CN102552600B - Traditional Chinese medicine for preventing and treating chicken infectious laryngotracheitis and production method thereof - Google Patents
Traditional Chinese medicine for preventing and treating chicken infectious laryngotracheitis and production method thereof Download PDFInfo
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- CN102552600B CN102552600B CN201210025529XA CN201210025529A CN102552600B CN 102552600 B CN102552600 B CN 102552600B CN 201210025529X A CN201210025529X A CN 201210025529XA CN 201210025529 A CN201210025529 A CN 201210025529A CN 102552600 B CN102552600 B CN 102552600B
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Abstract
The invention discloses a traditional Chinese medicine for preventing and treating chicken infectious laryngotracheitis and a production method of the traditional Chinese medicine. The traditional Chinese medicine is prepared from the following raw material drugs according to a weight ratio: 100-400 of honeysuckle, 100-400 of radix scutellariae, 100-400 of tuber pinellia processed with ginger, 100-400 of dried orange peel, 100-400 of tuckahoe and 60-200 of licorice, wherein the honeysuckle, radix scutellariae, tuber pinellia processed with ginger, dried orange peel, tuckahoe and licorice are processed and extracted according to the amount so as to prepare into oral liquid, granulates, fluid extract, extract, powder, ultramicro powder and any pharmaceutical preparations capable of being clinically applied. The traditional Chinese medicine is significant in curative effect, is taken by drinking water or mixing with other materials, and is very convenient for transportation, storage and use.
Description
Technical field
The invention belongs to the animal and veterinary field, relate to a kind of Chinese medicine of preventing and treating infectious laryngotracheitis of chicken and preparation method thereof that is mainly used in.
Background technology
Infectious laryngotracheitis of chicken (ILT) is the chicken acute upper respiratory tract infectious disease caused by a kind of herpes simplex virus group.Primary disease be characterized as dyspnea, breathe, expectoration band blood system secretion, throat and tracheal mucosa swelling, hemorrhage, and form rotten to the cornly, sickness rate during the acute outburst of this disease can reach 100%, case fatality rate is generally in 20% left and right.There is laryngotracheitis to exist majority state is verified at present, and remain particularly a kind of serious disease of large chicken group of susceptible chicken group, often to poultry husbandry, cause heavy blow.
Aspect the prevention of primary disease, the immune effect of inactivated vaccine is poor, and there is again loose malicious danger in weak malicious Seedling.For this reason, Drug therapy remains indispensable control measure.Yet at present the unique medicine that is allowed for treating ILT of country is only " HOUYANJING SAN " that " two ones of Chinese veterinary pharmacopoeias " records.This powder dosage is large, processing technology thereof is coarse simple, with low content of technology, and a large amount of useless compositions even harmful components are taken simultaneously, cause curative effect not satisfactory.And HOUYANJING SAN needs spice to add, transportation, storage and use are all very inconvenient, and more inconvenient for the spice interpolation of pellet, therefore large-scale intensive culture field is just more and more lower to the frequency of utilization of HOUYANJING SAN.HOUYANJING SAN, because containing two mineral substance medicines of Realgar and Matrii Sulfas Exsiccatus, is made oral liquid, granule and extractum etc. and be not suitable for further extraction.
Summary of the invention
Purpose of the present invention solves the above-mentioned problems in the prior art exactly, provides a kind of evident in efficacy, and drinking-water or spice add, and transportation, storage and use all prevent and treat Chinese medicine of infectious laryngotracheitis of chicken and preparation method thereof very easily.
For achieving the above object, technical solution of the present invention is: a kind of Chinese medicine of preventing and treating infectious laryngotracheitis of chicken, it is made by following crude drug, by weight calculating, Flos Lonicerae 100-400, Radix Scutellariae 100-400, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 100-400, Pericarpium Citri Reticulatae 100-400, Poria 100-400, Radix Glycyrrhizae 60-200.
The manufacture method of the Chinese medicine of control infectious laryngotracheitis of chicken described above, extract described Flos Lonicerae, Radix Scutellariae, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Pericarpium Citri Reticulatae, Poria and Radix Glycyrrhizae to make oral liquid or granulation agent or make fluid extract or make extractum or make powder or make superfine powder according to described amount processing.Usage and the consumption of this pharmaceutical preparation are: the corresponding preparations that the 2g raw medicinal herbs is made is watered 1L or spice 0.5kg, for fowl, is used in conjunction 4～6 days.Take oral liquid as example, can be made into the oral liquid of 1ml containing the 1g raw medicinal herbs, mixed drink, every 2ml is watered 1L, for fowl, drinks, and is used in conjunction 4～6 days.
From Chinese veterinarian's medicine theory, this Chinese medicine is with the Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) drying dampness to eliminate phlegm, and stopping nausea and vomiting by lowering the adverse flow of QI is principal agent; Because having pathogenic heat more, productive cough due to phlegm-damp violates lung and pestilential pathogen, therefore with Flos Lonicerae, Radix Scutellariae reducing heat and dispersing lung-QI, the removing toxic substances pathogenic fire purging; With the Pericarpium Citri Reticulatae activating QI to eliminate phlegm, the suitable expectorant of gas falls again, and the expectorant that gasifies disappears; Again because of expectorant by humidogene, the spleen rehabilitation is transported turbid damp and can be changed, and wetly goes expectorant to disappear, therefore take the Poria invigorating spleen to remove dampness as assistant; Make, with Radix Glycyrrhizae and middle spleen invigorating, to coordinate all medicines.Six medicines share, and play altogether the effect of heat clearing and damp drying, preventing phlegm from forming and stopping coughing, regulating the flow of Qi and the middle Jiao, for the control of infectious laryngotracheitis of chicken and the warm cough that causes thereof.
From the modern medicine theory, the Flos Lonicerae heat-clearing and toxic substances removing, the heat radiation dispelling wind, cure mainly the epidemic febrile disease heating, anemopyretic cold, cough due to lung-heat, laryngopharynx swelling and pain, toxic-heat and blood stasis etc.; The Radix Scutellariae heat clearing and damp drying, eliminating fire and detoxication, cure mainly the cough due to lung-heat, the greedy drink of high heat, carbuncle sore tumefacting virus, damp-heat dysentery etc.Silver yellow two medicines are all the key medicine of heat-clearing and toxic substances removing, are widely used in the treatment of Various Diseases viral disease.Infectious laryngotracheitis of chicken is the commonly encountered diseases toxicity disease of veterinary clinic, belongs to the pestilence category, controls suitable heat-clearing and toxic substances removing, thus first-selected silver yellow two medicines, and inhibition and killing action that this two medicine share avian infectious laryngotracheitis virus significantly strengthen.Simultaneously, the Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) of compatibility drying dampness to eliminate phlegm, Pericarpium Citri Reticulatae, the Poria of invigorating spleen to remove dampness, and coordinating the actions of various ingredients in a prescription Radix Glycyrrhizae, reach the effect of the ILT of the warm cough for the treatment of performance jointly.
The present invention is evident in efficacy, and drinking-water or spice add, and transportation, storage and use are all very convenient.
The clinical effect trial report
1 experimental animal is processed and grouping
240 60 basically identical age in days test chickens of body condition are divided into to the VI group, 40 every group at random.According to the trial test observed result, most chickens 36h morbidity after contamination in the chicken group.Therefore, the drug test group, after collunarium contamination 36h, is thrown in respectively the medicine of corresponding dosage in drinking-water or feedstuff, 2 times/d, is used in conjunction 5d.Test chicken is freely drunk water and is searched for food.Observe the clinical symptoms of chicken before and after medication, from administration, record the death toll of chicken every day, and before medication, (after counteracting toxic substances within 36h) died is disregarded, and finally adds up mortality rate and medicine effective percentage and the cure rate to chickling.The normal healthy controls group is virus inoculation not, also to medicine, does not process.Refer to table 1.
Table 1 test grouping and medication
2 result of the tests
After administration 7 days, statistics is respectively organized mortality rate, cure rate, effective percentage, in Table 2.
The therapeutic outcome of the different Chinese medicinal formulaes of table 2 to artificial challenge ILT
As can be seen from Table 2, the normal healthy controls group is not contaminated and is raised separately, without morbidity and dead; The middle and high dosage group of the present invention mortality rate is only 5.0% and 7.5%, is starkly lower than the model control group that low dose group and HOUYANJING SAN group and contamination are not treated.From effective percentage, middle and high dosage group reaches respectively 95.0% and 92.5%, apparently higher than low dose group and HOUYANJING SAN group.From cure rate, middle and high dosage group reaches respectively 92.5% and 90.0%, equally higher than low dose group and HOUYANJING SAN group.
Result of the test shows, after medication, the middle and high dosage group of the present invention mortality rate is minimum, and effective percentage and cure rate are the highest, curative effect the best.Therefore in the recommendering folder invention, dosage is the clinical application amount.
3 conclusions
Chinese medicine drinking-water of the present invention administration, high, middle dosage group all can significantly improve the cure rate of the infectious laryngotracheitis of chicken of the warm cough of performance.Therefore in recommending, the dosage group is quantity, that is, drinking-water, chicken, 2ml/L water (0.2%), every day 2 times, be used in conjunction 5 days.
The specific embodiment
Below in conjunction with specific embodiment, the present invention will be further described.
Embodiment 1, a kind of Chinese medicine of preventing and treating infectious laryngotracheitis of chicken, and it is made by following crude drug, by weight calculating, Flos Lonicerae 100, Radix Scutellariae 400, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 100, Pericarpium Citri Reticulatae 100, Poria 240, Radix Glycyrrhizae 60.
Embodiment 2: a kind of Chinese medicine of preventing and treating infectious laryngotracheitis of chicken, and it is made by following crude drug, by weight calculating, Flos Lonicerae 200, Radix Scutellariae 300, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 200, Pericarpium Citri Reticulatae 100, Poria 100, Radix Glycyrrhizae 100.
Embodiment 3: a kind of Chinese medicine of preventing and treating infectious laryngotracheitis of chicken, and it is made by following crude drug, by weight calculating, Flos Lonicerae 300, Radix Scutellariae 200, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 100, Pericarpium Citri Reticulatae 100, Poria 150, Radix Glycyrrhizae 150.
Embodiment 4: a kind of Chinese medicine of preventing and treating infectious laryngotracheitis of chicken, and it is made by following crude drug, by weight calculating, Flos Lonicerae 400, Radix Scutellariae 100, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 100, Pericarpium Citri Reticulatae 100, Poria 100, Radix Glycyrrhizae 200.
Embodiment 5: a kind of Chinese medicine of preventing and treating infectious laryngotracheitis of chicken, and it is made by following crude drug, by weight calculating, Flos Lonicerae 160, Radix Scutellariae 160, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 300, Pericarpium Citri Reticulatae 200, Poria 100, Radix Glycyrrhizae 80.
Embodiment 6: a kind of Chinese medicine of preventing and treating infectious laryngotracheitis of chicken, and it is made by following crude drug, by weight calculating, Flos Lonicerae 120, Radix Scutellariae 150, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 100, Pericarpium Citri Reticulatae 300, Poria 200, Radix Glycyrrhizae 130.
Embodiment 7: a kind of Chinese medicine of preventing and treating infectious laryngotracheitis of chicken, and it is made by following crude drug, by weight calculating, Flos Lonicerae 100, Radix Scutellariae 100, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 100, Pericarpium Citri Reticulatae 400, Poria 180, Radix Glycyrrhizae 120.
Embodiment 8: a kind of Chinese medicine of preventing and treating infectious laryngotracheitis of chicken, and it is made by following crude drug, by weight calculating, Flos Lonicerae 150, Radix Scutellariae 150, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 400, Pericarpium Citri Reticulatae 100, Poria 100, Radix Glycyrrhizae 100.
Embodiment 9: a kind of Chinese medicine of preventing and treating infectious laryngotracheitis of chicken, and it is made by following crude drug, by weight calculating, Flos Lonicerae 100, Radix Scutellariae 120, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 180, Pericarpium Citri Reticulatae 200, Poria 300, Radix Glycyrrhizae 100.
Embodiment 10: a kind of Chinese medicine of preventing and treating infectious laryngotracheitis of chicken, and it is made by following crude drug, by weight calculating, Flos Lonicerae 200, Radix Scutellariae 100, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 100, Pericarpium Citri Reticulatae 100, Poria 400, Radix Glycyrrhizae 100.
The Chinese medicine of above embodiment can be processed to extract and make oral liquid, also can be made into granule, fluid extract, extractum, powder, superfine powder and any pharmaceutical preparation for clinical practice.
Claims (2)
1. a Chinese medicine of preventing and treating infectious laryngotracheitis of chicken, it is characterized in that: it is made by following crude drug, by weight calculating, Flos Lonicerae 100-400, Radix Scutellariae 100-400, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 100-400, Pericarpium Citri Reticulatae 100-400, Poria 100-400, Radix Glycyrrhizae 60-200.
2. the manufacture method of the Chinese medicine of a control infectious laryngotracheitis of chicken claimed in claim 1, is characterized in that: described Flos Lonicerae, Radix Scutellariae, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Pericarpium Citri Reticulatae, Poria and Radix Glycyrrhizae are extracted and make oral liquid or granulation agent or make fluid extract or make extractum or make powder or make superfine powder according to described amount processing.
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| CN104206710B (en) * | 2014-08-15 | 2017-05-17 | 亚太兴牧(北京）科技有限公司 | Traditional Chinese medicinal feed additive containing N-carbamylglutamic acid, and its application |
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| CN101269168A (en) * | 2008-04-14 | 2008-09-24 | 王鲁云 | Traditional Chinese medicine for treating cough and asthma of children |
| CN101417065A (en) * | 2008-11-24 | 2009-04-29 | 律北平 | Oral traditional Chinese medicine formulation for treating chronic tracheitis |
| CN101584806A (en) * | 2009-05-26 | 2009-11-25 | 韩四缺 | Pure traditional Chinese medicine composition for treating avian influenza, preparing method and application thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101269168A (en) * | 2008-04-14 | 2008-09-24 | 王鲁云 | Traditional Chinese medicine for treating cough and asthma of children |
| CN101417065A (en) * | 2008-11-24 | 2009-04-29 | 律北平 | Oral traditional Chinese medicine formulation for treating chronic tracheitis |
| CN101584806A (en) * | 2009-05-26 | 2009-11-25 | 韩四缺 | Pure traditional Chinese medicine composition for treating avian influenza, preparing method and application thereof |
Non-Patent Citations (2)
| Title |
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| 中药防治鸡传染性呼吸道疾病的研究现况与展望;朱连勤等;《中兽医学杂志》;20030430(第4期);35-36页 * |
| 朱连勤等.中药防治鸡传染性呼吸道疾病的研究现况与展望.《中兽医学杂志》.2003,(第4期), |
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Denomination of invention: A traditional Chinese medicine for prevention and treatment of infectious laryngotracheitis and its preparation method Effective date of registration: 20210115 Granted publication date: 20131204 Pledgee: China Construction Bank Gaoyang sub branch Pledgor: BAODING JIZHONG PHARMACEUTICAL Co.,Ltd. Registration number: Y2021980000409 |
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