WO1988003142A3 - 7-deazaguanines as immunomodulators - Google Patents

7-deazaguanines as immunomodulators Download PDF

Info

Publication number
WO1988003142A3
WO1988003142A3 PCT/US1987/002727 US8702727W WO8803142A3 WO 1988003142 A3 WO1988003142 A3 WO 1988003142A3 US 8702727 W US8702727 W US 8702727W WO 8803142 A3 WO8803142 A3 WO 8803142A3
Authority
WO
WIPO (PCT)
Prior art keywords
deazaguanines
immunomodulators
hydrogen
furanyl
thienyl
Prior art date
Application number
PCT/US1987/002727
Other languages
French (fr)
Other versions
WO1988003142A2 (en
Inventor
Thomas C Malone
Jagadish C Sircar
Original Assignee
Warner Lambert Co
Thomas C Malone
Jagadish C Sircar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co, Thomas C Malone, Jagadish C Sircar filed Critical Warner Lambert Co
Publication of WO1988003142A3 publication Critical patent/WO1988003142A3/en
Publication of WO1988003142A2 publication Critical patent/WO1988003142A2/en
Priority to DK344788A priority Critical patent/DK344788D0/en
Priority to NO882781A priority patent/NO166185C/en
Priority to KR1019880700721A priority patent/KR880701721A/en
Priority to FI891870A priority patent/FI891870A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)

Abstract

Various 7-deazaguanines of formula (I), wherein R6 is OH or SH, R2 is hydrogen or NH2, R7 and R8 are hydrogen or NH2, n is an integer of from one through four, Ar is (i) phenyl unsubstituted or substituted by halogen, trifluoromethyl, alkyl, hydroxy or alkoxy, (ii) 2- or 3-thienyl, or (iii) 2- or 3-furanyl; having activity as immunomodulators. Also included are pharmaceutical compositions and methods of use thereof.
PCT/US1987/002727 1986-10-24 1987-10-19 7-deazaguanines as immunomodulators WO1988003142A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
DK344788A DK344788D0 (en) 1986-10-24 1988-06-23 7-DEAZAGUANINES AS IMMUNOMODULATORS
NO882781A NO166185C (en) 1986-10-24 1988-06-23 ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE 2-AMINO-7- (2-THIENTYLMETHYL) -4-PYRROLO (2,3-D) PYRIMIDONE OR A PHARMACEUTICAL ACCEPTABLE BASE OR ACID ADDICTION.
KR1019880700721A KR880701721A (en) 1986-10-24 1988-06-24 7-diazaguanine as an immunomodulator
FI891870A FI891870A0 (en) 1986-10-24 1989-04-19 7-DEAZAGUANINER SAOSOM IMMUNOMODULATORER.

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US92352186A 1986-10-24 1986-10-24
US923,521 1986-10-24
US8623187A 1987-08-20 1987-08-20
US086,231 1987-08-20

Publications (2)

Publication Number Publication Date
WO1988003142A3 true WO1988003142A3 (en) 1988-05-19
WO1988003142A2 WO1988003142A2 (en) 1988-05-25

Family

ID=26774505

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1987/002727 WO1988003142A2 (en) 1986-10-24 1987-10-19 7-deazaguanines as immunomodulators

Country Status (9)

Country Link
EP (1) EP0327590A1 (en)
JP (1) JPH02501306A (en)
KR (1) KR880701721A (en)
AU (1) AU614947B2 (en)
CA (1) CA1294960C (en)
ES (1) ES2008756A6 (en)
FI (1) FI891870A0 (en)
GR (1) GR871606B (en)
WO (1) WO1988003142A2 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE60433B1 (en) * 1986-08-26 1994-07-13 Warner Lambert Co Novel 9-deazaguanines
USRE36187E (en) * 1988-04-08 1999-04-06 The Regents Of The University Of Michigan Acyclic pyrrolo 2,3-d!pyrimidine analogs as antiviral agents
US4968686A (en) * 1988-04-08 1990-11-06 The Regents Of The University Of Michigan Acyclic pyrrolo [2,3-d]pyrimidine analogs as antiviral agents
US5047407A (en) * 1989-02-08 1991-09-10 Iaf Biochem International, Inc. 2-substituted-5-substituted-1,3-oxathiolanes with antiviral properties
WO1990010631A1 (en) * 1989-02-27 1990-09-20 Biocryst 9-substituted-8-unsubstituted-9-deazaguanines
CA2072123C (en) * 1989-10-31 2001-06-12 John A. Secrist, Iii Inhibitors of purine nucleoside phosphorylase
US5726311A (en) * 1989-11-29 1998-03-10 Biocryst Pharmaceuticals, Inc. 7-disubstituted-methyl-4-oxo-3H,5H-pyrrolo 3,2-d!pyrimidine and pharmaceutical uses and compositions containing the same
US5248672A (en) * 1990-11-01 1993-09-28 The Regents Of The University Of Michigan Polysubstituted benzimidazole nucleosides as antiviral agents
JPH10501532A (en) * 1994-06-09 1998-02-10 スミスクライン・ビーチャム・コーポレイション Endothelin receptor antagonist
GB201417165D0 (en) * 2014-09-29 2014-11-12 Provost Fellows & Scholars College Of The Holy Undivided Trinity Of Queen Elizabeth Near Dublin Treatments for Autoimmune Disease
GB201417163D0 (en) 2014-09-29 2014-11-12 Provost Fellows & Scholars College Of The Holy Undivided Trinity Of Queen Elizabeth Near Dublin Substituted pyrimidine derivatives useful in the treatment of autoimmune diseases

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0156559A2 (en) * 1984-03-26 1985-10-02 Warner-Lambert Company 8-Substituted guanine derivatives
FR2574407A1 (en) * 1984-12-12 1986-06-13 Rhone Poulenc Sante New pyrrolo[2,3-d]pyrimidine derivatives, a process for preparing them and pharmaceutical compositions containing them.

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE60433B1 (en) * 1986-08-26 1994-07-13 Warner Lambert Co Novel 9-deazaguanines
DE3739366A1 (en) * 1987-04-10 1988-10-27 Boehringer Mannheim Gmbh DESAZA-PURIN-NUCLEOSIDE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE IN NUCLEIC ACID SEQUENCING AND AS AN ANTIVIRAL AGENT

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0156559A2 (en) * 1984-03-26 1985-10-02 Warner-Lambert Company 8-Substituted guanine derivatives
FR2574407A1 (en) * 1984-12-12 1986-06-13 Rhone Poulenc Sante New pyrrolo[2,3-d]pyrimidine derivatives, a process for preparing them and pharmaceutical compositions containing them.

Also Published As

Publication number Publication date
ES2008756A6 (en) 1989-08-01
AU8328187A (en) 1988-05-25
FI891870A (en) 1989-04-19
WO1988003142A2 (en) 1988-05-25
AU614947B2 (en) 1991-09-19
JPH02501306A (en) 1990-05-10
KR880701721A (en) 1988-11-04
GR871606B (en) 1988-02-23
EP0327590A1 (en) 1989-08-16
FI891870A0 (en) 1989-04-19
CA1294960C (en) 1992-01-28

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