JP2006043061A - Medical multi-chamber container - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a medical multi-chamber container preventing liquid medicine from being administered without peeling off a partition weak seal part and allowing an operator to prepare an administration in an easy operation. <P>SOLUTION: This medical multi-chamber container 1 is provided with a container body 2 made of a flexible material and having its inside space partitioned into a first medical agent chamber 21 and a second medical agent chamber 22 by the peelable partition weak seal part 9, a discharge port 3 communicating with the lower end of the first medical agent chamber 21, first medical agent stored in the first medical agent chamber 21 and second medical agent stored in the second medical agent chamber 22. The partition weak seal part 9 is provided with a first weak seal part 9a and a second weak seal part 9b whose peeling is more difficult than that of the first weak seal part 9a, and this medical multi-chamber container 1 is provided with a communication inhibiting weak seal part 11 inhibiting the communication between the first medical agent chamber 21 and the exhaust port 3. <P>COPYRIGHT: (C)2006,JPO&NCIPI

Description

  The present invention relates to a medical multi-chamber container that is divided into two drug chambers by a peelable weak seal portion and each drug chamber is filled with a drug.

Among drugs that administer nutritional components intravenously to patients, there are unstable drugs that tend to change over time when pre-mixed. For example, when an amino acid solution and a glucose solution are blended and stored in advance, the mixed solution is colored (brown) by the Maillard reaction. Moreover, when a calcium compound is blended with a phosphate compound, precipitation of calcium phosphate occurs in a solution having a high pH, and the product value is significantly reduced. When such a drug is administered to a patient, for example, as shown in Japanese Patent No. 2675075 (patent document 1), a medical multi-chamber container that individually accommodates components before mixing is used, and then mixed before administration. Is starting to do.
This medical multi-chamber container includes a plurality of chambers for individually storing different component drugs, and a partition weak seal that separates the chambers and peels and opens them by pressure from the outside.
However, in many cases, the multiple medical containers contain the liquid agent in the storage part on the discharge port side, and the bottle needle is inserted into the rubber stopper without peeling off the weak seal for partitioning, and the liquid agent is discharged from the discharge port. There is a possibility of taking it out.
For this reason, a method has been devised to ensure that drugs stored in each storage unit are mixed and then administered to the patient, and to prevent accidents in which the drug is administered to the patient without accidental mixing. For example, as shown in Japanese Patent Laid-Open No. 9-327498 (Patent Document 2) and Japanese Patent Application Laid-Open No. 2002-136570 (Patent Document 3), a weak seal portion for preventing communication is provided that separates a medicine discharge port from a compartment for storing the medicine. A multi-chamber container has been proposed.

Japanese Patent No. 2675075 JP-A-9-327498 JP 2002-136570 A

In the ones shown in Patent Documents 2 and 3, the possibility of inserting the bottle needle into the stopper and taking out the liquid agent from the discharge port without peeling off the partitioning weak seal portion is considerably reduced. However, since it has a plurality of weak seals for partitioning the weak seal part for partitioning the compartment for storing the medicine and the weak seal part for blocking communication between the medicine discharge port and the compartment for storing the medicine, the weak seal part for partition is provided. After peeling and mixing the chemicals, it is necessary to peel the weak seal portion for communication inhibition. For this reason, it took time to prepare for administration.
An object of the present invention is to divide into two drug chambers by a detachable partition weak seal portion, and in a medical multi-chamber container filled with a drug in the drug chamber, the partition weak seal portion is not peeled off. Thus, it is intended to provide a medical multi-chamber container in which a chemical solution is not administered and preparation for administration can be performed with an easy operation.

What achieves the above object is as follows.
(1) A container body which is made of a flexible material and is divided into a first drug chamber and a second drug chamber by a partition weak seal portion from which an internal space can be peeled, and a lower end of the first drug chamber A medical multi-chamber container comprising a discharge port communicating with a portion, a first drug stored in the first drug chamber, and a second drug stored in the second drug chamber, The partition weak seal portion includes a first weak seal portion and a second weak seal portion that is less likely to be peeled off than the first weak seal portion, and the medical multi-chamber container includes the first weak seal portion. A medical multi-chamber container provided with a weak seal portion for preventing communication between a medicine chamber and the discharge port.

(2) The medical multi-chamber container according to (1), wherein a seal strength of the first weak seal portion is smaller than a seal strength of the second weak seal.
(3) The medical multi-chamber container according to (1) or (2), wherein a difference in seal strength between the first weak seal portion and the second weak seal portion is 3 to 30 N / 10 mm.
(4) The medical multi-chamber container according to any one of (1) to (3), wherein the first weak seal portion is provided above the communication blocking weak seal portion.
(5) The medical multi-chamber container according to any one of (1) to (4), wherein the second weak seal portion is provided on both sides of the first weak seal portion.
(6) The medical multi-chamber container according to any one of (1) to (5), wherein the second medicine accommodated in the second medicine chamber is a liquid agent.
(7) The first weak seal portion is peelable by pressing the first drug chamber or the second drug chamber, and the second weak seal portion is the first weak seal portion. The medical multi-chamber container according to any one of (1) to (6), wherein the medical chamber or the second chemical chamber is not substantially peeled by being pressed and can be peeled off.
(8) The medical multi-chamber container presses the first drug chamber or the second drug chamber, thereby simultaneously or subsequently following the peeling of the first weak seal portion, the weak seal for communication inhibition. The medical multi-chamber container according to any one of (1) to (7), wherein the part is peeled off.

(9) The ratio (La / Lb) of the lateral length (La) of the first weak seal portion to the lateral length (Lb) of the first drug chamber of the container body is 0. The medical multi-chamber container according to any one of (1) to (8), which is 2 to 0.8.
(10) The medical multi-chamber container has a lateral length (Lc) of the first weak seal portion with respect to a length (Lc) between the upper end of the communication inhibiting weak seal portion and the upper end of the discharge port ( The medical multi-chamber container according to any one of (1) to (9), wherein a ratio of La) (La / Lc) is 0.2 to 3.
(11) The seal strength of the weak seal portion for blocking communication is substantially the same as, slightly smaller or slightly larger than the seal strength of the first weak seal portion, and is greater than the seal strength of the second weak seal portion. The medical multi-chamber container according to any one of (1) to (10), which is small.
(12) The medical multi-chamber container according to any one of (1) to (11), wherein the first weak seal portion is made narrower than the second weak seal portion.
(13) The medical multi-chamber container according to any one of (1) to (12), wherein the partition weak seal portion and the communication inhibition weak seal portion are manufactured by heat sealing.

The present invention provides a container main body made of a flexible material and partitioned into a first drug chamber and a second drug chamber by a partition weak seal portion from which an internal space can be peeled, and the first drug chamber A medical multi-chamber container comprising a discharge port communicating with a lower end, a first drug stored in the first drug chamber, and a second drug stored in the second drug chamber. The partition weak seal portion includes a first weak seal portion and a second weak seal portion that is more difficult to peel off than the first weak seal portion, and the medical multi-chamber container includes the first weak seal portion. A weak seal portion for inhibiting communication between the drug chamber and the discharge port.
For this reason, the present invention provides a medical multi-chamber container in which a drug is not administered before the first drug and the second drug are mixed, and can be prepared for administration by an easy operation. Can be provided.

The medical multi-chamber container of the present invention will be described using an embodiment shown in the drawings.
FIG. 1 is a plan view of an embodiment of the medical multi-chamber container of the present invention. In addition, the upper side in the figure is described as “upper end” and the lower side is described as “lower end”.
The medical multi-chamber container 1 of the present invention is made of a flexible material, and is divided into a first drug chamber 21 and a second drug chamber 22 by a partition weak seal portion 9 whose internal space can be peeled off. The main body 2, the discharge port 3 communicating with the lower end of the first drug chamber 21, the first drug stored in the first drug chamber 21, and the second drug stored in the second drug chamber 22 It is the medical multi-chamber container 1 provided with a medicine. The partition weak seal portion 9 includes a first weak seal portion 9a and a second weak seal portion 9b that is more difficult to peel off than the first weak seal portion 9a. Furthermore, the medical multi-chamber container 1 includes a communication inhibiting weak seal portion 11 that inhibits communication between the first drug chamber 21 and the discharge port 3.
In the medical multi-chamber container 1 of this embodiment, the partition weak seal portion 9 is provided on both sides of the first weak seal portion 9a and the first weak seal portion 9a, and the first weak seal portion 9a. A second weak seal portion 9b that is more difficult to peel off is provided.

As shown in FIG. 1, the medical multi-chamber container 1 of the embodiment includes a container main body 2 formed of a sheet-like cylindrical body, and the container main body 2 has a weak seal for partitioning an internal storage portion. A portion 9 is formed, and the storage portion is divided into a first medicine chamber 21 and a second medicine chamber 22.
Moreover, as shown in FIG. 1, the seal | sticker part 5 provided in the upper end side of the container main body 2 and the seal | sticker part 6 provided in the lower end side are provided. In addition, the medical multi-chamber container 1 of the embodiment includes a medicine discharge port 3 provided on the first medicine chamber 21 side. Furthermore, the medical multi-chamber container 1 of this embodiment includes a drug injection port 4 provided on the second drug chamber 22 side.

The container body 2 of the medical multi-chamber container 1 is formed of a soft synthetic resin. The container body 2 is preferably formed into a cylindrical shape by an inflation molding method. The container body 2 may be manufactured by various methods such as a blow molding method and a coextrusion inflation method. In addition, the container body 2 is one in which the entire outer periphery (four sides) of the cylindrical body as described above is sealed, two sheet materials are stacked, and the entire outer periphery is sealed, one sheet. It may be a bag-like object such as one that is folded in two and three sides other than the bent part are sealed. In addition, a hole 25 for suspending the medical multi-chamber container 1 on a hanger or the like is provided at a substantially central portion of the seal portion 5 on the upper end side of the container body 2.
The container body 2 preferably has a water vapor barrier property. As the degree of water vapor barrier property, the water vapor permeability is preferably 50 g / m ² · 24 hrs · 40 ° C. · 90% RH or less, more preferably 10 g / m ² · 24 hrs · 40 ° C. · 90% RH or less. More preferably, it is 1 g / m ² · 24 hrs · 40 ° C. · 90% RH or less. This water vapor permeability is measured by the method described in JISK7129 (Method A).
Thus, the container main body 2 has a water vapor barrier property, so that the evaporation of moisture from the inside of the medical multi-chamber container 1 can be prevented. As a result, it is possible to prevent reduction and concentration of the medicine (specifically, chemical solution) to be filled. Moreover, the invasion of water vapor from the outside of the medical multi-chamber container 1 can be prevented.

When polyolefin is contained as a material for forming such a container body 2, the usefulness of the present invention is great. Therefore, in the present invention, it is preferable that the material for forming the container body 2 includes polyolefins. Particularly preferable materials for forming the container body 2 include polyolefins such as polyethylene (PE), polypropylene (PP), polybutadiene, and ethylene-vinyl acetate copolymer (EVA), styrene-butadiene copolymer and styrene. -Flexible by blending styrene thermoplastic elastomers such as ethylene-butylene-styrene block copolymers or olefinic thermoplastic elastomers such as ethylene-propylene copolymers, ethylene-butene copolymers, propylene-α olefin copolymers A softened resin may be used. This material is preferable in that it has high strength and flexibility, heat resistance (particularly heat resistance during sterilization) and water resistance, and is particularly excellent in workability and can reduce manufacturing costs.
Further, when the above blend resin is used, two or more kinds of materials having different melting points are used, and the seal portion 5 on the upper end side and the seal portion 6 on the lower end side of the container body 2, and a partition weak seal described later. It is possible to easily and satisfactorily set the seal conditions of the portion 9 and the weak seal portion 11 for inhibiting communication and stabilize the seal strength of each seal portion.

Further, the container body may have a single layer structure (single layer body) made of the material as described above, or a multilayer in which a plurality of layers (particularly layers of different materials) are stacked for various purposes. A laminated body may be sufficient. In the case of a multilayer laminate, a plurality of resin layers may be stacked, or a metal layer may be stacked on at least one resin layer. In the case where a plurality of resin layers are stacked, the advantages of the respective resins can be provided together. For example, the impact resistance of the container body 2 can be improved, or blocking resistance can be imparted. Further, in the case of a metal layer, the gas barrier property of the container body 2 can be improved. For example, when a film such as an aluminum foil is laminated, the gas barrier property can be improved and the light shielding property can be imparted. In addition, when a layer made of an oxide such as titanium oxide, aluminum oxide, or silicon oxide is formed, the transparency of the container body 2 can be maintained while the gas barrier property is improved, and the internal visibility is ensured. Can do. In addition, when the container main body 2 is a multilayer laminated body, it is preferable that the material which forms the inner surface part is the material mentioned above.
The thickness of the sheet material constituting the container body 2 is appropriately determined according to the layer configuration and the characteristics of the material used (flexibility, strength, water vapor permeability, heat resistance, etc.), and is not particularly limited. However, it is usually preferably about 100 to 550 μm, and more preferably about 200 to 400 μm.
In addition, the volume of the medical multi-chamber container 1 varies depending on the type of medicine accommodated therein, but it is usually preferable that the volume of the first medicine chamber is about 50 to 3000 mL, and the second medicine The chamber volume is preferably about 50 to 3000 mL.

  The volume ratio between the first drug chamber 21 and the second drug chamber 22 is preferably 1: 1 to 1: 5. By doing in this way, when the 2nd chemical | medical agent chamber is pressed, the stress to the weak seal part for communication inhibition can be enlarged more, and peeling of the weak seal part for communication inhibition is more reliable. Further, the amount of fluid to be filled [including the medicine and the head space (gas)] is 20 to 50% by volume of the total capacity of the multi-chamber container (capacity in a state where the weak seal portion is peeled to be one chamber). The effect of the invention becomes more remarkable. In medical containers such as infusion bags, other drugs are co-injected. For this reason, the medical container is made in a bag in anticipation of a reserve volume that is the same amount to several times as much as the amount of fluid to be filled. The amount of fluid in the medical multi-chamber container having the partition weak seal portion is about 20 to 50% by volume. Even with such a small fluid filling amount, according to the present invention, the first weak seal portion is used. In addition, stress is easily applied to the weak seal portion for inhibiting communication, and both seal portions can be opened more reliably by a single opening operation.

By dividing the drug chamber into the first drug chamber 21 and the second drug chamber 22 in this way, it can be stored separately until a liquid containing a substance that causes alteration or deterioration due to reaction or the like is used. In use, it can be applied when it is preferable to mix both solutions. As a medicine stored in each medicine room, a medicine, a powder, etc. can be considered. In particular, in the medical multi-chamber container of the present invention, the first drug is preferably a chemical solution. The second drug may be either a chemical solution or a powder. A chemical solution is preferable. As a combination of the first drug and the second drug, for example, in the case of an infusion, a combination of an amino acid electrolyte solution and a glucose solution is used in order to prevent coloring due to the Maillard reaction. In addition, the pH of the side on which glucose is added as a peritoneal dialysis solution is adjusted to 3 to 5, and the other electrolyte solution is mixed, and then adjusted so that the pH is almost neutral at the time of administration. It is done.
In the present invention, the first drug and the second drug are not particularly limited. For example, physiological saline, electrolyte solution, Ringer's solution, high-calorie infusion, glucose solution, amino acid infusion, fat infusion, water for injection, peritoneum Any of dialysate, oral and enteral nutrients, etc. may be used.

A drug discharge port 3 that can communicate with the first drug chamber 21 is provided at the tip of the container body 2. The medicine discharge port 3 is fused in a state of being sandwiched between the sheet materials of the discharge port fixing portion of the seal portion 6 on the lower end side, and is firmly fixed to the container body 2.
The medicine discharge port 3 is for discharging the medicine filled in the container body 2. As shown in FIG. 1, the discharge port 3 in this embodiment is liquid-tightly attached to a cylindrical member 3 a having an open upper end (first drug chamber side end) and a lower end side of the cylindrical member 3 a. The communication part which can be connected by the medicine discharge needle is provided. The communicating part includes a cap member 3b and an elastic member 3c that seals the rear end opening and allows the needle for discharging the medicine to pass through. The communicating part is not limited to such a form.
The drug injection port 4 is for injecting a drug into the container body 2. As shown in FIG. 1, the injection port 4 in this embodiment includes a cylindrical member 4a having an open lower end (second drug chamber side end), and a drug that is liquid-tightly attached to the upper end side of the cylindrical member. A communication portion is provided which can be communicated with an injection needle. The communicating portion includes a cap member 4b and an elastic member 4c that seals the rear end opening and can be pierced with a drug injection needle. The communicating part is not limited to such a form.

  The elastic members 3c and 4c can pierce a needle tube (not shown) such as a bottle needle or a cannula needle. When necessary, the elastic member 3c or 4c pierces the needle tube to discharge the medicine from the container body 2 or the container body 2. Addition of chemicals and the like to the inside can be performed. In addition, the elastic member has a self-occlusion property, and after the needle tube is extracted from the elastic member, the puncture hole is instantaneously closed to prevent the medicine from leaking. Various materials such as styrene elastomer, olefin elastomer, polyamide elastomer, polyester elastomer, and other thermoplastic elastomers, natural rubber, isoprene rubber, silicone rubber, butadiene rubber, and styrene-butadiene rubber are used as the constituent material of the elastic member. Elastic materials such as rubber materials, or combinations of any two or more of these (blends, laminates, etc.), polyolefins such as polyethylene, polypropylene, ethylene-propylene copolymers, or ethylene-vinyl acetate Examples thereof include a polymer, a crosslinked ethylene-vinyl acetate copolymer, polyester, polyvinyl chloride, polyurethane, polyamide, and other polymer materials.

  Constituent materials of the cylindrical member 3a and cap member 3b of the drug discharge port 3 and the cylindrical member 4a and cap member 4b of the drug injection port 4 include conditions, such as hardness, strength, toughness, and resistance to resistance. Materials having chemical properties, transparency, and other conditions are used, and it is preferable that the materials are composed of relatively hard materials. Examples of these materials include polyolefins such as polyethylene and polypropylene (low density to high density). ), Polyvinyl chloride (soft to hard), polycarbonate, polystyrene, polymethyl methacrylate, polyester (PET, PBT, etc.), polyamide, ABS resin, AS resin, polyacetal, polyphenylene sulfide, fluorine-based resin, etc. According to such conditions, the cylindrical member 3a and the cap part 3b, it can be appropriately selected in consideration of the fixing means with the tubular member 4a and the cap member 4b and the container body 2.

In the medical multi-chamber container 1 of this embodiment, as shown in FIG. 1, the partition weak seal portions 9 are provided on both sides of the first weak seal portion 9a and the first weak seal portion 9a. And a second weak seal portion 9b that is more difficult to peel off than the weak seal portion.
With such a configuration, by pressing the second drug chamber 22, the first weak seal portion 9a is not peeled off or prior to peeling of the second weak seal portion 9b. Peels off. Then, a fluid such as a liquid (specifically, a chemical solution and a gas) flows into the first drug chamber 21 from the peeling portion (the peeled first weak seal portion). The first medicine chamber 21 is pushed and expanded by the inflow of fluid such as liquid, and the internal pressure of the first medicine chamber is also increased by continuing the pressing of the second medicine chamber 22. When a fluid such as a liquid flows in, the first weak seal portion 9a becomes a peeling portion, and the entire weak seal portion 9 does not peel off. For this reason, the first medicine chamber 21 receives an inflow of a fluid such as a liquid in a state where the capacity does not increase so much. Therefore, the first drug chamber 21 is reliably expanded, and the weak seal portion 11 for inhibiting communication is reliably peeled accordingly. Further, by pressing the first medicine chamber 21, the weak seal portion 11 for inhibiting communication is peeled off together with the first weak seal portion 9a or with a slight delay.
Therefore, regardless of which drug chamber is pressed, a single operation is performed in which one drug chamber is pressed for the communication operation between the first drug chamber and the second drug chamber and the peeling operation of the weak seal portion for blocking communication. Can be performed.

In the medical multi-chamber container 1 of this embodiment, the partition weak seal portion 9 is formed so as to traverse the container body 2 in the entire lateral direction, as shown in FIG. Moreover, the partition weak seal part 9 is formed by fusing the sheet material of the container body 2 in a strip shape.
As shown in FIG. 1, the first weak seal portion 9 a is provided near the center of the container body 2, and the second weak seal portion 9 b is formed from both sides to the side of the container body 2 or near the side. ing. In this embodiment, the first weak seal portion 9a is preferably provided above the communication blocking weak seal portion 11, specifically, vertically above. Moreover, it is preferable that the 2nd weak seal part 9b is provided in the both sides of the position which becomes the upper direction of the weak seal part 11 for a communication inhibition so that it may show in figure. Since the weak seal portion for preventing communication is provided at such a position, when the first weak seal portion is peeled off, the portion where the weak seal portion for preventing communication is formed swells greatly. The seal portion is easily peeled off. In the embodiment of the present invention, the first weak seal portion 9a and the second weak seal portion 9b are formed to have substantially the same width except for both side portions. In this embodiment, both side portions of the second weak seal portion 9b are formed wide. As shown in FIG. 1, seal portions 12 that cannot substantially be peeled off are provided at both ends of the partition weak seal portion 9 (second weak seal portion 9b in the embodiment of the present invention). It is preferable. In addition, the 1st weak seal part or the 2nd weak seal part does not need to be formed in strip | belt shape. In this embodiment, since the discharge port and the weak seal portion for inhibiting communication are provided near the center in the lateral direction of the container body 2, the first weak seal portion 9 a is also provided in the container body 2 correspondingly. It is provided near the center in the horizontal direction. When the discharge port and the weak seal portion for inhibiting communication are provided at a position close to one side of the container body 2, the first weak seal portion is also corresponding to the vicinity of the center in the lateral direction of the container body. It is preferable to provide at a position close to one side.

In the embodiment of the present invention, the seal strength of the first weak seal portion 9a is smaller than the seal strength of the second weak seal portion 9b.
In the embodiment of the present invention, the first weak seal portion 9a presses the first drug chamber 21 or the second drug chamber 22 of the container body 2 by hand, and the first drug chamber 21 or the second drug chamber 22 is pressed. By increasing the internal pressure of the drug chamber 22 and manually squeezing the first drug chamber 21 or the second drug 22 portion of the container body 2 with the medical multi-chamber container 1 hung on the hanger. It has a sealing strength that can be peeled off by increasing the internal pressure of the first drug chamber 21 or the second drug chamber 22. Thereby, the interruption | blocking by the weak seal part 9 for a partition is cancelled | released by a simple operation | work, without using a special instrument etc., and the chemical | medical agent of the 1st chemical | medical agent chamber 21 and the 2nd chemical | medical agent chamber 22 can be mixed.
The second weak seal portion 9b is peeled by increasing the internal pressure of the first drug chamber 21 or the second drug chamber 22 to be higher than the peelable internal pressure of the first weak seal portion by the above-described method. The seal strength is as follows. Moreover, the 2nd weak seal | sticker part 9b may be provided with the seal | sticker intensity | strength of the grade which does not peel substantially by pressing the 1st chemical | medical agent chamber 21 or the 2nd chemical | medical agent chamber 22. FIG.

Specifically, the seal strength (initial peel strength) of the first weak seal portion is preferably 0.1 to 5 N / 10 mm, particularly preferably 0.3 to 3 N / 10 mm. If the seal strength is within this range, the first weak seal part will not be accidentally peeled off during transportation or storage, and the work of peeling off the first weak seal part is easy. The seal strength (initial peel strength) of the second weak seal portion is preferably 3N / 10 mm or more, particularly 4N / 10 mm or more.
The seal strength difference (initial peel strength difference) between the first weak seal portion and the second weak seal portion is 3 to 30 N / 10 mm from the seal strength (initial peel strength) of the first weak seal portion, In particular, it is preferably 4 to 25 N / 10 mm larger. In this way, when any one of the drug chambers is pressed, it is possible to prevent the entire weak partitioning portion for partitioning from being peeled at once, and to ensure at least peeling from the first weak sealing portion.

In addition, as a concrete measuring method of seal strength, it can carry out as follows.
The medical multi-chamber container was cut at a portion including each measurement target seal portion into a length of 10 mm in the width direction of the container, and a cut piece included in each seal strength portion was measured at a tensile speed of 300 mm / min. It is an average value of each seal strength portion.
The first weak seal portion can be peeled by pressing the first drug chamber or the second drug chamber, and the second weak seal portion is the first drug chamber or the second drug chamber. It may be one that does not substantially peel by pressing the drug chamber and can be peeled off. Specifically, the first weak seal portion of the medical multi-chamber container of the present invention is formed with a seal strength that can be peeled by pressing the first drug chamber or the second drug chamber. The weak seal portion is preferably formed with a seal strength that does not peel off and can be peeled off by pressing the first drug chamber or the second drug chamber. By having such a configuration, the first drug chamber swells greatly during the first weak seal portion peeling operation, so that the weak seal for blocking communication can be more reliably peeled off almost simultaneously with the operation. In addition, since the second weak seal portion can be peeled off, the second drug chamber that has not been peeled off can be peeled off with fingers or the like after the weak seal portion for inhibiting communication is peeled off. The medicine inside can be discharged reliably. Further, the scale (not shown) on the bag surface can be read with the same accuracy as that of the single chamber container.

The ratio (La / Lb) of the lateral length (La) of the first weak seal portion 9a to the lateral length (Lb) of the first drug chamber 21 of the container body 2 is 0.2. It is preferable that it is -0.8. In particular, it is preferably 0.3 to 0.7.
Further, the medical multi-chamber container 1 has a lateral length of the first weak seal portion 9a with respect to the length (Lc: shortest distance) between the upper end of the communication inhibiting weak seal portion 11 and the upper end of the medicine discharge port. The ratio (La / Lc) of the thickness (La) is preferably 0.2 to 3, and more preferably 0.5 to 2. In particular, it is preferably 0.7 to 1.5.
If La / Lc is greater than 0.2, the first weak seal portion is not easily peeled off, and if it is less than 3, the first weak seal portion is peeled off when the first weak seal portion is peeled off. Separation of the seal portion is also ensured. Moreover, the width (band width) of the weak seal portion 11 for peeling inhibition is preferably 2 to 20 mm, particularly 4 to 12 mm.

Specific examples of the size of the medical multi-chamber container include the following.
The inside width of the second drug chamber 22 is 190 mm, the distance between the partition weak seal portion 9 and the seal portion 5 is 135 mm, and the second drug chamber is filled with 350 ml of drug solution (specifically, glucose electrolyte solution). The amount of air 60 cc, the width (band width) of the partition seal part 15 mm, the inner lateral width 190 mm of the first drug chamber 21, the distance 110 mm between the partition weak seal part 9 and the intermediate part of the inclined part of the seal part 6, 150 ml of drug solution (specifically amino acid solution) filled in one drug chamber, 15 cc of filled air, width (band width) of weak seal portion 11 for communication inhibition 8 mm, La 100 mm, Lb 180 mm, Lc 50 mm, reserve capacity (Preliminary capacity in a state where the weak seal is peeled off to form one chamber) 800 ml
The weak seal portion is preferably formed by heat sealing. Specifically, it is preferably performed by a hot press, and the mold temperature can be formed by a temperature lower by 10 ° C. or more than the melting temperature of the forming material of the container body 2.
The partition weak seal portion is not limited to the above-described one, and any partition may be used as long as it includes the first weak seal portion and the second weak seal portion that is more difficult to peel off than the first weak seal portion. It may be configured.

Moreover, as the weak seal part 9 for a partition, as shown in FIG. 2, when the 2nd weak seal part 9b is wider than the 1st weak seal part 9a, the 2nd weak seal part is It may be more difficult to peel off than the first weak seal portion. The partition seal portion 9 shown in FIG. 2 is provided at both ends of the narrow band-shaped first weak seal portion 9a, second weak seal portions 9b provided on both sides thereof, and the partition seal portion 9. A strong seal portion 12 is provided. In addition, the boundary between the first weak seal portion and the second weak seal portion may be gradually narrowed from the second weak seal portion side toward the first weak seal portion side. The seal strength of the first weak seal portion and the seal strength of the second weak seal portion of such a partition weak seal portion are substantially the same or the seal strength of the first seal portion is greater than the seal strength of the second seal portion. It is preferable that it is small.
Moreover, the 1st weak seal | sticker part 9a may be a shape which protrudes toward the 1st chemical | medical agent chamber 21, as shown in FIG. Specifically, the first weak seal portion 9a includes a deformable portion 19 that bends or curves toward the first drug chamber 21 side. By having such a configuration, when the first drug chamber 21 is expanded or when the internal pressure of the first drug chamber becomes high, the start of peeling at the tip of the deformable portion 19 occurs with certainty. 1 weak seal part becomes easier to peel.

And the medical multiple-chamber container 1 of this invention is provided with the weak seal part 11 for communication inhibition formed so that the upper direction of the chemical | medical agent discharge port 3 might be surrounded, as shown in FIG. A third chamber 23 isolated from the first medicine chamber 21 is formed by the weak seal portion 11 for inhibiting communication. The third chamber 23 is an empty room. However, a predetermined liquid (for example, physiological saline) may be placed in the third chamber. The third chamber 23 may be in a dry state, but may be filled with a small amount of moisture for sterilization. Furthermore, a passage through which some water vapor or medicine passes through the communication inhibiting weak seal portion 11 may be formed and communicated with the first medicine chamber 21 at the above-described level. The weak seal portion 11 for inhibiting communication can be formed by heat-sealing the sheet material in a band shape (thermal fusion, high frequency fusion, ultrasonic fusion, etc.).
In the embodiment shown in FIG. 1, the weak seal portion 11 for inhibiting communication is formed in an inverted trapezoidal shape. In addition, the weak seal portion for blocking communication has a U shape with a short side on the upper side, a triangular shape with the discharge port at the top, a triangular shape with the discharge port at the bottom, a polygonal shape such as a quadrangle, a substantially semicircular shape, A substantially semi-elliptical shape or an inverted U-shape may be used. In the case of a polygon, the corners are preferably rounded.

Moreover, it is preferable that the weak seal part for communication inhibition is provided under the 1st weak seal part 9a, as shown in FIG. By being provided below the first weak seal part, the weak seal part for communication inhibition is more easily and reliably peeled off during the partition seal part peeling operation.
Moreover, the front-end | tip part of the weak seal part for communication inhibition may become easy to peel from another part. Examples of the tip of the weak seal portion 11a for inhibiting communication include those that are recessed toward the discharge port 3 side. With such a configuration, when the first drug chamber or the second drug chamber is pressed, the pressing force is concentrated on the distal end portion, so that the weak seal portion for preventing communication is easily peeled off. Specifically, as shown in FIG. 4, the weak seal portion for inhibiting communication is preferably formed to be bent or curved toward the discharge port. Moreover, as such a weak seal part 11b for connection inhibition, as shown in FIG. 5, the thing by which the front-end | tip part was formed narrower than the other part is mentioned. Further, the seal strength at the tip may be made smaller than that of other portions.

  Further, the seal strength of the weak seal portion 11 for inhibiting communication is equal to, slightly larger or slightly smaller than the seal strength of the first weak seal portion 9a, and smaller than the seal strength of the second weak seal portion 9b. It is preferable. If it is such, a chemical | medical solution will not be administered in the state in which the 1st weak seal | sticker part does not peel, and administration preparation can be performed by easy operation. In particular, it is preferable that the seal strength of the weak seal portion 11 for inhibiting communication is slightly larger than the seal strength of the first weak seal portion 9a and smaller than the seal strength of the second weak seal portion 9b. Moreover, the weak seal part for communication inhibition presses the 1st chemical | medical agent chamber 21, and the weak seal part 11 for communication inhibition peels substantially simultaneously or subsequently with peeling of the 1st weak seal part 9a. It is preferable. By doing in this way, the weak seal part 11 for communication inhibition does not peel before the 1st weak seal part 9a.

Further, in the medical multi-chamber container, by pressing the second drug chamber 22, the weak seal portion 11 for inhibiting communication is almost simultaneously with the peeling of the first weak seal portion 9a or following the peeling of the seal portion 9a. It may be peeled off. For example, as described above, the weak seal portion 11 for preventing communication has the same seal strength as that of the first weak seal portion or the seal strength of the first weak seal portion 9a. It can be configured by slightly strengthening.
The seal strength (initial peel strength) of the weak seal portion for inhibiting communication is preferably 1 to 25 N / 10 mm, and particularly preferably 2 to 20 N / 10 mm.

Moreover, when the 1st chemical | medical agent chamber 21 or the 2nd chemical | medical agent chamber 22 is pressed, the upper end side part of the weak seal part 11 for communication inhibition, especially an upper end part may be formed in the part to which strong peeling force is applied. preferable.
In such a medical multi-chamber container, the ratio (La) of the length La of the first weak seal portion 9a to the length (distance) Lc between the upper end of the weak seal portion 11 for preventing communication and the upper end of the medicine discharge port 3 is obtained. / Lc) is preferably 0.2 to 3, and particularly preferably 0.5 to 2. With such a configuration, when the first drug chamber 21 or the second drug chamber 22 is pressed, the upper end side portion of the weak seal portion 11 for blocking communication is located near a position where a large peeling force is applied. It is considered that the weak seal portion can be easily peeled off.
The length Lc between the upper end of the communication inhibiting weak seal portion 11 and the upper end of the drug discharge port 3 is a length of a straight line perpendicular to the central axis of the drug discharge port 3 from the upper end of the communication inhibiting weak seal portion 11. is there.

In the medical multi-chamber container of the present invention, in the above-described relationship, when the length La of the first weak seal portion is short, the weak seal portion for communication inhibition as in the medical multi-chamber container 1 shown in FIG. The length Lc between the upper end and the upper end of the medicine discharge port is short (the length in the longitudinal direction of the weak seal portion for communication inhibition is short), while the medical multi-chamber container 20 shown in FIG. When the length La of the first weak seal portion is long, the length Lc between the upper end of the communication inhibiting weak seal portion and the upper end of the medicine discharge port is long (in the longitudinal direction of the communication inhibiting weak seal portion). It is preferable that the length is long).
The method for forming the partition weak seal portion 9 and the communication blocking weak seal portion 11 is not particularly limited, and can be performed using a heat seal heating mold (heat seal bar) or the like that is normally used. Moreover, you may use the method of producing blocking in the site | part of the weak seal part 9 for partition and the weak seal part 11 for communication inhibition at the time of heat sterilization, such as high pressure steam sterilization.

Hereinafter, a method for producing the medical multi-chamber container 1 will be described. The method is not limited to this method.
First, a tube body formed of a soft synthetic resin is prepared. Then, the upper end side seal portion 5 having a partially unsealed portion and the partially unsealed portion are connected to the tube body at two locations (the space communicating with the weak seal portion 11 for inhibiting communication, the first The container main body 2 is formed by forming the lower end side seal portion 6, the partition seal portion 9, and the weak seal portion 11 for inhibiting communication. Subsequently, the discharge port 3 is inserted and fixed to the partially unsealed portion of the lower end side seal portion 6.
Then, the cylindrical member 4a of the injection port 4 is fixed to the unsealed part of the upper end side seal part 5 and the second drug is injected through the cylindrical member 4a. In a state where the container is fixed, the cap member 4b having the elastic member 4c attached to the cylindrical member 4 is fixed and sealed. The cylindrical member 3a of the discharge port 3 is fixed to the lower end side seal portion 6 in a partially unsealed portion communicating with the space surrounded by the weak seal portion 11 for inhibiting communication, and the elastic member 3c is attached to the cylindrical member 3a. The attached cap member 3b is fixed and sealed. Next, immediately after the second drug is injected into the first drug chamber from the partially unsealed portion communicating with the first drug chamber 21, the unsealed portion is sealed with a heat seal.

In this manner, a medical multi-chamber container filled with a medicine as shown in FIG. 1 is produced. The first medicine injection and the first medicine chamber sealing operation may be performed before the second medicine injection and the second medicine chamber sealing operation.
As a method of forming the first weak seal portion 9a and the second weak seal portion 9b, the heat seal condition of the partition weak seal portion 9 is made slightly stronger only at the portion where the second seal strength 9b is obtained, or Only the part that becomes the second weak seal portion 9b can be performed by performing the heat treatment again. Specifically, heat is applied using a heating die under the sealing conditions (temperature, pressure, and time are adjusted) such that the entire width direction becomes the seal strength of the first weak seal portion of the partition weak seal portion. Sealing is performed by performing heat treatment again using a heating mold under a sealing condition (adjusting temperature, pressure, and time) in a region where the second weak seal portion has a desired seal strength. A strong portion can be formed.

Moreover, you may perform preparation of the medical multiple-chamber container 1 as follows.
First, a tube body formed of a soft synthetic resin is prepared. And the container main body 2 which has the upper end side seal part 5 which has a partially unsealed part, the lower end side seal part 6 which has a partially unsealed part, and the weak seal part 9 for a partition in this tube body is produced.
And the cylindrical member 3a of the discharge port 3 adheres to the partially unsealed part of the lower end side seal part 6, the 1st chemical | medical agent is inject | poured through the cylindrical member 3a, and the cylindrical member 3a becomes upper side After forming the weak seal portion 11 for inhibiting communication in a state where the container is fixed as described above, the elastic member 3c and the cap member 3b are fixed to the cylindrical member 3 and sealed. And the cylindrical member 4a of the injection | pouring port 4 adheres to the partially unsealed part of the upper end side seal part 5, a 2nd chemical | medical agent is inject | poured through the cylindrical member 4a, and the cylindrical member 4a becomes upper side With the container fixed in this manner, the elastic member 4c and the cap member 4b are fixed to the cylindrical member 4 and sealed. In this manner, a medical multi-chamber container filled with a medicine as shown in FIG. 1 is produced. In addition, you may perform formation of the weak seal | sticker part 11 for communication inhibition after sealing an exhaust port. The first medicine may be injected from a partially unsealed portion of the lower end side seal portion 6 and the discharge port may be fixed after the injection. Further, the second drug injection and the second drug chamber sealing operation are performed before the first drug injection, the communication blocking weak seal portion 11 is formed, and the first drug chamber sealing operation is performed. It may be. As a method of forming the first weak seal portion 9a and the second weak seal portion 9b, the method described above is preferably performed.

Next, the usage method of the medical multi-chamber container 1 of this invention is demonstrated.
The container body 2 in a state where the outer surface portion of the medical multi-chamber container 1 on the first drug chamber 21 side is pressed by hand or is hung on a hanger or the like through a hole 25 for hanging the medical multi-chamber container 1 When the internal pressure of the first drug chamber 21 is increased by manually squeezing the portion on the first drug chamber 21 side, the first weak seal portion 9a is peeled off, and the first drug chamber 21 in the first drug chamber 21 is peeled off. While the medicine and the second medicine in the second medicine chamber are mixed, the weak seal of the communication inhibiting weak seal portion 11 is also peeled off simultaneously or slightly behind. Then, the second weak seal part is peeled off almost simultaneously with or behind the weak seal part 11 for communication inhibition. Further, in the case where the second weak seal portion 9b is not completely peeled off, if necessary, the medicine chamber is further pushed or peeled off with fingers or the like. Thereafter, a bottle needle or the like (not shown) is inserted into the medicine discharge port 3 to discharge the mixed medicine. Note that the bottle needle or the like may be inserted into the medicine discharge port 3 in advance before the partition weak seal portion 9 and the communication blocking weak seal portion 11 are peeled off.

As another method, a hanger or the like is provided by manually pressing the outer surface portion of the medical multi-chamber container 1 on the second drug chamber 22 side or through the hole 25 for hanging the medical multi-chamber container 1. When the internal pressure of the first drug chamber 22 is increased by manually squeezing the portion of the container body 2 on the first drug chamber 22 side while being hung on the first weak seal portion 9a, The second medicine in the second medicine chamber and the first medicine in the first medicine chamber are mixed, and at the same time or slightly delayed, the weak seal of the weak seal portion 11 for inhibiting communication is also peeled off. The second weak seal portion is peeled off almost at the same time or after the weak seal portion 11 for inhibiting communication. Further, in the case where the second weak seal portion 9b is not completely peeled off, if necessary, the medicine chamber is further pushed or peeled off with fingers or the like. Thereafter, a bottle needle or the like (not shown) is inserted into the medicine discharge port 3 to discharge the mixed medicine. Note that the bottle needle or the like may be inserted into the medicine discharge port 3 in advance before the partition weak seal portion 9 and the communication blocking weak seal portion 11 are peeled off.
As described above, the medical multi-chamber container of the present invention has been described based on the illustrated embodiments, but the present invention is not limited to these, and the configuration of each part is an arbitrary configuration that can exhibit the same function. In addition, an arbitrary configuration may be added.

Moreover, as a medical multi-chamber container, the medical multi-chamber container 20 as shown in FIG. 6 may be sufficient. The difference between the medical multi-chamber container 1 of the above-described embodiment and the medical multi-chamber container 20 of this embodiment is only the form of the weak seal part for partitioning and the form of the weak seal part for communication inhibition, and other configurations. Are the same and refer to the above description.
In the multi-chamber container 20 of this embodiment, as compared with the partition weak seal portion 9 in the multi-chamber container 1, the lateral length of the container body 2 at the first weak seal portion 9a is shown in FIG. Is long, and the lateral length of the container body 2 of the second weak seal portion 9b on both sides is short. Further, in the multi-chamber container 20 of this embodiment, the length La of the first weak seal portion and the length Lc between the upper end of the communication blocking weak seal portion 31 and the upper end of the medicine discharge port 3 are long. It has become. In addition, compared to the weak seal portion for preventing communication in the multi-chamber container 1, the tip of the weak seal portion 31 for preventing communication is in a state of being close to the weak seal portion 9 for partitioning. When the length La of the first weak seal portion is long like the medical multi-chamber container 20, the length Lc between the upper end of the communication inhibiting weak seal portion 31 and the upper end of the medicine discharge port 3 is It is preferable that the length is long (the length in the longitudinal direction of the weak seal portion for inhibiting communication is long). In other words, like this medical multi-chamber container 20, the length Lc between the upper end of the communication inhibiting weak seal portion 31 and the upper end of the medicine discharge port 3 is long (in the longitudinal direction of the communication inhibiting weak seal portion). When the length is long), the length La of the first weak seal portion 9a may be long.

The medical multi-chamber container may be a medical multi-chamber container 30 as shown in FIG. The difference between the medical multi-chamber container 1 of the embodiment described above and the medical multi-chamber container 30 of this embodiment is only the form of the weak seal portion for partitioning, and the other configurations are the same. Refer to it.
The partition weak seal portion 9 of the medical multi-chamber container 30 of this embodiment is provided with the second weak seal portion 9b only on one side, not on both sides of the first weak seal portion 9a and the weak seal portion 9a. . And in the medical multiple-chamber container 30 of this Example, the 1st weak seal part 9a in the partition weak seal part 9 is not near the center of the container main body 2, but from the center vicinity of the container main body 2 to the side side. It is provided at a shifted position. Further, in the medical multi-chamber container 30 of this embodiment, the first weak seal portion 9a is provided at a position that is not above the communication blocking weak seal portion 11 in the vertical direction.
Even in such a case, by pressing the second drug chamber 22, the second weak seal portion 9b is not peeled off or prior to peeling of the second weak seal portion 9b. The seal portion 9a is peeled off. Then, a fluid such as a liquid flows into the first drug chamber 21 from the peeling portion (the peeled first weak seal portion). The first medicine chamber 21 is pushed and expanded by the inflow of fluid such as liquid, and the internal pressure of the first medicine chamber is also increased by continuing the pressing of the second medicine chamber 22. When a fluid such as a liquid flows in, the first weak seal portion 9a becomes a peeling portion, and the entire weak seal portion 9 does not peel. For this reason, the first medicine chamber 21 receives an inflow of a fluid such as a liquid in a state where the capacity does not increase so much. Therefore, the first drug chamber 21 is reliably expanded, and the weak seal portion 11 for inhibiting communication is reliably peeled accordingly.
Therefore, also in the medical multi-chamber container 30 of this embodiment, by pressing the second drug chamber 22, the weak seal portion 11 for inhibiting communication is almost simultaneously with or slightly delayed from the peeling of the first weak seal portion 9a. Therefore, the communication between the first drug chamber and the second drug chamber and the weak seal portion for blocking communication can be peeled by a single operation of pressing the drug chamber.

FIG. 1 is a plan view of an embodiment of the medical multi-chamber container of the present invention. FIG. 2 is an explanatory view for explaining the vicinity of a partition weak seal portion of a medical multi-chamber container according to another embodiment of the present invention. FIG. 3 is an explanatory view for explaining the vicinity of a partition weak seal portion of a medical multi-chamber container according to another embodiment of the present invention. FIG. 4 is an explanatory diagram for explaining the vicinity of a weak seal portion for communication inhibition of a medical multi-chamber container according to another embodiment of the present invention. FIG. 5 is an explanatory diagram for explaining the vicinity of a weak seal portion for communication inhibition of a medical multi-chamber container according to another embodiment of the present invention. FIG. 6 is a plan view of another embodiment of the medical multi-chamber container of the present invention. FIG. 7 is a plan view of another embodiment of the medical multi-chamber container of the present invention.

Explanation of symbols

DESCRIPTION OF SYMBOLS 1 Medical multiple-chamber container 2 Container main body 3 Drug discharge | emission port 4 Drug injection | pouring ports 5, 6 Seal part 9 Partition weak seal part 9a 1st weak seal part 9b 2nd weak seal part 11 Weak seal part 21 for communication inhibition First drug room 22 second drug room

Claims (13)

A container main body made of a flexible material and separated into a first drug chamber and a second drug chamber by a partition weak seal portion from which an internal space can be peeled, and a lower end portion of the first drug chamber communicated with each other A medical multi-chamber container comprising a discharge port, a first medicine housed in the first medicine chamber, and a second medicine housed in the second medicine chamber, The weak seal portion includes a first weak seal portion and a second weak seal portion that is more difficult to peel off than the first weak seal portion, and the medical multi-chamber container includes the first drug chamber and A medical multi-chamber container comprising a weak seal portion for communication inhibition that inhibits communication with the discharge port. The medical multi-chamber container according to claim 1, wherein a seal strength of the first weak seal portion is smaller than a seal strength of the second weak seal portion. The medical multi-chamber container according to claim 1 or 2, wherein a difference in seal strength between the first weak seal portion and the second weak seal portion is 3 to 30 N / 10 mm. The medical multi-chamber container according to any one of claims 1 to 3, wherein the first weak seal portion is provided so as to be above the weak seal portion for communication inhibition. 5. The medical multi-chamber container according to claim 1, wherein the second weak seal portion is provided on both sides of the first weak seal portion. The medical multi-chamber container according to any one of claims 1 to 5, wherein the second medicine accommodated in the second medicine chamber is a liquid agent. The first weak seal portion is peelable by pressing the first drug chamber or the second drug chamber, and the second weak seal portion is the first drug chamber or The medical multi-chamber container according to any one of claims 1 to 6, wherein the container is substantially non-peelable and can be peeled off by pressing the second drug chamber. The medical multi-chamber container presses the first drug chamber or the second drug chamber, so that the weak seal part for preventing communication is peeled off simultaneously with or subsequent to the peeling of the first weak seal part. The medical multi-chamber container according to any one of claims 1 to 7. The ratio (La / Lb) of the lateral length (La) of the first weak seal portion to the lateral length (Lb) of the first drug chamber of the container body is 0.2-0. The medical multi-chamber container according to any one of claims 1 to 8, which is .8. The medical multi-chamber container has a lateral length (La) of the first weak seal portion with respect to a length (Lc) between an upper end of the communication inhibiting weak seal portion and an upper end of the discharge port. The medical multi-chamber container according to any one of claims 1 to 9, wherein the ratio (La / Lc) is 0.2 to 3. The seal strength of the weak seal portion for blocking communication is substantially the same as, slightly smaller or slightly larger than the seal strength of the first weak seal portion, and smaller than the seal strength of the second weak seal portion. The medical multi-chamber container according to any one of claims 1 to 10. The medical multi-chamber container according to any one of claims 1 to 11, wherein the first weak seal portion is made narrower than the second weak seal portion. The medical multi-chamber container according to any one of claims 1 to 12, wherein the partition weak seal portion and the communication blocking weak seal portion are manufactured by heat sealing.

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