IT1140523B - N-benzil-immidazoli come inibitori selettivi dell'enzima trombossano sintetasi,loro composizioni - Google Patents

N-benzil-immidazoli come inibitori selettivi dell'enzima trombossano sintetasi,loro composizioni

Info

Publication number: IT1140523B
Authority: IT; Italy
Prior art keywords: immidazols; thrombose; benzyl; compositions; selective inhibitors
Prior art date: 1979-01-19

Application number

IT19276/80A

Other languages

English (en)

Other versions

IT8019276A0 (it

Inventor

Peter Edward Cross

Roger Peter Dickinson

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1979-01-19

Filing date

1980-01-17

Publication date

1986-10-01

1980-01-17 Application filed by Pfizer filed Critical Pfizer

1980-01-17 Publication of IT8019276A0 publication Critical patent/IT8019276A0/it

1986-10-01 Application granted granted Critical

1986-10-01 Publication of IT1140523B publication Critical patent/IT1140523B/it

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C07D233/60—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to ring nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pain & Pain Management (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

IT19276/80A 1979-01-19 1980-01-17 N-benzil-immidazoli come inibitori selettivi dell'enzima trombossano sintetasi,loro composizioni IT1140523B (it)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB7902114		1979-01-19

Publications (2)

Publication Number	Publication Date
IT8019276A0 IT8019276A0 (it)	1980-01-17
IT1140523B true IT1140523B (it)	1986-10-01

Family

ID=10502633

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IT19276/80A IT1140523B (it)	1979-01-19	1980-01-17	N-benzil-immidazoli come inibitori selettivi dell'enzima trombossano sintetasi,loro composizioni

Country Status (31)

Country	Link
US (2)	US4555516A (it)
JP (1)	JPS5946504B2 (it)
KR (1)	KR840001707B1 (it)
AR (1)	AR222204A1 (it)
AT (1)	AT373880B (it)
AU (1)	AU517241B2 (it)
BE (1)	BE881245A (it)
CA (1)	CA1137481A (it)
CH (1)	CH646154A5 (it)
DD (1)	DD148773A5 (it)
DE (1)	DE3001762A1 (it)
DK (1)	DK531479A (it)
ES (1)	ES487843A0 (it)
FI (1)	FI800143A (it)
FR (1)	FR2446828A1 (it)
GR (1)	GR71914B (it)
HU (1)	HU184227B (it)
IE (1)	IE49364B1 (it)
IL (1)	IL59150A (it)
IT (1)	IT1140523B (it)
LU (1)	LU82087A1 (it)
NL (1)	NL8000333A (it)
NO (1)	NO800131L (it)
NZ (1)	NZ192640A (it)
PH (1)	PH14910A (it)
PL (1)	PL123985B1 (it)
PT (1)	PT70707A (it)
SE (1)	SE8000435L (it)
SU (1)	SU906374A3 (it)
YU (1)	YU11380A (it)
ZA (1)	ZA80298B (it)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK157860C (da) *	1979-06-07	1990-07-30	Shionogi & Co	Analogifremgangsmaade til fremstilling af benzylimidazolderivater samt farmaceutisk acceptable syreadditionssalte deraf
JPS56113766A (en) *	1980-02-12	1981-09-07	Teijin Ltd	Novel 1-substituted imidazole derivative and its preparation
JPS57169452A (en) *	1981-04-14	1982-10-19	Teikoku Hormone Mfg Co Ltd	Novel phenoxyalkylamide derivative
DE3235589A1 (de) *	1982-09-25	1984-03-29	Hoechst Ag, 6230 Frankfurt	Benzylether von phenol-mannich-basen, verfahren zu ihrer herstellung, ihre verwendung sowie pharmazeutische praeparate auf basis dieser verbindungen, zwischenprodukte und verfahren zu deren herstellung
DE3424944A1 (de) *	1984-07-06	1986-02-06	Hoechst Ag, 6230 Frankfurt	Neue imidazolyverbindungen, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
US4978672A (en) *	1986-03-07	1990-12-18	Ciba-Geigy Corporation	Alpha-heterocyclc substituted tolunitriles
US4937250A (en) *	1988-03-07	1990-06-26	Ciba-Geigy Corporation	Alpha-heterocycle substituted tolunitriles
US5138069A (en) *	1986-07-11	1992-08-11	E. I. Du Pont De Nemours And Company	Angiotensin II receptor blocking imidazoles
CA1338238C (en)	1988-01-07	1996-04-09	David John Carini	Angiotensin ii receptor blocking imidazoles and combinations thereof with diuretics and nsaids
US5210079A (en) *	1988-01-07	1993-05-11	E. I. Du Pont De Nemours And Company	Treatment of chronic renal failure with imidazole angiotensin-II receptor antagonists
US4880804A (en) *	1988-01-07	1989-11-14	E. I. Du Pont De Nemours And Company	Angiotensin II receptor blocking benzimidazoles
US5354867A (en) *	1988-12-06	1994-10-11	E. I. Du Pont De Nemours And Company	Angiotensin II receptor blocking imidazoles
EP0479892A1 (en) *	1989-06-30	1992-04-15	E.I. Du Pont De Nemours And Company	Fused-ring aryl substituted imidazoles
US5073566A (en) *	1989-11-30	1991-12-17	Eli Lilly And Company	Angiotensin ii antagonist 1,3-imidazoles and use thereas
US5616599A (en) *	1991-02-21	1997-04-01	Sankyo Company, Limited	Angiotensin II antagosist 1-biphenylmethylimidazole compounds and their therapeutic use
US5332820A (en) *	1991-05-20	1994-07-26	E. I. Du Pont De Nemours And Company	Dibenzobicyclo(2.2.2) octane angiotensin II antagonists
US5401851A (en) *	1992-06-03	1995-03-28	Eli Lilly And Company	Angiotensin II antagonists
US5612360A (en) *	1992-06-03	1997-03-18	Eli Lilly And Company	Angiotensin II antagonists
JP3501484B2 (ja) *	1992-12-17	2004-03-02	三共株式会社	ビフェニル誘導体
EP0757988A4 (en) *	1994-04-27	2000-07-26	Nippon Soda Co	IMIDAZOLE DERIVATIVE AND PROCESS FOR PRODUCING THE SAME
TW434240B (en) *	1995-06-20	2001-05-16	Zeneca Ltd	Aromatic compounds, preparation thereof and pharmaceutical composition comprising same
CN1092645C (zh) *	1995-12-27	2002-10-16	卫福有限公司	糖尿病并发症的预防/治疗药
JP4056589B2 (ja) *	1996-07-19	2008-03-05	武田薬品工業株式会社	複素環化合物、その製造法および用途
IT1295405B1 (it)	1997-09-30	1999-05-12	Merck Sharp & Dohme Italia S P	Uso di un antagonista recettoriale di angiotensina ii per la preparazione di farmaci per aumentare il tasso di sopravvivenza di
KR100423890B1 (ko) *	2000-10-19	2004-03-24	씨제이 주식회사	세팔로스포린 유도체의 새로운 제조방법
TW200505913A (en) *	2003-03-28	2005-02-16	Hoffmann La Roche	Novel oxazole derivatives, their manufacture and use as pharmaceutical agents
CN117624052B (zh) *	2024-01-26	2024-04-12	四川益能康生环保科技有限公司	一种用于捕集二氧化碳的离子液体及其制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH271776A (de) *	1949-01-06	1950-11-15	Ag J R Geigy	Verfahren zur Herstellung eines basischen Äthers eines ortho-substituierten Phenols.
US3498999A (en) *	1966-04-20	1970-03-03	Bristol Myers Co	1-phenoxy and substituted phenoxy-3-(5-tetrazolyl) propanes
IE40911B1 (en) *	1974-04-11	1979-09-12	Schering Ag	Imidazole derivatives and process for their manufacture
DE2461406C2 (de) *	1974-12-24	1984-06-14	Bayer Ag, 5090 Leverkusen	Azolyl-(1)-methane und deren Salze, Verfahren zu ihrer Herstellung sowie diese enthaltende Arzneimittel
US4085209A (en) *	1975-02-05	1978-04-18	Rohm And Haas Company	Preparation and safening effect of 1-substituted imidazole metal salt complexes
DE2646143A1 (de) *	1976-10-13	1978-04-20	Bayer Ag	4,5-dichlor-imidazol-1-carbonsaeure- arylester, verfahren zu ihrer herstellung sowie ihre verwendung als pflanzenschutzmittel
JPS5951943B2 (ja) *	1978-08-21	1984-12-17	キツセイ薬品工業株式会社	新規なイミダゾ−ル誘導体

1979
- 1979-12-13 DK DK531479A patent/DK531479A/da not_active Application Discontinuation
1980
- 1980-01-09 US US06/110,711 patent/US4555516A/en not_active Expired - Lifetime
- 1980-01-15 LU LU82087A patent/LU82087A1/fr unknown
- 1980-01-17 PT PT70707A patent/PT70707A/pt unknown
- 1980-01-17 ZA ZA00800298A patent/ZA80298B/xx unknown
- 1980-01-17 GR GR60978A patent/GR71914B/el unknown
- 1980-01-17 AT AT0024680A patent/AT373880B/de not_active IP Right Cessation
- 1980-01-17 AR AR279667A patent/AR222204A1/es active
- 1980-01-17 FI FI800143A patent/FI800143A/fi not_active Application Discontinuation
- 1980-01-17 YU YU00113/80A patent/YU11380A/xx unknown
- 1980-01-17 IL IL59150A patent/IL59150A/xx unknown
- 1980-01-17 IT IT19276/80A patent/IT1140523B/it active
- 1980-01-18 ES ES487843A patent/ES487843A0/es active Granted
- 1980-01-18 SE SE8000435A patent/SE8000435L/xx not_active Application Discontinuation
- 1980-01-18 CA CA000343989A patent/CA1137481A/en not_active Expired
- 1980-01-18 IE IE102/80A patent/IE49364B1/en unknown
- 1980-01-18 CH CH42080A patent/CH646154A5/de not_active IP Right Cessation
- 1980-01-18 SU SU802872552A patent/SU906374A3/ru active
- 1980-01-18 HU HU80105A patent/HU184227B/hu unknown
- 1980-01-18 NL NL8000333A patent/NL8000333A/nl not_active Application Discontinuation
- 1980-01-18 FR FR8001082A patent/FR2446828A1/fr active Granted
- 1980-01-18 AU AU54743/80A patent/AU517241B2/en not_active Ceased
- 1980-01-18 DD DD80218534A patent/DD148773A5/de unknown
- 1980-01-18 NO NO800131A patent/NO800131L/no unknown
- 1980-01-18 JP JP55004474A patent/JPS5946504B2/ja not_active Expired
- 1980-01-18 BE BE0/199041A patent/BE881245A/fr not_active IP Right Cessation
- 1980-01-18 DE DE19803001762 patent/DE3001762A1/de not_active Ceased
- 1980-01-19 PL PL1980221461A patent/PL123985B1/pl unknown
- 1980-01-19 KR KR1019800000190A patent/KR840001707B1/ko active
- 1980-01-21 PH PH23530A patent/PH14910A/en unknown
- 1980-06-17 NZ NZ192640A patent/NZ192640A/en unknown
1981
- 1981-07-27 US US06/286,808 patent/US4448781A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
US4448781A (en)	1984-05-15
DE3001762A1 (de)	1980-07-24
FR2446828B1 (it)	1983-05-13
IE49364B1 (en)	1985-09-18
SE8000435L (sv)	1980-07-20
KR830001905A (ko)	1983-05-19
PL221461A1 (it)	1980-09-22
IE800102L (en)	1980-07-19
KR840001707B1 (ko)	1984-10-16
HU184227B (en)	1984-07-30
AU517241B2 (en)	1981-07-16
NZ192640A (en)	1984-07-31
FR2446828A1 (fr)	1980-08-14
IT8019276A0 (it)	1980-01-17
IL59150A (en)	1983-11-30
ATA24680A (de)	1983-07-15
DK531479A (da)	1980-07-20
LU82087A1 (fr)	1980-04-23
NL8000333A (nl)	1980-07-22
FI800143A (fi)	1980-07-20
GR71914B (it)	1983-08-16
BE881245A (fr)	1980-07-18
ZA80298B (en)	1981-08-26
AT373880B (de)	1984-02-27
ES8101557A1 (es)	1980-12-16
AR222204A1 (es)	1981-04-30
YU11380A (en)	1983-04-30
US4555516A (en)	1985-11-26
SU906374A3 (ru)	1982-02-15
PT70707A (en)	1980-02-01
NO800131L (no)	1980-07-21
PH14910A (en)	1982-01-29
PL123985B1 (en)	1982-12-31
JPS5946504B2 (ja)	1984-11-13
DD148773A5 (de)	1981-06-10
IL59150A0 (en)	1980-05-30
JPS55100368A (en)	1980-07-31
CA1137481A (en)	1982-12-14
ES487843A0 (es)	1980-12-16
AU5474380A (en)	1980-07-24
CH646154A5 (de)	1984-11-15

Publication	Publication Date	Title
IT1140523B (it)	1986-10-01	N-benzil-immidazoli come inibitori selettivi dell'enzima trombossano sintetasi,loro composizioni
NL930098I1 (nl)	1993-10-01	Cefalosporineverbindingen hun bereiding en samenstellingen die deze bevatten
IT1113314B (it)	1986-01-20	Procedimento di sintesi dell'ammoniaca
IT1171339B (it)	1987-06-10	Composti inibitori dell'enzima aromatasi e procedimento per la loro preparazione
IT8022240A0 (it)	1980-05-21	Tiovinil-3 cefalosporine, loro preparazione e composizioni che le contengono.
ZA805517B (en)	1981-08-26	Sulphur concrete compositions, methods of forming articles therefrom and the articles as formed
IT8023087A0 (it)	1980-06-26	Procedimento per la produzione di p-cloroalchilbenzene.
IT1141012B (it)	1986-10-01	"6-piridazioni utili come cardiotonici,e loro preparazione"
IT8024157A0 (it)	1980-08-14	Ammide dell'acido poliprenilcarbossilico.
IT8048978A0 (it)	1980-06-16	Procedimento per la produzione dell'antibiotico cefamicina c
IT7851332A0 (it)	1978-10-02	Acetanilidi sostituite composizioni diserbanti che le contengono e procedimento per la loro produzione ed il loro impiego
IT8025261A0 (it)	1980-10-09	Procedimento per la produzione di teatrafluoruro di zolfo.
BE860162A (fr)	1978-04-27	Derives actifs de l'uree leur procede de preparation ainsi que les compositions therapeutiques les contenant
IT7827718A0 (it)	1978-09-15	Metodo per la determinazione dell'urea.
NO811751L (no)	1981-11-24	Fremgangsmaate for fremstilling av 3-pikolin.
IT1157319B (it)	1987-02-11	Composizioni fertilizzanti, procedimenti per la loro produzione e procedimenti per la loro utilizzazione
IT7827490A0 (it)	1978-09-08	Imidi dell'acido n-fenil-succinico sostituite, procedimento per laloro preparazione e loro impiegocome fungicidi.
IT7823470A0 (it)	1978-05-16	Derivati dell'idrossi-4tiazolidintione-2, loro preparazione e composizioni che licontengono.
IT8021543A0 (it)	1980-04-22	Preparazione di idrossiderivati dell'isopropilammino-pirimidina (attraverso riduzione conidrogeno).
IT7829635A0 (it)	1978-11-09	Derivati dell'isochinolina, loro preparazione, e composizioni che li contengono.
IT7821264A0 (it)	1978-03-15	Composizione per il trattamento dell'asma.
FI892912A0 (fi)	1989-06-14	Komposition foer framstaellning av artificiella stenmaterialier.
NO852418L (no)	1985-12-16	Fremgangsmaate for fremstilling av aminderivater.
IT1075589B (it)	1985-04-22	Procedimento per la produzione di composizioni ad enzimi fissati
IT1195033B (it)	1988-09-28	Procedimento per la produzione di acil-coa ossidasi