CH156933A - Process for the preparation of a double compound of the pyridine series. - Google Patents

Process for the preparation of a double compound of the pyridine series.

Info

Publication number
CH156933A
CH156933A CH156933DA CH156933A CH 156933 A CH156933 A CH 156933A CH 156933D A CH156933D A CH 156933DA CH 156933 A CH156933 A CH 156933A
Authority
CH
Switzerland
Prior art keywords
double compound
preparation
pyridine
pyridine series
compound
Prior art date
Application number
Other languages
German (de)
Inventor
Gesellschaft Fuer Chemis Basel
Original Assignee
Chem Ind Basel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chem Ind Basel filed Critical Chem Ind Basel
Publication of CH156933A publication Critical patent/CH156933A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)

Description

  

      Verfahren    zur Darstellung     einer    Doppelverbindung der     Pyridinreihe.       Es wurde gefunden, dass man zu einer  Doppelverbindung der     Pyridinreihe    gelangen  kann, wenn man 2     Mol        Nicotinsäurediäthyl-          amid    auf 1     Mol        Galciumbromid    einwirken  lässt. Die Reaktion kann in An- oder Ab  wesenheit eines Lösungsmittels ausgeführt  werden.  



  Die neue Doppelverbindung bildet weisse  Kristalle. Sie ist in Wasser und warmem  Alkohol löslich, in Aceton und Essigäther  unlöslich.  



  Das neue Produkt soll sowohl zur Ab  scheidung und Reinigung der zugrunde lie  genden     Pyridinverbindung,    wie auch zu thera  peutischen Zwecken Verwendung finden.  



  <I>Beispiel:</I>  35,6 Teile     Nicotinsäurediäthylamid    und  20 Teile     Calciumbromid    werden in Wasser  gelöst und die Lösung zur Trockne verdampft.  Die gebildete Doppelverbindung lässt sich aus  Alkohol     umkristallisieren.  



      Process for the preparation of a double compound of the pyridine series. It has been found that a double compound of the pyridine series can be obtained if 2 moles of diethyl nicotinic acid are allowed to act on 1 mole of calcium bromide. The reaction can be carried out in the presence or absence of a solvent.



  The new double compound forms white crystals. It is soluble in water and warm alcohol, insoluble in acetone and vinegar ether.



  The new product is intended to be used both for separating and purifying the underlying pyridine compound as well as for therapeutic purposes.



  <I> Example: </I> 35.6 parts of nicotinic acid diethylamide and 20 parts of calcium bromide are dissolved in water and the solution is evaporated to dryness. The double compound formed can be recrystallized from alcohol.

Claims (1)

PATENTANSPRUCH Verfahren zur Darstellung einer Doppel verbindung der Pyridinreihe, dadurch ge kennzeichnet, dass man 2 Mol Nicotinsäure- diäthylamid auf 1 Mol Calciumbromid ein wirken lässt. ' Die neue Doppelverbindung bildet weisse .Kristalle. Sie ist in Wasser und warmem Alkohol löslich, in Aceton und Essigäther unlöslich. Das neue Produkt soll sowohl zur Ab scheidung und Reinigung der zugrunde lie genden Pyridinverbindung, wie auch zu thera peutischen Zwecken Verwendung finden. PATENT CLAIM Process for the production of a double compound of the pyridine series, characterized in that 2 mol of nicotinic acid diethylamide are allowed to act on 1 mol of calcium bromide. 'The new double compound forms white crystals. It is soluble in water and warm alcohol, insoluble in acetone and vinegar ether. The new product is intended to be used both for separating and purifying the underlying pyridine compound as well as for therapeutic purposes. - UNTERANSPRUCH: Verfahren nach Patentanspruch, dadurch gekennzeichnet, dass man die Reaktion in Gegenwart eines Lösungsmittels ausführt. - SUBCLAIM: Process according to claim, characterized in that the reaction is carried out in the presence of a solvent.
CH156933D 1931-03-07 1931-03-07 Process for the preparation of a double compound of the pyridine series. CH156933A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH154815T 1931-03-07
CH156933T 1931-03-07

Publications (1)

Publication Number Publication Date
CH156933A true CH156933A (en) 1932-08-31

Family

ID=25716503

Family Applications (1)

Application Number Title Priority Date Filing Date
CH156933D CH156933A (en) 1931-03-07 1931-03-07 Process for the preparation of a double compound of the pyridine series.

Country Status (1)

Country Link
CH (1) CH156933A (en)

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