LU82087A1 - N-benzylimidazoles inhibiteurs selectifs de thromboxannesynthetase,leur procede de production et compositions pharmaceutiques les contenant - Google Patents

N-benzylimidazoles inhibiteurs selectifs de thromboxannesynthetase,leur procede de production et compositions pharmaceutiques les contenant Download PDF

Info

Publication number
LU82087A1
LU82087A1 LU82087A LU82087A LU82087A1 LU 82087 A1 LU82087 A1 LU 82087A1 LU 82087 A LU82087 A LU 82087A LU 82087 A LU82087 A LU 82087A LU 82087 A1 LU82087 A1 LU 82087A1
Authority
LU
Luxembourg
Prior art keywords
group
imidazolylmethyl
compound
compound according
phenoxy
Prior art date
Application number
LU82087A
Other languages
English (en)
French (fr)
Inventor
R Dickinson
P Cross
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of LU82087A1 publication Critical patent/LU82087A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/60—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
LU82087A 1979-01-19 1980-01-15 N-benzylimidazoles inhibiteurs selectifs de thromboxannesynthetase,leur procede de production et compositions pharmaceutiques les contenant LU82087A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB7902114 1979-01-19
GB7902114 1979-01-19

Publications (1)

Publication Number Publication Date
LU82087A1 true LU82087A1 (fr) 1980-04-23

Family

ID=10502633

Family Applications (1)

Application Number Title Priority Date Filing Date
LU82087A LU82087A1 (fr) 1979-01-19 1980-01-15 N-benzylimidazoles inhibiteurs selectifs de thromboxannesynthetase,leur procede de production et compositions pharmaceutiques les contenant

Country Status (31)

Country Link
US (2) US4555516A (it)
JP (1) JPS5946504B2 (it)
KR (1) KR840001707B1 (it)
AR (1) AR222204A1 (it)
AT (1) AT373880B (it)
AU (1) AU517241B2 (it)
BE (1) BE881245A (it)
CA (1) CA1137481A (it)
CH (1) CH646154A5 (it)
DD (1) DD148773A5 (it)
DE (1) DE3001762A1 (it)
DK (1) DK531479A (it)
ES (1) ES487843A0 (it)
FI (1) FI800143A (it)
FR (1) FR2446828A1 (it)
GR (1) GR71914B (it)
HU (1) HU184227B (it)
IE (1) IE49364B1 (it)
IL (1) IL59150A (it)
IT (1) IT1140523B (it)
LU (1) LU82087A1 (it)
NL (1) NL8000333A (it)
NO (1) NO800131L (it)
NZ (1) NZ192640A (it)
PH (1) PH14910A (it)
PL (1) PL123985B1 (it)
PT (1) PT70707A (it)
SE (1) SE8000435L (it)
SU (1) SU906374A3 (it)
YU (1) YU11380A (it)
ZA (1) ZA80298B (it)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2458545A1 (fr) * 1979-06-07 1981-01-02 Shionogi & Co Procede de preparation de derives de benzylimidazole, nouveaux produits ainsi obtenus, et leur utilisation pour leurs activites antimycotique et fongicide

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56113766A (en) * 1980-02-12 1981-09-07 Teijin Ltd Novel 1-substituted imidazole derivative and its preparation
JPS57169452A (en) * 1981-04-14 1982-10-19 Teikoku Hormone Mfg Co Ltd Novel phenoxyalkylamide derivative
DE3235589A1 (de) * 1982-09-25 1984-03-29 Hoechst Ag, 6230 Frankfurt Benzylether von phenol-mannich-basen, verfahren zu ihrer herstellung, ihre verwendung sowie pharmazeutische praeparate auf basis dieser verbindungen, zwischenprodukte und verfahren zu deren herstellung
DE3424944A1 (de) * 1984-07-06 1986-02-06 Hoechst Ag, 6230 Frankfurt Neue imidazolyverbindungen, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
US4978672A (en) * 1986-03-07 1990-12-18 Ciba-Geigy Corporation Alpha-heterocyclc substituted tolunitriles
US4937250A (en) * 1988-03-07 1990-06-26 Ciba-Geigy Corporation Alpha-heterocycle substituted tolunitriles
US5138069A (en) * 1986-07-11 1992-08-11 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking imidazoles
CA1338238C (en) 1988-01-07 1996-04-09 David John Carini Angiotensin ii receptor blocking imidazoles and combinations thereof with diuretics and nsaids
US5210079A (en) * 1988-01-07 1993-05-11 E. I. Du Pont De Nemours And Company Treatment of chronic renal failure with imidazole angiotensin-II receptor antagonists
US4880804A (en) * 1988-01-07 1989-11-14 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking benzimidazoles
US5354867A (en) * 1988-12-06 1994-10-11 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking imidazoles
EP0479892A1 (en) * 1989-06-30 1992-04-15 E.I. Du Pont De Nemours And Company Fused-ring aryl substituted imidazoles
US5073566A (en) * 1989-11-30 1991-12-17 Eli Lilly And Company Angiotensin ii antagonist 1,3-imidazoles and use thereas
US5616599A (en) * 1991-02-21 1997-04-01 Sankyo Company, Limited Angiotensin II antagosist 1-biphenylmethylimidazole compounds and their therapeutic use
US5332820A (en) * 1991-05-20 1994-07-26 E. I. Du Pont De Nemours And Company Dibenzobicyclo(2.2.2) octane angiotensin II antagonists
US5401851A (en) * 1992-06-03 1995-03-28 Eli Lilly And Company Angiotensin II antagonists
US5612360A (en) * 1992-06-03 1997-03-18 Eli Lilly And Company Angiotensin II antagonists
JP3501484B2 (ja) * 1992-12-17 2004-03-02 三共株式会社 ビフェニル誘導体
EP0757988A4 (en) * 1994-04-27 2000-07-26 Nippon Soda Co IMIDAZOLE DERIVATIVE AND PROCESS FOR PRODUCING THE SAME
TW434240B (en) * 1995-06-20 2001-05-16 Zeneca Ltd Aromatic compounds, preparation thereof and pharmaceutical composition comprising same
CN1092645C (zh) * 1995-12-27 2002-10-16 卫福有限公司 糖尿病并发症的预防/治疗药
JP4056589B2 (ja) * 1996-07-19 2008-03-05 武田薬品工業株式会社 複素環化合物、その製造法および用途
IT1295405B1 (it) 1997-09-30 1999-05-12 Merck Sharp & Dohme Italia S P Uso di un antagonista recettoriale di angiotensina ii per la preparazione di farmaci per aumentare il tasso di sopravvivenza di
KR100423890B1 (ko) * 2000-10-19 2004-03-24 씨제이 주식회사 세팔로스포린 유도체의 새로운 제조방법
TW200505913A (en) * 2003-03-28 2005-02-16 Hoffmann La Roche Novel oxazole derivatives, their manufacture and use as pharmaceutical agents
CN117624052B (zh) * 2024-01-26 2024-04-12 四川益能康生环保科技有限公司 一种用于捕集二氧化碳的离子液体及其制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH271776A (de) * 1949-01-06 1950-11-15 Ag J R Geigy Verfahren zur Herstellung eines basischen Äthers eines ortho-substituierten Phenols.
US3498999A (en) * 1966-04-20 1970-03-03 Bristol Myers Co 1-phenoxy and substituted phenoxy-3-(5-tetrazolyl) propanes
IE40911B1 (en) * 1974-04-11 1979-09-12 Schering Ag Imidazole derivatives and process for their manufacture
DE2461406C2 (de) * 1974-12-24 1984-06-14 Bayer Ag, 5090 Leverkusen Azolyl-(1)-methane und deren Salze, Verfahren zu ihrer Herstellung sowie diese enthaltende Arzneimittel
US4085209A (en) * 1975-02-05 1978-04-18 Rohm And Haas Company Preparation and safening effect of 1-substituted imidazole metal salt complexes
DE2646143A1 (de) * 1976-10-13 1978-04-20 Bayer Ag 4,5-dichlor-imidazol-1-carbonsaeure- arylester, verfahren zu ihrer herstellung sowie ihre verwendung als pflanzenschutzmittel
JPS5951943B2 (ja) * 1978-08-21 1984-12-17 キツセイ薬品工業株式会社 新規なイミダゾ−ル誘導体

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2458545A1 (fr) * 1979-06-07 1981-01-02 Shionogi & Co Procede de preparation de derives de benzylimidazole, nouveaux produits ainsi obtenus, et leur utilisation pour leurs activites antimycotique et fongicide

Also Published As

Publication number Publication date
US4448781A (en) 1984-05-15
DE3001762A1 (de) 1980-07-24
FR2446828B1 (it) 1983-05-13
IE49364B1 (en) 1985-09-18
SE8000435L (sv) 1980-07-20
KR830001905A (ko) 1983-05-19
PL221461A1 (it) 1980-09-22
IE800102L (en) 1980-07-19
KR840001707B1 (ko) 1984-10-16
HU184227B (en) 1984-07-30
AU517241B2 (en) 1981-07-16
NZ192640A (en) 1984-07-31
IT1140523B (it) 1986-10-01
FR2446828A1 (fr) 1980-08-14
IT8019276A0 (it) 1980-01-17
IL59150A (en) 1983-11-30
ATA24680A (de) 1983-07-15
DK531479A (da) 1980-07-20
NL8000333A (nl) 1980-07-22
FI800143A (fi) 1980-07-20
GR71914B (it) 1983-08-16
BE881245A (fr) 1980-07-18
ZA80298B (en) 1981-08-26
AT373880B (de) 1984-02-27
ES8101557A1 (es) 1980-12-16
AR222204A1 (es) 1981-04-30
YU11380A (en) 1983-04-30
US4555516A (en) 1985-11-26
SU906374A3 (ru) 1982-02-15
PT70707A (en) 1980-02-01
NO800131L (no) 1980-07-21
PH14910A (en) 1982-01-29
PL123985B1 (en) 1982-12-31
JPS5946504B2 (ja) 1984-11-13
DD148773A5 (de) 1981-06-10
IL59150A0 (en) 1980-05-30
JPS55100368A (en) 1980-07-31
CA1137481A (en) 1982-12-14
ES487843A0 (es) 1980-12-16
AU5474380A (en) 1980-07-24
CH646154A5 (de) 1984-11-15

Similar Documents

Publication Publication Date Title
LU82087A1 (fr) N-benzylimidazoles inhibiteurs selectifs de thromboxannesynthetase,leur procede de production et compositions pharmaceutiques les contenant
EP0506532B1 (fr) Nouveaux dérivés de l'indole, procédé de préparation et médicaments les contenant
LU82224A1 (fr) Nouveaux 3-(1-imidazolylalkyl)indoles, leur procede de production et composition pharmaceutique les contenant
FR2607493A1 (fr) Nouveaux composes pharmacologiquement actifs, leurs procedes de preparation et les compositions en contenant
FR2517303A1 (fr) Derives d'imidazole
EP0054417B1 (en) Indole thromboxane synthetase inhibitors, processes for their preparation, and pharmaceutical compositions containing them
LU85747A1 (fr) Derives d'imidazole leur preparation et utilisation ainsi que les compositions pharmaceutiques contenant des derives
EP0069513B1 (en) Indole thromboxane synthetase inhibitors, processes for their preparation, and pharmaceutical compositions containing them
EP0010460B1 (fr) Nouveaux dérivés de pyrrolidine-2-méthanol, procédé pour leur préparation et médicaments les contenant
EP0117771B1 (fr) Imino-2 pyrrolidines, leur procédé de préparation et leurs applications en thérapeutique
LU81598A1 (fr) Nouveaux derives d'imidazole,leur procede de production et composition pharmaceutique les contenant
EP1165491B1 (fr) Inhibiteurs de lta4 hydrolase
CH631179A5 (fr) Tetrahydro-4,5,6,7 thieno (2,3-c) et (3,2-c) pyridines et leur procede de preparation.
CA2089349C (fr) Nouveaux derives de pyrrolidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2521992A1 (fr) Nouveaux composes de pyridine utiles comme medicaments
EP0021924B1 (fr) Dérivés de l'indole, procédé pour leur préparation, leur application comme médicaments et compositions pharmaceutiques les contenant
EP0259206B1 (fr) Dérivés de la dihydro-1,4 pyridine leurs procédés de préparation et les compositions pharmaceutiques qui les contiennent
EP0238401B1 (fr) Nouveaux sulfonamides dérivés de diarylméthanes et leurs procédés de préparation et les compositions pharmaceutiques les contenant
EP0119107A1 (fr) Nouveaux dérivés du bicyclo(4.2.0)octatriène-1,3,5, leur préparation et leur application en thérapeutique
JPH02275846A (ja) カルボン酸誘導体
FR2528844A1 (fr) Nouvelles thiazolyl-2 hydrazones, leur procede de preparation et leur application en therapeutique
FR2514352A1 (it)
EP0039646A1 (fr) Nouvelles benzo (1,4) dioxines, leurs méthodes de préparation et leur application en thérapeutique
BE856055A (fr) Derives de 4-hydroxyphenylalcanolamine et leur preparation
EP0033432A1 (fr) Composition thérapeutique à base d'imidazoles destinée notamment au traitement des thromboses, nouveaux imidazoles et leur procédé de préparation