디톨릴구아니딘

Ditolylguanidine
디톨릴구아니딘
1,3-Ditolylguanidine.svg
임상자료
ATC 코드
  • 없는
식별자
  • 1,2-bis(2-methylphenyl)guanidine
CAS 번호
펍켐 CID
IUPHAR/BPS
켐스파이더
유니
켐벨
CompTox 대시보드 (EPA)
ECHA InfoCard100.002.344 Edit this at Wikidata
화학 및 물리적 데이터
공식C15H17N3
어금질량239.322 g·1998−1
3D 모델(JSmol)
  • N(=C(/Nc1ccc1C)N)\c2ccc2c
  • InChi=1S/C15H17N3/c1-11-7-3-5-9-13(11)17-15(16)18-14-6-8-8-12(14)2/h3-10H,1-2H3, (H3,16,17,18) checkY
  • 키:OPNUROKUBTKLF-UHFFFAOYSA-N checkY
(iii)

디톨릴구아니딘은 시그마 수용체 작용제다.[1] 시그마 수용체에는 다소[2] 선택적이지만, 두 시그마 수용체 하위 유형 사이에는 비선택성이며, affinity1과 22 모두에 동일한 친화력으로 결합된다.[3] 신경보호제[4], 항우울제 효과가 있으며 [5]NMDA 적대제 효과를 강화한다.[6]

참고 항목

참조

  1. ^ Weber E, Sonders M, Quarum M, McLean S, Pou S, Keana JF (November 1986). "1,3-Di(2-5-3Htolyl)guanidine: a selective ligand that labels sigma-type receptors for psychotomimetic opiates and antipsychotic drugs". Proc. Natl. Acad. Sci. U.S.A. 83 (22): 8784–8. doi:10.1073/pnas.83.22.8784. PMC 387016. PMID 2877462.
  2. ^ Pubchem. "1,3-Di-o-tolylguanidine C15H17N3 - PubChem". pubchem.ncbi.nlm.nih.gov. Archived from the original on 2021-01-08. Retrieved 2017-06-07.
  3. ^ Glennon, RA (2005). "Pharmacophore identification for sigma-1 (sigma1) receptor binding: application of the "deconstruction-reconstruction-elaboration" approach". Mini Reviews in Medicinal Chemistry. 5 (10): 927–40. doi:10.2174/138955705774329519. PMID 16250835.
  4. ^ Katnik, C; Guerrero, WR; Pennypacker, KR; Herrera, Y; Cuevas, J (2006). "Sigma-1 receptor activation prevents intracellular calcium dysregulation in cortical neurons during in vitro ischemia". The Journal of Pharmacology and Experimental Therapeutics. 319 (3): 1355–65. doi:10.1124/jpet.106.107557. PMID 16988055. S2CID 14582181.
  5. ^ Skuza, G; Rogóz, Z (2003). "Sigma1 receptor antagonists attenuate antidepressant-like effect induced by co-administration of 1,3 di-o-tolylguanidine (DTG) and memantine in the forced swimming test in rats". Polish Journal of Pharmacology. 55 (6): 1149–52. PMID 14730114.
  6. ^ Monnet, FP; Morin-Surun, MP; Leger, J; Combettes, L (2003). "Protein kinase C-dependent potentiation of intracellular calcium influx by sigma1 receptor agonists in rat hippocampal neurons". The Journal of Pharmacology and Experimental Therapeutics. 307 (2): 705–12. doi:10.1124/jpet.103.053447. PMID 12975497. S2CID 35397107.


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신경계통에 관한 이 약물 기사는 단조롭다. 위키피디아를 확장하여 도울 수 있다.