PE20080181A1 - Anticuerpos que se unen al peptido beta-amiloide en el tratamiento de alzheimer - Google Patents

Anticuerpos que se unen al peptido beta-amiloide en el tratamiento de alzheimer

Info

Publication number
PE20080181A1
PE20080181A1 PE2007000354A PE2007000354A PE20080181A1 PE 20080181 A1 PE20080181 A1 PE 20080181A1 PE 2007000354 A PE2007000354 A PE 2007000354A PE 2007000354 A PE2007000354 A PE 2007000354A PE 20080181 A1 PE20080181 A1 PE 20080181A1
Authority
PE
Peru
Prior art keywords
seq
beta
peptide
alzheimer
treatment
Prior art date
Application number
PE2007000354A
Other languages
English (en)
Inventor
Stephen Anthony Burbidge
Jonathan Henry Ellis
Susannah K Ford
Volker Germanschewski
Umesh Kumar
Karen Louise Philpott
Peter Ernest Soden
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of PE20080181A1 publication Critical patent/PE20080181A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

SE REFIERE A UN ANTICUERPO QUE COMPRENDE LAS SIGUIENTES CDR: CDRH1: SEC ID N0:1; CDRH2: SEC ID N0: 2; CDRH3: SEC ID N0:3; SEC ID N0: 3DENTRO DE UNA REGION VARIABLE DE CADENA PESADA HUMANA PROCEDENTE DE LA FAMILIA GENICA VH3 Y CDRL1: SEC ID N0:4; CDRL2: SEC ID N0:5; CDRL3: SEC ID N0: 6 DENTRO DE UNA REGION VARIABLE DE CADENA LIGERA HUMANA PROCEDENTE DE LA SECUENCIA DE AMINOACIDOS DESCRITA EN GENPEPT SEC ID N0:24. EL ANTICUERPO SE UNE AL PEPTIDO BETA-AMILIODE 1-12 CON UNA CONSTANTE DE EQUILIBRIO KD MENOR DE 100 pM Y TIENE UNA CONSTANTE DE EQUILIBRIO KD PARA LA UNION AL PEPTIDO BETA-AMILIODE 2-13 QUE SE 1000 VECES MAYOR QUE LA DEL PEPTIDO 1-12. DICHO ANTICUERPO ES UN ISOTOPO IgG1 UTIL EN EL TRATAMIENTO DE ALZHEIMER
PE2007000354A 2006-03-30 2007-03-28 Anticuerpos que se unen al peptido beta-amiloide en el tratamiento de alzheimer PE20080181A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US78758806P 2006-03-30 2006-03-30

Publications (1)

Publication Number Publication Date
PE20080181A1 true PE20080181A1 (es) 2008-03-16

Family

ID=38284050

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2007000354A PE20080181A1 (es) 2006-03-30 2007-03-28 Anticuerpos que se unen al peptido beta-amiloide en el tratamiento de alzheimer

Country Status (33)

Country Link
US (3) US8227576B2 (es)
EP (2) EP1996621B1 (es)
JP (1) JP5103466B2 (es)
KR (2) KR101263294B1 (es)
CN (2) CN101415729B (es)
AR (1) AR060332A1 (es)
AT (1) ATE451392T1 (es)
AU (1) AU2007233831B2 (es)
BR (1) BRPI0709246A2 (es)
CA (1) CA2647808C (es)
CR (1) CR10347A (es)
CY (1) CY1109877T1 (es)
DE (1) DE602007003703D1 (es)
DK (2) DK1996621T3 (es)
EA (1) EA015654B9 (es)
ES (2) ES2484967T3 (es)
HK (2) HK1122311A1 (es)
HR (2) HRP20100115T1 (es)
IL (1) IL193695A (es)
JO (1) JO2576B1 (es)
MA (1) MA30337B1 (es)
MX (1) MX2008012483A (es)
MY (1) MY149630A (es)
NO (1) NO20083793L (es)
NZ (1) NZ571038A (es)
PE (1) PE20080181A1 (es)
PL (2) PL2177536T3 (es)
PT (2) PT1996621E (es)
SI (2) SI1996621T1 (es)
TW (1) TWI385179B (es)
UA (1) UA94734C2 (es)
WO (1) WO2007113172A2 (es)
ZA (1) ZA200807911B (es)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080050367A1 (en) 1998-04-07 2008-02-28 Guriq Basi Humanized antibodies that recognize beta amyloid peptide
TWI239847B (en) 1997-12-02 2005-09-21 Elan Pharm Inc N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease
CN1747747B (zh) 2003-01-06 2012-09-05 安吉奥开米公司 作为穿过血脑屏障的载体的抑酶肽及类似物
DE10303974A1 (de) 2003-01-31 2004-08-05 Abbott Gmbh & Co. Kg Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung
WO2006066089A1 (en) 2004-12-15 2006-06-22 Neuralab Limited Humanized amyloid beta antibodies for use in improving cognition
AU2006208226A1 (en) 2005-01-24 2006-08-03 Amgen Inc. Humanized anti-amyloid antibody
ES2527661T3 (es) 2005-11-30 2015-01-28 Abbvie Inc. Método de exploración, proceso para purificar oligómeros Abeta no difundibles, anticuerpos selectivos contra dichos oligómeros Abeta no difundibles y un proceso para fabricar dichos anticuerpos
PL1976877T5 (pl) 2005-11-30 2017-09-29 Abbvie Inc Przeciwciała monoklonalne przeciwko białku amyloidu beta oraz ich zastosowania
US8784810B2 (en) 2006-04-18 2014-07-22 Janssen Alzheimer Immunotherapy Treatment of amyloidogenic diseases
MX2009000476A (es) * 2006-07-14 2009-01-28 Ac Immune Sa Anticuerpo humanizado contra beta amiloide.
US8455626B2 (en) 2006-11-30 2013-06-04 Abbott Laboratories Aβ conformer selective anti-aβ globulomer monoclonal antibodies
EP2486928A1 (en) 2007-02-27 2012-08-15 Abbott GmbH & Co. KG Method for the treatment of amyloidoses
US7931899B2 (en) 2007-05-14 2011-04-26 Medtronic, Inc Humanized anti-amyloid beta antibodies
US8323654B2 (en) 2007-05-14 2012-12-04 Medtronic, Inc. Anti-amyloid beta antibodies conjugated to sialic acid-containing molecules
US9365634B2 (en) 2007-05-29 2016-06-14 Angiochem Inc. Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues
US8613923B2 (en) 2007-06-12 2013-12-24 Ac Immune S.A. Monoclonal antibody
US8048420B2 (en) 2007-06-12 2011-11-01 Ac Immune S.A. Monoclonal antibody
ES2498040T3 (es) * 2007-07-27 2014-09-24 Janssen Alzheimer Immunotherapy Tratamiento de enfermedades amiloidogénicas con anticuerpos anti-beta humanizados
CN101848936B (zh) 2007-08-20 2017-05-03 葛兰素集团有限公司 生产方法
GB0718737D0 (en) * 2007-09-25 2007-11-07 Glaxo Group Ltd Antibodies
NZ601858A (en) * 2007-10-05 2014-03-28 Genentech Inc Methods and compositions for diagnosis and treatment of amyloidosis
RU2482876C2 (ru) 2007-10-05 2013-05-27 Дженентек, Инк. Применение антитела против амилоида-бета при глазных заболеваниях
EP2207881A1 (en) * 2007-10-12 2010-07-21 F. Hoffmann-Roche AG Protein expression from multiple nucleic acids
JO3076B1 (ar) 2007-10-17 2017-03-15 Janssen Alzheimer Immunotherap نظم العلاج المناعي المعتمد على حالة apoe
EP2586797A3 (en) * 2007-11-27 2013-07-24 Medtronic, Inc. Humanized anti-amyloid beta antibodies
KR101629365B1 (ko) * 2007-12-11 2016-06-14 글락소 그룹 리미티드 항원 결합성 단백질
WO2009085200A2 (en) 2007-12-21 2009-07-09 Amgen Inc. Anti-amyloid antibodies and uses thereof
EP2441447A1 (en) 2008-05-06 2012-04-18 Glaxo Group Limited Encapsulation of biologically active agents
WO2010043047A1 (en) 2008-10-15 2010-04-22 Angiochem Inc. Conjugates of glp-1 agonists and uses thereof
US9067981B1 (en) 2008-10-30 2015-06-30 Janssen Sciences Ireland Uc Hybrid amyloid-beta antibodies
CN102307904A (zh) 2008-12-05 2012-01-04 安吉奥开米公司 神经降压素或神经降压素类似物的缀合物及其用途
US9173891B2 (en) 2009-04-20 2015-11-03 Angiochem, Inc. Treatment of ovarian cancer using an anticancer agent conjugated to an angiopep-2 analog
AU2010268726A1 (en) * 2009-07-02 2012-01-19 Angiochem Inc. Multimeric peptide conjugates and uses thereof
CN102695546B (zh) 2009-09-11 2014-09-10 前体生物药物股份公司 作为谷氨酰胺酰环化酶抑制剂的杂环衍生物
EP2308897A1 (en) * 2009-10-09 2011-04-13 Pierre Fabre Medicament Chimeric antibodies specific for CD151 and use thereof in the treatment of cancer
UY33253A (es) 2010-03-03 2011-09-30 Boehringer Ingelheim Int Polipéptidos de unión a a-beta
EP2558494B1 (en) 2010-04-15 2018-05-23 AbbVie Inc. Amyloid-beta binding proteins
WO2011149461A1 (en) * 2010-05-27 2011-12-01 Medtronic, Inc. Anti-amyloid beta antibodies conjugated to sialic acid-containing molecules
JP6081356B2 (ja) 2010-07-30 2017-02-15 エーシー イミューン エス．エー． 安全で機能的なヒト化抗βアミロイド抗体
MX358739B (es) 2010-08-14 2018-09-03 Abbvie Inc Star Proteinas de union a amiloide beta.
CN110251668A (zh) * 2010-11-30 2019-09-20 霍夫曼-拉罗奇有限公司 低亲和力血脑屏障受体抗体及其用途
EP2670434B1 (en) 2011-01-31 2018-12-26 Tau Bio-Logic Corp. Treatment of tauopathies
CN103687872A (zh) 2011-04-22 2014-03-26 新兴产品开发西雅图有限公司 前列腺特异性膜抗原结合蛋白和相关组合物以及方法
GB201113570D0 (en) 2011-08-05 2011-09-21 Glaxosmithkline Biolog Sa Vaccine
AU2013266611B2 (en) 2012-05-21 2016-08-11 Genentech, Inc. Methods for improving safety of blood-brain barrier transport
RU2509155C1 (ru) * 2012-10-25 2014-03-10 Федеральное государственное бюджетное учреждение науки Институт биохимии им. А.Н. Баха Российской академии наук Способ детекции белков в амилоидном состоянии и набор для детекции белков в амилоидном состоянии
EP3011343A2 (en) 2013-06-19 2016-04-27 Glaxosmithkline Intellectual Property (No. 2) Limited Assay for complement factor i (cfi) bioactivity
CN104558172A (zh) * 2015-01-04 2015-04-29 东南大学 一种针对β淀粉样蛋白的单域重链纳米抗体及其应用
CA2989400A1 (en) 2015-06-15 2016-12-22 Angiochem Inc. Ang1005 for the treatment of leptomeningeal carcinomatosis
AU2016326449B2 (en) 2015-09-21 2024-10-31 Aptevo Research And Development Llc CD3 binding polypeptides
WO2017072090A1 (en) * 2015-10-27 2017-05-04 Glaxosmithkline Intellectual Property Development Limited Combination therapy
WO2019006062A1 (en) * 2017-06-29 2019-01-03 The Trustees Of Columbia University In The City Of New York CHIMERIC ANTIBODIES FOR THE TREATMENT OF AMYLOID DETECTION DISEASES
US11382974B2 (en) 2017-08-01 2022-07-12 The Trustees Of Columbia University In The City Of New York Methods and compositions for treatment of amyloid deposition diseases
DK3461819T3 (da) 2017-09-29 2020-08-10 Probiodrug Ag Inhibitorer af glutaminylcyklase
US12018069B2 (en) 2018-06-28 2024-06-25 The Trustees Of Columbia University In The City Of New York Methods and compositions for imaging amyloid deposits
WO2020015637A1 (zh) * 2018-07-17 2020-01-23 江苏恒瑞医药股份有限公司 抗Abeta抗体、其抗原结合片段及应用
WO2020201828A1 (en) 2019-04-05 2020-10-08 Tauc3 Biologics Limited Anti-tauc3 antibodies and uses thereof
AU2021310926A1 (en) 2020-07-23 2023-03-23 Othair Prothena Limited Anti-abeta antibodies
TW202300517A (zh) 2021-03-12 2023-01-01 美商美國禮來大藥廠 抗類澱粉β抗體及其用途
WO2022251048A1 (en) 2021-05-24 2022-12-01 Eli Lilly And Company Anti-amyloid beta antibodies and uses thereof
CN114591918B (zh) * 2022-05-07 2022-07-26 北京第一生物化学药业有限公司 产生抗β-淀粉样蛋白抗体的杂交瘤细胞及其用途
CN114591917B (zh) * 2022-05-07 2022-09-02 北京第一生物化学药业有限公司 产生结合β-淀粉样蛋白的抗体的杂交瘤细胞及其用途
KR102530956B1 (ko) * 2022-09-08 2023-05-11 주식회사 알츠코리아 아밀로이드 베타 유래 에피토프를 유효성분으로 포함하는 알츠하이머성 치매 백신 조성물 및 이의 용도
CN118638219A (zh) * 2024-08-19 2024-09-13 成都迈科康生物科技有限公司 一种抗轮状病毒vp8蛋白的抗体或其抗原结合片段、抗体偶联物、核酸、载体、细胞及其应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5811517A (en) * 1992-01-27 1998-09-22 Icos Corporation ICAM-related protein variants
EP2006303A1 (en) * 1997-04-09 2008-12-24 Intellect Neurosciences, Inc. Recombinant antibodies specific for Beta-Amyloid ends, DNA encoding and methods of use thereof
US7179892B2 (en) 2000-12-06 2007-02-20 Neuralab Limited Humanized antibodies that recognize beta amyloid peptide
JP2002530122A (ja) * 1998-11-25 2002-09-17 サイオス インコーポレイテッド アミロイド関連疾患の予防及び治療
CN101670105B (zh) * 2000-02-24 2014-08-06 华盛顿大学 螯合淀粉样蛋白β肽的人源化抗体
WO2002038108A2 (en) * 2000-11-03 2002-05-16 The J. David Gladstone Institutes Methods of treating disorders related to apoe
WO2004029629A1 (en) * 2002-09-27 2004-04-08 Janssen Pharmaceutica N.V. N-11 truncated amyloid-beta nomoclonal antibodies, compositions, methods and uses
ITTO20020867A1 (it) * 2002-10-08 2004-04-09 Pro Cord Spa Schienale di sedia.
EP1633786A4 (en) 2002-10-09 2007-07-25 Rinat Neuroscience Corp METHOD FOR TREATING ALZHEIMER DISEASE WITH ANTIBODIES TO AMYLOID BETA PEPTIDE AND COMPOSITIONS THEREOF

Also Published As

Publication number Publication date
HK1138015A1 (en) 2010-08-13
CR10347A (es) 2008-10-29
IL193695A0 (en) 2011-08-01
PL2177536T3 (pl) 2014-11-28
EA015654B1 (ru) 2011-10-31
UA94734C2 (ru) 2011-06-10
DK2177536T3 (da) 2014-07-14
US20110142824A1 (en) 2011-06-16
KR20120093400A (ko) 2012-08-22
WO2007113172A2 (en) 2007-10-11
AR060332A1 (es) 2008-06-11
SI2177536T1 (sl) 2014-09-30
PT2177536E (pt) 2014-08-22
JO2576B1 (en) 2011-02-27
HRP20100115T1 (hr) 2010-04-30
AU2007233831B2 (en) 2013-02-14
EP1996621B1 (en) 2009-12-09
CA2647808C (en) 2015-11-17
PT1996621E (pt) 2010-03-08
MY149630A (en) 2013-09-13
KR101263294B1 (ko) 2013-06-04
US20140050719A1 (en) 2014-02-20
ATE451392T1 (de) 2009-12-15
JP5103466B2 (ja) 2012-12-19
HK1122311A1 (en) 2009-05-15
US9193784B2 (en) 2015-11-24
WO2007113172A3 (en) 2007-11-29
HRP20140618T1 (hr) 2014-08-15
SI1996621T1 (sl) 2010-04-30
US8227576B2 (en) 2012-07-24
EA200801842A1 (ru) 2009-02-27
IL193695A (en) 2012-05-31
DE602007003703D1 (de) 2010-01-21
JP2009531380A (ja) 2009-09-03
CA2647808A1 (en) 2007-10-11
ZA200807911B (en) 2009-11-25
AU2007233831A1 (en) 2007-10-11
US20160024197A1 (en) 2016-01-28
KR20080113273A (ko) 2008-12-29
CN101415729A (zh) 2009-04-22
EA015654B9 (ru) 2012-01-30
EP2177536B1 (en) 2014-06-04
TW200815466A (en) 2008-04-01
CN103539857A (zh) 2014-01-29
DK1996621T3 (da) 2010-04-19
MA30337B1 (fr) 2009-04-01
ES2484967T3 (es) 2014-08-12
BRPI0709246A2 (pt) 2011-07-12
NO20083793L (no) 2008-10-13
EP2177536A1 (en) 2010-04-21
MX2008012483A (es) 2008-10-10
NZ571038A (en) 2011-03-31
TWI385179B (zh) 2013-02-11
EP1996621A2 (en) 2008-12-03
CY1109877T1 (el) 2014-09-10
ES2338179T3 (es) 2010-05-04
PL1996621T3 (pl) 2010-05-31
CN101415729B (zh) 2013-09-04

Similar Documents

Publication Publication Date Title
PE20080181A1 (es) Anticuerpos que se unen al peptido beta-amiloide en el tratamiento de alzheimer
PE20121579A1 (es) Proteinas de enlace al antigeno il-23 humanas
PE20170687A1 (es) Proteinas de enlace a cd127
PE20090518A1 (es) Proteinas enlazantes de antigenos que enlazan al receptor de la interleucina 18 (il-18)
JP2020500538A5 (es)
CL2013003140A1 (es) Un anticuerpo monoclonal humano aislado o fragmento de union a antigeno del mismo que se une a masp-2 humana; molecula de acido nucleico, casette de expresion, celula que la expresa, metodo de produccion, composicion que la contiene, articulo que lo contiene.
EA201190132A1 (ru) Гуманизированные антитела, связывающиеся с cd19, и их применение
AU2016204274A1 (en) Antibodies that bind to OX40 and their uses
RS54088B1 (en) B-CELL REDUCTION BY USING CD37-SPECIFIC AND CD20-SPECIFIC BINDING MOLECULES
AR068723A1 (es) Proteina que se une a antigenos que se une a il-23 humana y sus usos
IL259940B2 (en) A method for treating or improving metabolic disorders using gastric inhibitory peptide receptor binding proteins in combination with glucagon-like peptide 1 agonists
RU2588467C3 (ru) Стабильные и растворимые антитела, ингибирующие vegf
NZ603972A (en) Anti-fgfr2 antibodies
AR086579A1 (es) Proteinas de union a antigeno
PE20131334A1 (es) Anticuerpo igg1 humanizado
PE20120554A1 (es) Polipeptidos y metodo de tratamiento
PE20161033A1 (es) Proteinas de union al antigeno gitr
ES2571129T3 (es) Anticuerpos anti-CTLA4 humanizados
PE20131400A1 (es) Proteinas de union a antigeno contra proproteina converstasa subtilisina/kexina tipo 9 (pcsk9)
RU2011105062A (ru) Нейтрализующие антитела против вируса гриппа а и их использование
HRP20171472T1 (hr) Optimizirana monoklonska protutijela protiv inhibitora puta tkivnog faktora (tfpi)
PE20080214A1 (es) Moleculas de anticuerpo que se unen a la il-17 humana
AR080698A1 (es) Anticuerpo o fragmento del mismo que especificamente enlaza la variante de csf -1r humano, composicion farmaceutica que lo comprende, su uso para la manufactura de un medicamento util para el tratamiento de cancer y metodo para determinar si un sujeto es candidato para tratamiento de cancer basado e
PE20090768A1 (es) Metodos y composiciones para el tratamiento de enfermedades alergicas
ES2776179T3 (es) Anticuerpos dirigidos contra determinantes de la superficie de S. aureus

Legal Events

Date Code Title Description
FG Grant, registration
FD Application declared void or lapsed