HRP20140501T1 - Derivati benzazepina korisni kao antagonisti vazopresina - Google Patents

Derivati benzazepina korisni kao antagonisti vazopresina Download PDF

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Publication number
HRP20140501T1
HRP20140501T1 HRP20140501AT HRP20140501T HRP20140501T1 HR P20140501 T1 HRP20140501 T1 HR P20140501T1 HR P20140501A T HRP20140501A T HR P20140501AT HR P20140501 T HRP20140501 T HR P20140501T HR P20140501 T1 HRP20140501 T1 HR P20140501T1
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HR
Croatia
Prior art keywords
group
salt
substituted
derivatives useful
dihydroxyphosphoryloxy
Prior art date
Application number
HRP20140501AT
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English (en)
Inventor
Kazumi Kondo
Yasuhiro Menjo
Takahiro Tomoyasu
Shin Miyamura
Yuso Tomohira
Takakuni Matsuda
Keigo Yamada
Yusuke Kato
Original Assignee
Otsuka Pharmaceutical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Otsuka Pharmaceutical Co., Ltd. filed Critical Otsuka Pharmaceutical Co., Ltd.
Publication of HRP20140501T1 publication Critical patent/HRP20140501T1/hr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/5532—Seven-(or more) membered rings
    • C07F9/5535—Seven-(or more) membered rings condensed with carbocyclic rings or ring systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Claims (4)

1. Spoj benzazepina, naznačen time, da je predstavljen općom formulom (1) [image] u kojoj R1 je skupina kako slijedi (1-5): (1-5)-CO-R8-skupina (gdje R8 je (8-1) alkil-skupina po želji supstituirana atomom halogena, C2-6alkanoiloksi skupina ili fenil-skupina (supstituirana s dihidroksifosforiloksi-skupinom u kojoj su hidroksi-skupine po želji supstituirane s benzil-skupinama, i C1-6alkil-skupinom), (8-2) C1-6alkoksi- skupina supstituirana s atomom halogena, C2-6alkanoiloksi-skupina ili dihidroksifosforiloksi-skupina, (8-3) piridil-skupina, ili (8-4) C1-6alkoksifenil-skupina); ili njegova sol.
2. Spoj prema zahtjevu 1, naznačen time, da u formuli (1), R1 je -CO-R8-skupina u kojoj R8 je alkil-skupina, ili njegova sol.
3. Farmaceutski pripravak, naznačen time, da obuhvaća spoj benzazepina prema zahtjevu 1, ili njegovu farmakološki prihvatljivu sol, te farmakološki prihvatljiv razrjeđivač i/ili nosač.
4. Farmaceutski pripravak prema zahtjevu 3, naznačen time, da se upotrebljava kao vazodilatorsko sredstvo, lijek za snižavanje krvnog tlaka, akvaretičko sredstvo, ili kao inhibitor agregacije pločastih stanica.
HRP20140501AT 2007-06-26 2014-05-30 Derivati benzazepina korisni kao antagonisti vazopresina HRP20140501T1 (hr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2007167207 2007-06-26

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HRP20140501T1 true HRP20140501T1 (hr) 2014-07-04

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HRP20120310AT HRP20120310T1 (hr) 2007-06-26 2012-04-10 Derivati benzazepina korisni kao antagonisti vazopresina
HRP20131095AT HRP20131095T1 (hr) 2007-06-26 2013-11-18 Derivati benzazepina korisni kao antagonisti vazopresina
HRP20140501AT HRP20140501T1 (hr) 2007-06-26 2014-05-30 Derivati benzazepina korisni kao antagonisti vazopresina

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HRP20120310AT HRP20120310T1 (hr) 2007-06-26 2012-04-10 Derivati benzazepina korisni kao antagonisti vazopresina
HRP20131095AT HRP20131095T1 (hr) 2007-06-26 2013-11-18 Derivati benzazepina korisni kao antagonisti vazopresina

Country Status (27)

Country Link
US (3) US8669229B2 (hr)
EP (3) EP2374797B1 (hr)
JP (3) JP5653043B2 (hr)
KR (1) KR101487201B1 (hr)
CN (3) CN103342680A (hr)
AR (1) AR067176A1 (hr)
AT (1) ATE545633T1 (hr)
AU (1) AU2008269918B2 (hr)
BR (1) BRPI0813768A2 (hr)
CA (1) CA2690335A1 (hr)
CO (1) CO6160295A2 (hr)
CY (3) CY1113519T1 (hr)
DK (3) DK2374798T3 (hr)
ES (3) ES2460018T3 (hr)
HK (3) HK1163077A1 (hr)
HR (3) HRP20120310T1 (hr)
IL (1) IL202561A0 (hr)
MY (3) MY152805A (hr)
NZ (3) NZ581723A (hr)
PL (3) PL2374798T3 (hr)
PT (3) PT2170831E (hr)
RU (1) RU2471784C2 (hr)
SG (2) SG182231A1 (hr)
SI (3) SI2374797T1 (hr)
TW (1) TWI459947B (hr)
UA (1) UA98966C2 (hr)
WO (1) WO2009001968A1 (hr)

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JP5656399B2 (ja) * 2008-12-26 2015-01-21 大塚製薬株式会社 医薬及び医薬製剤
CN102030709B (zh) * 2009-09-25 2013-10-16 江苏豪森医药集团有限公司 用作加压素受体拮抗剂的苯并氮杂卓类化合物
EA022253B1 (ru) 2009-10-26 2015-11-30 Оцука Фармасьютикал Ко., Лтд. Соединение бензазепина и его применения
GB201105537D0 (en) 2011-03-31 2011-05-18 Vantia Ltd New process
CN102260213B (zh) * 2011-05-31 2013-05-15 重庆福安药业(集团)股份有限公司 一种托伐普坦的制备方法
TWI704919B (zh) 2012-05-31 2020-09-21 日商大塚製藥股份有限公司 用於預防及/或治療多囊性腎臟病之藥物
CA2894516A1 (en) * 2012-12-28 2014-07-03 Otsuka Pharmaceutical Co., Ltd. Injectable depot formulation comprising optically active tolvaptan and process of producing the same
US9505737B2 (en) 2013-01-11 2016-11-29 Corsair Pharma, Inc. Treprostinil derivative compounds and methods of using same
TWI660748B (zh) * 2013-03-01 2019-06-01 日商大塚製藥股份有限公司 用於口服投藥之包含非晶型托伐普坦（Ｔｏｌｖａｐｔａｎ）的懸浮液
TW201605488A (zh) 2013-10-15 2016-02-16 大塚製藥股份有限公司 用以預防及／或治療多囊腎病之藥物
US11911369B2 (en) * 2015-03-03 2024-02-27 Biohaven Therapeutics Ltd. Prodrugs of riluzole and their method of use
WO2019003433A1 (ja) * 2017-06-30 2019-01-03 大塚製薬株式会社 ベンゾアゼピン誘導体
CN107540672A (zh) * 2017-10-10 2018-01-05 牡丹江医学院 一种治疗肝硬化的药物及其合成方法
HU231206B1 (hu) 2017-12-15 2021-10-28 Richter Gedeon Nyrt. Triazolobenzazepinek
TW201938171A (zh) 2017-12-15 2019-10-01 匈牙利商羅特格登公司 作為血管升壓素Ｖ１ａ受體拮抗劑之三環化合物
JP2020011957A (ja) * 2019-07-22 2020-01-23 コルセア ファーマ インコーポレイテッド トレプロスチニル誘導体化合物およびその使用方法
CN112851583B (zh) * 2021-01-19 2023-09-08 徐州医科大学 新型苯并氮杂䓬类化合物、组合物及其用途
WO2022171160A1 (zh) 2021-02-10 2022-08-18 上海森辉医药有限公司 苯并氮杂䓬类化合物及其制备方法和医药用途
CN113112528A (zh) * 2021-04-26 2021-07-13 中南财经政法大学 异常行为监控方法、装置、设备及存储介质

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DK2170831T3 (da) 2012-05-21
PL2374797T3 (pl) 2014-08-29
SG182231A1 (en) 2012-07-30
RU2471784C2 (ru) 2013-01-10
SI2374797T1 (sl) 2014-05-30
ES2380085T3 (es) 2012-05-08
HRP20120310T1 (hr) 2012-06-30
US20140024640A1 (en) 2014-01-23
US8669229B2 (en) 2014-03-11
EP2374797A1 (en) 2011-10-12
CA2690335A1 (en) 2008-12-31
BRPI0813768A2 (pt) 2014-12-30
AU2008269918A1 (en) 2008-12-31
JP5893085B2 (ja) 2016-03-23
PT2374798E (pt) 2013-11-05
CY1113519T1 (el) 2016-06-22
AR067176A1 (es) 2009-09-30
CN101687805A (zh) 2010-03-31
EP2170831A1 (en) 2010-04-07
AU2008269918B2 (en) 2012-12-06
HRP20131095T1 (hr) 2014-01-03
IL202561A0 (en) 2010-06-30
US9073868B2 (en) 2015-07-07
ES2431515T3 (es) 2013-11-26
JP2010531293A (ja) 2010-09-24
JP2014208680A (ja) 2014-11-06
CN103342680A (zh) 2013-10-09
TWI459947B (zh) 2014-11-11
MY150941A (en) 2014-03-14
EP2170831B1 (en) 2012-02-15
ATE545633T1 (de) 2012-03-15
NZ598067A (en) 2012-12-21
HK1141994A1 (en) 2010-11-26
PL2170831T3 (pl) 2012-08-31
ES2460018T3 (es) 2014-05-13
UA98966C2 (ru) 2012-07-10
SG182230A1 (en) 2012-07-30
EP2374797B1 (en) 2014-03-26
SI2374798T1 (sl) 2013-10-30
EP2374798B1 (en) 2013-09-04
KR20100040873A (ko) 2010-04-21
CN103342679A (zh) 2013-10-09
PL2374798T3 (pl) 2014-01-31
TW200911271A (en) 2009-03-16
CY1115226T1 (el) 2017-01-04
NZ581723A (en) 2012-03-30
US20110071084A1 (en) 2011-03-24
MY152805A (en) 2014-11-28
US20140024619A1 (en) 2014-01-23
CO6160295A2 (es) 2010-05-20
EP2374798A1 (en) 2011-10-12
JP5689195B2 (ja) 2015-03-25
HK1163660A1 (en) 2012-09-14
HK1163077A1 (en) 2012-09-07
DK2374797T3 (da) 2014-05-12
MY148312A (en) 2013-03-29
CY1114491T1 (el) 2016-10-05
RU2010102229A (ru) 2011-08-10
JP5653043B2 (ja) 2015-01-14
NZ598064A (en) 2013-04-26
SI2170831T1 (sl) 2012-04-30
DK2374798T3 (da) 2013-10-07
US8785386B2 (en) 2014-07-22
PT2374797E (pt) 2014-05-02
JP2014205703A (ja) 2014-10-30
WO2009001968A1 (en) 2008-12-31
PT2170831E (pt) 2012-04-13
KR101487201B1 (ko) 2015-01-28

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