NO307473B1 - Fremgangsmõte for fremstilling av et pasteurisert trombinkonsentrat - Google Patents

Fremgangsmõte for fremstilling av et pasteurisert trombinkonsentrat Download PDF

Info

Publication number: NO307473B1
Authority: NO; Norway
Prior art keywords: thrombin; anion; prothrombin; prothrombin complex; complex
Prior art date: 1991-11-19

Application number

NO924453A

Other languages

English (en)

Norwegian (no)

Other versions

NO924453L (no

NO924453D0 (no

Inventor

Hermann Karges

Horst Naumann

Original Assignee

Aventis Behring Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-11-19

Filing date

1992-11-18

Publication date

2000-04-10

1992-11-18 Application filed by Aventis Behring Gmbh filed Critical Aventis Behring Gmbh

1992-11-18 Publication of NO924453D0 publication Critical patent/NO924453D0/no

1993-05-20 Publication of NO924453L publication Critical patent/NO924453L/no

2000-04-10 Publication of NO307473B1 publication Critical patent/NO307473B1/no

Links

108090000190 Thrombin Proteins 0.000 title claims abstract description 33
229960004072 thrombin Drugs 0.000 title claims abstract description 33
238000004519 manufacturing process Methods 0.000 title claims description 5
239000012141 concentrate Substances 0.000 title abstract description 13
108010094028 Prothrombin Proteins 0.000 claims abstract description 23
102100027378 Prothrombin Human genes 0.000 claims abstract description 23
229940039716 prothrombin Drugs 0.000 claims abstract description 23
238000000034 method Methods 0.000 claims abstract description 18
150000003839 salts Chemical class 0.000 claims description 15
150000001450 anions Chemical class 0.000 claims description 9
230000002779 inactivation Effects 0.000 claims description 8
241000700605 Viruses Species 0.000 claims description 6
-1 DEAE ion Chemical class 0.000 claims description 5
KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims description 4
241001465754 Metazoa Species 0.000 claims description 4
238000002360 preparation method Methods 0.000 claims description 4
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical group [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 3
102000005701 Calcium-Binding Proteins Human genes 0.000 claims description 3
108010045403 Calcium-Binding Proteins Proteins 0.000 claims description 3
229910019142 PO4 Inorganic materials 0.000 claims description 2
QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims description 2
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 2
239000010452 phosphate Substances 0.000 claims description 2
238000000746 purification Methods 0.000 claims description 2
230000003612 virological effect Effects 0.000 claims description 2
229910021653 sulphate ion Inorganic materials 0.000 claims 1
239000003814 drug Substances 0.000 abstract 1
230000000694 effects Effects 0.000 description 7
239000001509 sodium citrate Substances 0.000 description 6
101000651439 Homo sapiens Prothrombin Proteins 0.000 description 5
230000004913 activation Effects 0.000 description 5
238000001994 activation Methods 0.000 description 5
229940039715 human prothrombin Drugs 0.000 description 5
HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 description 5
229940038773 trisodium citrate Drugs 0.000 description 5
108010000499 Thromboplastin Proteins 0.000 description 3
102000002262 Thromboplastin Human genes 0.000 description 3
229910001424 calcium ion Inorganic materials 0.000 description 3
238000004090 dissolution Methods 0.000 description 3
244000052769 pathogen Species 0.000 description 3
102000004169 proteins and genes Human genes 0.000 description 3
108090000623 proteins and genes Proteins 0.000 description 3
241000283690 Bos taurus Species 0.000 description 2
239000000203 mixture Substances 0.000 description 2
229960003766 thrombin (human) Drugs 0.000 description 2
BFSVOASYOCHEOV-UHFFFAOYSA-N 2-diethylaminoethanol Chemical compound CCN(CC)CCO BFSVOASYOCHEOV-UHFFFAOYSA-N 0.000 description 1
208000030507 AIDS Diseases 0.000 description 1
108090000790 Enzymes Proteins 0.000 description 1
102000004190 Enzymes Human genes 0.000 description 1
108010074860 Factor Xa Proteins 0.000 description 1
108010049003 Fibrinogen Proteins 0.000 description 1
102000008946 Fibrinogen Human genes 0.000 description 1
239000003513 alkali Substances 0.000 description 1
150000001447 alkali salts Chemical class 0.000 description 1
150000003863 ammonium salts Chemical class 0.000 description 1
238000005349 anion exchange Methods 0.000 description 1
239000011575 calcium Substances 0.000 description 1
229910052791 calcium Inorganic materials 0.000 description 1
230000003197 catalytic effect Effects 0.000 description 1
238000006243 chemical reaction Methods 0.000 description 1
238000011109 contamination Methods 0.000 description 1
230000001419 dependent effect Effects 0.000 description 1
229940088598 enzyme Drugs 0.000 description 1
229940012952 fibrinogen Drugs 0.000 description 1
238000010438 heat treatment Methods 0.000 description 1
208000006454 hepatitis Diseases 0.000 description 1
231100000283 hepatitis Toxicity 0.000 description 1
238000009928 pasteurization Methods 0.000 description 1
230000001717 pathogenic effect Effects 0.000 description 1
239000011505 plaster Substances 0.000 description 1
238000011084 recovery Methods 0.000 description 1
NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
230000006641 stabilisation Effects 0.000 description 1
238000011105 stabilization Methods 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6429—Thrombin (3.4.21.5)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/10—Polypeptides; Proteins
- A61L24/106—Fibrin; Fibrinogen
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21005—Thrombin (3.4.21.5)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/829—Blood
- Y10S530/83—Plasma; serum

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Genetics & Genomics (AREA)
Biomedical Technology (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Microbiology (AREA)
Biotechnology (AREA)
Molecular Biology (AREA)
Surgery (AREA)
Epidemiology (AREA)
Hematology (AREA)
Chemical Kinetics & Catalysis (AREA)
Diabetes (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Enzymes And Modification Thereof (AREA)
External Artificial Organs (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

NO924453A 1991-11-19 1992-11-18 Fremgangsmõte for fremstilling av et pasteurisert trombinkonsentrat NO307473B1 (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE4137996A DE4137996A1 (de)	1991-11-19	1991-11-19	Verfahren zur herstellung eines virussicheren thrombinkonzentrates

Publications (3)

Publication Number	Publication Date
NO924453D0 NO924453D0 (no)	1992-11-18
NO924453L NO924453L (no)	1993-05-20
NO307473B1 true NO307473B1 (no)	2000-04-10

Family

ID=6445112

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO924453A NO307473B1 (no)	1991-11-19	1992-11-18	Fremgangsmõte for fremstilling av et pasteurisert trombinkonsentrat

Country Status (12)

Country	Link
US (1)	US5723123A (ko)
EP (1)	EP0543178B1 (ko)
JP (1)	JPH05194261A (ko)
KR (1)	KR100261360B1 (ko)
AT (1)	ATE162218T1 (ko)
AU (1)	AU658238B2 (ko)
CA (1)	CA2083243C (ko)
DE (2)	DE4137996A1 (ko)
DK (1)	DK0543178T3 (ko)
ES (1)	ES2113910T3 (ko)
GR (1)	GR3026253T3 (ko)
NO (1)	NO307473B1 (ko)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AT398079B (de) *	1991-11-04	1994-09-26	Immuno Ag	Präparation mit thrombinaktivität sowie verfahren zu ihrer herstellung
JPH07308190A (ja) *	1994-05-18	1995-11-28	Green Cross Corp:The	トロンビンの製造方法
DE4440892A1 (de) *	1994-11-17	1996-05-23	Gruenenthal Gmbh	Proteine mit fibrinolytischen und gerinnungshemmenden Eigenschaften
AUPN436995A0 (en) *	1995-07-24	1995-08-17	Csl Limited	Method for the production of thrombin
JP3944267B2 (ja) *	1996-08-09	2007-07-11	財団法人化学及血清療法研究所	プロトロンビンの活性化方法および該方法に基づくトロンビンの製造方法
EP0993311B1 (en)	1997-06-18	2012-11-14	Angiotech Pharmaceuticals (US), Inc.	Compositions containing thrombin and microfibrillar collagen, and methods for preparation and use thereof
US6096872A (en) *	1997-10-14	2000-08-01	Ortho Diagnostic Systems, Inc.	Viral clearance process
US6245548B1 (en) *	2000-03-09	2001-06-12	American National Red Cross	Activation of pure prothrombin to thrombin with about 30% to about 40% sodium citrate
DE10012732A1 (de) *	2000-03-18	2001-09-20	Aventis Behring Gmbh	Thrombin-Zubereitungen und Verfahren zu ihrer Herstellung
AU784808B2 (en) *	2001-04-02	2006-06-29	Kedrion Melville Inc.	Prion and viral clearance process
WO2003100080A2 (en) *	2002-05-23	2003-12-04	Ortho-Clinical Diagnostics, Inc.	Capture, concentration and quantitation of abnormal prion protein from biological fluids using depth filtration
GB0216002D0 (en)	2002-07-10	2002-08-21	Nat Blood Authority	Process and composition
AU2005229674B2 (en) *	2004-11-18	2010-11-04	Kedrion Melville Inc.	Low concentration solvent/detergent process of immuneglobulin with pre-treatment

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2394566A (en) *	1942-07-13	1946-02-12	Parke Davis & Co	Process for obtaining products derived from blood
US4357321A (en) *	1980-01-28	1982-11-02	Baxter Travenol Laboratories, Inc.	Method and composition for treating clotting factor inhibitors
US4442655A (en) *	1981-06-25	1984-04-17	Serapharm Michael Stroetmann	Fibrinogen-containing dry preparation, manufacture and use thereof
US4380511A (en) *	1981-08-12	1983-04-19	Miles Laboratories, Inc.	Purification of bovine thrombin
US4965203A (en) *	1987-01-28	1990-10-23	Warner-Lambert Company	Purified thrombin preparations
JPS63243032A (ja) *	1987-03-27	1988-10-07	Green Cross Corp:The	トロンビンの加熱処理方法
DE3843126C3 (de) *	1988-12-22	1994-10-06	Octapharma Ag	Verfahren zur Herstellung eines hochreinen Thrombinkonzentrates
US5525498A (en) *	1989-12-18	1996-06-11	Warner-Lambert Company	Process for preparing an ultra-pure thrombin preparation
US5281528A (en) *	1989-12-18	1994-01-25	Warner-Lambert Company	Process for purified thromboplastin for ultra-pure thrombin preparation
IE73210B1 (en) *	1990-01-24	1997-05-07	Warner Lambert Co	Process for the production of thrombin and high purity thrombin preparation thereby obtained
EP0443724B1 (en) *	1990-02-20	1999-03-17	Baxter International Inc.	Viral-safe purified human thrombin
JPH0813750B2 (ja) *	1990-03-01	1996-02-14	持田製薬株式会社	経口用トロンビン製剤
US5328898A (en) *	1990-06-22	1994-07-12	Duke University	Factor XIIIA fibrin binding fragments
DE69122376D1 (de) *	1991-03-28	1996-10-31	Warner Lambert Co	Hochreine Thrombinzubereitung
JPH04365481A (ja) *	1991-06-11	1992-12-17	Green Cross Corp:The	トロンビンの製造法
FR2679251B1 (fr) *	1991-07-18	1993-11-12	Nord Assoc Essor Transfusion San	Procede de preparation d'un concentre de thrombine humaine destine a un usage therapeutique.
AT398079B (de) *	1991-11-04	1994-09-26	Immuno Ag	Präparation mit thrombinaktivität sowie verfahren zu ihrer herstellung
AT397390B (de) *	1992-04-06	1994-03-25	Immuno Ag	Verfahren zur spaltung von proteinen
US5428014A (en) *	1993-08-13	1995-06-27	Zymogenetics, Inc.	Transglutaminase cross-linkable polypeptides and methods relating thereto
US5506127A (en) *	1994-09-21	1996-04-09	Proba; Zbigniew	Therapeutic grade thrombin produced by chromatography

1991
- 1991-11-19 DE DE4137996A patent/DE4137996A1/de not_active Withdrawn
1992
- 1992-10-24 DK DK92118227T patent/DK0543178T3/da active
- 1992-10-24 EP EP92118227A patent/EP0543178B1/de not_active Expired - Lifetime
- 1992-10-24 AT AT92118227T patent/ATE162218T1/de active
- 1992-10-24 ES ES92118227T patent/ES2113910T3/es not_active Expired - Lifetime
- 1992-10-24 DE DE59209133T patent/DE59209133D1/de not_active Expired - Lifetime
- 1992-11-17 KR KR1019920021542A patent/KR100261360B1/ko not_active IP Right Cessation
- 1992-11-18 CA CA002083243A patent/CA2083243C/en not_active Expired - Lifetime
- 1992-11-18 JP JP4308726A patent/JPH05194261A/ja active Pending
- 1992-11-18 AU AU28502/92A patent/AU658238B2/en not_active Ceased
- 1992-11-18 NO NO924453A patent/NO307473B1/no not_active IP Right Cessation
1995
- 1995-06-05 US US08/465,191 patent/US5723123A/en not_active Expired - Lifetime
1998
- 1998-02-27 GR GR980400430T patent/GR3026253T3/el unknown

Also Published As

Publication number	Publication date
ES2113910T3 (es)	1998-05-16
KR930009612A (ko)	1993-06-21
US5723123A (en)	1998-03-03
AU2850292A (en)	1993-05-20
DE4137996A1 (de)	1993-05-27
EP0543178A2 (de)	1993-05-26
JPH05194261A (ja)	1993-08-03
CA2083243A1 (en)	1993-05-20
AU658238B2 (en)	1995-04-06
DE59209133D1 (de)	1998-02-19
DK0543178T3 (da)	1998-09-14
ATE162218T1 (de)	1998-01-15
CA2083243C (en)	2005-02-22
EP0543178B1 (de)	1998-01-14
NO924453L (no)	1993-05-20
NO924453D0 (no)	1992-11-18
EP0543178A3 (en)	1994-07-06
GR3026253T3 (en)	1998-05-29
KR100261360B1 (ko)	2000-07-01

Legal Events

Date	Code	Title	Description
2012-06-25	MM1K	Lapsed by not paying the annual fees

Publication	Publication Date	Title
AU645715B2 (en)	1994-01-20	Thrombin and method of producing the same
NO307473B1 (no)	2000-04-10	Fremgangsmõte for fremstilling av et pasteurisert trombinkonsentrat
US4405603A (en)	1983-09-20	Method for rendering factors IX and X hepatitis-safe with calcium ions
US5011695A (en)	1991-04-30	Sterilization of blood and its derivatives with vitamins
HU213470B (en)	1997-06-30	Process for producing virus-inactivated blood-product
US5639730A (en)	1997-06-17	Method of producing a virus-safe biological preparation
JP2002275090A (ja)	2002-09-25	安定化蛋白質調製物およびその調製方法
JPH01100129A (ja)	1989-04-18	血漿または血漿分画の滅菌方法
EP0782616B1 (en)	2006-01-11	Therapeutic grade thrombin production and products
US4562072A (en)	1985-12-31	Process for the pasteurization of antihemophilic cryoprecipitate (AHC) and antihemophilic cryoprecipitate prepared thereby
JPH0143728B2 (ko)	1989-09-22
EP0173242B1 (de)	1992-03-18	Verfahren zur Herstellung einer pasteurisierten, isoagglutininfreien Faktor VIII Präparation aus einem Kryopräzipitat
CA1297011C (en)	1992-03-10	Method of producing a factor viii (ahf) containing fraction
US4579735A (en)	1986-04-01	Process for the pasteurization of human residual plasma
AU752271B2 (en)	2002-09-12	Method for preparing by filtration a virally secure factor VIII solution
JPS6237010B2 (ko)	1987-08-10
JP3143507B2 (ja)	2001-03-07	低温殺菌された鉄不含ヒトトランスフェリンの調製方法およびその使用
US5116950A (en)	1992-05-26	Process for heat treating fibrinogen
ES2232345T3 (es)	2005-06-01	Procedimiento para la inactivacion de virus.
JP2965069B2 (ja)	1999-10-18	蛋白質含有組成物の製造方法
NO175622B (ko)	1994-08-01
NO311662B1 (no)	2002-01-02	Fremgangsmåte for fremstilling av et virussikkert, terapeutisk, biologisk preparat fra humanplasma ved anvendelse avikke-ioniske tensider