BR112021023794A2 - Agente de direcionamento de antígeno, molécula de ácido nucleico isolada, composição farmacêutica, célula citotóxica, e, métodos para produzir uma célula citotóxica, para realizar uma terapia celular adotiva, para realizar uma imunoterapia e para detectar câncer em um sujeito mamífero - Google Patents

Agente de direcionamento de antígeno, molécula de ácido nucleico isolada, composição farmacêutica, célula citotóxica, e, métodos para produzir uma célula citotóxica, para realizar uma terapia celular adotiva, para realizar uma imunoterapia e para detectar câncer em um sujeito mamífero

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Publication number
BR112021023794A2
BR112021023794A2 BR112021023794A BR112021023794A BR112021023794A2 BR 112021023794 A2 BR112021023794 A2 BR 112021023794A2 BR 112021023794 A BR112021023794 A BR 112021023794A BR 112021023794 A BR112021023794 A BR 112021023794A BR 112021023794 A2 BR112021023794 A2 BR 112021023794A2
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BR
Brazil
Prior art keywords
cytotoxic cell
antigen targeting
targeting agent
immunotherapy
cell
Prior art date
Application number
BR112021023794A
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English (en)
Inventor
Craig Rive
Robert Holt
Simon Turcotte
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Provincial Health Services Authority
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Provincial Health Services Authority filed Critical Provincial Health Services Authority
Publication of BR112021023794A2 publication Critical patent/BR112021023794A2/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/463—Cellular immunotherapy characterised by recombinant expression
    • A61K39/4632—T-cell receptors [TCR]; antibody T-cell receptor constructs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • A61K39/4644—Cancer antigens
    • A61K39/464454—Enzymes
    • A61K39/464464—GTPases, e.g. Ras or Rho
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
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    • C12N5/0646—Natural killers cells [NK], NKT cells
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    • C12Y—ENZYMES
    • C12Y306/00—Hydrolases acting on acid anhydrides (3.6)
    • C12Y306/05—Hydrolases acting on acid anhydrides (3.6) acting on GTP; involved in cellular and subcellular movement (3.6.5)
    • C12Y306/05002—Small monomeric GTPase (3.6.5.2)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
    • G—PHYSICS
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
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    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5748—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving oncogenic proteins
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    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
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    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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Abstract

uagente de direcionamento de antígeno, molécula de ácido nucleico isolada, composição farmacêutica, célula citotóxica, e, métodos para produzir uma célula citotóxica, para realizar uma terapia celular adotiva, para realizar uma imunoterapia e para detectar câncer em um sujeito mamífero. um agente de direcionamento de antígeno é provido. o agente de direcionamento de antígeno se liga a uma proteína homóloga do oncogene viral do sarcoma de rato kirsten mutado (kras) tendo uma mutação missense na posição 12 quando um peptídeo incorporando a mutação missense é apresentado por uma molécula hla-a*02. a mutação missense na posição 12 da proteína kras pode ser g12d, g12v ou g12c. os agentes de direcionamento de antígeno podem ser usados para diagnóstico ou para imunoterapia.
BR112021023794A 2019-05-27 2020-05-26 Agente de direcionamento de antígeno, molécula de ácido nucleico isolada, composição farmacêutica, célula citotóxica, e, métodos para produzir uma célula citotóxica, para realizar uma terapia celular adotiva, para realizar uma imunoterapia e para detectar câncer em um sujeito mamífero BR112021023794A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962853102P 2019-05-27 2019-05-27
PCT/CA2020/050715 WO2020237368A1 (en) 2019-05-27 2020-05-26 Immunotherapy constructs targeting kras antigens

Publications (1)

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BR112021023794A2 true BR112021023794A2 (pt) 2022-01-04

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ID=73552510

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112021023794A BR112021023794A2 (pt) 2019-05-27 2020-05-26 Agente de direcionamento de antígeno, molécula de ácido nucleico isolada, composição farmacêutica, célula citotóxica, e, métodos para produzir uma célula citotóxica, para realizar uma terapia celular adotiva, para realizar uma imunoterapia e para detectar câncer em um sujeito mamífero

Country Status (8)

Country Link
US (1) US20220227883A1 (pt)
EP (1) EP3976641A4 (pt)
JP (1) JP2022534051A (pt)
KR (1) KR20220013569A (pt)
AU (1) AU2020285380A1 (pt)
BR (1) BR112021023794A2 (pt)
CA (1) CA3141651A1 (pt)
WO (1) WO2020237368A1 (pt)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116640218B (zh) * 2023-06-01 2024-06-04 皖南医学院第一附属医院（皖南医学院弋矶山医院） 一种靶向kras g12v单链抗体片段、嵌合抗原受体car及应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3666288B1 (en) * 2014-11-26 2023-09-27 The United States of America, as represented by The Secretary, Department of Health and Human Services Anti-mutated kras t cell receptors
CN107922950B (zh) * 2015-06-01 2021-12-31 基因医疗免疫疗法有限责任公司 T细胞受体文库
EA202090757A1 (ru) * 2017-09-29 2020-08-21 Дзе Юнайтед Стейтс Оф Америка, Эз Репрезентед Бай Дзе Секретари, Департмент Оф Хелс Энд Хьюман Сёрвисез T-КЛЕТОЧНЫЕ РЕЦЕПТОРЫ, РАСПОЗНАЮЩИЕ МУТАНТНЫЙ p53

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KR20220013569A (ko) 2022-02-04
AU2020285380A1 (en) 2022-01-20
EP3976641A4 (en) 2023-06-14
US20220227883A1 (en) 2022-07-21
WO2020237368A1 (en) 2020-12-03
CA3141651A1 (en) 2020-12-03
JP2022534051A (ja) 2022-07-27
EP3976641A1 (en) 2022-04-06

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