PTPN7

PTPN7
사용 가능한 구조
PDB	Ortholog 검색: PDBe RCSB
PDB ID 코드 목록
	1ZC0, 2A3K, 2GP0, 2GPH, 2HVL, 2QDC, 2QDM, 2QDP, 3D42, 3D44, 3O4S, 3O4T, 3O4U
식별자
에일리어스	PTPN7, BPTP-4, HEPTP, LC-PTP, LPTP, PTPNI, 단백질티로신포스파타아제, 비수용체형 7, 단백질티로신포스파타아제 비수용체형 7
외부 ID	OMIM : 176889 MGI : 2156893 HomoloGene : 15411 GenCard : PTPN7
유전자 위치(인간)
크르.	1번 염색체(인간)
끝.	202,580,588 bp
유전자 위치(마우스)
크르.	1번 염색체(마우스)
끝.	135,073,055 bp
RNA발현패턴
	상단 표시 위치:
	림프절; ; 골수 세포; ; 부록; ; 흉선; ; 피; ; 비장; ; 창호; ; 미산핵; ; 담낭; ; 단구;
	추가 참조 표현식 데이터
	추가 참조 표현식 데이터
유전자 존재론
분자 함수	단백질티로신인산가수분해효소활성; 포스파타아제활성; GO:0001948 단백질 결합; 인단백인산가수분해효소활성; 가수분해효소활성;
셀룰러 컴포넌트	혈장막세포질측; 세포골격; 세포질; 세포; 핵소체;
생물학적 과정	탈인산화; 펩티딜티로신탈인산화; 단백질 탈인산화; 사이토카인 자극에 대한 세포 반응;
	출처:아미고 / QuickGO
맞춤법
	5778
	320139
	ENSG00000143851
	ENSMUSG000031506
	P35236
	문제 8BUM3
NM_001199797; NM_002832; NM_080588; NM_080589; NM_00136487;
	NM_001364878
	NM_177081; NM_001356382
	NP_001186726; NP_002823; NP_542155; NP_001351806; NP_001351807
	NP_796055; NP_001343311
	위키데이터
인간 보기/편집	마우스 표시/편집

단백질 티로신인산가수분해효소 비수용체 타입 7은 PTPN7 ^[5]^[6]유전자에 의해 인체 내에서 암호화되는 효소이다.

기능.

이 유전자에 의해 암호화된 단백질은 단백질 티로신 포스파타아제(PTP) 계열의 구성원이다.PTP는 세포 성장, 분화, 유사분열 주기, 그리고 발암성 변형을 포함한 다양한 세포 과정을 조절하는 신호 분자로 알려져 있다.이 유전자는 다양한 조혈세포에서 우선적으로 발현되며 림포카인 자극세포에서 초기 반응 유전자이다.이 PTP의 비촉매 N-말단은 MAP 키나아제와의 상호작용을 할 수 있으며 MAP 키나아제 활성을 억제할 수 있다.이 PTP는 MAP 키나제 경로와 관련된 분자의 탈인산화를 통해 기능하는 것으로 생각되는 T 세포 항원 수용체(TCR) 신호 조절에 관여하는 것으로 나타났다.이 ^[6]유전자에 대해 다른 아이소폼을 코드하는 2개의 대체 스플라이스 전사 변형이 발견되었다.

상호 작용

PTPN7은 MAPK3^[7]^[8]^[9] 및 MAPK1과 ^[7]^[9]대화하는 것으로 나타났습니다.

레퍼런스

^ ^a ^b ^c GRCh38: 앙상블 릴리즈 89: ENSG00000143851 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리즈 89: ENSMUSG000031506 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Adachi M, Sekiya M, Isobe M, Kumura Y, Ogita Z, Hinoda Y, Imai K, Yachi A (September 1992). "Molecular cloning and chromosomal mapping of a human protein-tyrosine phosphatase LC-PTP". Biochem Biophys Res Commun. 186 (3): 1607–15. doi:10.1016/S0006-291X(05)81592-X. PMID 1510684.
^ ^a ^b "Entrez Gene: PTPN7 protein tyrosine phosphatase, non-receptor type 7".
^ ^a ^b Pettiford SM, Herbst R (February 2000). "The MAP-kinase ERK2 is a specific substrate of the protein tyrosine phosphatase HePTP". Oncogene. 19 (7): 858–69. doi:10.1038/sj.onc.1203408. PMID 10702794.
^ Saxena M, Williams S, Taskén K, Mustelin T (September 1999). "Crosstalk between cAMP-dependent kinase and MAP kinase through a protein tyrosine phosphatase". Nat. Cell Biol. 1 (5): 305–11. doi:10.1038/13024. PMID 10559944. S2CID 40413956.
^ ^a ^b Saxena M, Williams S, Brockdorff J, Gilman J, Mustelin T (April 1999). "Inhibition of T cell signaling by mitogen-activated protein kinase-targeted hematopoietic tyrosine phosphatase (HePTP)". J. Biol. Chem. 274 (17): 11693–700. doi:10.1074/jbc.274.17.11693. PMID 10206983.

추가 정보

Adachi M, Sekiya M, Arimura Y, Takekawa M, Itoh F, Hinoda Y, Imai K, Yachi A (1992). "Protein-tyrosine phosphatase expression in pre-B cell NALM-6". Cancer Res. 52 (3): 737–40. PMID 1370651.
Zanke B, Suzuki H, Kishihara K, Mizzen L, Minden M, Pawson A, Mak TW (1992). "Cloning and expression of an inducible lymphoid-specific, protein tyrosine phosphatase (HePTPase)". Eur. J. Immunol. 22 (1): 235–9. doi:10.1002/eji.1830220134. PMID 1530918. S2CID 29146172.
Swieter M, Berenstein EH, Swaim WD, Siraganian RP (1995). "Aggregation of IgE receptors in rat basophilic leukemia 2H3 cells induces tyrosine phosphorylation of the cytosolic protein-tyrosine phosphatase HePTP". J. Biol. Chem. 270 (37): 21902–6. doi:10.1074/jbc.270.37.21902. PMID 7545170.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Zanke B, Squire J, Griesser H, Henry M, Suzuki H, Patterson B, Minden M, Mak TW (1994). "A hematopoietic protein tyrosine phosphatase (HePTP) gene that is amplified and overexpressed in myeloid malignancies maps to chromosome 1q32.1". Leukemia. 8 (2): 236–44. PMID 8309248.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Saxena M, Williams S, Gilman J, Mustelin T (1998). "Negative regulation of T cell antigen receptor signal transduction by hematopoietic tyrosine phosphatase (HePTP)". J. Biol. Chem. 273 (25): 15340–4. doi:10.1074/jbc.273.25.15340. PMID 9624114.
Saxena M, Williams S, Brockdorff J, Gilman J, Mustelin T (1999). "Inhibition of T cell signaling by mitogen-activated protein kinase-targeted hematopoietic tyrosine phosphatase (HePTP)". J. Biol. Chem. 274 (17): 11693–700. doi:10.1074/jbc.274.17.11693. PMID 10206983.
Oh-hora M, Ogata M, Mori Y, Adachi M, Imai K, Kosugi A, Hamaoka T (1999). "Direct suppression of TCR-mediated activation of extracellular signal-regulated kinase by leukocyte protein tyrosine phosphatase, a tyrosine-specific phosphatase". J. Immunol. 163 (3): 1282–8. PMID 10415025.
Saxena M, Williams S, Taskén K, Mustelin T (1999). "Crosstalk between cAMP-dependent kinase and MAP kinase through a protein tyrosine phosphatase". Nat. Cell Biol. 1 (5): 305–11. doi:10.1038/13024. PMID 10559944. S2CID 40413956.
Pettiford SM, Herbst R (2000). "The MAP-kinase ERK2 is a specific substrate of the protein tyrosine phosphatase HePTP". Oncogene. 19 (7): 858–69. doi:10.1038/sj.onc.1203408. PMID 10702794.
Gjörloff-Wingren A, Saxena M, Han S, Wang X, Alonso A, Renedo M, Oh P, Williams S, Schnitzer J, Mustelin T (2000). "Subcellular localization of intracellular protein tyrosine phosphatases in T cells". Eur. J. Immunol. 30 (8): 2412–21. doi:10.1002/1521-4141(2000)30:8<2412::AID-IMMU2412>3.0.CO;2-J. PMID 10940933.
Tartaglia M, Mehler EL, Goldberg R, Zampino G, Brunner HG, Kremer H, van der Burgt I, Crosby AH, Ion A, Jeffery S, Kalidas K, Patton MA, Kucherlapati RS, Gelb BD (2001). "Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome". Nat. Genet. 29 (4): 465–8. doi:10.1038/ng772. PMID 11704759. S2CID 14627986.
Wang ZX, Zhou B, Wang QM, Zhang ZY (2002). "A kinetic approach for the study of protein phosphatase-catalyzed regulation of protein kinase activity". Biochemistry. 41 (24): 7849–57. doi:10.1021/bi025776m. PMID 12056917.
Digilio MC, Conti E, Sarkozy A, Mingarelli R, Dottorini T, Marino B, Pizzuti A, Dallapiccola B (2002). "Grouping of Multiple-Lentigines/LEOPARD and Noonan Syndromes on the PTPN11 Gene". Am. J. Hum. Genet. 71 (2): 389–94. doi:10.1086/341528. PMC 379170. PMID 12058348.
Kosaki K, Suzuki T, Muroya K, Hasegawa T, Sato S, Matsuo N, Kosaki R, Nagai T, Hasegawa Y, Ogata T (2002). "PTPN11 (protein-tyrosine phosphatase, nonreceptor-type 11) mutations in seven Japanese patients with Noonan syndrome". J. Clin. Endocrinol. Metab. 87 (8): 3529–33. doi:10.1210/jcem.87.8.8694. PMID 12161469.
Pettiford SM, Herbst R (2003). "The protein tyrosine phosphatase HePTP regulates nuclear translocation of ERK2 and can modulate megakaryocytic differentiation of K562 cells". Leukemia. 17 (2): 366–78. doi:10.1038/sj.leu.2402767. PMID 12592337.

인간 염색체 1번 유전자에 대한 이 기사는 뭉툭한 것이다.위키피디아를 확장함으로써 위키피디아를 도울 수 있습니다.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리즈 89: ENSG00000143851 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리즈 89: ENSMUSG000031506 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1510684-5] Adachi M, Sekiya M, Isobe M, Kumura Y, Ogita Z, Hinoda Y, Imai K, Yachi A (September 1992). "Molecular cloning and chromosomal mapping of a human protein-tyrosine phosphatase LC-PTP". Biochem Biophys Res Commun. 186 (3): 1607–15. doi:10.1016/S0006-291X(05)81592-X. PMID 1510684.

[entrez-6] "Entrez Gene: PTPN7 protein tyrosine phosphatase, non-receptor type 7".

[pmid10702794-7] Pettiford SM, Herbst R (February 2000). "The MAP-kinase ERK2 is a specific substrate of the protein tyrosine phosphatase HePTP". Oncogene. 19 (7): 858–69. doi:10.1038/sj.onc.1203408. PMID 10702794.

[pmid10559944-8] Saxena M, Williams S, Taskén K, Mustelin T (September 1999). "Crosstalk between cAMP-dependent kinase and MAP kinase through a protein tyrosine phosphatase". Nat. Cell Biol. 1 (5): 305–11. doi:10.1038/13024. PMID 10559944. S2CID 40413956.

[pmid10206983-9] Saxena M, Williams S, Brockdorff J, Gilman J, Mustelin T (April 1999). "Inhibition of T cell signaling by mitogen-activated protein kinase-targeted hematopoietic tyrosine phosphatase (HePTP)". J. Biol. Chem. 274 (17): 11693–700. doi:10.1074/jbc.274.17.11693. PMID 10206983.

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PTPN7

네임스페이스

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목차

기능.

상호 작용

레퍼런스

추가 정보