커밀-페가클론

CUMYL-PEGACLONE
커밀-페가클론
CUMYL-PEGACLONE.svg
법적현황
법적현황
식별자
  • 2,5-디하이드로-2-1(1-메틸-1-페닐틸틸)-5-펜틸-1H-피리도[4,3-b]인돌-1-1
CAS 번호
  • 2160555-55-3
펍켐 CID
켐스파이더
유니
화학 및 물리적 데이터
공식C25H28N2O
어금질량372.5 g·190−1
3D 모델(JSmol)
  • CC(C1=CC=CC=C1)N2C=CC(N(CCCCCC)C3=C4C=CC3)=C4C2=C4C2=C4C2=o
  • InChi=1S/C25H28N2O/c1-4-5-11-17-26-21-15-9-14-20(21)23-22(26)16-18-27(24(23)28)
  • 키:AWHWWTKXMUJLSRM-UHFFFAOYSA-N

CUMYL-PEGACLONE(SGT-151)은 감마 카르볼린 기반의 합성 카나비노이드로, 디자이너 약품으로 판매되어 왔다.[1][2][3][4][5][6] CUMIL-PEGACLONE에서 볼 수 있는 감마-카볼린 코어 구조는 2001년 브리스톨-마이어스 스퀴브에 의해 공개된 다른 감마-카볼린 카나비노이드와 구조가 유사하지만, 이전에는 디자이너 카나비노이드에서 만난 적이 없었다.[7][8][9]

법적현황

스웨덴 보건국은 2019년 1월 18일 CUMIL-PEGACLONE을 마약성 물질로 분류했다.[10]

참고 항목

참조

  1. ^ Ernst L, Brandhorst K, Papke U, Altrogge A, Zodel S, Langer N, Beuerle T (August 2017). "Identification and quantification of synthetic cannabinoids in 'spice-like' herbal mixtures: Update of the German situation in early 2017". Forensic Science International. 277: 51–58. doi:10.1016/j.forsciint.2017.05.019. PMID 28601726.
  2. ^ Angerer V, Mogler L, Steitz JP, Bisel P, Hess C, Schoeder CT, Müller CE, Huppertz LM, Westphal F, Schäper J, Auwärter V (July 2017). "Structural characterization and pharmacological evaluation of the new synthetic cannabinoid CUMYL-PEGACLONE". Drug Testing and Analysis. 10 (3): 597–603. doi:10.1002/dta.2237. PMID 28670781.
  3. ^ Mogler L, Wilde M, Huppertz LM, Weinfurtner G, Franz F, Auwärter V (January 2018). "Phase I metabolism of the recently emerged synthetic cannabinoid CUMYL-PEGACLONE and detection in human urine samples". Drug Testing and Analysis. 10 (5): 886–891. doi:10.1002/dta.2352. PMID 29314750.
  4. ^ Halter S, Angerer V, Röhrich J, Groth O, Roider G, Hermanns-Clausen M, Auwärter V (February 2019). "Cumyl-PEGACLONE: A comparatively safe new synthetic cannabinoid receptor agonist entering the NPS market?". Drug Testing and Analysis. 11 (2): 347–349. doi:10.1002/dta.2545. PMID 30468574.
  5. ^ Janssens L, Cannaert A, Connolly MJ, Liu H, Stove CP (September 2020). "In vitro activity profiling of Cumyl-PEGACLONE variants at the CB1 receptor: Fluorination versus isomer exploration". Drug Testing and Analysis. 12 (9): 1336–1343. doi:10.1002/dta.2870. hdl:1854/LU-8687072. PMID 32490586. S2CID 219285656.
  6. ^ Tiemensma M, Rutherford JD, Scott T, Karch S (November 2020). "Emergence of Cumyl-PEGACLONE-related fatalities in the Northern Territory of Australia". Forensic Science, Medicine, and Pathology. 17 (1): 3–9. doi:10.1007/s12024-020-00334-0. PMID 33185835. S2CID 226309264.
  7. ^ WO application 2001058869, Leftheris K, Zhao, R, Chen BC, Kiener P, Wu H, Pandit C, Chennagiri R, Wrobleski S, Chen P, Hynes j, Longphre M, Norris D, Spergel S, Tokarski J, "Cannabinoid Receptor Modulators, Their Processes of Preparation, and Use of Cannabinoid Receptor Modulators in Treating Respiratory and Non-Respiratory Diseases", published 16 2001년 8월, Bristol-Myers Squibb Company에 배정됨
  8. ^ Wrobleski ST, Chen P, Hynes J, Lin S, Norris DJ, Pandit CR, Spergel S, Wu H, Tokarski JS, Chen X, Gillooly KM, Kiener PA, McIntyre KW, Patil-Koota V, Shuster DJ, Turk LA, Yang G, Leftheris K (May 2003). "Rational design and synthesis of an orally active indolopyridone as a novel conformationally constrained cannabinoid ligand possessing antiinflammatory properties". Journal of Medicinal Chemistry. 46 (11): 2110–6. doi:10.1021/jm020329q. PMID 12747783.
  9. ^ {{cite journal vauthors = Alam RM, Keating JJ title = Adding more "spice" to the pot: A review of the chemistry and pharmacology of newly emerging heterocyclic synthetic cannabinoid receptor agonists journal = Drug Testing and Analysis volume = 12 issue = 3 pages = 297–315 date = March 2020 pmid = 31854124 doi = 10.1002/dta.2752 }
  10. ^ "Sexton nya ämnen klassas som narkotika eller hälsofarlig vara" (in Swedish). Folkhälsomyndigheten. 18 January 2019.
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이 카나비노이드 관련 기사는 단조롭다. 위키피디아를 확장하여 도울 수 있다.