CH156931A - Process for the preparation of a double compound of the pyridine series. - Google Patents

Process for the preparation of a double compound of the pyridine series.

Info

Publication number
CH156931A
CH156931A CH156931DA CH156931A CH 156931 A CH156931 A CH 156931A CH 156931D A CH156931D A CH 156931DA CH 156931 A CH156931 A CH 156931A
Authority
CH
Switzerland
Prior art keywords
double compound
preparation
pyridine
pyridine series
compound
Prior art date
Application number
Other languages
German (de)
Inventor
Gesellschaft Fuer Chemis Basel
Original Assignee
Chem Ind Basel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chem Ind Basel filed Critical Chem Ind Basel
Publication of CH156931A publication Critical patent/CH156931A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)

Description

  

  Verfahren zur Darstellung einer Doppelverbindung der     Pyridinreihe.       Es wurde gefunden, dass man zu einer  Doppelverbindung der     Pyridinreihe    gelangen  kann, wenn man 2     Mol        Nicotinsäurediäthyl-          amid    auf 1     Mol        Calciumchlorid    einwirken  lässt. Die Reaktion kann in An- oder in  Abwesenheit eines Lösungsmittels ausgeführt  werden.  



  Die neue Doppelverbindung bildet weisse  Kristalle. Sie ist in Wasser und Essigäther  löslich, aber unlöslich in Aceton.  



  Das neue Produkt soll sowohl zur Ab  scheidung und Reinigung der zu Grunde  liegenden     Pyridinverbindung,    wie auch zu  therapeutischen Zwecken Verwendung finden.  <I>Beispiel:</I>  356 Teile     Nicotinsäurediäthylamid    wer  den mit 111 Teilen fein gepulvertem Cal  ciumchlorid gut verrührt. Unter Selbsterwär  mung setzt die     Reaktion    ein. Sie wird durch  Erwärmen auf dem Wasserbad vervollstän  digt. Die gebildete Doppelverbindung erstarrt    zu einer festen Masse, die aus Alkohol um  kristallisiert, weisse Kristalle bildet.



  Process for the preparation of a double compound of the pyridine series. It has been found that a double compound of the pyridine series can be obtained if 2 mol of nicotinic acid diethyl amide are allowed to act on 1 mol of calcium chloride. The reaction can be carried out in the presence or in the absence of a solvent.



  The new double compound forms white crystals. It is soluble in water and vinegar, but insoluble in acetone.



  The new product is intended to be used for separating and purifying the underlying pyridine compound as well as for therapeutic purposes. <I> Example: </I> 356 parts of nicotinic acid diethylamide who are mixed well with 111 parts of finely powdered calcium chloride. The reaction starts with self-heating. It is completed by heating on the water bath. The double compound formed solidifies to a solid mass, which crystallizes from alcohol to form white crystals.

Claims (1)

PATENTANSPRUCH: Verfahren zur Darstellung einer Doppel verbindung der Pyridinreihe, dadurch ge kennzeichnet, dass man 2 Mol Nicotinsäure- diäthylamid auf 1 Mol Galciumchlorid ein wirken lässt. Die neue Doppelverbindung bildet weisse Kristalle. Sie ist in Wasser und Essigäther löslich, aber unlöslich in Aceton. Das neue Produkt soll sowohl zur Ab scheidung und Reinigung der zu Grunde liegenden Pyridinverbindung, wie auch zu therapeutischen Zwecken Verwendung finden. PATENT CLAIM: Process for the production of a double compound of the pyridine series, characterized in that 2 mol of nicotinic acid diethylamide are allowed to act on 1 mol of calcium chloride. The new double compound forms white crystals. It is soluble in water and vinegar, but insoluble in acetone. The new product is intended to be used for separating and purifying the underlying pyridine compound as well as for therapeutic purposes. UNTERANSPRUCH: Verfahren nach Patentanspruch, dadurch gekennzeichnet, dass man die Reaktion in Gegenwart eines Lösungsmittels ausführt. SUBCLAIM: Process according to claim, characterized in that the reaction is carried out in the presence of a solvent.
CH156931D 1931-03-07 1931-03-07 Process for the preparation of a double compound of the pyridine series. CH156931A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH154815T 1931-03-07
CH156931T 1931-03-07

Publications (1)

Publication Number Publication Date
CH156931A true CH156931A (en) 1932-08-31

Family

ID=25716501

Family Applications (1)

Application Number Title Priority Date Filing Date
CH156931D CH156931A (en) 1931-03-07 1931-03-07 Process for the preparation of a double compound of the pyridine series.

Country Status (1)

Country Link
CH (1) CH156931A (en)

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