SE7705745L - PROCEDURES AND INTERMEDIATES FOR THE PREPARATION OF CHINAZOLE COMPOUNDS - Google Patents
PROCEDURES AND INTERMEDIATES FOR THE PREPARATION OF CHINAZOLE COMPOUNDSInfo
- Publication number
- SE7705745L SE7705745L SE7705745A SE7705745A SE7705745L SE 7705745 L SE7705745 L SE 7705745L SE 7705745 A SE7705745 A SE 7705745A SE 7705745 A SE7705745 A SE 7705745A SE 7705745 L SE7705745 L SE 7705745L
- Authority
- SE
- Sweden
- Prior art keywords
- compounds
- dimethoxyquinazoline
- carbon atoms
- chinazole
- intermediates
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Compounds of the formula <IMAGE> or of a hydrochloric or hydrobromic acid addition salt thereof, in which R1 is hydrogen or methoxy, and R2 denotes benzoyl, furoyl, thienylcarbonyl, alkoxycarbonyl having 2 to 5 carbon atoms or (2-hydroxyalkoxy)carbonyl having 4 or 5 carbon atoms, are prepared in accordance with a novel process. Initially, a 2-chloro-6,7-dimethoxyquinazoline or a 2-bromo-6,7-dimethoxyquinazoline, whose amino group situated in the 4 position is substituted, is reacted, in an inert organic solvent and at 50-200 DEG C, with a corresponding piperazine. In a second reaction step, the substituents of the amino group are removed by hydrogenolysis. The compounds which are obtained can be used as agents for lowering blood pressure.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US69620176A | 1976-06-15 | 1976-06-15 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SE7705745L true SE7705745L (en) | 1977-12-16 |
| SE435380B SE435380B (en) | 1984-09-24 |
Family
ID=24796111
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE7705745A SE435380B (en) | 1976-06-15 | 1977-05-16 | PROCEDURE FOR THE PREPARATION OF CHINAZOLINE COMPOUNDS |
| SE8107554A SE450120B (en) | 1976-06-15 | 1981-12-16 | NEW DIMETOXICINAZOLINE DERIVATIVES TO USE FOR PREPARATION OF 2 (4-SUBSTITUTED PIPERAZIN-1-YL) -4-AMINO-6,7-DIMETOXICINAZOLINES |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE8107554A SE450120B (en) | 1976-06-15 | 1981-12-16 | NEW DIMETOXICINAZOLINE DERIVATIVES TO USE FOR PREPARATION OF 2 (4-SUBSTITUTED PIPERAZIN-1-YL) -4-AMINO-6,7-DIMETOXICINAZOLINES |
Country Status (34)
| Country | Link |
|---|---|
| JP (1) | JPS52153985A (en) |
| AR (1) | AR218251A1 (en) |
| AT (1) | AT356115B (en) |
| BE (1) | BE855656A (en) |
| BG (3) | BG35747A3 (en) |
| CA (1) | CA1068698A (en) |
| CH (3) | CH638203A5 (en) |
| CS (1) | CS202069B2 (en) |
| DD (1) | DD131021A5 (en) |
| DE (1) | DE2725019A1 (en) |
| DK (1) | DK146625C (en) |
| EG (1) | EG12922A (en) |
| ES (1) | ES459364A1 (en) |
| FI (1) | FI66853C (en) |
| FR (1) | FR2355015A1 (en) |
| GB (1) | GB1548856A (en) |
| GR (1) | GR72288B (en) |
| HK (1) | HK31481A (en) |
| HU (1) | HU177883B (en) |
| IE (1) | IE45423B1 (en) |
| IL (1) | IL52167A (en) |
| LU (1) | LU77530A1 (en) |
| MY (1) | MY8100270A (en) |
| NL (1) | NL172543C (en) |
| NO (1) | NO147838C (en) |
| NZ (1) | NZ184168A (en) |
| PH (1) | PH22196A (en) |
| PL (3) | PL105558B1 (en) |
| PT (1) | PT66617B (en) |
| RO (3) | RO73050A (en) |
| SE (2) | SE435380B (en) |
| SU (2) | SU1033002A3 (en) |
| YU (1) | YU40164B (en) |
| ZA (1) | ZA773014B (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3346675A1 (en) * | 1983-12-23 | 1985-07-04 | Beiersdorf Ag, 2000 Hamburg | SUBSTITUTED 1- (4-AMINO-6,7-DIALKOXY-CHINAZOLINYL) -4- CYCLOHEXENYL DERIVATIVES OF PIPERAZINE AND HOMOPIPERAZINE, METHODS FOR THE PRODUCTION THEREOF, AND THEIR USE, AND ITS RELATED PRODUCTS |
| AT384218B (en) * | 1985-12-04 | 1987-10-12 | Gerot Pharmazeutika | METHOD FOR PRODUCING NEW CHINAZOLINE DERIVATIVES |
| CA2077252C (en) * | 1992-08-31 | 2001-04-10 | Khashayar Karimian | Methods of making ureas and guanidines, and intermediates therefor |
| US5679683A (en) * | 1994-01-25 | 1997-10-21 | Warner-Lambert Company | Tricyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family |
| IL112249A (en) | 1994-01-25 | 2001-11-25 | Warner Lambert Co | Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds |
| IL112248A0 (en) | 1994-01-25 | 1995-03-30 | Warner Lambert Co | Tricyclic heteroaromatic compounds and pharmaceutical compositions containing them |
| US5932538A (en) * | 1996-02-02 | 1999-08-03 | Nitromed, Inc. | Nitrosated and nitrosylated α-adrenergic receptor antagonist compounds, compositions and their uses |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3511836A (en) | 1967-12-13 | 1970-05-12 | Pfizer & Co C | 2,4,6,7-tetra substituted quinazolines |
| US3669968A (en) | 1970-05-21 | 1972-06-13 | Pfizer | Trialkoxy quinazolines |
| JPS536156B2 (en) * | 1972-10-30 | 1978-03-04 | ||
| US3935213A (en) | 1973-12-05 | 1976-01-27 | Pfizer Inc. | Process for hypotensive 4-amino-2-(piperazin-1-yl) quinazoline derivatives |
| JPS50126682A (en) * | 1974-03-25 | 1975-10-04 |
-
1977
- 1977-05-16 SE SE7705745A patent/SE435380B/en not_active IP Right Cessation
- 1977-05-18 CA CA278,728A patent/CA1068698A/en not_active Expired
- 1977-05-20 GR GR53521A patent/GR72288B/el unknown
- 1977-05-20 ZA ZA00773014A patent/ZA773014B/en unknown
- 1977-05-20 NZ NZ184168A patent/NZ184168A/en unknown
- 1977-05-25 IL IL52167A patent/IL52167A/en unknown
- 1977-05-27 YU YU1326/77A patent/YU40164B/en unknown
- 1977-05-31 PT PT66617A patent/PT66617B/en unknown
- 1977-05-31 JP JP6391877A patent/JPS52153985A/en active Granted
- 1977-05-31 NL NLAANVRAGE7705939,A patent/NL172543C/en not_active IP Right Cessation
- 1977-05-31 DE DE19772725019 patent/DE2725019A1/en active Pending
- 1977-06-01 ES ES459364A patent/ES459364A1/en not_active Expired
- 1977-06-01 EG EG338/77A patent/EG12922A/en active
- 1977-06-01 AT AT386977A patent/AT356115B/en not_active IP Right Cessation
- 1977-06-01 NO NO771919A patent/NO147838C/en unknown
- 1977-06-01 CH CH673777A patent/CH638203A5/en not_active IP Right Cessation
- 1977-06-01 FI FI771741A patent/FI66853C/en not_active IP Right Cessation
- 1977-06-01 DK DK240877A patent/DK146625C/en not_active IP Right Cessation
- 1977-06-02 AR AR267927A patent/AR218251A1/en active
- 1977-06-03 BG BG057395A patent/BG35747A3/en unknown
- 1977-06-03 BG BG036493A patent/BG35594A3/en unknown
- 1977-06-03 BG BG057396A patent/BG35748A3/en unknown
- 1977-06-13 LU LU77530A patent/LU77530A1/en unknown
- 1977-06-14 BE BE178416A patent/BE855656A/en not_active IP Right Cessation
- 1977-06-14 SU SU772497901A patent/SU1033002A3/en active
- 1977-06-14 RO RO7790683A patent/RO73050A/en unknown
- 1977-06-14 GB GB24841/77A patent/GB1548856A/en not_active Expired
- 1977-06-14 RO RO7798088A patent/RO77330A/en unknown
- 1977-06-14 HU HU77PI578A patent/HU177883B/en not_active IP Right Cessation
- 1977-06-14 FR FR7718206A patent/FR2355015A1/en active Granted
- 1977-06-14 RO RO7798087A patent/RO77308A/en unknown
- 1977-06-14 IE IE1212/77A patent/IE45423B1/en not_active IP Right Cessation
- 1977-06-15 PL PL1977198874A patent/PL105558B1/en unknown
- 1977-06-15 DD DD7700199502A patent/DD131021A5/en unknown
- 1977-06-15 PL PL1977211797A patent/PL113012B1/en unknown
- 1977-06-15 CS CS773960A patent/CS202069B2/en unknown
- 1977-06-15 PL PL1977211798A patent/PL111221B1/en unknown
-
1978
- 1978-01-03 PH PH20606A patent/PH22196A/en unknown
- 1978-06-28 SU SU782630798A patent/SU946402A3/en active
-
1981
- 1981-07-02 HK HK314/81A patent/HK31481A/en unknown
- 1981-12-16 SE SE8107554A patent/SE450120B/en not_active IP Right Cessation
- 1981-12-30 MY MY270/81A patent/MY8100270A/en unknown
-
1982
- 1982-04-22 CH CH245682A patent/CH638516A5/en not_active IP Right Cessation
- 1982-04-22 CH CH245782A patent/CH638517A5/en not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| NUG | Patent has lapsed |
Ref document number: 7705745-3 Effective date: 19941210 Format of ref document f/p: F |
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| NUG | Patent has lapsed |
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