SI2170831T1 - Benzazepinski derivati, uporabni kot antagonisti vazopresina - Google Patents

Benzazepinski derivati, uporabni kot antagonisti vazopresina

Info

Publication number
SI2170831T1
SI2170831T1 SI200830557T SI200830557T SI2170831T1 SI 2170831 T1 SI2170831 T1 SI 2170831T1 SI 200830557 T SI200830557 T SI 200830557T SI 200830557 T SI200830557 T SI 200830557T SI 2170831 T1 SI2170831 T1 SI 2170831T1
Authority
SI
Slovenia
Prior art keywords
derivatives useful
vasopressin antagonists
benzazepine derivatives
benzazepine
vasopressin
Prior art date
Application number
SI200830557T
Other languages
English (en)
Inventor
Kazumi Kondo
Yasuhiro Menjo
Takahiro Tomoyasu
Shin Miyamura
Yuso Tomohira
Takakuni Matsuda
Keigo Yamada
Yusuke Kato
Original Assignee
Otsuka Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharma Co Ltd filed Critical Otsuka Pharma Co Ltd
Publication of SI2170831T1 publication Critical patent/SI2170831T1/sl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D223/00Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16Benzazepines; Hydrogenated benzazepines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/02Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10Antioedematous agents; Diuretics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12Antidiuretics, e.g. drugs for diabetes insipidus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/02Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/08Vasodilators for multiple indications
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/14Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/5532Seven-(or more) membered rings
    • C07F9/5535Seven-(or more) membered rings condensed with carbocyclic rings or ring systems
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SI200830557T 2007-06-26 2008-06-26 Benzazepinski derivati, uporabni kot antagonisti vazopresina SI2170831T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2007167207 2007-06-26
PCT/JP2008/062033 WO2009001968A1 (en) 2007-06-26 2008-06-26 Benzazepine derivatives useful as vasopressin antagonists
EP08765871A EP2170831B1 (en) 2007-06-26 2008-06-26 Benzazepine derivatives useful as vasopressin antagonists

Publications (1)

Publication Number Publication Date
SI2170831T1 true SI2170831T1 (sl) 2012-04-30

Family

ID=39773045

Family Applications (3)

Application Number Title Priority Date Filing Date
SI200831177T SI2374797T1 (sl) 2007-06-26 2008-06-26 Benzazepinski derivati, uporabni kot antagonisti vazopresina
SI200830557T SI2170831T1 (sl) 2007-06-26 2008-06-26 Benzazepinski derivati, uporabni kot antagonisti vazopresina
SI200831051T SI2374798T1 (sl) 2007-06-26 2008-06-26 Benzazepinski derivati, uporabni kot antagonisti vazopresina

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SI200831177T SI2374797T1 (sl) 2007-06-26 2008-06-26 Benzazepinski derivati, uporabni kot antagonisti vazopresina

Family Applications After (1)

Application Number Title Priority Date Filing Date
SI200831051T SI2374798T1 (sl) 2007-06-26 2008-06-26 Benzazepinski derivati, uporabni kot antagonisti vazopresina

Country Status (27)

Country Link
US (3) US8669229B2 (sl)
EP (3) EP2374797B1 (sl)
JP (3) JP5653043B2 (sl)
KR (1) KR101487201B1 (sl)
CN (3) CN103342680A (sl)
AR (1) AR067176A1 (sl)
AT (1) ATE545633T1 (sl)
AU (1) AU2008269918B2 (sl)
BR (1) BRPI0813768A2 (sl)
CA (1) CA2690335A1 (sl)
CO (1) CO6160295A2 (sl)
CY (3) CY1113519T1 (sl)
DK (3) DK2374798T3 (sl)
ES (3) ES2460018T3 (sl)
HK (3) HK1163077A1 (sl)
HR (3) HRP20120310T1 (sl)
IL (1) IL202561A0 (sl)
MY (3) MY152805A (sl)
NZ (3) NZ581723A (sl)
PL (3) PL2374798T3 (sl)
PT (3) PT2170831E (sl)
RU (1) RU2471784C2 (sl)
SG (2) SG182231A1 (sl)
SI (3) SI2374797T1 (sl)
TW (1) TWI459947B (sl)
UA (1) UA98966C2 (sl)
WO (1) WO2009001968A1 (sl)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI459947B (zh) * 2007-06-26 2014-11-11 Otsuka Pharma Co Ltd 苯并氮呯化合物及藥學製劑
JP5656399B2 (ja) * 2008-12-26 2015-01-21 大塚製薬株式会社 医薬及び医薬製剤
CN102030709B (zh) * 2009-09-25 2013-10-16 江苏豪森医药集团有限公司 用作加压素受体拮抗剂的苯并氮杂卓类化合物
EA022253B1 (ru) 2009-10-26 2015-11-30 Оцука Фармасьютикал Ко., Лтд. Соединение бензазепина и его применения
GB201105537D0 (en) 2011-03-31 2011-05-18 Vantia Ltd New process
CN102260213B (zh) * 2011-05-31 2013-05-15 重庆福安药业(集团)股份有限公司 一种托伐普坦的制备方法
TWI704919B (zh) 2012-05-31 2020-09-21 日商大塚製藥股份有限公司 用於預防及/或治療多囊性腎臟病之藥物
CA2894516A1 (en) * 2012-12-28 2014-07-03 Otsuka Pharmaceutical Co., Ltd. Injectable depot formulation comprising optically active tolvaptan and process of producing the same
US9505737B2 (en) 2013-01-11 2016-11-29 Corsair Pharma, Inc. Treprostinil derivative compounds and methods of using same
TWI660748B (zh) * 2013-03-01 2019-06-01 日商大塚製藥股份有限公司 用於口服投藥之包含非晶型托伐普坦(Tolvaptan)的懸浮液
TW201605488A (zh) 2013-10-15 2016-02-16 大塚製藥股份有限公司 用以預防及/或治療多囊腎病之藥物
US11911369B2 (en) * 2015-03-03 2024-02-27 Biohaven Therapeutics Ltd. Prodrugs of riluzole and their method of use
WO2019003433A1 (ja) * 2017-06-30 2019-01-03 大塚製薬株式会社 ベンゾアゼピン誘導体
CN107540672A (zh) * 2017-10-10 2018-01-05 牡丹江医学院 一种治疗肝硬化的药物及其合成方法
HU231206B1 (hu) 2017-12-15 2021-10-28 Richter Gedeon Nyrt. Triazolobenzazepinek
TW201938171A (zh) 2017-12-15 2019-10-01 匈牙利商羅特格登公司 作為血管升壓素V1a受體拮抗劑之三環化合物
JP2020011957A (ja) * 2019-07-22 2020-01-23 コルセア ファーマ インコーポレイテッド トレプロスチニル誘導体化合物およびその使用方法
CN112851583B (zh) * 2021-01-19 2023-09-08 徐州医科大学 新型苯并氮杂䓬类化合物、组合物及其用途
WO2022171160A1 (zh) 2021-02-10 2022-08-18 上海森辉医药有限公司 苯并氮杂䓬类化合物及其制备方法和医药用途
CN113112528A (zh) * 2021-04-26 2021-07-13 中南财经政法大学 异常行为监控方法、装置、设备及存储介质

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5045478A (en) * 1986-03-03 1991-09-03 Becton Dickinson And Company Vesicles and use thereof in an assay
US5258510A (en) * 1989-10-20 1993-11-02 Otsuka Pharma Co Ltd Benzoheterocyclic compounds
TW249201B (sl) 1992-07-02 1995-06-11 Otsuka Pharma Co Ltd
TW270927B (sl) * 1992-10-16 1996-02-21 Otsuka Pharma Co Ltd
GB9726695D0 (en) 1997-12-17 1998-02-18 Smithkline Beecham Plc Novel compounds
JP4210355B2 (ja) 1997-07-03 2009-01-14 大塚製薬株式会社 固形製剤組成物
WO2000018761A1 (en) 1998-09-29 2000-04-06 American Cyanamid Company Substituted 3-cyanoquinolines as protein tyrosine kinases inhibitors
DE60102815D1 (de) * 2000-05-15 2004-05-19 Paratek Pharm Innc 7-substituierte kondensierte ring-tetrazyclin- verbindungen
EP1812039A1 (en) 2004-11-02 2007-08-01 New River Pharmaceuticals Inc. Prodrugs of ribavirin with improved hepatic delivery
AU2006330277B2 (en) * 2005-12-27 2011-10-06 Otsuka Pharmaceutical Co., Ltd. Water-soluble benzoazepine compound and its pharmaceutical composition
TWI459947B (zh) * 2007-06-26 2014-11-11 Otsuka Pharma Co Ltd 苯并氮呯化合物及藥學製劑

Also Published As

Publication number Publication date
DK2170831T3 (da) 2012-05-21
PL2374797T3 (pl) 2014-08-29
SG182231A1 (en) 2012-07-30
RU2471784C2 (ru) 2013-01-10
SI2374797T1 (sl) 2014-05-30
ES2380085T3 (es) 2012-05-08
HRP20120310T1 (hr) 2012-06-30
US20140024640A1 (en) 2014-01-23
US8669229B2 (en) 2014-03-11
EP2374797A1 (en) 2011-10-12
CA2690335A1 (en) 2008-12-31
BRPI0813768A2 (pt) 2014-12-30
AU2008269918A1 (en) 2008-12-31
JP5893085B2 (ja) 2016-03-23
PT2374798E (pt) 2013-11-05
CY1113519T1 (el) 2016-06-22
AR067176A1 (es) 2009-09-30
CN101687805A (zh) 2010-03-31
EP2170831A1 (en) 2010-04-07
AU2008269918B2 (en) 2012-12-06
HRP20131095T1 (hr) 2014-01-03
IL202561A0 (en) 2010-06-30
US9073868B2 (en) 2015-07-07
ES2431515T3 (es) 2013-11-26
JP2010531293A (ja) 2010-09-24
JP2014208680A (ja) 2014-11-06
CN103342680A (zh) 2013-10-09
TWI459947B (zh) 2014-11-11
MY150941A (en) 2014-03-14
EP2170831B1 (en) 2012-02-15
ATE545633T1 (de) 2012-03-15
NZ598067A (en) 2012-12-21
HK1141994A1 (en) 2010-11-26
PL2170831T3 (pl) 2012-08-31
ES2460018T3 (es) 2014-05-13
UA98966C2 (ru) 2012-07-10
SG182230A1 (en) 2012-07-30
EP2374797B1 (en) 2014-03-26
SI2374798T1 (sl) 2013-10-30
EP2374798B1 (en) 2013-09-04
KR20100040873A (ko) 2010-04-21
CN103342679A (zh) 2013-10-09
PL2374798T3 (pl) 2014-01-31
TW200911271A (en) 2009-03-16
CY1115226T1 (el) 2017-01-04
HRP20140501T1 (hr) 2014-07-04
NZ581723A (en) 2012-03-30
US20110071084A1 (en) 2011-03-24
MY152805A (en) 2014-11-28
US20140024619A1 (en) 2014-01-23
CO6160295A2 (es) 2010-05-20
EP2374798A1 (en) 2011-10-12
JP5689195B2 (ja) 2015-03-25
HK1163660A1 (en) 2012-09-14
HK1163077A1 (en) 2012-09-07
DK2374797T3 (da) 2014-05-12
MY148312A (en) 2013-03-29
CY1114491T1 (el) 2016-10-05
RU2010102229A (ru) 2011-08-10
JP5653043B2 (ja) 2015-01-14
NZ598064A (en) 2013-04-26
DK2374798T3 (da) 2013-10-07
US8785386B2 (en) 2014-07-22
PT2374797E (pt) 2014-05-02
JP2014205703A (ja) 2014-10-30
WO2009001968A1 (en) 2008-12-31
PT2170831E (pt) 2012-04-13
KR101487201B1 (ko) 2015-01-28

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