JP6091156B2 - Medical container, method for manufacturing medical container, and seal mold used therefor - Google Patents

Description

  The present invention relates to a medical container, a method for manufacturing a medical container, and a seal mold used therefor.

  As medical containers such as infusion bags, those in which the upper and lower openings of a sheet-like cylindrical body made of a soft resin sheet are heat-sealed and filled with a medicine are widely used. This heat fusion is generally performed by pressing the open end of the sheet-like cylindrical body with a hot mold and then pressing the melted seal portion formed by the hot press with a cooling mold. Then, a medicine is filled in the medicine chamber formed by the heating press.

The present applicant has proposed the following JP2012-183181 (Patent Document 1).
The medical multi-chamber container 1 of Patent Document 1 is made of a flexible material, and includes an upper part (upper seal part) 5, a lower part (lower seal part) 6, and two opposing side parts (side seal parts) 7. , 8), and a soft bag 2 having a separation part 11 that divides the internal space into a first drug chamber 21 and a second drug chamber 22, and a discharge fixed to the first drug chamber 21 side. Communication between the port 3, the first drug stored in the first drug chamber 21, the second drug stored in the second drug chamber 22, and the first drug chamber 21 and the discharge port 3. The peelable communication inhibiting part 12 is provided. The partition portion 11 includes two partition portion side seal portions 13a and 13b extending from the respective side portions (side seal portions) 7 and 8 of the soft bag 2 toward the center of the soft bag, and two partition portions. A central weak seal portion 11a provided to connect the side seal portions 13a and 13b. The upper part (upper seal part) 5 has an upper protrusion part (upper seal protrusion part) 31 in the central part toward the central direction of the second drug chamber 22 and the central weak seal part direction, and has two side parts (sides). Part seal portions) 7, 8 are provided at the center portions of the portions forming the second drug chamber 22, facing side inner curved portions (side portions) curved toward the center direction of the second drug chamber 22. Seal inner curved portions) 33a and 33b.

Furthermore, in the Example of patent document 1, the upper seal part 5 is provided at the upper end of the soft bag 2, the lower seal part 6 is provided at the lower end, the left seal part 7 is provided on the left side, and the right side part is provided on the right side. Is provided with a right side seal portion 8. As shown in FIG. 1, a discharge port fixing portion 27 to which the discharge port 3 is attached is provided at the lower end portion of the soft bag 2, and the side seal portion 7 is provided in the first drug chamber 21. A drug injection part 26 for injecting a drug is provided, and a mixed injection port fixing part 28 is provided at the upper end of the soft bag 2. The discharge port fixing portion 27 and the mixed injection port fixing portion 28 are formed by heat sealing after inserting the discharge port 3 and the mixed injection port 4 into a non-sealing portion formed in a part of the soft bag 2. The drug injection part 26 is formed by heat-sealing a non-sealed part formed in a part of the soft bag 2 for filling the drug solution in the first drug chamber 21 after filling the drug solution. .
Further, the present applicant has proposed Japanese Patent Application Laid-Open No. 2011-177443 (Patent Document 2).

Patent Document 2 discloses a method of manufacturing a medical container that includes side edges 17 and 18, sealed upper end portion 5 and lower end portion 6, a medicine chamber 15 formed therein, and a medicine accommodated in the medicine chamber. A sheet-like cylindrical body preparation step, an upper and lower portion heating press step for forming an upper seal portion and a lower seal portion on the sheet-like tubular body 3, and side seal portions on both sides of the sheet-like tubular body 3 7 and 8 and a side heating press process. The side heating press process includes a side seal portion 71 on both sides of the sheet-like cylindrical body 3, a side internal seal portion 72 that is close to the side seal portion and located on the drug chamber 15 side, and a seal portion 71. The sheet-like tubular body 3 in the side seal portion 71 is formed so that the thickness of the sheet-like tubular body 3 in the side inner seal portion 72 is such that a thin strip-like non-seal portion 73 located between the seal portion 72 and the side seal portion 72 is formed. It discloses that the film is hot pressed to be thinner.
Patent Document 2 discloses a method for manufacturing a medical container in which an upper seal portion and a lower seal portion are formed by pressing an upper end portion and a lower end portion of a sheet-like cylindrical body with a hot mold. The present invention provides a medical container, a method for manufacturing a medical container, and a seal mold used for the medical container that can more reliably prevent liquid leakage due to the occurrence of pinholes or the like at the drug chamber side end portions on both sides.

JP2012-183181 JP2011-177443

  When the inventor of the present application diligently studied, as in Patent Document 1, when the drug filling port is formed between the sheets that are the unsealed portion of the peripheral part of the drug chamber, the space between the sheets is widened when the drug is filled. After filling the medicine, it is necessary to seal the medicine filling port by heat sealing. However, as described above, if the space between the sheets is widened when the medicine is filled, air may be caught between the sheets when the medicine filling port is sealed. There was a possibility that leakage would occur due to holes. In addition, there is a possibility that the medicine may be sandwiched between the sheets after filling the medicine, and if heat sealing is performed as it is, the medicine between the sheets may foam and a pinhole may occur in the vicinity of the medicine chamber, causing liquid leakage was there.

As described above, Patent Document 2 relates to prevention of liquid leakage due to occurrence of pinholes or the like at the drug chamber side end portions on both sides of the upper seal portion and the lower seal portion. The thing of patent document 2 is not equipped with the medicine filling port formed between the sheets of the peripheral part of a chemical | medical agent chamber, and there is no necessity of the sealing of the medicine filling port after chemical | medical agent filling, The chemical | medical agent which this invention makes object It does not relate to the filling port seal.
Accordingly, an object of the present invention is to form a medicine filling port between sheets that are unsealed at the peripheral edge of the medicine chamber. In a medical container of the type sealed by heat sealing, a method for manufacturing a medical container capable of more reliably preventing the occurrence of pinholes in the vicinity of the drug chamber of the seal portion of the drug filling port and the liquid leakage associated therewith, and A medical container is provided.

What achieves the above object is as follows.
(1) A method for manufacturing a medical container, comprising: a medicine chamber formed inside; a medicine accommodated in the medicine chamber; and a discharge port for discharging the medicine at a lower portion thereof, wherein the medical container The manufacturing method includes a peripheral seal portion having an unsealed portion for use as a medicine filling port, using a container material made of a soft thermoplastic resin sheet having a first sheet portion and a second sheet portion . A container body forming step for forming a container body, a medicine filling step for filling a medicine chamber into the medicine chamber of the container body using the unsealed portion, and after the medicine filling, the unsealed portion is heated by a press. A filling port sealing step for sealing so that a seal is continuously formed from the drug chamber side toward the outside, and the filling port sealing step is performed on the filling port sealing portion to be formed. Saga A thin and flat drug chamber side seal portion, an outer seal portion that is adjacent to the drug chamber side seal portion and is thicker and flatter than the drug chamber side seal portion, and the drug chamber side seal portion of the first sheet portion. The entire filling port seal part is heated so that a difference in height between the outer surface and the outer surface of the outer seal part and a flat outer surface over the entire filling port seal part of the second sheet portion are formed. The manufacturing method of the medical container which is what is heat-pressed by .
(2) In the filling port sealing step, an outer seal portion forming surface having a flat end surface and extending for a predetermined length is provided substantially in parallel with the outer seal portion forming surface and protrudes from the outer seal portion forming surface. in the possess the medicament compartment seal forming surface having a flat end face, wherein a first of the first mold pressed against the seat portion, the filling port seal portions entire seal end faces flat for forming a The method for manufacturing a medical container according to (1) , wherein a heating mold including a second mold pressed against the second sheet portion is used.
(3) In the filling port sealing step, the heating mold having an inclined portion whose thickness increases toward the outer seal portion between the drug chamber side seal portion forming surface and the outer seal portion forming surface. The manufacturing method of the medical container as described in said (2) which uses this.
(4) After filling the medicine, before performing the filling port sealing step, performing a filling port preliminary sealing step for forming a filling port preliminary sealing portion that heat-presses the outer edge side of the portion that becomes the filling port sealing portion. The method for producing a medical container according to any one of (1) to (3) above.
(5) The method for manufacturing a medical container according to (4), wherein the filling port preliminary seal portion and the filling port seal portion are separated from each other, and an unsealed portion is present therebetween.
(6) Prior to the medicine filling step, the medicine chamber can be separated into a first medicine chamber adjacent to the discharge port and a second medicine chamber located above the first medicine chamber. A partition forming step for forming a partition is performed,
The peripheral seal portion includes an upper seal portion that forms an upper end of the second drug chamber, a lower seal portion that forms a lower end of the first drug chamber, the first drug chamber, and the second drug chamber. Comprising side seals that form the side edges of each of the drug chambers,
The unsealed portion is provided on each of the first drug chamber side and the second drug chamber side of the side seal portion, and the unsealed portion on the first drug chamber side and the second The unsealed portion on the drug chamber side is the method for producing a medical container according to any one of (1) to (5) provided on the same side with respect to the container body.

Moreover, what achieves the said objective is as follows.
(7) A medical container comprising a medicine chamber formed inside, a medicine accommodated in the medicine chamber, and a discharge port for discharging the medicine at a lower portion, wherein the medical container is soft A container body formed of a thermoplastic resin sheet is provided, and the container body includes a first sheet portion, a second sheet portion, a peripheral seal portion that forms the drug chamber, and a lower portion of the peripheral seal portion. The fixed discharge port and the peripheral seal portion are used as a medicine filling port for filling medicine into the medicine chamber, and a seal is continuously formed from the medicine chamber side to the outside after filling the medicine. The filling port seal part is adjacent to the drug chamber side seal part, the drug chamber side seal part, and the drug chamber side Thicker and flatter than the seal A heating press seal part having a flat outer seal part, and the filling port seal part is a height between the medicine chamber side seal part and the outer seal part formed on the outer surface of the first sheet part. A difference in thickness, an inclined portion formed on the outer surface of the first sheet portion, and increasing in thickness from the drug chamber side seal portion toward the outer seal portion, and the filling port of the second sheet portion A flat surface formed over the entire seal portion, and the thickness formed by the first sheet portion and the second sheet portion is greater than the adjacent unsealed portion in the entire filling port seal portion. A medical container that is also thinner .
(8) The thickness of the medical container in the drug chamber side seal portion is 0.5 t to 1.1 t with respect to the thickness t of the single sheet constituting the container material, and the outer seal The medical container according to (7) above, wherein the thickness of the medical container is 1.5t to 2.6t.
(9) The said container main body is a medical container as described in said (7) or (8) which has the filling port preliminary | backup seal | sticker part provided outside the said filling port seal | sticker part.
(10) The medical container according to (9), wherein the container body has an unsealed portion provided between the filling port preliminary seal portion and the filling port seal portion.
(11) The medical container has a detachable partition that divides the drug chamber into a first drug chamber adjacent to the discharge port and a second drug chamber positioned above the first drug chamber. A first medicine housed in the first medicine chamber, and a second medicine housed in the second medicine chamber,
The peripheral seal portion includes an upper seal portion that forms an upper end of the second drug chamber, a lower seal portion that forms a lower end of the first drug chamber, the first drug chamber, and the second drug chamber. Comprising side seals that form the side edges of each of the drug chambers,
The filling port seal portion is provided on each of the first drug chamber side and the second drug chamber side of the side seal portion, and the filling port seal portion on the first drug chamber side and the The medical container according to any one of (7) to (10), wherein the filling port seal portion on the second drug chamber side is provided on the same side with respect to the container body.

Moreover, what achieves the said objective is as follows.
(12) A medical container filling port heat sealing mold for use in the filling port sealing step in the medical container manufacturing method according to (1) above, wherein the heat sealing molds are arranged to face each other. The first mold and the second mold, the first mold and the second mold have heat-sealing surfaces on opposite end faces, and the heat-sealing of the first mold The formation surface is a flat surface and has an outer seal portion formation surface extending a predetermined length, and a drug chamber having a flat end surface provided substantially parallel to the outer seal portion formation surface and projecting from the outer seal portion formation surface. A medical container filling port heat sealing mold , wherein the heat sealing forming surface of the second mold is flat as a whole .
(13) The medical container filling port according to (12), wherein the heat seal forming surface has an inclined portion located between the drug chamber side seal portion forming surface and the outer seal portion forming surface. Mold for heat sealing.

The method for manufacturing a medical container according to the present invention is a method for manufacturing a medical container comprising a drug chamber formed inside, a drug stored in the drug chamber, and a discharge port for discharging the drug at the bottom. The medical container manufacturing method is a container including a peripheral seal portion having an unsealed portion for use as a medicine filling port, using a container material made of a soft thermoplastic resin sheet. A container body forming process for forming the body, a drug filling process for filling the medicine chamber of the container body using the unsealed portion, and after filling the medicine, the unsealed portion is moved outward from the medicine chamber side by a heating press. A filling port sealing step of sealing so that a seal is continuously formed, and the filling port sealing step is a drug chamber side seal that is a drug chamber side portion of the filling port sealing portion to be formed Part The thickness of the container body, in which hot pressing to be thinner than the thickness of the container body of the outer sealing portion is an outer portion of the fill port seal portion.
For this reason, at the time of forming the filling port seal portion, the air remaining between the sheets forming the container material, in particular, the air and the drug that existed in the strongly pressurized portion that forms the thin portion on the drug chamber side Does not remain in the strong seal portion that is pushed and strongly pressed compared to the portion forming the thin portion (in other words, the drug chamber side portion of the filling port seal portion). For this reason, the filling port seal portion can reliably prevent the occurrence of pinholes due to foaming of residual air and residual medicine in the thin portion (near the medicine chamber) on the drug chamber side, and liquid leakage associated therewith. .

The medical container of the present invention is a medical container provided with a medicine chamber formed therein, a medicine accommodated in the medicine chamber, and a discharge port for discharging the medicine in the lower part, the medical container being A container main body formed of a soft thermoplastic resin sheet, the container main body being formed at the peripheral seal portion forming the drug chamber, the discharge port fixed to the lower portion of the peripheral seal portion, and the peripheral seal portion. A filling port seal portion that is used as a medicine filling port for filling the medicine into the chamber and is sealed so that a seal is continuously formed from the medicine chamber side to the outside after the medicine filling, and further filling The mouth seal portion is entirely a seal portion, and the thickness of the medical container of the drug chamber side seal portion, which is the drug chamber side portion of the fill port seal portion, is the outer portion of the outer portion of the fill port seal portion. Medical seal It has become thinner than a thickness of the vessel.
In this medical container, it is possible to reliably prevent occurrence of pinholes due to foaming of residual air and residual medicine in the medicine chamber side seal portion (near the medicine chamber) of the filling port seal portion and liquid leakage associated therewith. .

The medical container filling port heat sealing mold of the present invention is a medical container filling port heat sealing mold for use in the filling port sealing step in the above-described medical container manufacturing method, and the heat sealing mold Includes a first mold and a second mold disposed so as to face each other, and the first mold and the second mold each include a heat seal forming surface on the opposite end surface, and at least one of the molds. The heat seal forming surface of the mold is a flat surface extending a predetermined length, and has a flat end surface that is provided substantially parallel to the outer seal portion forming surface and protrudes from the outer seal portion forming surface. And a medicine chamber side seal portion forming surface.
For this reason, by using this mold, the thickness of the medical container of the drug chamber side seal portion, which is the drug chamber side portion of the filling port seal portion, is the same as that of the outer seal portion, which is the outer portion of the filling port seal portion. The filling port seal portion that is thinner than the container for use and that is free from the occurrence of pinholes due to residual air in the drug chamber side seal portion and the foaming of the residual drug and the associated liquid leakage can be reliably and easily formed.

FIG. 1 is a front view of an embodiment of the medical container of the present invention. 2 is a cross-sectional view taken along line AA in FIG. FIG. 3 is an explanatory view for explaining the method for producing the medical container of the present invention. FIG. 4 is an explanatory view for explaining the method for producing the medical container of the present invention. FIG. 5 is an explanatory view for explaining the method for producing the medical container of the present invention. FIG. 6 is an explanatory diagram for explaining the method for producing the medical container of the present invention. FIG. 7 is an explanatory diagram for explaining the method for producing the medical container of the present invention. FIG. 8 is an explanatory view for explaining the method for producing the medical container of the present invention. FIG. 9 is an explanatory diagram for explaining the drug filling port seal portion of the medical container of the present invention. FIG. 10 is an explanatory diagram for explaining a drug filling port seal portion of the medical container of the present invention. FIG. 11 is an explanatory diagram of a seal mold used in the method for producing a medical container of the present invention. FIG. 12 is an explanatory diagram for explaining another drug filling port seal portion of the medical container of the present invention. FIG. 13 is a longitudinal sectional view of an example of the discharge port used in the medical container of the present invention. FIG. 14 is a front view of another embodiment of the medical container of the present invention.

Hereinafter, the medical container of this invention is demonstrated using the Example shown on drawing.
The medical container 1 of the present invention includes drug chambers 11 and 12 formed inside, a drug accommodated in the drug chambers 11 and 12, and a discharge port 4 for discharging the drug at the lower part.
The medical container 1 includes a container main body 2 formed of a soft thermoplastic resin sheet, and the container main body is fixed to the peripheral seal portions 5, 6, 7, and 8 that form a medicine chamber, and the lower portion of the peripheral seal portion 6. The discharge port 4 is formed on the peripheral seal portion and used as a medicine filling port for filling medicine into the medicine chamber, and a seal is continuously formed from the medicine chamber side to the outside after filling the medicine. It has the filling port seal parts 22 and 32 sealed. Furthermore, the filling port seal portions 22 and 32 are entirely sealed portions, and the thickness of the drug chamber side seal portions 22a and 32a, which is the drug chamber side portion of the filling port seal portion (in other words, the drug chamber side). The thickness of the medical container in the seal portion) is thinner than the thickness of the outer seal portions 22b and 32b that are the outer portions of the filling port seal portions 22 and 32 (in other words, the thickness of the medical container in the outer seal portion). It has become a thing.

In particular, the medical container 1 of the illustrated embodiment includes a container body 2 made of a soft thermoplastic synthetic resin sheet, and the container body 2 includes an upper seal portion 5, a lower seal portion 6, and side seal portions 7 and 8. The discharge port 4 fixed to the lower seal portion 6 and the filling port seal portion (inner edge side) formed in any of the seal portions and used as a medicine filling port into the medical container and sealed after filling the medicine Seal portions) 22 and 32. Further, in the filling port seal portion 22, the thickness of the drug chamber side seal portion 22 a of the filling port seal portion is thinner than the thickness of the medical container of the outer seal portion 22 b of the filling port seal portion 22. Further, the medical container 1 of this embodiment has a filling port preliminary seal portion (outer edge side seal portion) 23 provided on the outer edge side of the medical container 1 with respect to the filling port seal portion 22.
As shown in FIG. 1, the medical container 1 of this embodiment is a so-called multi-chamber container, and includes a container body 2, a first medicine, a second medicine, a discharge port 4, and a mixed injection port 10. I have. The medical container 1 of the present invention is not limited to a multi-chamber container, and may be a single-chamber container.

In addition, as shown in FIG. 1, the container 1 of the present invention includes a first medicine chamber 11, a second medicine chamber 12, a partition portion 9, a communication inhibition portion 13, a discharge port fixing portion 28, and mixed injection. A port fixing portion 27 and filling port seal portions 22 and 32 are provided.
The container body 2 is preferably formed as a cylindrical sheet by an inflation molding method. The container body 2 may be manufactured by various methods such as a blow molding method, a laminate of two sheets, a folded one sheet, or the like. Further, in this embodiment, the container body 2 is formed by sealing almost the entire circumference of the outer peripheral portion of the cylindrical body, and the front surface side sheet portion 2a and the back surface side sheet portion 2b (in other words, the first sheet). Part and the second sheet part) .
In this embodiment, the container body 2 has an upper seal 5 at the upper end, a lower seal 6 at the lower end, a left seal 7 at the left side, and a right seal at the right side. A right side seal portion 8 is provided. The lower portion 7a of the left side seal portion 7 of the container body 2 is provided with a filling port seal portion 22 that communicates with the first drug chamber 11 and is sealed. An upper portion 7 b of the left side seal portion 7 of the container body 2 is provided with a filling port seal portion 32 that communicates with the second drug chamber 12 and is sealed.
As shown in FIG. 1, a discharge port fixing portion 28 to which the discharge port 4 is attached is provided at the lower end portion of the container main body 2, and a mixed injection port fixing portion 27 is provided at the upper end portion of the container main body 2. It has been.
The discharge port fixing portion 28 and the mixed injection port fixing portion 27 are formed by heat sealing after inserting the discharge port 4 and the mixed injection port 10 into a non-sealing portion formed in a part of the container body 2.

Moreover, the filling port seal part 22 is formed by heat-sealing a non-seal part formed in a part of the container body 2 for filling the drug solution into the first drug chamber 11 after filling the drug solution. Yes. Similarly, the filling port seal portion 32 is also formed by heat-sealing a non-sealed portion formed in a part of the container body 2 for filling the chemical solution into the second drug chamber 12 after filling the chemical solution. ing. In addition, you may provide the filling port seal | sticker part (drug filling port) 22 in the right side part or a lower end part. Similarly, the filling port seal part (drug filling port) 32 may be provided on the right side or the upper end.
By providing two drug filling ports on the same side as in the medical container 1 of this embodiment, it becomes possible to inject drugs simultaneously or within the same station. Filling is easy and efficient.
In the medical container 1 of this embodiment, the first drug chamber side seal portions 7 a and 8 a that form the side portions of the first drug chamber 11 are the first drug chamber side seal portions 7 a and 8 a that form the side portions of the second drug chamber 12. 2 The width | variety is wider than the chemical | medical chamber side part seal | sticker parts 7b and 8b. A first drug chamber filling port seal portion 22 is formed on one of the wide side seal portions 7a and 8a (specifically, the left side seal portion 7a).

The medicine filling port of the first medicine chamber 11 is sealed by a filling port sealing portion 21 formed by heat sealing after filling the medicine. In particular, in the medical container 1 of this embodiment, the filling port sealing portion 21 is provided on the outer edge side of the medical container from the filling port sealing portion 22 provided on the drug chamber 11 side and the filling port sealing portion 22. The filling port preliminary seal portion 23 is provided. Further, in the medical container 1 of this embodiment, the sealing portion 21 of the first drug chamber 11 is sealed from the drug chamber 11 toward the outside as shown in FIGS. 1, 9 and 10. A portion 22, an unsealed portion 24, and a filling port preliminary seal portion 23 are provided.
In the filling port seal portion 22, the thickness of the filling port seal portion in the medicine chamber side seal portion 22 a is thinner than the thickness of the outer seal portion 22 b of the filling port seal portion 22. Furthermore, between the chemical | medical chamber side seal part 22a and the outer side seal part 22b, it is the inclination part (transition part) 22c from which thickness changes gradually.

Further, the thickness S1 of the medical container in the medicine chamber side seal part 22a of the filling port seal part 22 is 0.5t to 1.1t with respect to the thickness t of one sheet constituting the container body. Is preferred. Moreover, it is preferable that thickness S2 of the medical container of the outer side seal part 22b of the filling port seal part 22 is 1.5t-2.6t. The outer seal portion 22b also includes a seal portion 22d, the inclined portion (transition portion) 22c also has a seal portion, and the filling port seal portion 22 is entirely a seal portion. Note that the pressure applied to the filling port seal portion 22 during heat sealing is proportional to the thickness, and in order from the highest one, the drug chamber side seal portion 22a, the inclined portion (transition portion) 22c, and the outer seal portion 22b. . For this reason, during heat sealing, the outer seal portion 22b is not compressed more strongly than the drug chamber side seal portion 22a. It can escape to the inclined part (transition part) 22c. For this reason, the filling port seal part 22 is a heat seal part in which there is no possibility of occurrence of pinholes due to foaming of residual air and residual medicine in the medicine chamber side seal part 22a and liquid leakage associated therewith. .
In addition, since the pressure applied to the inclined portion (transition portion) 22c becomes weaker from the inner edge side toward the outer edge side during heat sealing, the air and the medicine that are located in the portion that becomes the medicine chamber side sealing portion 22a are further removed. It can escape to the outer side seal part 22b side reliably.
The inclined portion (transition portion) 22c may not be provided. Even in this case, at the time of heat sealing, the air and the medicine located in the portion that becomes the medicine chamber side seal portion 22a can escape to the outer seal portion 22b that is not strongly compressed by the medicine chamber side seal portion 22a. For this reason, the filling port seal portion 22 is a heat seal portion in which there is no possibility of occurrence of pinholes due to foaming of residual air and residual drug in the drug chamber side seal portion 22a and liquid leakage associated therewith. it can.

  Further, the thickness S4 of the medical container in the filling port preliminary seal portion 23 is preferably 1.5t to 2.2t with respect to the thickness t of one sheet constituting the container body. And it is preferable that the filling port seal part 22 is thinner than the filling port preliminary seal part 23, in other words, is strongly sealed. Further, the thickness of the medical container in the filling port preliminary seal portion 23 is thicker than the thickness of the medical container in the drug chamber side seal portion 22a of the filling port seal portion, and is equal to the outer seal portion 22b of the filling port seal portion 22. It is preferably slightly thin or slightly thick, and particularly preferably 1.8 to 2.2 t.

And as above-mentioned, in the filling port seal part 22, the filling port preliminary seal part 23 and the filling port seal part 22 are spaced apart, and the unsealed part 24 exists between both. For this reason, when the filling port seal portion 22 is formed, the air and medicine remaining between the sheets 2a and 2b are particularly located in the portions that become the inclined portion (transition portion) 22c and the outer seal portion 22b. Since air flows into the unsealed portion 24 that is pushed and not heat sealed, the residual amount of air and medicine in the inclined portion (transition portion) 22c and the outer seal portion 22b can be eliminated or reduced. (Transition part) 22c and the outer seal part 22b have no or little foaming due to foaming of residual air or residual medicine. For this reason, the external appearance of the filling port seal part 22 becomes favorable. The thickness S3 of the medical container in the unsealed portion is approximately 2t.
The width A of the drug chamber side seal portion 22a of the filling port seal portion 22 is preferably 2 to 5 mm, the width B of the inclined portion (transition portion) 22c is preferably 0.5 to 2 mm, and the outer seal portion 22b The width C is preferably 1 to 5 mm, the width D of the unsealed portion 24 is preferably 2 mm or more, particularly preferably 3 mm or more, and the width E of the filling port preliminary seal portion 23 is preferably 5 to 10 mm.
And as shown in FIG. 1, the filling port preliminary seal part 23 and the filling port seal part 22 are formed so that the upper edge and lower edge of a chemical | medical agent filling port may be exceeded.
Moreover, it is preferable that the horizontal extension line of the lower edge of the unsealed part 24 (lower edge of the medicine filling port) is located above the upper edge of the communication inhibiting part 13 described later. By doing in this way, it is suppressed that the medicine flow with which it fills from a medicine filling port contacts the upper edge of the communication inhibition part 13, and peeling of the communication inhibition part at the time of medicine filling is prevented.
And since it has sealed to the outer edge of a chemical | medical agent filling port by having this preliminary filling port seal part, the unsealed part between sheets does not exist in the outer edge of the container main body 2. FIG.

The medicine filling port of the second medicine chamber 12 is sealed by a filling port sealing portion 31 formed by heat sealing after filling the medicine. In particular, in the medical container 1 of this embodiment, the filling port sealing portion 31 is provided on the outer edge side of the medical container from the filling port sealing portion 32 provided on the drug chamber 12 side and the filling port sealing portion 32. The filling port preliminary seal portion 33 is provided. Furthermore, in the medical container 1 of this embodiment, the filling port sealing portion 31 of the second drug chamber 12 is provided with a filling port seal portion outward from the drug chamber 12 as shown in FIGS. 1 and 12. 32, a seal portion multi-layer portion 34, and a filling port preliminary seal portion 33.
As shown in FIGS. 1 and 12, the filling port seal portion 32 is similar to the above-described filling port seal portion 22 in that the thickness of the filling port seal portion in the drug chamber side seal portion 32 a is the filling port. The thickness of the seal portion 32 is thinner than that of the outer seal portion 32b. Furthermore, between the chemical | medical chamber side seal part 32a and the outer side seal part 32b, it is the inclination part (transition part) 32c from which thickness changes gradually. The inclined portion 32c gradually increases in thickness toward the outer edge side.

In addition, the filling port sealing portion 31 of this embodiment includes a sealing portion multi-layer portion 34 in which a filling port seal portion 32 and a filling port preliminary seal portion 33 partially overlap. Note that the seal portion multilayer portion 34 is formed by overlapping a part of the outer seal portion 32 b of the filling port seal portion 32 with the filling port preliminary seal portion 33. Therefore, in the seal portion multi-layer portion 34, the medicine chamber side seal portion 32 a of the filling port seal portion 32 and the filling port preliminary seal portion 33 do not overlap. At the time of heat sealing, the outer seal portion 32b is not pressed more strongly than the drug chamber side seal portion 32a, so that the air and the drug located in the portion that becomes the drug chamber side seal portion are removed from the outer seal portion 32b or the inclined portion (transition). Part) 32c can escape. For this reason, the filling port seal part 32 is a heat seal part in which there is no possibility of occurrence of pinholes due to foaming of residual air and residual medicine in the medicine chamber side seal part 32a and liquid leakage associated therewith. . Moreover, it is preferable that the filling port preliminary seal portion 33 does not overlap with the inclined portion (transition portion) 32 c of the filling port seal portion 32.
The inclined portion (transition portion) 32c may not be provided. Even in this case, at the time of heat sealing, the air and the medicine located in the portion that becomes the medicine chamber side seal portion 32a can escape to the outer seal portion 32b that is not strongly compressed by the medicine chamber side seal portion 32a. For this reason, it can be set as the heat seal part without generation | occurrence | production of the pinhole resulting from the residual air in the chemical | medical agent chamber side seal | sticker part 32a and foaming of a residual chemical | medical agent, and the liquid leak accompanying it.

And it is preferable that the thickness of the medical container in the chemical | medical chamber side part of the filling port seal | sticker part 32 is 0.5t-1.1t with respect to the thickness t of one sheet | seat which comprises a container main body. Moreover, it is preferable that the thickness of the medical container in the seal part multi-layer part 34 and the filling port preliminary seal part 33 is 1.5 t to 2.6 t. The width of only the filling port seal portion 32 is preferably 3 to 5 mm, the width of only the filling port preliminary seal portion is preferably 4 to 6 mm, and the width of the sealing portion multilayer portion is 0 to 2 mm. preferable. Note that the filling port sealing portion of the second drug chamber 12 may not have the seal multilayer portion 34, and the unsealed portion like the sealing portion 21 of the first drug chamber 11 described above. It may have. In particular, when there is an unsealed portion, the appearance of the filling port seal portion 32 is reduced because there is little or no foaming due to foaming of residual air or residual medicine in the inclined portion (transition portion) 32c and the outer seal portion 32b. Can be cleaned.
And as shown in FIG. 1, the filling port preliminary seal part 33 and the filling port seal part 32 are formed so that the upper edge and lower edge of a chemical | medical agent filling port may be exceeded.

  As shown in FIG. 1, the medical container 1 of this embodiment is partitioned into a first drug chamber 11 and a second drug chamber 12 by a partition 9. And in the medical multiple-chamber container 1 of this Example, the partition part 9 has two partition part side part seal parts 9b extended toward the center of a soft bag from the side part seal parts 7 and 8 of the container main body 2. FIG. And a central weak seal portion 9a provided so as to connect the two partition portion side seal portions 9b. The central weak seal portion 9a is formed by fusing the sheet material of the container body 2 in a strip shape so as to be peelable. With such a configuration, only the central weak seal portion 9a is formed near the center of the medicine chamber, and the partition portion side seal formed so as to overlap both ends of the central weak seal portion 9a on both sides thereof. It has a portion 9b. Further, in this embodiment, the partition part side seal part 9b is wider than the central weak seal part 9a, and the upper edge and the lower edge thereof are directed to the upper end side and the lower end side of the soft bag toward the side part. It is going to go.

The peeling strength of the central weak seal portion 9a of the partition portion 9 was not peeled by the pressure applied to the container body 2 in the form of two-fold packaging during transportation, and the container body 2 was strongly pressed with fingers or the like (squeezed) ) It is preferable that the degree of peeling sometimes. The partition portion 9 is preferably formed by fusing the container body 2. The fusion is preferably thermal fusion, high frequency fusion, ultrasonic fusion or the like. Since the container main body 2 has the two drug chambers 11 and 12 divided into the partition portions 9 in this way, drugs of different components can be mixed aseptically in the container main body 2.
Specifically, the seal strength (initial peel strength) of the central weak seal portion 9a is preferably 0.1 to 5 N / 10 mm, and more preferably 0.3 to 3 N / 10 mm. If the seal strength is within this range, the central weak seal part will not be accidentally peeled off during transportation or storage, and the work of peeling the central weak seal part is easy.

Further, in the embodiment shown in FIG. 1, the central weak seal portion 9a has a non-seal portion at the edge on the first drug chamber side and the second drug chamber side. In particular, in the case shown in FIG. 1, both the edge portions on the first drug chamber side and the second drug chamber side of the central weak seal portion 9a have a saw blade shape, and the overall width is substantially the same. It is the same thing. Specifically, the edge on the second drug chamber side has a relatively wide apex angle, and a wave having an approximately isosceles triangle shape has a continuous sawtooth (sawtooth wave) shape, and Similarly, the edge on the first drug chamber side has a relatively wide apex angle, and a wave having an approximately isosceles triangle shape has a continuous saw blade (sawtooth wave) shape, and Each vertex and each trough of the edge of the central weak seal portion 9a on the first and second drug chamber sides are substantially in the same position in the axial direction. As a result, the blades have a saw-tooth shape and the overall width is substantially the same. Thus, since the edge part by the side of the 1st and 2nd chemical | medical agent chambers of the weak seal part 9a for center is not linear, the strong seal part which is hard to peel is not formed in the case of high pressure steam sterilization. .
Moreover, as shown in FIG. 1, it is preferable that the center weak seal | sticker part 9a is provided in the position which becomes the upper direction of the communication inhibition part 13 mentioned later, especially the perpendicular direction. Moreover, it is preferable that the partition part side part seal | sticker part 9b is provided in the both sides of the position which becomes the perpendicular direction upper direction of the communication inhibition part 13, as shown in the figure. By providing the central weak seal portion 9a at such a position, when the central weak seal portion 9a is peeled off, the portion where the communication inhibition portion 13 of the container body 2 is formed swells greatly, so the communication inhibition portion 13 Becomes easy to peel.

And the medical multiple-chamber container 1 is provided with the communication inhibition part 13 as shown in FIG. In the medical multi-chamber container 1 of this embodiment, the communication inhibition part is formed by a communication inhibition weak seal part. In the medical multi-chamber container 1 of this embodiment, the communication inhibiting part 13 is formed so as to surround the upper part of the discharge port 4. A third chamber 14 isolated from the first drug chamber 11 is formed by the communication inhibition unit 13. The third chamber 14 is an empty room. However, the third chamber 14 may contain a predetermined liquid (for example, water for injection or physiological saline). The third chamber 14 may be in a dry state, but may be filled with a small amount of liquid for sterilization. The communication inhibiting part 13 can be formed by heat sealing (heat fusion, high frequency fusion, ultrasonic fusion) of the sheet material.
It is preferable that the communication inhibiting part 13 is formed at a position on the lower side of the central weak seal part 9a of the partition part 9. By being formed in such a position, when the first drug chamber 11 or the second drug chamber 12 is pressed (for example, when pressed or squeezed), the communication inhibiting portion 13 is peeled off as described above. It becomes easy to do.

In the embodiment shown in FIG. 1, the communication inhibiting portion 13 is formed in an inverted U-shape (in other words, a U-shape) whose legs are open (in other words, a trapezoid whose short side is on the upper side). Further, the communication inhibiting unit 13 may have a triangular shape with the discharge port 4 as a vertex, a triangular shape with the discharge port 4 as a base, a polygonal shape such as a quadrangle, a substantially semicircular shape, or a substantially semielliptical shape. In addition, when the communication inhibition part 13 has a corner | angular part in an outer periphery, it is preferable that the edge is not formed in a corner | angular part.
The strength for peeling of the communication inhibiting portion 13 is greater than the strength for peeling of the central weak seal portion 9a. Moreover, in this communication inhibition part 13, the some non-seal part is formed in the front-end | tip part which faces the center weak seal part 9a. By providing such a non-seal part, the edge part of the front-end | tip part which faces the center weak seal part 9a of the communication inhibition part 13 becomes a thing which is not linear, and a high-pressure steam sterilization WHEREIN: It is never formed.

Moreover, the communication inhibition part 13 can be comprised by making a seal | sticker intensity | strength equivalent to the center weak seal part 9a, or a little stronger than the seal strength of the center weak seal part 9a. The seal strength (initial peel strength) of the communication hindering seal portion is 1 to 25 N / 10 mm, preferably 2 to 20 N / 10 mm, and particularly preferably 3 to 12 N / 10 mm.
A specific method for measuring the peel strength can be performed as follows. Measurement when medical multi-chamber container is cut at 10 mm length in the width direction of the container, and each sealing piece is peeled off at a pulling speed of 300 mm / min. The average value.
In the medical multi-chamber container 1 of this embodiment, the volume of the second drug chamber 12 is larger than the volume of the first drug chamber 11. For this reason, the surface area which can be compressed is large and work is easy. Further, the second medicine chamber 12 is filled with a larger amount of medicine than the first medicine chamber 11. For this reason, a large amount of liquid is pressed during compression.
Further, in the medical multi-chamber container 1, the ratio of the lateral length of the central weak seal portion 9a to the length (shortest distance) between the upper end of the communication inhibiting portion 13 and the upper end of the medicine discharge port is 0. It is preferably 2 to 3, and more preferably 0.5 to 2. In particular, it is preferably 0.7 to 1.5. Moreover, it is preferable that the width | variety (band width) of the communication inhibition part 13 is 2-20 mm, especially 4-12 mm.

The container main body (container base) 2 used for the medical container 1 preferably has a water vapor barrier property. As the degree of water vapor barrier property, the water vapor permeability is preferably 50 g / m 2 · 24 hrs · 40 ° C. · 90% RH or less, more preferably 10 g / m 2 · 24 hrs · 40 ° C. · 90% RH or less, More preferably, it is 1 g / m 2 · 24 hrs · 40 ° C. · 90% RH or less. This water vapor permeability is measured by the method described in JISK7129 (Method A).
Thus, since the container main body (container base body) 2 has a water vapor barrier property, the evaporation of moisture from the inside of the medical multi-chamber container 1 can be prevented. As a result, it is possible to prevent reduction and concentration of the medicine (specifically, chemical solution) to be filled. Moreover, the invasion of water vapor from the outside of the medical multi-chamber container 1 can be prevented.

  As a forming material of such a container main body (container base) 2, it is preferable that a polyolefin is included. As a material for forming the container body (container base) 2, particularly preferred are polyolefins such as polyethylene (PE), polypropylene (PP), polybutadiene, and ethylene-vinyl acetate copolymer (EVA), and styrene-butadiene copolymer. Styrenic thermoplastic elastomers such as polymers, styrene-ethylene-butylene-styrene block copolymers, or olefinic thermoplastic elastomers such as ethylene-propylene copolymers, ethylene-butene copolymers, propylene-α olefin copolymers A soft resin obtained by blending and softening may be used. This material is preferable in that it has high strength and flexibility, heat resistance (particularly heat resistance during sterilization) and water resistance, and is particularly excellent in workability and can reduce manufacturing costs.

Furthermore, when using the above blend resin, two or more kinds of materials having different melting points are used, and the upper seal portion 5, the lower seal portion 6, the side seal portion 7 of the container body (container base) 2, 8. It is possible to easily and satisfactorily set each seal condition of the central weak seal portion 9a, the partition side seal portion 9b, and the communication inhibition portion 13 and to stabilize the peel strength of each seal portion.
The container body (container base) 2 may have a single-layer structure (single-layer body) made of the material as described above, or a plurality of layers (particularly layers of different materials) for various purposes. ) May be a multilayer laminate. In the case of a multilayer laminate, a plurality of resin layers may be stacked, or a metal layer may be stacked on at least one resin layer. In the case where a plurality of resin layers are stacked, the advantages of the respective resins can be obtained together, for example, improving the heat resistance and impact resistance of the container body (container base) 2 or providing blocking resistance. Or transparency can be improved. Moreover, in the case of a thing having a metal layer, the gas barrier property of the container main body (container base) 2 can be improved. For example, when a film such as an aluminum foil is laminated, gas barrier properties can be improved. In addition, when the container main body (container base | substrate) 2 is a multilayer laminated body, it is preferable that the material which forms the inner surface part is the material mentioned above.

The thickness of the sheet material constituting the container body (container base) 2 is appropriately determined according to the layer structure and the characteristics of the material used (flexibility, strength, water vapor permeability, heat resistance, etc.), and is particularly limited. Although it is not a thing, Usually, it is preferable that it is about 100-550 micrometers, and it is more preferable that it is about 200-400 micrometers. Further, as the container main body (container base) 2, it is preferable to use an extruded film or a blown tube having a tensile elastic modulus of 500 MPa or less, preferably 50 to 300 MPa.
The container main body (container base) 2 is formed by blow molding using the above resin and fusing the peripheral part, or by fusing the peripheral part of two sheets formed by the resin. Any of the sheet folded and formed by fusing the necessary peripheral edge may be used.

Drugs are stored in the drug chambers 11 and 12 of the container main body (container base) 2. The chemical chambers 11 and 12 are different in that they coexist with each other, such as precipitation due to coexistence, separation of components that may cause changes in composition such as coloring and decomposition over time or temporary heating. It is preferred that the components are contained. As such a drug (infusion solution), for example, it is necessary to mix two or more drugs at the time of infusion, such as peritoneal dialysis solution, transcentral vein infusion, transperipheral vein injection, liquid nutrient, etc. Some are preferable. Examples of the infusion include physiological saline, electrolyte solution, Ringer's solution, high-calorie infusion, glucose solution, water for injection, amino acid electrolyte solution, and the like, but are not limited thereto. For example, a glucose electrolyte solution is stored in one of the drug rooms and an amino acid solution is stored in the other, and water-soluble vitamins such as vitamin B1, vitamin B2, vitamin B6, vitamin C, panthenol, and nicotinamide are stabilized in both chambers. It can be sorted and stored as appropriate in consideration of the properties and the like.
Further, the upper seal portion 5 of the container body (container base) 2 is provided with a hole (hanging portion) for hanging on a hanger or the like.

  As shown in FIG. 1, the discharge port 4 is attached to a discharge port fixing portion 28 formed in the lower seal portion 6 of the container main body (container base) 2. The medical multi-chamber container 1 is provided with a mixed injection port 10 for mixing chemical solutions. By doing in this way, components other than the chemical | medical agent put into the medical multiple-chamber container 1 can be mixedly injected before use. The discharge port 4 and the mixed injection port 10 are attached to the container main body (container base) 2 by high frequency fusion, thermal fusion, ultrasonic fusion or the like. A known port can be used as the discharge port 4 and the mixed injection port 10.

  In the medical container 1 of this embodiment, an appropriate amount of medicine 48 is accommodated in the discharge port 4 as shown in FIG. Moreover, it is preferable that the formation part of the chemical | medical agent storage part 44 of the discharge port 4 is transparently formed so that an internal chemical | medical agent can be visually observed. The medicine to be stored may be any powder, granule or other solid form or liquid form. Drugs are formulated and dissolved in infusions. For example, antibiotics, vitamins (general vitamins), various amino acids, antithrombotics such as heparin, insulin, antitumor agents, analgesics, cardiotonics, statics Note: Anesthetic agents, anti-Parkinson agents, ulcer treatment agents, corticosteroid agents, arrhythmia agents, correction electrolytes, antiviral agents, immunostimulants, and the like. Further, the inside of the cylindrical portion 41a (the medicine storage portion 44) of the discharge port 4 may be normal pressure, but may be reduced pressure or vacuum. As described above, when the medicine container is in a reduced pressure or vacuum state, the effect of preventing the degradation / degradation of the medicine is improved, and the infusate is sucked when the breakable portion 41c is ruptured, so that the tubular shape can be obtained more quickly. It can be introduced into the part 41a.

As shown in FIGS. 1 and 2, the discharge port 4 is fixed to the chemical chamber 11 and has a port main body 41 including an openable portion (in other words, a flow restricting portion) that is opened by an opening operation, and the port main body. A discharge port 43 having a sealing portion 42 that can be connected to a drug discharge needle tube that closes the other end of the portion 41, and a drug outflow inhibiting member 70 provided in the port main body portion 41. In this embodiment, the port main body 41 includes a breakable portion as an openable portion.
The port main body 41 includes a tubular portion 41a, an end-side closed portion (partition wall portion) 41e that closes one end side of the tubular portion 41a, and a tubular portion 41a other than the one-end side closed portion (partition wall portion) 41e. A breakable portion 41c that is located on the end side and enables communication between the chemical chamber 11 and the inside of the tubular portion 41a by breakage, and an operation portion 41b for performing breakage operation of the breakable portion 41c. The breakable portion 41c is a portion where a wedge-shaped annular recess is formed, and is thinner than other portions. For this reason, the breakable portion 41c is weaker than other portions, and by pushing the operation portion 41b from the outside of the bag, the breakable portion 41c is broken at the breakable portion 41c. Separated from the portion 41a. And it is preferable that the operation part 41b to isolate | separate is hollow so that it may illustrate. By doing in this way, the fracture | ruptureable part 41c will be a thing without a thickness deviation. The distance between the inner upper surface of the tubular portion 41a and the breakable portion 41c is preferably 1 to 2 mm.

The sealing portion 42 is formed of an elastic member that seals the rear end opening of the port main body portion and can be pierced by the needle tube for discharging medicine. In this embodiment, the port main body portion 41 is formed by the cap portion 43a. A discharge port 43 is configured by being fixed to the rear end.
In the medical container 1 of this embodiment, the drug outflow inhibiting member 70 is stored in the drug storage part 44 of the discharge port 4. As shown in FIG. 13, the medicine outflow inhibiting member 70 in this embodiment is brought into contact with a medicine discharge needle tube (not shown) that has entered from the discharge port 43 side, and suppresses insertion of the medicine discharge needle tube. Specifically, as shown in FIG. 13, the insertion of the medicine outflow is inhibited, and the insertion of the medicine discharge needle tube in a state where the breakable portion 41c is not broken, in other words, the medicine outflow is inhibited.

Next, the manufacturing method of the medical container of this invention is demonstrated using drawing.
The method for manufacturing a medical container according to the present invention is a method for manufacturing a medical container including a drug chamber formed inside, a drug stored in the drug chamber, and a discharge port for discharging the drug at the bottom. . And the manufacturing method of a medical container uses the container raw material which consists of a soft thermoplastic resin sheet, The container main body formation process which forms the container main body provided with the peripheral seal part which has an unsealed part for using as a chemical | medical agent filling port And a medicine filling step of filling the medicine chamber of the container body with the medicine using the unsealed portion, and after filling the medicine, a seal is continuously formed from the medicine chamber side to the outside by the heating press. The filling port sealing step is performed so that the thickness of the container body of the drug chamber side seal portion, which is the drug chamber side portion of the filling port seal portion to be formed, is determined. The hot pressing is performed so that the outer seal portion, which is the outer portion of the filling port seal portion, is thinner than the thickness of the container body.

First, the container main body formation process which forms the container main body provided with the peripheral seal part which has an unsealed part for using as a chemical | medical agent filling port using the container raw material which consists of a soft thermoplastic resin sheet is performed.
The thickness of the sheet material constituting the container material is appropriately determined according to the layer structure and the characteristics of the material used (flexibility, strength, water vapor permeability, heat resistance, etc.), and is not particularly limited. Usually, it is preferably about 100 to 550 μm, and more preferably about 200 to 400 μm. Further, as the container main body (container base) 2, it is preferable to use an extruded film or a blown tube-like sheet having a tensile elastic modulus of 500 MPa or less, preferably 50 to 300 MPa. As the material for forming the container material, those described above are preferably used.

  And the container base | substrate formation process which forms a container base | substrate provided with the peripheral seal part which has an unsealed part for using as a chemical | medical agent filling port using a container raw material is performed. In this embodiment, a container base 20 having a form as shown in FIG. 3 is prepared. The container base 20 is subjected to a peripheral seal portion forming step of forming the upper seal portion 5, the lower seal portion 6, and the side seal portions 7 and 8 by pressing the blow-molded one with a hot mold. In addition, in this container base | substrate 20, it is in the state by which all the peripheral parts were sealed, and a chemical | medical agent chamber does not communicate with the exterior until it cut | disconnects by the lines L1, L2, and L3 shown in FIG. For this reason, it is possible to prevent foreign substances from entering the medicine chamber from the peripheral seal portion forming step to the next step. The container base 20 is not limited to an inflation molded product, and may be formed by fusing the peripheral portions of two laminated thermoplastic resin sheets. The sheet may be folded and formed by fusing a necessary peripheral portion.

Furthermore, in this embodiment, after the peripheral seal portion is formed, the separable partition portion 9 (9a) and the communication inhibition portion 13 formed under different sealing conditions (low heating) from the peripheral seal portion are formed. In other words, in this embodiment, the partition portion forming step and the communication inhibition portion forming step are performed separately from the peripheral seal portion forming step. As described above, the inside of the container base 20 is divided into the first drug chamber 11 and the second drug chamber 12 by the partition portion 9.
In this embodiment, the container base 20 is cut along lines L1, L2, and L3 shown in FIG. 3, thereby having a peripheral seal portion and two drug filling ports as shown in FIG. (Unsealed portion) 26, 36, unsealed portion 27a for mixed injection port mounting, and unsealed portion 28a for discharging port mounting.
In the container base 20 shown in FIG. 4, an unsealed portion 27 a for mixed injection port attachment is formed in the upper seal portion 5, and an unsealed portion 28 a for discharge port attachment is formed in the lower seal portion 6. In addition, two ears (a first ear 25 and a second ear 35) are formed on one side 7 of the container base 20. Moreover, the inside of the ear | edge parts 25 and 35 becomes the unsealed part 26 and 36, and is connected with the chemical | medical agent chambers 11 and 12 formed in the container base | substrate 20. FIG. The first ear portion 25 described above extends from the side portion of the first drug chamber 11, and the unsealed portion 26 communicates with the first drug chamber 11. Similarly, the second ear portion 35 described above extends from the side portion of the second drug chamber 12, and the unsealed portion 36 communicates with the second drug chamber 12.
Note that it is only necessary to form the container base 20 having a form as shown in FIG. 4. For example, in the case where the medical container 1 is manufactured consistently in a clean space, the circumferentially sealed peripheral part as shown in FIG. 3 is used. It is not always necessary to provide A container substrate having a form as shown in FIG. 4 may be directly produced.

In addition, it is preferable that the temperature of the thermal mold in the peripheral seal portion forming step is 55 ° C. or more higher than the melting temperature of the forming material of the container base 20. In particular, it is preferably 75 to 105 ° C. higher. Further, the sealing surface pressure in the filling port preliminary seal portion forming step is different depending on the forming material of the container base 20, but is preferably 0.15 to 1.5 MPa, and preferably 0.35 to 0.75 MPa. It is more preferable.
In the medical container 1 of this embodiment, the first drug chamber side seal portions 7 a and 8 a that form the side portions of the first drug chamber 11 are the first drug chamber side seal portions 7 a and 8 a that form the side portions of the second drug chamber 12. 2 The width is wider than the drug chamber side seal portions 7b and 8b. The unsealed portion 26 for filling the medicine chamber is formed on one of the wide side seal portions 7a and 8a (specifically, the left side seal portion 7a), and the second drug chamber side having a narrow width is formed. Heat sealing is performed so that the unsealed portion 36 for filling the medicine chamber is formed on one of the seal portions 7b and 8b (specifically, the left side seal portion 7b).

  Then, as shown in FIG. 5, a discharge port fixing step for fixing the discharge port 4 to the container base 20 is performed. The discharge port fixing step is performed by expanding the space between the sheets constituting the discharge port mounting unsealed portion 28 a, inserting the discharge port 4, and then heat-sealing to form the discharge port seal portion 28. Since the medical container 1 of this embodiment includes the mixed injection port 10, the mixed injection port fixing step is performed after or before the discharge port fixing step. The mixed injection port adhering step is performed by expanding the space between the portions of the portion constituting the non-sealed portion 27a for attaching the mixed injection port, inserting the mixed injection port 10 and then heat-sealing to form the mixed injection port seal portion 27.

Next, a drug filling step of filling the drug into the drug chambers 11 and 12 of the container body 2 is performed using the unsealed portions (drug filling ports) 26 and 36 in the ear part 25 and the ear part 35.
In the medicine filling step, as shown in FIG. 6, the space between the sheets constituting the unsealed part 26 of the ear part 25 is expanded, the medicine injection tube 27 is inserted, and the medicine is filled into the first medicine chamber 11. Is done. Similarly, the second drug chamber 12 is also filled with the drug in the second drug chamber 12 by spreading the sheet between portions of the unsealed portion 36 of the ear 35 and inserting a drug injection tube 37. . As shown in FIG. 6, it is preferable that the drug filling be performed in a state where the ear portions 25 and 35 (side seal portion 7 side) are on the upper side and the side seal portion 8 side is on the lower side. By doing so, there is little possibility of drug leakage during the filling process.
In addition, the container body 2 used in the manufacturing method of this embodiment has two ears (drug filling ports) 25 and 35 provided on the same side of the container body 2 so that the drug can be injected simultaneously. Alternatively, it can be performed in the same station.

And in the manufacturing method of this Example, after filling the medicine into the medicine chamber and before the filling port sealing step, the medicine injection tubes 27 and 37 are removed, and the outer edge side of the unsealed part of the ear part is heated by a press. A filling port preliminary sealing step for sealing is performed.
In the filling port preliminary sealing step, the filling port preliminary sealing step is the same as the above-described drug filling step, and the container body filled with the drug is placed with the ear portions 25 and 35 (side seal portion 7 side) on the upper side. It is preferable to carry out in a state where the seal portion 8 side is downward.
In the filling port preliminary sealing step, the portions of the ears 25 and 35 to be the filling port preliminary sealing portion are located in the vicinity of the drug chamber and slightly on the outer edge side from the inner edge of the drug chamber between both sides of the container body 2 with a heat seal mold. This is done by sealing. The filling port preliminary seal portions 23 and 33 may be formed so as to form a strong seal portion at a pressure higher than or equal to the melting temperature of the forming material. Although it is impossible to peel off at a low pressure, it is preferably performed to such an extent that it does not become a strong seal. Further, in the filling port preliminary seal portion forming step, as shown in FIG. 7, the formed filling port preliminary seal portions 23 and 33 are sealed so as to cross the drug filling port, and both end portions are side seal portions. It is formed in such a length as to reach 7a and 7b. Moreover, it is preferable to perform a filling port preliminary seal part formation process so that the width E of the filling port preliminary seal part 23 may be 2-6 mm. In the filling port preliminary sealing step, the thickness S4 of the medical container in the filling port preliminary sealing portion 23 is 1.5t to 2.2t with respect to the thickness t of one sheet constituting the container main body. It is preferable to do so.

The temperature of the hot mold in forming the filling port preliminary seal portion is preferably higher by 5 ° C. or more than the melting temperature of the forming material of the container body 2. In particular, it is preferably 10 to 30 ° C. higher. Further, the sealing surface pressure in the filling port preliminary seal portion forming step is different depending on the forming material of the container body 2, but is preferably 0.7 to 1.8 MPa, and is 1.3 to 1.6 MPa. It is more preferable. Further, the filling port preliminary seal portions 23 and 33 may be performed simultaneously or individually. The seal surface pressure is preferably equal to or higher than the saturated vapor pressure at the mold temperature. By doing so, even if moisture is present in the seal portion, it is prevented from becoming steam.
This filling port preliminary sealing step may not be performed. However, by performing this step, it is possible to prevent the medicine from flowing out before the filling port sealing step to be performed next. Compared with the case of performing the mouth sealing step, the working time can be shortened and the working efficiency is increased.

Next, a filling port sealing step of sealing the inner edge side of the unsealed portion where the filling port preliminary seal portion is formed with a hot press is performed.
In this filling port sealing step, similarly to the above-described drug filling step, the container body filled with the drug is in a state in which the ear portions 25 and 35 (side seal portion 7 side) are upward and the side seal portion 8 side is downward. It is preferable to carry out at.
In this embodiment, the first drug chamber side seal portions 7a and 8a of the first drug chamber 11 are formed wide. For this reason, the unsealed part 26 has a certain length (width). The filling port preliminary seal portion 23 that seals the unsealed portion (chemical solution filling port) of the first ear portion 25 is formed on the outer edge side that is separated from the inner edge of the first drug chamber 11 described above.

The filling port sealing process in the first medicine chamber is separated from the filling port preliminary seal portion 23 as shown in FIGS. 9 and 10, and the inner edge of the medicine chamber 11 and the inner edge of the filling port seal portion 22 are almost the same. Provided to match. For this reason, the unsealed part 24 remains between the filling port preliminary seal part 23 and the filling port seal part 22.
In addition, when manufacturing the medical container 1 from which the internal volume of the 1st chemical | medical agent chamber 11 differs using the same container base material, the width | variety of 1st chemical | medical agent chamber side part seal part 7a, 8a is the 1st chemical | medical agent. It is necessary to change depending on the content of the chamber 11. In this case, since the inner edge of the first drug chamber 11 changes depending on the inner volume of the first drug chamber 11, the position of the filling port seal portion 22 also needs to be changed accordingly. For this reason, the length (width) of the unsealed portion 24 varies depending on the internal volume of the first drug chamber 11. Unlike this embodiment, there is a case where there is no unsealed portion, similar to the filling port seal portion 32.
In this embodiment, the second drug chamber 12 has a narrow width side seal portion. For this reason, the unsealed portion 36 has a shorter length (width) than the unsealed portion 26. The filling port preliminary seal portion 33 that seals the second ear portion 35 is formed on the outer edge side slightly spaced from the inner edge of the second drug chamber 11. Then, as shown in FIG. 9, the filling port sealing step in the second drug chamber is overlapped with the filling port preliminary seal portion 23 and one end side, and the inner edge of the drug chamber 12 and the inner edge of the filling port seal portion 32 are almost the same. Provided to match. For this reason, a seal multilayer portion 34 is formed between the filling port preliminary seal portion 33 and the filling port seal portion 32.

Then, in the filling port seal portion forming step, as shown in FIG. 7, the formed filling port seal portions 22 and 32 are sealed so as to cross the drug filling port, and both end portions thereof are side seal portions 7a, It is formed in such a length as to reach 7b. Moreover, it is preferable that the width | variety of the filling port seal parts 22 and 32 is 4-8 mm.
The filling port seal portion (particularly, the filling port seal portion 22 provided on the first drug chamber 11 side) is a medical container of the drug chamber side seal portion 22a of the fill port seal portion 22 as shown in FIG. In other words, the thickness of the medical container of the outer seal portion 22b of the filling port seal portion 22 is smaller than the thickness of the medical container of the outer seal portion 22b of the filling port seal portion 22. Further, heat sealing is performed so as to be thicker than the thickness of the medical container of the medicine chamber side seal portion 22a of the filling port seal portion 22. As shown in FIG. 10, the thickness formed by the sheet portion 2a and the sheet portion 2b is thinner than the adjacent unsealed portions in the entire filling port seal portion (A, B, C).

Such heat seal portions having different thicknesses on the inner side and the outer side can be formed by using, for example, a seal mold 5 as shown in FIG.
And it is preferable to perform this filling port sealing process using the metal mold | die 5 as shown in FIG. A mold 5 shown in FIG. 11 is a medical container filling port heat sealing mold for use in the filling port sealing step. The heat seal mold 5 includes a first mold 51 and a second mold 61 disposed so as to face each other, and the first mold 51 and the second mold 61 include a heat seal forming surface on opposite end surfaces. The heat seal end surface of at least one mold 51 is a flat surface and is provided substantially in parallel with the outer seal portion forming surface 53 and the outer seal portion forming surface 53 extending a predetermined length, and the outer seal. The medicine chamber side seal part forming surface 52 having a flat end surface protruding from the part forming surface 53 is provided.

  Specifically, the seal mold 5 includes a first mold 51 and a second mold 61. And the heat seal formation surface is formed in the end surface which each metal mold | die 51,61 opposes. In the mold of this embodiment, the first mold 51 is formed with a protruding thin seal portion forming surface (drug chamber side seal portion forming surface) 52 and a recessed portion recessed from the thin seal portion forming surface 52 on the seal end surface. And a thick seal portion forming surface (outer partial seal portion forming surface) 53. An inclined portion (transition portion) 54 is formed between the thin seal portion forming surface 52 and the thick seal portion forming surface 53. Further, the outer edge 55 of the thick seal portion forming surface (outer partial seal portion forming surface) 53 is chamfered. Further, the outer edge 56 of the thin seal portion forming surface (outer partial seal portion forming surface) 52 has an edge.

  The step H between the thin seal portion forming surface 52 and the thick seal portion forming surface 53 is preferably 0.05 to 0.25 mm, and particularly preferably 0.1 to 0.2 mm. If it is 0.05 mm or more, air bubbles can be surely escaped, and if it is 0.25 or less, the sealing strength at the thick seal portion forming surface (outer partial seal portion forming surface) 53 is sufficient. Become. The width L of the thin seal portion forming surface 52 is preferably 2 to 4 mm, and particularly preferably 2 to 3 mm. If it is 2 mm or more, sufficient sealing can be performed, and if it is 4 mm or less, the movement of bubbles is reliable. The width M of the thick seal portion forming surface 53 is preferably 1 to 5 mm, and particularly preferably 1 to 3 mm. The width N of the inclined portion 54 is preferably 0.5 to 3 mm, particularly preferably 0.5 to 1.5 mm. The inclination angle of the inclined portion 54 is preferably 10 to 60 degrees.

  As described above, the seal end surface of the first mold is formed by the thin seal portion forming surface 52, the thick seal portion forming surface 53, and the inclined portion 54. The seal end face 62 of the second mold 61 has substantially the same shape as the seal end face of the first mold except that the whole is flat. Furthermore, the outer edge 63 facing the outer edge 55 of the first mold on the seal end surface of the second mold 61 is chamfered. Further, the outer edge 64 facing the outer edge 56 of the first mold on the seal end surface of the second mold 61 has an edge.

By forming the filling port seal portion 22 using such a seal mold 5, as shown in FIG. 10, the filling port seal portion 22 includes a thin drug chamber side seal portion 22a and the drug chamber side. The outer seal portion 22b is thicker than the seal portion 22a. Furthermore, between the medicine chamber side seal portion 22a and the outer seal portion 22b, there is an inclined portion (transition portion) 22c whose thickness gradually increases toward the outer portion.
For this reason, when the filling port seal portion 22 is formed, the air remaining between the sheets forming the container material, in particular, the air and the drug present in the portion forming the thin drug chamber side seal portion 22a. Does not remain in the drug chamber side seal portion 22a that is pushed and strongly pressed compared to the portion forming the thin portion. Therefore, it is possible to form a seal portion where there is no possibility of occurrence of pinholes due to foaming of residual air and residual medicine in the medicine chamber side seal portion 22a and liquid leakage associated therewith.

Further, the pressure applied to the inclined portion (transition portion) 22c when the filling port seal portion 22 is formed by the inclined portion 54 of the first mold 51 becomes weaker from the inner edge side toward the outer edge side. It is possible to reliably push out the air and chemicals present in the portion forming the seal portion 22a to the outer edge side. In particular, when the inclination angle of the inclined portion 54 is 10 to 60 degrees, the pressure applied to the inclined portion (transition portion) 22c is more reliably weakened from the inner edge side toward the outer edge side. It is possible to more reliably push out the air and the medicine existing in the forming portion to the outer edge side.
The inclined portion 54 of the first mold 51 may be omitted. Even in this case, the air and the medicine that existed in the portion forming the thinned drug chamber side seal portion 22a are pushed to the outer edge side that is not strongly pressurized compared to the portion forming the thinned portion, and the drug chamber side that is strongly pressurized It does not remain in the seal portion 22a. Therefore, it is possible to form a seal portion where there is no possibility of occurrence of pinholes due to foaming of residual air and residual medicine in the medicine chamber side seal portion 22a and liquid leakage associated therewith.

  The filling port seal portion 22 is formed such that the thickness S1 of the medical container in the drug chamber side seal portion 22a of the filling port seal portion 22 is 0 with respect to the thickness t of one sheet constituting the container body. It is preferable that the thickness S2 of the medical container of the outer seal portion 22b of the filling port seal portion 22 is 1.5t to 2.6t so as to be 0.5t to 1.1t. In addition, the filling port seal portion is formed so that the filling port seal portion 22 is thinner than the filling port preliminary seal portion 23, in other words, is strongly sealed. Further, the thickness of the medical container in the filling port preliminary seal portion 23 is thicker than the thickness of the medical container in the drug chamber side seal portion 22a of the filling port seal portion, and is equal to the outer seal portion 22b of the filling port seal portion 22. It is preferable to carry out the process so as to be slightly thinner or slightly thicker.

As described above, in the filling port seal portion 22, the filling port preliminary seal portion 23 and the filling port seal portion 22 are separated from each other, and the unsealed portion 24 is formed between them, in other words, remains. For this reason, when the filling port seal portion 22 is formed, the air and medicine remaining between the sheets 2a and 2b are pushed and flow into the unsealed portion 24 which is not heat-sealed. The movement is more reliable. For this reason, since the chemical | medical agent does not remain in the inclination part (transition part) 22c and the outer side seal part 22b, and there is no foaming of a residual chemical | medical agent, the external appearance of the filling port seal | sticker part 22 can be made beautiful.
In the filling port seal portion forming step, the width B of the inclined portion (transition portion) 24 is 0.5 so that the width A of the drug chamber side seal portion 22a of the filling port seal portion 22 is 2 to 3 mm. It is preferable that the width D of the unsealed portion 24 is 2 mm or more so that the width C of the outer seal portion 22b is 0.5 to 1 mm so as to be ˜1 mm. The width D of the unsealed portion is more preferably 3 mm or more.

And as shown in FIG. 1, the filling port preliminary seal part 23 and the filling port seal part 22 are formed so that the upper edge and lower edge of a chemical | medical agent filling port may be exceeded.
Moreover, it is preferable that the horizontal extension line of the lower edge of the unsealed part 24 (lower edge of the medicine filling port) is located above the upper edge of the communication inhibiting part 13 described later. By doing in this way, it is suppressed that the medicine flow with which it fills from a medicine filling port contacts the upper edge of the communication inhibition part 13, and peeling of the communication inhibition part at the time of medicine filling is prevented.
It is preferable that the temperature of the hot mold in forming the filling port seal portion is higher by 5 ° C. or more than the melting temperature of the forming material of the container body 2. In particular, it is preferably 5 to 20 ° C higher. Further, the sealing surface pressure in the filling port preliminary seal portion forming step is different depending on the forming material of the container body 2, but is preferably 0.7 to 1.9 MPa, and 1.3 to 1.6 MPa. It is more preferable. The seal surface pressure is preferably equal to or higher than the saturated vapor pressure at the mold temperature. By doing so, even if moisture is present in the seal portion, it is prevented from becoming steam.

The filling port seal portion 32 on the second drug chamber side is also performed by the above-described method using the above-described mold 5.
For this reason, at the time of formation of the filling port seal portion 32, the air remaining between the sheets forming the container material, in particular, the air and the drug that existed in the portion forming the thin drug chamber side seal portion 32a. Does not remain in the drug chamber side seal portion 32a that is pushed and strongly pressed compared to the portion that forms the thin portion. Therefore, it is possible to form a seal portion in which there is no possibility of occurrence of pinholes due to foaming of residual air and residual medicine in the filling port seal portion 32 and liquid leakage associated therewith.

  The inclined portion 54 of the first mold 51 may be omitted. Even in this case, the air and the medicine that existed in the portion forming the thinned drug chamber side seal portion 32a are pushed to the outer edge side where no pressure is applied compared to the portion forming the thin portion, and the drug chamber side that is strongly pressurized It does not remain in the seal portion 32a. Therefore, it is possible to form a seal portion where there is no possibility of occurrence of pinholes due to foaming of residual air and residual medicine in the medicine chamber side seal portion 32a and liquid leakage associated therewith.

  After the formation of the filling port seal portions 22 and 32 is completed, the filling port seal portions 22 and 32 are cooled using a cooling mold in order to ensure the sealing of the filling port seal portions 22 and 32. A filling port seal portion cooling step is performed. Then, the 2nd side part cutting process which cut | disconnects a side part in the filling port preliminary seal parts 23 and 33 part by the YY line shown in FIG. 8 is performed. Here, since the filling port preliminary seal portions 23 and 33 are seals that cannot be peeled but do not become strong seals, the resin melted when the filling port preliminary seal portion was formed in the second side cutting step. It is possible to suppress the generation of burrs caused by By performing this second side cutting, the medical container 1 shown in FIG. 1 is manufactured.

  In addition, when manufacturing the medical container 1 in which the internal volume of the 1st chemical | medical agent chamber 11 differs and the lateral width of the side part direction is the same, in order to peel the communication inhibition part 13 reliably, the 1st chemical | medical agent chamber 11 The drug filling of the first drug chamber 11 is performed so that the pressure applied to the communication blocking unit 13 is the same when the drug chamber 11 or the second drug chamber 12 is compressed between the medical containers 1 having different internal volumes. The rate should be approximately the same. By changing the width of the first drug chamber side seals 7a, 8a depending on the inner volume of the first drug chamber 11, the first drug is different between the medical containers 1 having different inner volumes of the first drug chamber 11. The drug filling rate of the chamber 11 can be made substantially the same. In this case, since the inner edge of the first drug chamber 11 changes depending on the inner volume of the first drug chamber 11, the position of the filling port seal portion 22 also changes accordingly. For this reason, the length (width) of the unsealed portion 24 varies depending on the internal volume of the first drug chamber 11. Furthermore, when the internal volume of the first medicine chamber 11 is large, unlike the above-described embodiment, there may be no unsealed portion between the filling port seal portion 22 and the filling port preliminary seal portion.

Moreover, as a medical container and its manufacturing method of this invention, you may not have a filling port preliminary seal part and a filling port preliminary seal process.
FIG. 14 is a front view of another embodiment of the medical container of the present invention.
In the medical container 1a of this embodiment, the filling port sealing portion 21a is formed only by the filling port sealing portion 22, and similarly, the filling port sealing portion 31a is formed only by the filling port sealing portion 32. Yes.
The filling port seals 22 and 32 extend from the drug chamber side to the outer edge side and reach the outer edge. The filling port seal portions 22 and 32 are entirely sealed portions, and the thicknesses of the drug chamber side seal portions 22a and 32a that are the drug chamber side portions of the fill port seal portion (in other words, the drug chamber side seal portion). The thickness of the medical container in FIG. 5 is thinner than the thickness of the outer seal portions 22b and 32b which are the outer portions of the filling port seal portions 22 and 32 (in other words, the thickness of the medical container in the outer seal portion). It has become.

In the medical container 1a of this embodiment, the first drug chamber side seal portions 7a and 8a that form the side portions of the first drug chamber 11 also form the side portions of the second drug chamber 12. 2 The width | variety is wider than the chemical | medical chamber side part seal | sticker parts 7b and 8b. The drug chamber filling port seal portions 22 and 32 are formed on one of the wide side seal portions 7a and 8a (specifically, the left side seal portion 7a).
And as for the width | variety of the medicine chamber side seal | sticker parts 22a and 32a of the filling port seal | sticker parts 22 and 32, 2-5 mm is preferable, and the width | variety of the inclination part (transition part) 22c, 32c has preferable 0.5-2 mm, and the outer side The width of the seal portions 22b and 32b is preferably from the outer edge of the inclined portion to the outer edge of the drug chambers 11 and 12 (outer edge of the container body).

And the medical container 1a of this Example can be manufactured by the same method as the manufacturing method of the medical container mentioned above except not performing a filling port preliminary | backup seal | sticker process. The filling port seal portion 21a is formed with a wider heat seal surface than the mold 5 described above. Specifically, a mold is used in which the drug chamber side seal portion forming portion and the inclined portion have the same width and the outer seal portion forming portion has a wider width.
In the second side portion cutting step, the outer seal portions 22b and 32b are cut. At the time of heat sealing, the outer seal portions 22b and 32b are not pressed more strongly than the drug chamber side seal portions 22a and 32a, and therefore, less resin melts at the time of heat sealing. For this reason, generation | occurrence | production of the burr | flash by the resin fuse | melted at the time of heat sealing can be suppressed in the case of a 2nd side part cutting process.

DESCRIPTION OF SYMBOLS 1 Medical container 11 and 12 Drug chamber 4 Discharge port 2 Container main body 5 Upper seal part 6 Lower seal part 7 and 8 Side seal part

Claims (13)

A medical container manufacturing method comprising a drug chamber formed inside, a drug stored in the drug chamber, and a discharge port for discharging the drug at a lower part,
The medical container manufacturing method uses a container material made of a soft thermoplastic resin sheet having a first sheet portion and a second sheet portion, and a peripheral seal having an unsealed portion for use as a medicine filling port. A container body forming step for forming a container body with a section;
Using the unsealed portion, a medicine filling step for filling medicine into the medicine chamber of the container body,
A filling port sealing step for sealing the unsealed portion after the drug filling so that a seal is continuously formed from the drug chamber side toward the outside by a heating press; and
In the filling port sealing step, the formed filling port seal portion is adjacent to the thin and flat drug chamber side seal portion and the drug chamber side seal portion, and is thicker and flatter than the drug chamber side seal portion. The outer seal portion, the height difference between the outer surface of the medicine chamber side seal portion of the first sheet portion and the outer surface of the outer seal portion, and the flatness over the entire filling port seal portion of the second sheet portion A method for manufacturing a medical container, characterized in that the entire filling port seal portion is heated and pressed with a heating mold so that a smooth outer surface is formed . The filling port sealing step includes an outer seal portion forming surface having a flat end surface and extending for a predetermined length, a flat surface provided substantially parallel to the outer seal portion forming surface and protruding from the outer seal portion forming surface. possess the medicament compartment seal forming surface having an end face, a first mold pressed against the first sheet portion, the entire sealing end face for forming said filling port seal portion is flat, the The method for manufacturing a medical container according to claim 1, wherein a heating mold including a second mold pressed against the second sheet portion is used. The filling port sealing step uses the heating mold having an inclined portion whose thickness increases toward the outer seal portion between the drug chamber side seal portion forming surface and the outer seal portion forming surface. The method for producing a medical container according to claim 2. A filling port preliminary sealing step for forming a filling port preliminary sealing portion that heat-presses the outer edge side of the portion that becomes the filling port seal portion after the filling of the medicine and before the filling port sealing step is performed. Item 4. A method for producing a medical container according to any one of Items 1 to 3.   The method of manufacturing a medical container according to claim 4, wherein the filling port preliminary seal portion and the filling port seal portion are separated from each other, and an unsealed portion is present therebetween. Before the medicine filling step, a detachable partition section that divides the medicine chamber into a first medicine chamber adjacent to the discharge port and a second medicine chamber located above the first medicine chamber. The partition part forming step to be formed is performed,
The peripheral seal portion includes an upper seal portion that forms an upper end of the second drug chamber, a lower seal portion that forms a lower end of the first drug chamber, the first drug chamber, and the second drug chamber. Comprising side seals that form the side edges of each of the drug chambers,
The unsealed portion is provided on each of the first drug chamber side and the second drug chamber side of the side seal portion, and the unsealed portion on the first drug chamber side and the second The method for manufacturing a medical container according to claim 1, wherein the unsealed portion on the drug chamber side is provided on the same side with respect to the container body. A medical container comprising a medicine chamber formed inside, a medicine accommodated in the medicine chamber, and a discharge port for discharging the medicine at a lower portion,
The medical container includes a container main body formed of a soft thermoplastic resin sheet, and the container main body includes a first sheet portion, a second sheet portion, and a peripheral seal portion that forms the drug chamber, The discharge port fixed to the lower part of the peripheral seal part, and used as a drug filling port formed in the peripheral seal part and for filling a drug into the drug chamber, and from the drug chamber side to the outside after drug filling. And a filling port seal portion sealed so that a seal is continuously formed,
The filling port seal portion has a thin and flat drug chamber side seal portion, and a hot press seal having an outer seal portion adjacent to the drug chamber side seal portion and thicker and flatter than the drug chamber side seal portion. And the filling port seal portion includes a height difference between the medicine chamber side seal portion and the outer seal portion formed on an outer surface of the first sheet portion, and the first sheet portion. An inclined portion that increases in thickness toward the outer seal portion from the drug chamber side seal portion, and a flat surface formed over the entire filling port seal portion of the second sheet portion. And the thickness formed by the first sheet portion and the second sheet portion is thinner than the adjacent unsealed portion in the whole filling port seal portion. Container. The thickness of the medical container in the drug chamber side seal portion is 0.5 t to 1.1 t with respect to the thickness t of the single sheet constituting the container body , and the medical of the outer seal portion The medical container according to claim 7, wherein the container has a thickness of 1.5 to 2.6 t. The medical container according to claim 7 or 8, wherein the container main body has a filling port preliminary sealing portion provided outside the filling port sealing portion. The medical container according to claim 9, wherein the container main body includes an unsealed portion provided between the filling port preliminary seal portion and the filling port seal portion. The medical container includes a detachable partition section that divides the drug chamber into a first drug chamber adjacent to the discharge port and a second drug chamber positioned above the first drug chamber; A first drug stored in the first drug chamber; and a second drug stored in the second drug chamber;
The peripheral seal portion includes an upper seal portion that forms an upper end of the second drug chamber, a lower seal portion that forms a lower end of the first drug chamber, the first drug chamber, and the second drug chamber. Comprising side seals that form the side edges of each of the drug chambers,
The filling port seal portion is provided on each of the first drug chamber side and the second drug chamber side of the side seal portion, and the filling port seal portion on the first drug chamber side and the The medical container according to any one of claims 7 to 10, wherein the filling port seal part on the second drug chamber side is provided on the same side with respect to the container body. A medical container filling port heat sealing mold for use in a filling port sealing step in the medical container manufacturing method according to claim 1, wherein the heat sealing mold is arranged to face each other. A mold and a second mold, the first mold and the second mold are provided with heat-sealing surfaces on opposite end faces, and the heat-sealing surface of the first mold is Forming an outer seal portion forming surface that is a flat surface and extending a predetermined length, and a drug chamber side seal portion that is provided substantially parallel to the outer seal portion forming surface and has a flat end surface protruding from the outer seal portion forming surface. A medical container filling port heat sealing mold , wherein the heat sealing forming surface of the second mold is flat as a whole .   The medical container filling port heat seal gold according to claim 12, wherein the heat seal forming surface has an inclined portion positioned between the drug chamber side seal portion forming surface and the outer seal portion forming surface. Type.

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