ES2008756A6 - 7-deazaguanines as immunomodulators. - Google Patents

7-deazaguanines as immunomodulators.

Info

Publication number
ES2008756A6
ES2008756A6 ES8703043A ES8703043A ES2008756A6 ES 2008756 A6 ES2008756 A6 ES 2008756A6 ES 8703043 A ES8703043 A ES 8703043A ES 8703043 A ES8703043 A ES 8703043A ES 2008756 A6 ES2008756 A6 ES 2008756A6
Authority
ES
Spain
Prior art keywords
deazaguanines
immunomodulators
hydrogen
furanyl
thienyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8703043A
Other languages
Spanish (es)
Inventor
Thomas Charles Malone
Jagadish Chandr Sircar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Warner Lambert Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC
Publication of ES2008756A6 publication Critical patent/ES2008756A6/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)

Abstract

Various 7-deazaguanines of formula (I), wherein R6 is OH or SH, R2 is hydrogen or NH2, R7 and R8 are hydrogen or NH2, n is an integer of from one through four, Ar is (i) phenyl unsubstituted or substituted by halogen, trifluoromethyl, alkyl, hydroxy or alkoxy, (ii) 2- or 3-thienyl, or (iii) 2- or 3-furanyl having activity as immunomodulators. Also included are pharmaceutical compositions and methods of use thereof.
ES8703043A 1986-10-24 1987-10-23 7-deazaguanines as immunomodulators. Expired ES2008756A6 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US92352186A 1986-10-24 1986-10-24
US8623187A 1987-08-20 1987-08-20

Publications (1)

Publication Number Publication Date
ES2008756A6 true ES2008756A6 (en) 1989-08-01

Family

ID=26774505

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8703043A Expired ES2008756A6 (en) 1986-10-24 1987-10-23 7-deazaguanines as immunomodulators.

Country Status (9)

Country Link
EP (1) EP0327590A1 (en)
JP (1) JPH02501306A (en)
KR (1) KR880701721A (en)
AU (1) AU614947B2 (en)
CA (1) CA1294960C (en)
ES (1) ES2008756A6 (en)
FI (1) FI891870A0 (en)
GR (1) GR871606B (en)
WO (1) WO1988003142A2 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE60433B1 (en) * 1986-08-26 1994-07-13 Warner Lambert Co Novel 9-deazaguanines
USRE36187E (en) * 1988-04-08 1999-04-06 The Regents Of The University Of Michigan Acyclic pyrrolo 2,3-d!pyrimidine analogs as antiviral agents
US4968686A (en) * 1988-04-08 1990-11-06 The Regents Of The University Of Michigan Acyclic pyrrolo [2,3-d]pyrimidine analogs as antiviral agents
US5047407A (en) * 1989-02-08 1991-09-10 Iaf Biochem International, Inc. 2-substituted-5-substituted-1,3-oxathiolanes with antiviral properties
WO1990010631A1 (en) * 1989-02-27 1990-09-20 Biocryst 9-substituted-8-unsubstituted-9-deazaguanines
CA2072123C (en) * 1989-10-31 2001-06-12 John A. Secrist, Iii Inhibitors of purine nucleoside phosphorylase
US5726311A (en) * 1989-11-29 1998-03-10 Biocryst Pharmaceuticals, Inc. 7-disubstituted-methyl-4-oxo-3H,5H-pyrrolo 3,2-d!pyrimidine and pharmaceutical uses and compositions containing the same
US5248672A (en) * 1990-11-01 1993-09-28 The Regents Of The University Of Michigan Polysubstituted benzimidazole nucleosides as antiviral agents
JPH10501532A (en) * 1994-06-09 1998-02-10 スミスクライン・ビーチャム・コーポレイション Endothelin receptor antagonist
GB201417165D0 (en) * 2014-09-29 2014-11-12 Provost Fellows & Scholars College Of The Holy Undivided Trinity Of Queen Elizabeth Near Dublin Treatments for Autoimmune Disease
GB201417163D0 (en) 2014-09-29 2014-11-12 Provost Fellows & Scholars College Of The Holy Undivided Trinity Of Queen Elizabeth Near Dublin Substituted pyrimidine derivatives useful in the treatment of autoimmune diseases

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4748177A (en) * 1984-03-26 1988-05-31 Warner-Lambert Company Guanine derivatives
FR2574407B1 (en) * 1984-12-12 1987-06-05 Rhone Poulenc Sante NOVEL PYRROLO (2,3-D) PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
IE60433B1 (en) * 1986-08-26 1994-07-13 Warner Lambert Co Novel 9-deazaguanines
DE3739366A1 (en) * 1987-04-10 1988-10-27 Boehringer Mannheim Gmbh DESAZA-PURIN-NUCLEOSIDE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE IN NUCLEIC ACID SEQUENCING AND AS AN ANTIVIRAL AGENT

Also Published As

Publication number Publication date
AU8328187A (en) 1988-05-25
FI891870A (en) 1989-04-19
WO1988003142A2 (en) 1988-05-25
AU614947B2 (en) 1991-09-19
JPH02501306A (en) 1990-05-10
WO1988003142A3 (en) 1988-05-19
KR880701721A (en) 1988-11-04
GR871606B (en) 1988-02-23
EP0327590A1 (en) 1989-08-16
FI891870A0 (en) 1989-04-19
CA1294960C (en) 1992-01-28

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Legal Events

Date Code Title Description
SA6 Expiration date (snapshot 920101)

Free format text: 2007-10-23

FD1A Patent lapsed

Effective date: 20001204