RU95113171A - STRAINS OF MICROORGANISMS, METHOD OF OBTAINING, APPLICATION OF STRAINS - Google Patents

STRAINS OF MICROORGANISMS, METHOD OF OBTAINING, APPLICATION OF STRAINS

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Publication number
RU95113171A
RU95113171A RU95113171/13A RU95113171A RU95113171A RU 95113171 A RU95113171 A RU 95113171A RU 95113171/13 A RU95113171/13 A RU 95113171/13A RU 95113171 A RU95113171 A RU 95113171A RU 95113171 A RU95113171 A RU 95113171A
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RU
Russia
Prior art keywords
strains
allele
ser
microorganisms
metabolism
Prior art date
Application number
RU95113171/13A
Other languages
Russian (ru)
Other versions
RU2111247C1 (en
Inventor
Вих Гюнтер
Ляйнфельдер Вальфред
Бэкман Кейт
Original Assignee
Консортиум фюр Электрохемише Индустри ГмбХ
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Publication date
Priority claimed from DE4232468A external-priority patent/DE4232468A1/en
Application filed by Консортиум фюр Электрохемише Индустри ГмбХ filed Critical Консортиум фюр Электрохемише Индустри ГмбХ
Publication of RU95113171A publication Critical patent/RU95113171A/en
Application granted granted Critical
Publication of RU2111247C1 publication Critical patent/RU2111247C1/en

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Claims (9)

1. Штаммы микроорганизмов, обладающие разрегулированным метаболизмом триптофана и разрегулированным за счет устойчивого к регуляции по типу обратной связи ser A-аллеля метаболизмом серина, причем ser A-аллель имеет Ki - значение для серина 0,1 - 50 мМ.1. Strains of microorganisms with an upregulated tryptophan metabolism and deregulated due to the ser A metabolism resistant to feedback regulation by serine metabolism, and the ser A allele has a Ki value of 0.1 to 50 mM for serine. 2. Штаммы по п. 1, отличающиеся тем, что trp Е-аллель имеет Ki - значение для триптофана 0,1 - 20 мМ. 2. The strains according to claim 1, characterized in that the trp E-allele has a Ki - value for tryptophan of 0.1 - 20 mm. 3. Штаммы по п. 1 или 2, отличающиеся тем, что ser A-аллель интегрирован в хромосому. 3. The strains according to claim 1 or 2, characterized in that the ser A allele is integrated into the chromosome. 4. Штаммы по любому из пп. 1 - 3, отличающиеся тем, что микроорганизмами являются бактерии. 4. Strains according to any one of paragraphs. 1 to 3, characterized in that the microorganisms are bacteria. 5. Штаммы по п. 4, отличающиеся тем, что бактерии относятся к видам E. coli. 5. The strains of claim 4, wherein the bacteria are E. coli species. 6. Штаммы по п. 4, отличающиеся тем, что бактерии относятся к видам коринебактерии. 6. Strains according to claim 4, characterized in that the bacteria belong to the species of corynebacterium. 7. Способ получения штаммов по п. 1, отличающийся тем, что в штамм микроорганизмов с разрегулированным метаболизмом триптофана вводится устойчивый к регуляции по типу обратной связи ser A-аллель. 7. A method of producing strains according to claim 1, characterized in that a ser A allele resistant to regulation by feedback type is introduced into the microorganism strain with deregulated tryptophan metabolism. 8. Способ по п. 7, отличающийся тем, что ser A-аллель вводят в хромосому микроорганизма с разрегулированным метаболизмом триптофана. 8. The method according to p. 7, characterized in that the ser A allele is introduced into the chromosome of the microorganism with deregulated tryptophan metabolism. 9. Применение штаммов по любому из пп. 1 - 6 для продуцирования триптофана. 9. The use of strains according to any one of paragraphs. 1-6 for the production of tryptophan.
RU95113171A 1992-09-28 1993-09-23 Method of preparing microorganism strain, method of tryptopham producing RU2111247C1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE4232468A DE4232468A1 (en) 1992-09-28 1992-09-28 Microorganisms for the production of tryptophan and process for their production
DEP4232468.8 1992-09-28
PCT/EP1993/002588 WO1994008031A1 (en) 1992-09-28 1993-09-23 Microorganisms for the production of tryptophan and process for producing the same

Publications (2)

Publication Number Publication Date
RU95113171A true RU95113171A (en) 1997-09-10
RU2111247C1 RU2111247C1 (en) 1998-05-20

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Family Applications (1)

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RU95113171A RU2111247C1 (en) 1992-09-28 1993-09-23 Method of preparing microorganism strain, method of tryptopham producing

Country Status (18)

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US (1) US6180373B1 (en)
EP (1) EP0662143B1 (en)
JP (1) JP3032013B2 (en)
KR (1) KR950703653A (en)
CN (1) CN1065909C (en)
AU (1) AU673374B2 (en)
BR (1) BR9307125A (en)
CA (1) CA2145630C (en)
CZ (1) CZ282396B6 (en)
DE (2) DE4232468A1 (en)
ES (1) ES2089846T3 (en)
FI (1) FI106727B (en)
HU (1) HU218139B (en)
RU (1) RU2111247C1 (en)
SK (1) SK279854B6 (en)
TW (1) TW241303B (en)
UA (1) UA32566C2 (en)
WO (1) WO1994008031A1 (en)

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