TR200103273T2 - Hemisentetik yöntem ve yeni bileşimler. - Google Patents

Hemisentetik yöntem ve yeni bileşimler.

Info

Publication number
TR200103273T2
TR200103273T2 TR2001/03273T TR200103273T TR200103273T2 TR 200103273 T2 TR200103273 T2 TR 200103273T2 TR 2001/03273 T TR2001/03273 T TR 2001/03273T TR 200103273 T TR200103273 T TR 200103273T TR 200103273 T2 TR200103273 T2 TR 200103273T2
Authority
TR
Turkey
Prior art keywords
hemisynthetic
new compositions
hemisynthetic method
quinonamine
bilerasin
Prior art date
Application number
TR2001/03273T
Other languages
English (en)
Inventor
Cuevas Carmen
Perez Marta
Francesch Andres
Fernandez Carolina
Luis Chicharro Jose
Gallego Pilar
Zarzuelo Maria
De La Calle Fernando
Manzanares Ignacio
Original Assignee
Pharma Mar, S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9911345.8A external-priority patent/GB9911345D0/en
Priority claimed from GBGB9918178.6A external-priority patent/GB9918178D0/en
Priority claimed from GBGB9923632.5A external-priority patent/GB9923632D0/en
Priority claimed from GB0001063A external-priority patent/GB0001063D0/en
Application filed by Pharma Mar, S.A. filed Critical Pharma Mar, S.A.
Publication of TR200103273T2 publication Critical patent/TR200103273T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D515/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Bu bulus, bir hemisentetik sentezde, kuinonamin olarak da anilan bilinen bir bilesimin, safrasin B'nin kullanimina yöneliktir. Genelde, bulus dogal bis(tetrahidroisokuinolin) alkaloidlerden baslayarak ekteinasidin veya diger tetrahidroisokuinolinfenol bilesimlerinin ara ürünlerinin, türevlerinin ve ilgili yapilarinin formasyonu için bir hemisentetik prosesle ilgilidir.
TR2001/03273T 1999-05-14 2000-05-15 Hemisentetik yöntem ve yeni bileşimler. TR200103273T2 (tr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB9911345.8A GB9911345D0 (tr) 1999-05-14 1999-05-14
GBGB9918178.6A GB9918178D0 (en) 2000-05-15 1999-08-02 Synthetic methods
GBGB9923632.5A GB9923632D0 (en) 1999-10-06 1999-10-06 Hemisynthetic process towards ecteinascidin and phtalscidin compounds
GB0001063A GB0001063D0 (en) 2000-01-17 2000-01-17 Hemisynthetic process towards ecteinascidin and phtalascidin

Publications (1)

Publication Number Publication Date
TR200103273T2 true TR200103273T2 (tr) 2002-04-22

Family

ID=42632476

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2001/03273T TR200103273T2 (tr) 1999-05-14 2000-05-15 Hemisentetik yöntem ve yeni bileşimler.

Country Status (30)

Country Link
US (3) US7241892B1 (tr)
EP (1) EP1185536B1 (tr)
JP (1) JP4445136B2 (tr)
KR (1) KR100834601B1 (tr)
CN (3) CN1229382C (tr)
AR (1) AR035842A1 (tr)
AT (1) ATE283273T1 (tr)
AU (2) AU775580B2 (tr)
BG (1) BG65896B1 (tr)
BR (3) BRPI0010559B8 (tr)
CA (2) CA2372058C (tr)
CY (1) CY1108095T1 (tr)
CZ (3) CZ303536B6 (tr)
DE (1) DE60016209T2 (tr)
DK (1) DK1185536T3 (tr)
ES (2) ES2233367T3 (tr)
HK (1) HK1047432A1 (tr)
HU (1) HU230646B1 (tr)
MX (1) MXPA01011631A (tr)
MY (1) MY130271A (tr)
NO (2) NO322016B1 (tr)
NZ (1) NZ515424A (tr)
PL (1) PL226890B1 (tr)
PT (1) PT1185536E (tr)
RU (1) RU2237063C9 (tr)
SI (2) SI1185536T1 (tr)
SK (2) SK287835B6 (tr)
TR (1) TR200103273T2 (tr)
UA (1) UA75333C2 (tr)
WO (3) WO2000069862A2 (tr)

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MY164077A (en) 1999-05-13 2017-11-30 Pharma Mar Sa Compositions and uses of et743 for treating cancer
MY130271A (en) 1999-05-14 2007-06-29 Pharma Mar Sa Hemisynthetic method and new compounds
IL152094A (en) 2000-04-12 2011-10-31 Pharma Mar Sa History of actinacidin and pharmaceutical preparations containing them as anti-cancer substances
US7919493B2 (en) * 2000-04-12 2011-04-05 Pharma Mar, S.A. Anititumoral ecteinascidin derivatives
MXPA02011319A (es) 2000-05-15 2003-06-06 Pharma Mar Sa Analogos antitumorales de ecteinascidina 743.
JP4942900B2 (ja) * 2000-05-15 2012-05-30 ファルマ・マール・ソシエダード・アノニマ エクチナサイジン化合物の製造のための合成方法
US7420051B2 (en) 2000-05-15 2008-09-02 Pharma Mar, S.A. Synthetic process for the manufacture of an ecteinaschidin compound
JP2004529074A (ja) 2000-11-03 2004-09-24 プレジデント アンド フェロウズ オブ ハーバード カレッジ サフラマイシン、そのアナログ、およびその使用
MXPA03003975A (es) * 2000-11-06 2004-02-12 Pharma Mar Sa Composiciones para tratamiento antitumoral, que contienen ecteinascidina 743.
GB0117402D0 (en) * 2001-07-17 2001-09-05 Pharma Mar Sa New antitumoral derivatives of et-743
GB0119243D0 (en) * 2001-08-07 2001-10-03 Pharma Mar Sa Antitumoral analogs of ET-743
PL368458A1 (en) * 2001-10-19 2005-03-21 Pharmamar S.A. Improved use of antitumoral compound in cancer therapy
GB0202544D0 (en) * 2002-02-04 2002-03-20 Pharma Mar Sa The synthesis of naturally occuring ecteinascidins and related compounds
GB0229793D0 (en) * 2002-12-20 2003-01-29 Pharma Mar Sa The gene cluster involved in safracin biosynthesis and its uses for genetic engineering
GB0312407D0 (en) * 2003-05-29 2003-07-02 Pharma Mar Sau Treatment
US7183054B2 (en) 2003-06-03 2007-02-27 President And Fellows Of Harvard College Assay for identifying biological targets of polynucleotide-binding compounds
GB0324201D0 (en) * 2003-10-15 2003-11-19 Pharma Mar Sau Improved antitumoral combinations
US7622458B2 (en) * 2003-11-13 2009-11-24 Pharma Mar, S.A.U. Combination of ET-743 and a 5-fluorouracil pro-drug for cancer treatment
GB0326486D0 (en) * 2003-11-14 2003-12-17 Pharma Mar Sau Combination treatment
JP2007511509A (ja) * 2003-11-14 2007-05-10 ファルマ・マール・ソシエダード・アノニマ Ｅｔ−７４３およびパクリタキセルの使用を含むガンの併用療法
CN101068596A (zh) * 2004-09-29 2007-11-07 法马马私人股份有限公司 艾可特耐思地作抗炎药
RS50822B (sr) * 2004-10-26 2010-08-31 Pharma Mar S.A., Sociedad Unipersonal Pegilovani lipozomalni doksorubicin u kombinaciji sa ekteinescidinom 743
RS50510B (sr) * 2004-10-29 2010-03-02 Pharma Mar S.A., Sociedad Unipersonal Formulacije koje sadrže ekteinascidin i disaharid
GB0522082D0 (en) 2005-10-31 2005-12-07 Pharma Mar Sa Formulations
KR100712667B1 (ko) 2006-04-11 2007-05-02 재단법인서울대학교산학협력재단 신규한 디아자 헤테로고리 유도체 및 그의 고체상 제조방법
GB0708691D0 (en) * 2007-05-04 2007-06-13 Pharma Mar Sa Anticancer treatments a
US20090076017A1 (en) * 2007-09-15 2009-03-19 Protia, Llc Deuterium-enriched trabectedin
US20100267732A1 (en) * 2007-10-19 2010-10-21 Pharma Mar, S.A. Prognostic Molecular Markers for ET-743 Treatment
AU2009248039B2 (en) * 2008-05-16 2014-07-31 Pharma Mar, S.A. Multiple myeloma treatments
NZ589269A (en) * 2008-05-16 2013-03-28 Pharma Mar Sa Combination therapy with an antitumor alkaloid
WO2011048210A1 (en) 2009-10-22 2011-04-28 Pharma Mar, S.A. PDGFR-α AS RESPONSE MARKER FOR PM00104 TREATMENT
JP6037337B2 (ja) 2010-05-25 2016-12-07 ファルマ、マール、ソシエダード、アノニマＰｈａｒｍａ Ｍｒｓ，Ｓ．Ａ． エクチナサイジン化合物の製造のための合成方法
ES2569180T3 (es) 2010-11-12 2016-05-09 Pharma Mar S.A. Terapia de combinación con un alcaloide antitumoral
JOP20190254A1 (ar) * 2017-04-27 2019-10-27 Pharma Mar Sa مركبات مضادة للأورام
CN107739387B (zh) * 2017-10-16 2020-01-03 上海皓元生物医药科技有限公司 一种制备曲贝替定的关键中间体化合物的方法
CN109912629B (zh) * 2017-12-13 2021-12-24 浙江中科创越药业有限公司 天然产物Trabectedin的制备
TWI824043B (zh) 2018-10-25 2023-12-01 西班牙商瑪製藥股份有限公司 藥物抗體共軛物
CN111518110B (zh) * 2019-02-01 2023-11-03 博瑞生物医药（苏州）股份有限公司 一种海鞘素化合物及其中间体的制备方法
CN111620792B (zh) * 2019-02-28 2023-01-03 兰州大学 一种n,n-二取代氰基甲酰胺的合成方法
CN116217584A (zh) * 2021-12-06 2023-06-06 南通诺泰生物医药技术有限公司 Et743及其中间体的光催化合成方法
WO2024155565A2 (en) * 2023-01-17 2024-07-25 Yarrow Therapeutics, Inc. Ecteinascidin derivative antibody drug conjugates

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RU2217432C2 (ru) 1998-04-06 2003-11-27 Дзе Борд Оф Трастиз Оф Дзе Юниверсити Оф Иллинойс Эктеинасцидины, фармацевтическая композиция, содержащая их и способ лечения опухолей
SK285069B6 (sk) 1998-05-11 2006-05-04 Pharma Mar, S. A. Zlúčeniny, ktoré sú metabolitmi ekteinascidínu 743, farmaceutické prostriedky s ich obsahom a ich použitie
US6124292A (en) 1998-09-30 2000-09-26 President And Fellows Of Harvard College Synthetic analogs of ecteinascidin-743
MY130271A (en) 1999-05-14 2007-06-29 Pharma Mar Sa Hemisynthetic method and new compounds
CA2397597A1 (en) 2000-01-19 2001-07-26 The Trustees Of Columbia University In The City Of New York Compounds of the saframycin-ecteinascidin series, uses, and synthesis thereof
IL152094A (en) 2000-04-12 2011-10-31 Pharma Mar Sa History of actinacidin and pharmaceutical preparations containing them as anti-cancer substances
MXPA02011319A (es) 2000-05-15 2003-06-06 Pharma Mar Sa Analogos antitumorales de ecteinascidina 743.

Also Published As

Publication number Publication date
MXPA01011631A (es) 2002-07-30
RU2237063C2 (ru) 2004-09-27
JP4445136B2 (ja) 2010-04-07
PT1185536E (pt) 2005-04-29
BRPI0110801B1 (pt) 2018-02-27
DK1185536T3 (da) 2005-04-04
MY130271A (en) 2007-06-29
CN1441805A (zh) 2003-09-10
BRPI0010559B8 (pt) 2021-05-25
CZ304966B6 (cs) 2015-02-18
AU4597300A (en) 2000-12-05
NO20025186D0 (no) 2002-10-29
CA2406095A1 (en) 2001-11-22
SI1185536T1 (en) 2005-06-30
NO328301B1 (no) 2010-01-25
SK287835B6 (sk) 2011-12-05
CZ20023746A3 (cs) 2003-04-16
CN1211386C (zh) 2005-07-20
CA2406095C (en) 2010-02-16
CN100475822C (zh) 2009-04-08
DE60016209T2 (de) 2005-12-15
NO20025186L (no) 2003-01-14
WO2001087894A1 (en) 2001-11-22
US20040002602A1 (en) 2004-01-01
PL353002A1 (en) 2003-09-22
RU2237063C9 (ru) 2008-10-10
AU5649601A (en) 2001-11-26
BR0110443A (pt) 2003-04-08
HUP0201188A2 (en) 2002-07-29
UA75333C2 (uk) 2006-04-17
CA2372058C (en) 2010-10-26
EP1185536B1 (en) 2004-11-24
SK15272002A3 (sk) 2003-06-03
US20080045713A1 (en) 2008-02-21
CA2372058A1 (en) 2000-11-23
CZ20014102A3 (cs) 2002-06-12
CZ303536B6 (cs) 2012-11-21
CZ304973B6 (cs) 2015-02-25
JP2002544280A (ja) 2002-12-24
AU775580B2 (en) 2004-08-05
NO20015547D0 (no) 2001-11-13
CZ20023751A3 (en) 2004-05-12
BRPI0010559B1 (pt) 2016-08-30
DE60016209D1 (de) 2004-12-30
AR035842A1 (es) 2004-07-21
KR100834601B1 (ko) 2008-06-02
EP1185536A2 (en) 2002-03-13
BRPI0110443B1 (pt) 2018-06-26
ES2233367T3 (es) 2005-06-16
HK1047432A1 (en) 2003-02-21
BR0110801A (pt) 2003-02-11
CN1229382C (zh) 2005-11-30
BG107301A (bg) 2003-07-31
BRPI0110801B8 (pt) 2021-05-25
WO2000069862A3 (en) 2001-03-22
NO322016B1 (no) 2006-08-07
ATE283273T1 (de) 2004-12-15
WO2000069862A2 (en) 2000-11-23
PL226890B1 (pl) 2017-09-29
ES2231486T3 (es) 2005-05-16
BR0010559A (pt) 2002-07-02
CY1108095T1 (el) 2014-02-12
NZ515424A (en) 2004-06-25
CN1360588A (zh) 2002-07-24
US7524956B2 (en) 2009-04-28
KR20020021636A (ko) 2002-03-21
US7241892B1 (en) 2007-07-10
SK287879B6 (sk) 2012-02-03
HU230646B1 (hu) 2017-05-29
SI1287004T1 (sl) 2005-12-31
CN1440414A (zh) 2003-09-03
WO2001087895A1 (en) 2001-11-22
NO20015547L (no) 2002-01-14
BG65896B1 (bg) 2010-04-30
SK16502001A3 (sk) 2002-06-04
BRPI0110443B8 (pt) 2021-05-25

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