ORG-25935

ORG-25935
ORG-25935
Org 25935.svg
식별자
  • 2-([(1R,2S)-6-메톡시-1-페닐-1,2,3,4-테트라하이드로나프탈렌-2-yl]메틸-메틸아실라미노)아세트산
CAS 번호
펍켐 CID
켐스파이더
유니
화학 및 물리적 데이터
공식C21H25NO3
어금질량339.435 g·m−1&m
3D 모델(JSmol)
  • O=C(O)CN(C)C[C@H]2[C@@H](c1c(OC)cc1)cc1)CC2)c3ccc3
  • InChI=1S/C21H25NO3/c1-22(14-20(23)24)13-17-9-8-16-12-18(25-2)10-11-19(16)21(17)15-6-4-3-5-7-15/h3-7,10-12,17,21H,8-9,13-14H2,1-2H3,(H,23,24)/t17-,21+/m1/s1
  • 키:UEBBYLJZCHTLG-UTKZUKDTSA-N

OR-25935(SH-900435라고도 함)는 Organon International에서 개발한 합성 약물로 글리신 트랜스포터 글리T-1의 선택적 억제제 역할을 한다. 동물실험에서는 알코올 섭취를 줄이고 진통작용과 항경련작용 효과가 있으나 주로 항정신병적 성질을 연구해 왔으며, 인체실험에서는 항정신병 약물 케타민의 효과를 효과적으로 상쇄시키는 것으로 나타났다.[1][2][3][4][5][6][7][8]

참고 항목

참조

  1. ^ Molander A, Lidö HH, Löf E, Ericson M, Söderpalm B (2006). "The glycine reuptake inhibitor Org 25935 decreases ethanol intake and preference in male wistar rats". Alcohol and Alcoholism. 42 (1): 11–8. doi:10.1093/alcalc/agl085. PMID 17098748.
  2. ^ Morita K, Motoyama N, Kitayama T, Morioka N, Dohi T (December 2007). "Antinociceptive effects of glycine transporter inhibitors in neuropathic pain models in mice". Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica. 130 (6): 458–63. doi:10.1254/fpj.130.458. PMID 18079595.
  3. ^ Lidö HH, Stomberg R, Fagerberg A, Ericson M, Söderpalm B (July 2009). "The glycine reuptake inhibitor org 25935 interacts with basal and ethanol-induced dopamine release in rat nucleus accumbens". Alcoholism, Clinical and Experimental Research. 33 (7): 1151–7. doi:10.1111/j.1530-0277.2009.00938.x. PMID 19389199.
  4. ^ Kalinichev M, Starr KR, Teague S, Bradford AM, Porter RA, Herdon HJ (May 2010). "Glycine transporter 1 (GlyT1) inhibitors exhibit anticonvulsant properties in the rat maximal electroshock threshold (MEST) test". Brain Research. 1331: 105–13. doi:10.1016/j.brainres.2010.03.032. PMID 20303337. S2CID 5389997.
  5. ^ Vengeliene V, Leonardi-Essmann F, Sommer WH, Marston HM, Spanagel R (October 2010). "Glycine transporter-1 blockade leads to persistently reduced relapse-like alcohol drinking in rats". Biological Psychiatry. 68 (8): 704–11. doi:10.1016/j.biopsych.2010.05.029. PMID 20655511. S2CID 11014437.
  6. ^ Musante V, Summa M, Cunha RA, Raiteri M, Pittaluga A (May 2011). "Pre-synaptic glycine GlyT1 transporter--NMDA receptor interaction: relevance to NMDA autoreceptor activation in the presence of Mg2+ ions". Journal of Neurochemistry. 117 (3): 516–27. doi:10.1111/j.1471-4159.2011.07223.x. PMID 21348870. S2CID 25752716.
  7. ^ Jardemark K, Marcus MM, Malmerfelt A, Shahid M, Svensson TH (May 2012). "Differential effects of AMPA receptor potentiators and glycine reuptake inhibitors on antipsychotic efficacy and prefrontal glutamatergic transmission". Psychopharmacology. 221 (1): 115–31. doi:10.1007/s00213-011-2554-3. PMID 22068461. S2CID 18335206.
  8. ^ D'Souza DC, Singh N, Elander J, Carbuto M, Pittman B, Udo de Haes J, et al. (March 2012). "Glycine transporter inhibitor attenuates the psychotomimetic effects of ketamine in healthy males: preliminary evidence". Neuropsychopharmacology. 37 (4): 1036–46. doi:10.1038/npp.2011.295. PMC 3280648. PMID 22113087.
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신경계통에 관한 이 약물 기사는 단조롭다. 위키피디아를 확장하여 도울 수 있다.