MX2017006865A - Receptores de células t de kras anti-mutado. - Google Patents

Receptores de células t de kras anti-mutado.

Info

Publication number
MX2017006865A
MX2017006865A MX2017006865A MX2017006865A MX2017006865A MX 2017006865 A MX2017006865 A MX 2017006865A MX 2017006865 A MX2017006865 A MX 2017006865A MX 2017006865 A MX2017006865 A MX 2017006865A MX 2017006865 A MX2017006865 A MX 2017006865A
Authority
MX
Mexico
Prior art keywords
oncogene homolog
mammal
disclosed
methods
cell receptors
Prior art date
Application number
MX2017006865A
Other languages
English (en)
Inventor
Yu Zhiya
J Wang Qiong
c yang James
Original Assignee
Us Health
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Us Health filed Critical Us Health
Publication of MX2017006865A publication Critical patent/MX2017006865A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the cancer treated
    • A61K2239/54—Pancreas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001154—Enzymes
    • A61K39/001164—GTPases, e.g. Ras or Rho
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/463—Cellular immunotherapy characterised by recombinant expression
    • A61K39/4632—T-cell receptors [TCR]; antibody T-cell receptor constructs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • A61K39/4644—Cancer antigens
    • A61K39/464454—Enzymes
    • A61K39/464464—GTPases, e.g. Ras or Rho
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82—Translation products from oncogenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y306/00—Hydrolases acting on acid anhydrides (3.6)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5748—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving oncogenic proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Urology & Nephrology (AREA)
  • Toxicology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)

Abstract

Se expone un receptor de célula T (TCR) aislado o purificado que tiene especificidad antigénica para un epítopo HLA-A11-restringido del homólogo de oncogén viral de sarcoma de rata Kristen mutado (KRAS) (KRAS7-16), del homólogo de oncogén viral RAS (V-Ras) de neuroblastoma (NRAS), o del homólogo de oncogén viral de sarcoma de rata Harvey (HRAS). También se proporcionan polipéptidos y proteínas relacionados, así como ácidos nucleicos relacionados, vectores de expresión recombinante, células huésped, poblaciones de células y composiciones farmacéuticas. También se exponen métodos para detectar la presencia del cáncer en un mamífero y métodos para tratar o prevenir el cáncer en un mamífero.
MX2017006865A 2014-11-26 2015-11-24 Receptores de células t de kras anti-mutado. MX2017006865A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462084654P 2014-11-26 2014-11-26
US201562171321P 2015-06-05 2015-06-05
PCT/US2015/062269 WO2016085904A1 (en) 2014-11-26 2015-11-24 Anti-mutated kras t cell receptors

Publications (1)

Publication Number Publication Date
MX2017006865A true MX2017006865A (es) 2018-01-11

Family

ID=54838442

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2017006865A MX2017006865A (es) 2014-11-26 2015-11-24 Receptores de células t de kras anti-mutado.

Country Status (18)

Country Link
US (2) US11207394B2 (es)
EP (3) EP3666288B1 (es)
JP (2) JP6863893B2 (es)
KR (1) KR102622784B1 (es)
CN (2) CN107223134B (es)
AU (3) AU2015353720B2 (es)
CA (1) CA2968399A1 (es)
ES (2) ES2965689T3 (es)
HK (1) HK1243642A1 (es)
HU (1) HUE065689T2 (es)
IL (1) IL252258B (es)
MX (1) MX2017006865A (es)
PL (1) PL3223850T3 (es)
PT (1) PT3223850T (es)
SA (1) SA517381608B1 (es)
SG (2) SG10201913978RA (es)
SI (1) SI3223850T1 (es)
WO (1) WO2016085904A1 (es)

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Also Published As

Publication number Publication date
JP7297807B2 (ja) 2023-06-26
EP3223850B1 (en) 2020-01-08
SG11201704155UA (en) 2017-06-29
AU2015353720A1 (en) 2017-06-08
AU2015353720B2 (en) 2020-02-27
AU2023200614A1 (en) 2023-03-09
PT3223850T (pt) 2020-04-13
JP6863893B2 (ja) 2021-04-21
EP3666288A1 (en) 2020-06-17
CN113956349A (zh) 2022-01-21
WO2016085904A1 (en) 2016-06-02
KR102622784B1 (ko) 2024-01-09
IL252258A0 (en) 2017-07-31
CN107223134A (zh) 2017-09-29
CN107223134B (zh) 2021-11-16
ES2965689T3 (es) 2024-04-16
KR20170099905A (ko) 2017-09-01
PL3223850T3 (pl) 2020-08-24
US11207394B2 (en) 2021-12-28
ES2784261T3 (es) 2020-09-23
EP3223850A1 (en) 2017-10-04
SG10201913978RA (en) 2020-03-30
US20220088164A1 (en) 2022-03-24
AU2020203465B2 (en) 2022-11-17
JP2021104044A (ja) 2021-07-26
AU2020203465A1 (en) 2020-06-18
HUE065689T2 (hu) 2024-06-28
EP3666288B1 (en) 2023-09-27
JP2017536825A (ja) 2017-12-14
EP4286407A2 (en) 2023-12-06
CN113956349B (zh) 2024-09-06
SI3223850T1 (sl) 2020-09-30
HK1243642A1 (zh) 2018-07-20
IL252258B (en) 2021-12-01
EP4286407A3 (en) 2024-03-06
US20170304421A1 (en) 2017-10-26
CA2968399A1 (en) 2016-06-02
NZ732045A (en) 2024-04-26
SA517381608B1 (ar) 2021-03-11

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