CH156932A - Process for the preparation of a double compound of the pyridine series. - Google Patents

Process for the preparation of a double compound of the pyridine series.

Info

Publication number
CH156932A
CH156932A CH156932DA CH156932A CH 156932 A CH156932 A CH 156932A CH 156932D A CH156932D A CH 156932DA CH 156932 A CH156932 A CH 156932A
Authority
CH
Switzerland
Prior art keywords
water
double compound
preparation
pyridine
pyridine series
Prior art date
Application number
Other languages
German (de)
Inventor
Gesellschaft Fuer Chemis Basel
Original Assignee
Chem Ind Basel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chem Ind Basel filed Critical Chem Ind Basel
Publication of CH156932A publication Critical patent/CH156932A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Description

  

  Verfahren     zur    Darstellung einer     Doppelverbindung    der     Pyridinr        eihe.       Es wurde gefunden, dass man zu einer  Doppelverbindung der     Pyridinreihe    gelangen  kann, wenn man 2     Mo1        Nieotinsäurediäthyl-          amid    auf 1     Dlol        Calciumrhodanid    einwirken  lässt. Die Reaktion kann in An- oder in Ab  wesenheit eines Lösungsmittels ausgeführt  werden.  



  Die neue Doppelverbindung bildet weisse  Kristalle. Sie ist in Alkohol und Wasser  löslich, in Aceton und Essigäther schwer  löslich. Aus Wasser kristallisiert sie mit  2     Mol    Kristallwasser, das sie durch Erhitzen  im Vakuum verliert.  



  Das neue Produkt soll sowohl zur Ab  scheidung und Reinigung der zugrunde lie  genden     Pyridinverbindung,    wie auch zu thera  peutischen Zwecken Verwendung finden.  



  <I>Beispiel:</I>  229 Teile kristallwasserhaltiges     Calcium-          rhodanid,    entsprechend     156    Teilen wasser  freiem, werden in 230 Teilen Wasser gelöst  und mit 356 Teilen     Nicotinsäurediäthylamid     versetzt. Nachdem Lösung eingetreten ist,  beginnt unter Erwärmung die Kristallisation  der neuen Doppelverbindung.     .plan    erwärmt    kurz auf dem Wasserbade, kühlt und saugt  die weissen Kristalle ab.



  Process for the preparation of a double compound of the pyridine series. It has been found that a double compound of the pyridine series can be obtained if 2 mol of diethyl amide are allowed to act on 1 mol of calcium rhodanide. The reaction can be carried out in the presence or absence of a solvent.



  The new double compound forms white crystals. It is soluble in alcohol and water, sparingly soluble in acetone and vinegar ether. It crystallizes from water with 2 moles of water of crystallization, which it loses by heating in a vacuum.



  The new product is intended to be used both for separating and purifying the underlying pyridine compound as well as for therapeutic purposes.



  <I> Example: </I> 229 parts of calcium rhodanide containing water of crystallization, corresponding to 156 parts of anhydrous, are dissolved in 230 parts of water and mixed with 356 parts of nicotinic acid diethylamide. After the solution has occurred, the crystallization of the new double compound begins with heating. .plan warms up briefly on the water bath, cools and sucks off the white crystals.

Claims (1)

PATENTANSPRUCH: Verfahren zur Darstellung einer Doppel verbindung der Pyridinreihe, dadurch gekenn zeichnet, dass man 2 Mol Nicotinsäurediäthyl- amid auf 1 Mol Calciumrhodanid einwirken lässt. Die neue Doppelverbindung bildet weisse Kristalle. Sie ist in Alkohol und Wasser löslich, in Aceton und Essigäther schwer lös lich. Aus Wasser kristallisiert sie mit 2 Mo1 Kristallwasser, das sich durch Erhitzen im Vakuum verliert. PATENT CLAIM: Process for the production of a double compound of the pyridine series, characterized in that 2 moles of diethyl nicotinic acid are allowed to act on 1 mole of calcium rhodanide. The new double compound forms white crystals. It is soluble in alcohol and water, poorly soluble in acetone and vinegar ether. It crystallizes from water with 2 Mo1 of crystal water, which is lost by heating in a vacuum. Das neue Produkt soll sowohl zur Ab scheidung und Reinigung der zu Grunde liegenden Pyridinverbindung, wie auch zu therapeutischen Zwecken Verwendung finden UNTERANSPRUCH: Verfahren nach Patentanspruch, dadurch gekennzeichnet, dass man die Reaktion in Gegenwart eines Lösungsmittels ausführt. The new product is intended to be used both for separating and purifying the underlying pyridine compound, as well as for therapeutic purposes. SUBSTANTIAL CLAIM: Process according to patent claim, characterized in that the reaction is carried out in the presence of a solvent.
CH156932D 1931-03-07 1931-03-07 Process for the preparation of a double compound of the pyridine series. CH156932A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH154815T 1931-03-07
CH156932T 1931-03-07

Publications (1)

Publication Number Publication Date
CH156932A true CH156932A (en) 1932-08-31

Family

ID=25716502

Family Applications (1)

Application Number Title Priority Date Filing Date
CH156932D CH156932A (en) 1931-03-07 1931-03-07 Process for the preparation of a double compound of the pyridine series.

Country Status (1)

Country Link
CH (1) CH156932A (en)

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