RBP3

RBP3
식별자
에일리어스	RBP3, D10S64, D10S65, D10S66, IRBP, RBPI, RP66, 레티놀결합단백질3
외부 ID	OMIM: 180290 MGI: 97878 HomoloGene: 9261 GeneCard: RBP3
유전자 위치(인간)
크르.	10번 염색체(인간)
끝.	47,357,881 bp
유전자 위치(마우스)
크르.	14번 염색체(쥐)
끝.	33,686,173 bp
RNA발현패턴
	상단 표시 위치:
	망막 색소 상피; ; 해마 형성; ; 고유 해마; ; 간뇌; ; 전두엽; ; 전전두피질; ; 흑색 실체; ; 척수; ; 브로드만 9구역; ; 십이지장;
	상단 표시 위치:
	망막 색소 상피; ; 송과선; ; 외핵층; ; 우심실; ; 홍채; ; 각막; ; 안외근; ; 측두근; ; 결막공; ; 목덜미;
	추가 참조 표현식 데이터
	추가 참조 표현식 데이터
유전자 존재론
분자 함수	세린형펩티드가수분해효소활성; 레티노이드 결합; 망막 결합; 레티놀 결합;
셀룰러 컴포넌트	세포외 소포; 세포외 영역; 광수용체간매트릭스; 세포외 공간; 원추 매트릭스 시스;
생물학적 과정	단백질 분해; 레티노이드 대사 과정; 지질대사; 시각 지각; 운송;
	출처:아미고 / QuickGO
맞춤법
	5949
	19661
	ENSG00000265203
	ENSMUSG000041534
	P10745
	P49194
	NM_002900
	NM_015745
	NP_002891
	NP_056560
	위키데이터
인간 보기/편집	마우스 표시/편집

레티놀결합단백질3, 인터스티셜(RBP3)은 IRBP3 ^[5]유전자에 의해 인체 내에서 코드되는 단백질이다.RBP3 정형어는^[6] 텐렉과 아르마딜로를 제외한 대부분의 공정에서 확인되었습니다.

기능.

광수용체 간 레티노이드 결합 단백질은 레티노이드 결합으로 알려진 큰 당단백질이며 주로 망막 색소 상피와 광수용체 세포 사이의 망막의 광수용체 간 매트릭스에서 발견된다.그것은 망막 색소 상피와 광수용체 사이에서 레티노이드를 운반하는 것으로 생각되는데, 이는 시각 과정에서 중요한 역할을 한다.

진

인간의 IRBP 유전자는 길이가 약 9.5kbp이고 3개의 인트론으로 분리된 4개의 엑손으로 구성되어 있다.인트론의 길이는 1.6~1.9kbp입니다.이 유전자는 광수용체와 망막아세포종 세포에 의해 약 4.3킬로베이스의 mRNA로 전사되며, 이 mRNA는 135,000Da의 글리코실화 단백질로 번역 및 처리된다.

구조.

인간 IRBP의 아미노산 배열은 33-38%의 동일성을 가진 4개의 연속된 호몰로지 도메인으로 나눌 수 있으며, 이는 일련의 유전자 복제 현상을 시사한다.유전자에서 이들 도메인의 경계는 예상대로 엑손-인트론 접합에 의해 정의되지 않는다.첫 번째 3개의 호몰로지 도메인과 네 번째 도메인 중 일부는 모두 3,180개의 기본 쌍인 첫 번째 큰 exon에 의해 부호화됩니다.네 번째 도메인의 나머지 부분은 마지막 3개의 exon으로 부호화됩니다.^[5] exon은 각각 191, 143 및 약 740개의 기본 쌍입니다.

어플

rbp3 유전자는 동물에서 핵 DNA 계통 ^[6]발생학적 지표로 흔히 사용된다.엑손 1은 척추뼈의 ^[7]단생체에 대한 증거를 제공하기 위해 선구자 연구에서 처음 사용되었다.그리고 태반 포유류 ^[8]^[9]목의 계통 발생과 설치류, 마크로셀레아,^[10]^[11] ^[12]영장류의 주요 계통 발생을 추론하는 데 사용되었다.RBP3는 또한 하위 분류 수준, 예를 들어 뮤로이드^[13] 설치류 및 말라가시 영장류,^[14] 지리학적 수준인 지오미스 및 아포데무스 설치류,^[15]^[16] 그리고 육식동물 종 식별 ^[17]목적으로도 유용하다.

RBP3 인트론 1은 플라티린 영장류 계통유전학을 ^[18]조사하는데도 사용되었습니다.

레퍼런스

^ ^a ^b ^c GRCh38: 앙상블 릴리즈 89: ENSG00000265203 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리즈 89: ENSMUSG000041534 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: RBP3 retinol binding protein 3, interstitial".
^ ^a ^b "OrthoMaM phylogenetic marker: RBP3 gene, exon 1".
^ Stanhope MJ, Czelusniak J, Si JS, Nickerson J, Goodman M (Jun 1992). "A molecular perspective on mammalian evolution from the gene encoding interphotoreceptor retinoid binding protein, with convincing evidence for bat monophyly". Molecular Phylogenetics and Evolution. 1 (2): 148–60. doi:10.1016/1055-7903(92)90026-D. PMID 1342928.
^ Stanhope MJ, Smith MR, Waddell VG, Porter CA, Shivji MS, Goodman M (Aug 1996). "Mammalian evolution and the interphotoreceptor retinoid binding protein (IRBP) gene: convincing evidence for several superordinal clades". Journal of Molecular Evolution. 43 (2): 83–92. doi:10.1007/BF02337352. PMID 8660440. S2CID 25865281.
^ Madsen O, Scally M, Douady CJ, Kao DJ, DeBry RW, Adkins R, Amrine HM, Stanhope MJ, de Jong WW, Springer MS (Feb 2001). "Parallel adaptive radiations in two major clades of placental mammals". Nature. 409 (6820): 610–4. doi:10.1038/35054544. PMID 11214318. S2CID 4398233.
^ Huchon D, Madsen O, Sibbald MJ, Ament K, Stanhope MJ, Catzeflis F, de Jong WW, Douzery EJ (Jul 2002). "Rodent phylogeny and a timescale for the evolution of Glires: evidence from an extensive taxon sampling using three nuclear genes". Molecular Biology and Evolution. 19 (7): 1053–65. doi:10.1093/oxfordjournals.molbev.a004164. PMID 12082125.
^ Douady CJ, Catzeflis F, Raman J, Springer MS, Stanhope MJ (Jul 2003). "The Sahara as a vicariant agent, and the role of Miocene climatic events, in the diversification of the mammalian order Macroscelidea (elephant shrews)". Proceedings of the National Academy of Sciences of the United States of America. 100 (14): 8325–30. doi:10.1073/pnas.0832467100. PMC 166228. PMID 12821774.
^ Poux C, Douzery EJ (May 2004). "Primate phylogeny, evolutionary rate variations, and divergence times: a contribution from the nuclear gene IRBP". American Journal of Physical Anthropology. 124 (1): 01–16. doi:10.1002/ajpa.10322. PMID 15085543.
^ Jansa SA, Weksler M (Apr 2004). "Phylogeny of muroid rodents: relationships within and among major lineages as determined by IRBP gene sequences". Molecular Phylogenetics and Evolution. 31 (1): 256–76. doi:10.1016/j.ympev.2003.07.002. PMID 15019624.
^ Horvath JE, Weisrock DW, Embry SL, Fiorentino I, Balhoff JP, Kappeler P, Wray GA, Willard HF, Yoder AD (Mar 2008). "Development and application of a phylogenomic toolkit: resolving the evolutionary history of Madagascar's lemurs". Genome Research. 18 (3): 489–99. doi:10.1101/gr.7265208. PMC 2259113. PMID 18245770.
^ Genoways HH, Hamilton MJ, Bell DM, Chambers RR, Bradley RD (2008). "Hybrid zones, genetic isolation, and systematics of pocket gophers (genus Geomys) in Nebraska". J. Mammal. 89 (4): 826–836. doi:10.1644/07-mamm-a-408.1.
^ Tomozawa M, Suzuki H (Mar 2008). "A trend of central versus peripheral structuring in mitochondrial and nuclear gene sequences of the Japanese wood mouse, Apodemus speciosus". Zoological Science. 25 (3): 273–85. doi:10.2108/zsj.25.273. PMID 18393564. S2CID 38824060.
^ Oliveira R, Castro D, Godinho R, Luikart G, Alves PC (June 2009). "Species identification using a small nuclear gene: application to sympatric wild carnivores from South-western Europe". Conserv. Genet. 11 (3): 1023–1032. doi:10.1007/s10592-009-9947-4. S2CID 21422211.
^ Schneider H, Sampaio I, Harada ML, Barroso CM, Schneider MP, Czelusniak J, Goodman M (Jun 1996). "Molecular phylogeny of the New World monkeys (Platyrrhini, primates) based on two unlinked nuclear genes: IRBP intron 1 and epsilon-globin sequences". American Journal of Physical Anthropology. 100 (2): 153–79. doi:10.1002/(SICI)1096-8644(199606)100:2<153::AID-AJPA1>3.0.CO;2-Z. PMID 8771309.

추가 정보

Fong SL, Fong WB, Morris TA, Kedzie KM, Bridges CD (Mar 1990). "Characterization and comparative structural features of the gene for human interstitial retinol-binding protein". The Journal of Biological Chemistry. 265 (7): 3648–53. doi:10.1016/S0021-9258(19)39642-5. PMID 2303470.
Albini A, Toffenetti J, Zhu Z, Chader GJ, Noonan DM (Sep 1990). "Hypomethylation of the interphotoreceptor retinoid-binding protein (IRBP) promotor and first exon is linked to expression of the gene". Nucleic Acids Research. 18 (17): 5181–7. doi:10.1093/nar/18.17.5181. PMC 332140. PMID 2402443.
Liou GI, Ma DP, Yang YW, Geng L, Zhu C, Baehr W (May 1989). "Human interstitial retinoid-binding protein. Gene structure and primary structure". The Journal of Biological Chemistry. 264 (14): 8200–6. doi:10.1016/S0021-9258(18)83169-6. PMID 2542268.
Si JS, Borst DE, Redmond TM, Nickerson JM (Aug 1989). "Cloning of cDNAs encoding human interphotoreceptor retinoid-binding protein (IRBP) and comparison with bovine IRBP sequences". Gene. 80 (1): 99–108. doi:10.1016/0378-1119(89)90254-0. PMID 2792773.
Nakamura Y, Lathrop M, Bragg T, Leppert M, O'Connell P, Jones C, Lalouel JM, White R (Nov 1988). "An extended genetic linkage map of markers for human chromosome 10". Genomics. 3 (4): 389–92. doi:10.1016/0888-7543(88)90133-4. PMID 2907505.
Fong SL, Bridges CD (Oct 1988). "Internal quadruplication in the structure of human interstitial retinol-binding protein deduced from its cloned cDNA". The Journal of Biological Chemistry. 263 (30): 15330–4. doi:10.1016/S0021-9258(19)37592-1. PMID 3170584.
Liou GI, Fong SL, Gosden J, van Tuinen P, Ledbetter DH, Christie S, Rout D, Bhattacharya S, Cook RG, Li Y (Jul 1987). "Human interstitial retinol-binding protein (IRBP): cloning, partial sequence, and chromosomal localization". Somatic Cell and Molecular Genetics. 13 (4): 315–23. doi:10.1007/BF01534925. PMID 3455009. S2CID 20206120.
Fong SL, Cook RG, Alvarez RA, Liou GI, Landers RA, Bridges CD (Sep 1986). "N-terminal sequence homologies in interstitial retinol-binding proteins from 10 vertebrate species". FEBS Letters. 205 (2): 309–12. doi:10.1016/0014-5793(86)80918-8. PMID 3743780. S2CID 45787370.
Redmond TM, Wiggert B, Robey FA, Chader GJ (Nov 1986). "Interspecies conservation of structure of interphotoreceptor retinoid-binding protein. Similarities and differences as adjudged by peptide mapping and N-terminal sequencing". The Biochemical Journal. 240 (1): 19–26. doi:10.1042/bj2400019. PMC 1147370. PMID 3827838.
Chen Y, Houghton LA, Brenna JT, Noy N (Aug 1996). "Docosahexaenoic acid modulates the interactions of the interphotoreceptor retinoid-binding protein with 11-cis-retinal". The Journal of Biological Chemistry. 271 (34): 20507–15. doi:10.1074/jbc.271.34.20507. PMID 8702792.
Shaw NS, Noy N (Feb 2001). "Interphotoreceptor retinoid-binding protein contains three retinoid binding sites". Experimental Eye Research. 72 (2): 183–90. doi:10.1006/exer.2000.0945. PMID 11161734.
Foltz DR, Nye JS (Aug 2001). "Hyperphosphorylation and association with RBP of the intracellular domain of Notch1". Biochemical and Biophysical Research Communications. 286 (3): 484–92. doi:10.1006/bbrc.2001.5421. PMID 11511084.
Howard OM, Dong HF, Su SB, Caspi RR, Chen X, Plotz P, Oppenheim JJ (Jun 2005). "Autoantigens signal through chemokine receptors: uveitis antigens induce CXCR3- and CXCR5-expressing lymphocytes and immature dendritic cells to migrate". Blood. 105 (11): 4207–14. doi:10.1182/blood-2004-07-2697. PMC 1895027. PMID 15713799.

외부 링크

색소성 망막염에 대한 Gen Reviews/NCBI/NIH/UW 엔트리 개요
"Overview of the coding DNA and protein sequence alignments of the RBP3 marker". OrthoMaM – a biological database of orthologous mammalian markers. The rbp3 evolutionary marker can be found, together with the corresponding gene phylogeny

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리즈 89: ENSG00000265203 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리즈 89: ENSMUSG000041534 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: RBP3 retinol binding protein 3, interstitial".

[OrthoMaM-6] "OrthoMaM phylogenetic marker: RBP3 gene, exon 1".

[pmid1342928-7] Stanhope MJ, Czelusniak J, Si JS, Nickerson J, Goodman M (Jun 1992). "A molecular perspective on mammalian evolution from the gene encoding interphotoreceptor retinoid binding protein, with convincing evidence for bat monophyly". Molecular Phylogenetics and Evolution. 1 (2): 148–60. doi:10.1016/1055-7903(92)90026-D. PMID 1342928.

[pmid8660440-8] Stanhope MJ, Smith MR, Waddell VG, Porter CA, Shivji MS, Goodman M (Aug 1996). "Mammalian evolution and the interphotoreceptor retinoid binding protein (IRBP) gene: convincing evidence for several superordinal clades". Journal of Molecular Evolution. 43 (2): 83–92. doi:10.1007/BF02337352. PMID 8660440. S2CID 25865281.

[pmid11214318-9] Madsen O, Scally M, Douady CJ, Kao DJ, DeBry RW, Adkins R, Amrine HM, Stanhope MJ, de Jong WW, Springer MS (Feb 2001). "Parallel adaptive radiations in two major clades of placental mammals". Nature. 409 (6820): 610–4. doi:10.1038/35054544. PMID 11214318. S2CID 4398233.

[pmid12082125-10] Huchon D, Madsen O, Sibbald MJ, Ament K, Stanhope MJ, Catzeflis F, de Jong WW, Douzery EJ (Jul 2002). "Rodent phylogeny and a timescale for the evolution of Glires: evidence from an extensive taxon sampling using three nuclear genes". Molecular Biology and Evolution. 19 (7): 1053–65. doi:10.1093/oxfordjournals.molbev.a004164. PMID 12082125.

[pmid12821774-11] Douady CJ, Catzeflis F, Raman J, Springer MS, Stanhope MJ (Jul 2003). "The Sahara as a vicariant agent, and the role of Miocene climatic events, in the diversification of the mammalian order Macroscelidea (elephant shrews)". Proceedings of the National Academy of Sciences of the United States of America. 100 (14): 8325–30. doi:10.1073/pnas.0832467100. PMC 166228. PMID 12821774.

[pmid15085543-12] Poux C, Douzery EJ (May 2004). "Primate phylogeny, evolutionary rate variations, and divergence times: a contribution from the nuclear gene IRBP". American Journal of Physical Anthropology. 124 (1): 01–16. doi:10.1002/ajpa.10322. PMID 15085543.

[pmid15019624-13] Jansa SA, Weksler M (Apr 2004). "Phylogeny of muroid rodents: relationships within and among major lineages as determined by IRBP gene sequences". Molecular Phylogenetics and Evolution. 31 (1): 256–76. doi:10.1016/j.ympev.2003.07.002. PMID 15019624.

[pmid18245770-14] Horvath JE, Weisrock DW, Embry SL, Fiorentino I, Balhoff JP, Kappeler P, Wray GA, Willard HF, Yoder AD (Mar 2008). "Development and application of a phylogenomic toolkit: resolving the evolutionary history of Madagascar's lemurs". Genome Research. 18 (3): 489–99. doi:10.1101/gr.7265208. PMC 2259113. PMID 18245770.

[15] Genoways HH, Hamilton MJ, Bell DM, Chambers RR, Bradley RD (2008). "Hybrid zones, genetic isolation, and systematics of pocket gophers (genus Geomys) in Nebraska". J. Mammal. 89 (4): 826–836. doi:10.1644/07-mamm-a-408.1.

[pmid18393564-16] Tomozawa M, Suzuki H (Mar 2008). "A trend of central versus peripheral structuring in mitochondrial and nuclear gene sequences of the Japanese wood mouse, Apodemus speciosus". Zoological Science. 25 (3): 273–85. doi:10.2108/zsj.25.273. PMID 18393564. S2CID 38824060.

[Oliveira_2009-17] Oliveira R, Castro D, Godinho R, Luikart G, Alves PC (June 2009). "Species identification using a small nuclear gene: application to sympatric wild carnivores from South-western Europe". Conserv. Genet. 11 (3): 1023–1032. doi:10.1007/s10592-009-9947-4. S2CID 21422211.

[pmid8771309-18] Schneider H, Sampaio I, Harada ML, Barroso CM, Schneider MP, Czelusniak J, Goodman M (Jun 1996). "Molecular phylogeny of the New World monkeys (Platyrrhini, primates) based on two unlinked nuclear genes: IRBP intron 1 and epsilon-globin sequences". American Journal of Physical Anthropology. 100 (2): 153–79. doi:10.1002/(SICI)1096-8644(199606)100:2<153::AID-AJPA1>3.0.CO;2-Z. PMID 8771309.

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Search

RBP3

네임스페이스

더

목차

기능.

진

구조.

어플

레퍼런스

추가 정보

외부 링크