36, Fructus Gardeniae 18, Rhizoma Polygoni Cuspidati 20, Radix Scutellariae 18, Ramulus Uncariae Cum Uncis 20, make injection through extraction.
Preparation method: with above Chinese medicine of the five flavours, decoct with water secondary jointly, each 1.0 hours, collecting decoction, filter filtrate is concentrated into 1: 1 (medical material: medicinal liquid), add 2 times of amount ethanol, left standstill (4 ℃) 24 hours, filter, filtrate recycling ethanol, medicinal liquid add 5 times of amount 95% ethanol, leave standstill (4 ℃) 24 hours, filter, filtrate recycling ethanol adds the injection dilute with water, transfer PH to 5.0-7.0, add the injection water again and be adjusted to every 1ml and be equivalent to crude drug in whole 1.6g, filter, fill, sterilization, promptly.
This product contains Herba Artemisiae Scopariae with chlorogenic acid (C
16H
18O
9) meter, every 1ml must not be less than 0.35mg.
Every 100ml is equivalent to crude drug in whole 160g.
Embodiment 4: a kind of Chinese medicine veterinary drug that strengthens detoxifying function of liver and kidney of livestock and poultry, take by weighing raw material (kg) by following proportioning: Herba Artemisiae Scopariae 36, Fructus Gardeniae 18, Rhizoma Polygoni Cuspidati 10, Radix Scutellariae 18, Ramulus Uncariae Cum Uncis 10, preparation method according to embodiment 1 is made granule, and the content of Herba Artemisiae Scopariae is identical with embodiment 1 in the finished product.
Embodiment 5: a kind of Chinese medicine veterinary drug that strengthens detoxifying function of liver and kidney of livestock and poultry, take by weighing raw material (kg) by following proportioning: Herba Artemisiae Scopariae 18, Fructus Gardeniae 9, Rhizoma Polygoni Cuspidati 10, Radix Scutellariae 9, Ramulus Uncariae Cum Uncis 10, preparation method according to embodiment 1 is made granule, and the content of Herba Artemisiae Scopariae is identical with embodiment 1 in the finished product.
Embodiment 6: a kind of Chinese medicine veterinary drug that strengthens detoxifying function of liver and kidney of livestock and poultry, take by weighing raw material (kg) by following proportioning: Herba Artemisiae Scopariae 24, Fructus Gardeniae 14, Rhizoma Polygoni Cuspidati 15, Radix Scutellariae 14, Ramulus Uncariae Cum Uncis 15, preparation method according to embodiment 1 is made granule, and the content of Herba Artemisiae Scopariae is identical with embodiment 1 in the finished product.
Now the Chinese medicine veterinary drug granule with the enhancing detoxifying function of liver and kidney of livestock and poultry of embodiment 1 is an example, with the duck is animal model, experiment by artificial challenge duckling viral hepatitis (DVH) proves its potentiation to detoxifying function of liver and kidney of livestock and poultry, and embodiment 2-6 has close effect through similarly experimental results show that.
1 test material
1.1 be subjected to the reagent thing: the Chinese medicine veterinary drug granule of enhancing detoxifying function of liver and kidney of livestock and poultry provided by the invention, provide by the Zhejiang greatly healthy animal health product company limited of gold, specification is the 100g/ bag, every 100g contains crude drug in whole 160g.
1.2 experimental animal: buy the Shaoxing sheldrake of 700 plumages, 1 age in days from fledgling poultry market, Xiaoshan, prerun 2 days, the healthy duckling a little less than eliminating behind the young bird is for test.
1.3 counteracting toxic substances pathological material of disease: get that to have the sick duck liver of DVH of typical cytopathic clinically dirty, grind to form tissue homogenate, dilute by 1: 10 with sterile saline behind the multigelation, it is an amount of to add mycillin, through the centrifugal 15min of 2000rpm, get behind the supernatant liquid filtering and use for infection experiment.
1.4 control drug: the DVH hyper-immune serum, by the self-control of poultry epidemic prevention quarantine station of Zhejiang Province Department of Agriculture.
2 test methods
2.1 grouping: establish 6 groups altogether, all under same feeding and management condition, carry out.It is as follows that each organizes disposition:
A group: normal control group 50 plumages, an age in days rises, and does not carry out the artificial challenge, also need not any medicine, with other group isolated rearing.
The B group: the prophylactic group, 100 plumages, an age in days rises, and drinking-water is with being subjected to the reagent thing, and consumption is every plumage 0.15g every day, and logotype 7 days is after medicinal liquid has been drunk, again for no medicine clear water.(down together)
C group: tried medication therapy groups: divide into high dose, middle dosage and three groups of low dosage, all after morbidity, offer medicine.
C1 group: high-dose therapy group: 100 plumages, mix drink, dosage every plumage 0.5g every day, logotype 5 days.
C2 group: middle dosage treatment group: 100 plumages, mix drink, dosage every plumage 0.3g every day, logotype 5 days.
C3 group: low dose therapy group: 100 plumages, mix drink, dosage every plumage 0.1g every day, logotype 5 days.
D group: hyper-immune serum treatment group: in morbidity back subcutaneous injection DVH hyper-immune serum, every plumage 1mL.
E group: infect matched group: will not any processing after the morbidity.
2.2 infection method: carry out the artificial challenge when 3 ages in days, except that normal control group A group, all the other are respectively organized the duckling oral administration and infect, and infect in the liquid input drinking-water drink-service by every plumage 0.01ml.
2.3 observation index: observe each group morbidity and death condition every day, write down dead plumage number, from offeing medicine back observed and recorded five days.
Duck has the death toll of listing in of DHV typical cytopathic to add up through cuing open inspection 2.4 die of illness.
3 result of the tests
3.1 incidence: behind the artificial challenge 24h partly duckling begin to occur down in spirits, anorexia, necking down, the wing that hangs down, symptom such as peel off, what have has a specificity nervous symptoms, whole body is twitched, is faced upward neck, head bends towards attitudes such as back, opisthotonus.Dead duck is cutd open inspection, and liver surface has the hemorrhage speckle that differs in size, the gallbladder enlargement, and the also generation enlargement that spleen has is mottling.Any symptom does not appear in normal control group experimental period, and none death.
3.2 respectively organizing death condition sees the following form:
Death condition table (unit: plumage) is respectively organized in test
3.3 after the off-test, get normal control group duckling 10 plumages, every plumage gavages and is subjected to reagent thing 1g, does not find untoward reaction in 2 days.
4 conclusions
4.1 this result of the test shows, the mortality rate that is tried medication therapy groups can be controlled substantially back three days of treatment.From efficacy analysis, specific serum treatment group and prophylactic group are better than being tried medication therapy groups after the morbidity.
4.2 tried in the medication therapy groups, high dose group and middle dosage group therapeutic equivalence, the low dose group curative effect is relatively poor.
4.3 from test result analysis: be subjected to the reagent thing prevention of duckling viral hepatitis and therapeutical effect all obviously to be better than the matched group of not treating, show that this product can be used for the prevention and the treatment of duckling viral hepatitis, have the effect that strengthens duckling Liver and kidney function of detoxification, and safety, have no adverse reaction.
4.4 recommended drug amount: can adopt 0.3g/ plumage day during treatment, 0.15-0.2g/ plumage day during prevention.
At last, it is also to be noted that what more than enumerate only is some specific embodiments of the present invention.If those of ordinary skills from all distortion that content disclosed by the invention directly derives or associates, all should think protection scope of the present invention.
Claims (3)
1. a Chinese medicine veterinary drug that strengthens detoxifying function of liver and kidney of livestock and poultry is characterized in that its recipe ingredient (by weight) is: 18～36 parts of Herba Artemisiae Scopariaes, 9～18 parts of Fructus Gardeniaes, 10～20 parts of Rhizoma Polygoni Cuspidati, 9～18 parts of Radix Scutellariaes, 10～20 parts of Ramulus Uncariae Cum Uncis.
2. the Chinese medicine veterinary drug of the described enhancing detoxifying function of liver and kidney of livestock and poultry of claim 1 is characterized in that its recipe ingredient (by weight) is: 36 parts of Herba Artemisiae Scopariaes, 18 parts of Fructus Gardeniaes, 20 parts of Rhizoma Polygoni Cuspidati, 18 parts of Radix Scutellariaes, 20 parts of Ramulus Uncariae Cum Uncis.
3. the Chinese medicine veterinary drug of enhancing detoxifying function of liver and kidney of livestock and poultry according to claim 1 and 2 is characterized in that: its dosage form is granule, oral liquid, tablet, powder or injection.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200910101870A CN101637519A (en) | 2009-08-28 | 2009-08-28 | Traditional Chinese veterinary medicine for reinforcing detoxifying function of liver and kidney of livestock and poultry |
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|---|---|---|---|
| CN200910101870A CN101637519A (en) | 2009-08-28 | 2009-08-28 | Traditional Chinese veterinary medicine for reinforcing detoxifying function of liver and kidney of livestock and poultry |
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| CN101637519A true CN101637519A (en) | 2010-02-03 |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102100775A (en) * | 2011-01-24 | 2011-06-22 | 四川国康药业有限公司 | Anti-hepatitis-virus medicament composition as well as preparation method and application thereof |
| CN102526226A (en) * | 2011-12-31 | 2012-07-04 | 沈阳药科大学 | Application of traditional Chinese medicine prescription in aspect of relieving liver and kidney toxicity |
| CN102640876A (en) * | 2012-05-22 | 2012-08-22 | 山东新希望六和集团有限公司 | Feed and injection used for treating duck virus hepatitis and preparation method of feed and injection |
| CN102772738A (en) * | 2012-07-19 | 2012-11-14 | 江西正邦动物保健品有限公司 | Superfine powder traditional Chinese medicine for hepatorenal protection of livestock and preparation method thereof |
| CN106361854A (en) * | 2016-08-30 | 2017-02-01 | 林州中农颖泰生物肽有限公司 | Herba artemisiae scopariae and fructus gardeniae effervescent granules with detoxifying efficacy and preparation method thereof |
-
2009
- 2009-08-28 CN CN200910101870A patent/CN101637519A/en active Pending
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102100775A (en) * | 2011-01-24 | 2011-06-22 | 四川国康药业有限公司 | Anti-hepatitis-virus medicament composition as well as preparation method and application thereof |
| CN102526226A (en) * | 2011-12-31 | 2012-07-04 | 沈阳药科大学 | Application of traditional Chinese medicine prescription in aspect of relieving liver and kidney toxicity |
| CN102640876A (en) * | 2012-05-22 | 2012-08-22 | 山东新希望六和集团有限公司 | Feed and injection used for treating duck virus hepatitis and preparation method of feed and injection |
| CN102640876B (en) * | 2012-05-22 | 2013-06-12 | 山东新希望六和集团有限公司 | Feed and injection used for treating duck virus hepatitis and preparation method of feed and injection |
| CN102772738A (en) * | 2012-07-19 | 2012-11-14 | 江西正邦动物保健品有限公司 | Superfine powder traditional Chinese medicine for hepatorenal protection of livestock and preparation method thereof |
| CN102772738B (en) * | 2012-07-19 | 2014-03-19 | 江西正邦动物保健品有限公司 | Superfine powder traditional Chinese medicine for hepatorenal protection of livestock and preparation method thereof |
| CN106361854A (en) * | 2016-08-30 | 2017-02-01 | 林州中农颖泰生物肽有限公司 | Herba artemisiae scopariae and fructus gardeniae effervescent granules with detoxifying efficacy and preparation method thereof |
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Open date: 20100203 |