JP2004115409A - Poisonous bait agent for controlling flies - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a poisonous bait agent which is used for controlling flies and has a high control effect. <P>SOLUTION: This poisonous bait agent for controlling the flies is characterized by containing an oxadiazine compound represented by formula (1) and a feeding-inducing substance. The method for controlling the flies is characterized by treating a fly-breeding or flying place or its periphery with the poisonous bait agent. <P>COPYRIGHT: (C)2004,JPO

Description

で示されるオキサジアジン化合物（以下、本化合物と記す。）及び摂食誘導物質を含有することを特徴とするハエ類防除用毒餌剤（以下、本毒餌剤と記す）および本毒餌剤を施用することを特徴とするハエ類の防除方法に関するものである。
【０００８】
【発明の実施の形態】
本化合物は、一般名インドキサカルブとして知られた化合物である。本化合物には、（Ｓ）−メチル　７−クロロ−２，５−ジヒドロ−２−［［（メトキシカルボニル）［４−（トリフルオロメトキシ）フェニル］アミノ］カルボニル］インデノ［１，２−ｅ］［１，３，４］オキサジアジン−４ａ（３Ｈ）−カルボキシレート及び（Ｒ）−メチル　７−クロロ−２，５−ジヒドロ−２−［［（メトキシカルボニル）［４−（トリフルオロメトキシ）フェニル］アミノ］カルボニル］インデノ［１，２−ｅ］［１，３，４］オキサジアジン−４ａ（３Ｈ）−カルボキシレートの２種の異性体が存在する。本発明において、本化合物はこれらの異性体単独及び異性体の任意の割合の混合物であり得る。
【０００９】
本毒餌剤は通常、本毒餌剤がハエ類に摂食されることによりハエ類に対する防除効果を発揮するものである。
【００１０】
本毒餌剤中の本化合物の含有量は、通常０．０００５〜２０重量％である。
【００１１】
本毒餌剤には本化合物の他に摂食誘導物質を含有する。該摂食誘導物質は、ハエ類の定位、定着、摂食行動等を誘導、継続させるための物質である。摂食誘導物質としては、例えばショ糖、ブドウ糖、グラニュー糖、果糖、乳糖、麦芽糖、黒砂糖、赤砂糖、三温糖、デキストリン、アラビノース、ガラクトース、ソルビトース、糖蜜、蜂蜜等の糖類；トウモロコシ、ジャガイモ、サツマイモ等に由来する澱粉；小麦粉、米粉、トウモロコシ粉、ジャガイモ粉等の穀物粉；脱脂乳、脱脂粉乳、チーズ等の乳製品；ウシ、ブタ、魚介類、エビ、カニ、昆虫等の動物粉末や昆虫粉末；トリコセン、アセタール等の誘引物質を挙げることができ、該摂食誘導物質は１種単独で使用することができ、２種以上を混用（混合、併用）することもできる。
【００１２】
摂食誘導物質の本毒餌剤中の含有量は通常１〜９９．９重量％である。
【００１３】
また、本毒餌剤中には、必要によりエリソルビン散、没食子酸プロピル等の酸化防止剤；安息香酸、ソルビン酸、デヒドロ酢酸ナトリウム等の保存料；トウガラシ末、安息香酸デナトニウム等の誤食防止剤；ホワイトカーボン、ベントナイト等の増量剤；チーズ香料、バター香料、ピーナッツ香料、ストロベリー香料、ミルク香料、オニオン香料等の香料；黄色４号、赤色２号等の着色料等を含有していても良い。その含有量は通常０．００１〜５重量％である。
【００１４】
また本毒餌剤は適宜、本化合物に加え、他の殺虫活性成分を有効成分として含有することができる。かかる殺虫活性成分としては、アザメチフォス、ホウ酸、Ｎ−フェニルピラゾール系化合物、イミダクロプリド等のネオニコチノイド系化合物等を挙げることができる。
【００１５】
本毒餌剤は、粉状、顆粒状、塊状、錠剤形状、液状、半練り状、ゲル状等、種々の形態を取り得る。
【００１６】
本毒餌剤が粉状の場合は、本化合物、摂食誘導物質及び必要によりその他の成分、水、アセトン等の溶媒を混合し、必要により乾燥することにより得られる。該粉状の本毒餌剤に更に水を加えて成形することにより顆粒状や、塊状の本毒餌剤とすることができ、前記粉状の本毒餌剤に水を加え打錠することにより錠剤形状の本毒餌剤とすることができる。また、本化合物、摂食誘導物質及び必要によりその他の成分を水やアルコール等で希釈・分散することにより液状あるいは半練り状の本毒餌剤とすることができる。また、ゲル状の本毒餌剤は、該液状あるいは半練り状の本毒餌剤に、更にカラギーナン、ペクチン、寒天、ゼラチン、ゼラチンゴム、アルギン酸ソーダ、グァガム、ジェランガム、ローカストビーンガム等のゲル化剤を混合することにより得ることができる。
【００１７】
また、本化合物を本毒餌剤に用いるに当たっては、本化合物をそのまま使用しても良いし、本化合物を含有する粉剤、水和剤、乳剤、油剤等の製剤品を使用しても良い。
【００１８】
本毒餌剤により、効果的に防除し得るハエ類としては、例えばイエバエ（Ｍｕｓｃａ　ｄｏｍｅｓｔｉｃａ）、クロイエバエ（Ｍｕｓｃａ　ｃｏｒｖｉｎａ）、オオイエバエ（Ｍｕｓｃｉｎａ　ｓｔａｂｕｌａｎｓ）、ヒメイエバエ（Ｆａｎｎｉａ　ｃａｎｉｃｕｌａｒｉｓ）等のイエバエ類（Ｈｏｕｓｅ　ｆｌｉｅｓ）、オオキモンノミバエ（Ｍｅｇａｓｅｌｉａ　ｓｐｉｒａｃｕｌａｒｉｓ）等のノミバエ類（Ｓｃｕｔｔｌｅ　ｆｌｉｅｓ）、ツヤホソバエ類（Ｓｐｉｎｙ−ｌｅｇｇｅｄ　ｆｌｉｅｓ）、キイロショウジョウバエ（Ｄｒｏｓｏｐｈｉａ　ｍｅｌａｎｏｇａｓｔｅｒ）等のショウジョウバエ類（Ｆｒｕｉｔ−ｆｌｉｅｓ）、クロバエ類（Ｂｌｏｗ　ｆｌｉｅｓ）、ニクバエ類（Ｆｌｅｓｈ　ｆｌｉｅｓ）等が挙げられる。
【００１９】
本毒餌剤の施用方法としては、本毒餌剤が紛状、顆粒状、塊状、錠剤形状等の固形物の場合は、本毒餌剤を畜舎、家屋内の床やゴミ処理場周辺等のハエ類が集まり易い場所、即ちハエ類が発生または飛来する場所あるいはその周辺に、本毒餌剤を撒いたり、あるいは開放容器に入れた後に設置する方法等を挙げることができる。
【００２０】
その場合の施用量は本化合物に換算して１ｍ^２当たり、通常０．１〜１００ｍｇである。
【００２１】
本毒餌剤が液状の場合は、本化合物に換算して１ｍ^２当たり、通常０．１〜１００ｍｇとなる量の本毒餌剤を、畜舎、家屋内、ゴミ処理場周辺等のハエ類が発生または飛来する場所の床、壁、柱、ケージ枠等に塗布したり、本毒餌剤が充填された開放容器をこれらの場所またはその周辺に設置するする方法等を挙げることができる。
【００２２】
また、本毒餌剤がゲル状、または半練り状の場合は、本化合物に換算して１ｍ^２当たり、通常０．１〜１００ｍｇとなる量の本毒餌剤を、開放容器に入れた後に、畜舎、家屋内、ゴミ処理場周辺等のハエ類の発生または飛来する場所あるいはその周辺に設置する方法の他に、注射筒に充填された本毒餌剤をベイトガンを用いてかかる場所の壁や床等に付着させる方法等を挙げることができる。
【００２３】
【実施例】
製剤例１
（１）　トルネードフロアブル（クミアイ化学株式会社の商品名、インドキサカルブ１０重量％含有のフロアブル製剤）２５０ｍｌをエバポレーターで減圧濃縮した。残渣をアセトン２００ｍｌで３回洗浄後、グラスフィルターで濾過した。濾液をエバポレーターで減圧濃縮し、得られた濃縮物を、シリカゲルカラムクロマトグラフィー（ヘキサン：酢酸エチル＝１０：１容量比）で精製し、インドキサカルブ原体１８．０ｇを得た。
【００２４】
（２）　（１）で得たインドキサカルブ０．５重量部、グラニュー糖５０重量部およびデキストリン４９．５重量部を混合し、これに適量の水を加えて混練し、押し出し成型、乾燥して顆粒状の毒餌剤を得る。
【００２５】
製剤例２
製剤例１（１）で得られたインドキサカルブ０．１重量部、ジエチレングリコールモノエチルエーテル２０重量部、グラニュー糖５重量部及び蒸留水７４．９重量部を混合し、液状の毒餌剤を得る。
【００２６】
試験例１
（１）　製剤例１（１）で得られたインドキサカルブをアセトンに溶解させた薬液の所定量を、脱脂粉乳およびグラニュー糖（重量比２：１）からなる混合物２ｇに混合後、風乾させ、インドキサカルブを表１に示す濃度含有する毒餌剤を得た。
【００２７】
（２）　ナイロンネットケージ（２２×２２×２２ｃｍ）内に、無処理の餌（脱脂粉乳およびグラニュー糖の混合物、重量比２：１）２ｇを入れたアルミ皿（直径３．８ｃｍ）および水を入れたプラスチック製カップを配置し、この中に、イエバエ成虫２０頭（雄１０頭、雌１０頭）を放った。続いて、このケージ内に（１）で得た毒餌剤２ｇを入れたアルミ皿（直径３．８ｃｍ）を置いた。設置１日後にイエバエ致死数を観察し、致死率を求めた。各３反復実施した。結果を表１に示す。
【００２８】
比較として、有効成分がｄ−フェノトリンである以外は（１）と同様に処理して得られる毒餌剤、または１０％アザメチフォス粉剤（日本チバガイギー製、商品名：アルファクロンプラス）の所定量を同様に処理して得られる毒餌剤について、同様の試験を各３反復実施した。結果を表１に示す。
【００２９】
【表１】

【００３０】
参考試験例１
（１）　１０重量％インドキサカルブ　フロアブル剤（クミアイ化学社製、商品名：トルネードフロアブル）を水にて２００倍に希釈し、インドキサカルブ０．０５重量％を含有する薬液を調製した。
【００３１】
（２）　ガラス箱（７０×７０×７０ｃｍ）内にイエバエ成虫２０頭（雄１０頭、雌１０頭）を放ち、この中に上述の薬液２．１ｍｌをスプレーガンにて噴霧した。１０分間曝露させた後、全イエバエを清潔なプラスチック容器に回収し、餌と水を与え、１日後に致死数を観察し、致死率を求めた。各３反復実施した。結果を表２に示す。
【００３２】
また、５重量％ｄ−フェノトリン乳剤（組成：ｄ−フェノトリン：キシレン：ソルポールＳＭ２００（東邦化学製乳化剤）＝５：８５：１０重量％）を水にて１００倍に希釈し、ｄ−フェノトリン０．０５重量％を含有する薬液を調製し、（２）と同様の試験を実施した。各３反復実施した。結果を表２に示す。
【００３３】
【表２】

【００３４】
【発明の効果】
本発明のハエ類防除用毒餌剤は、ハエ類の防除において卓効を示す。[0001]
TECHNICAL FIELD OF THE INVENTION
The present invention relates to a poison bait for controlling flies and a method for controlling flies.
[0002]
Problems to be solved by the prior art and the invention
Conventionally, as an agent for controlling flies in places where flies fly or emerge, such as livestock houses, garbage disposal plants, restaurants, and homes, oil agents containing an organophosphorus insecticide compound or a pyrethroid insecticide compound as an active ingredient Emulsions and the like are known, and these are usually applied by direct spraying or spatial spraying on flies. However, this processing method has the disadvantage that the processing labor is enormous.
[0003]
On the other hand, recently, a poison bait containing an organophosphorus compound such as azamethifos has been marketed as a bait for controlling flies which is easy to treat, but the controlling effect of such poison bait is not always satisfactory. Was.
[0004]
An object of the present invention is to provide a poison bait for controlling flies having a high controlling effect.
[0005]
[Non-patent document 1]
"Applications of larvicides and toxicant bates to control the bleeding of houseflies in closed pourage sugesges" by Bajomi, Daniel et al. Pest Control (1990), 32 (2) 44-49
[0006]
[Means for Solving the Problems]
Under such circumstances, the present inventors have repeatedly studied the development of a new bait for controlling flies. As a result, the bait containing a specific insecticidal active ingredient as an active ingredient has a specific high control effect on flies. Have been found, and the present invention has been achieved.
[0007]
That is, the present invention relates to the formula (1)

Applying a poison bait for controlling flies (hereinafter referred to as a present poison bait) and a poison bait comprising the oxadiazine compound represented by the formula (hereinafter referred to as the present compound) and an inducing substance. And a method for controlling flies.
[0008]
BEST MODE FOR CARRYING OUT THE INVENTION
This compound is a compound known by the generic name indoxacarb. This compound includes (S) -methyl 7-chloro-2,5-dihydro-2-[[(methoxycarbonyl) [4- (trifluoromethoxy) phenyl] amino] carbonyl] indeno [1,2-e] [1,3,4] oxadiazine-4a (3H) -carboxylate and (R) -methyl 7-chloro-2,5-dihydro-2-[[(methoxycarbonyl) [4- (trifluoromethoxy) phenyl] There are two isomers of [amino] carbonyl] indeno [1,2-e] [1,3,4] oxadiazine-4a (3H) -carboxylate. In the present invention, the present compound may be an isomer alone or a mixture of the isomers in any ratio.
[0009]
The present poison bait usually exerts a control effect on flies when the poison bait is consumed by the flies.
[0010]
The content of the present compound in the present poison bait is usually 0.0005 to 20% by weight.
[0011]
The present poison bait contains an ingestion inducer in addition to the present compound. The feeding inducing substance is a substance for inducing and continuing the localization, colonization, feeding behavior, and the like of flies. Examples of the food-inducing substance include sugars such as sucrose, glucose, granulated sugar, fructose, lactose, maltose, brown sugar, brown sugar, warm sugar, dextrin, arabinose, galactose, sorbitol, molasses, and honey; corn, potato , Starch derived from sweet potato, etc .; cereal flour such as flour, rice flour, corn flour, potato flour; dairy products such as skim milk, skim milk, cheese; animal powder such as cow, pig, seafood, shrimp, crab, insects And insect powders; attractants such as trichosene and acetal; and the feed inducer can be used alone or in combination of two or more (mixed or combined).
[0012]
The content of the feed-inducing substance in the present poison bait is usually 1 to 99.9% by weight.
[0013]
In addition, in this poison bait, if necessary, an antioxidant such as erythorbin powder and propyl gallate; a preservative such as benzoic acid, sorbic acid, and sodium dehydroacetate; a wrong feeding inhibitor such as pepper powder and denatonium benzoate; An extender such as white carbon and bentonite; a flavor such as a cheese flavor, a butter flavor, a peanut flavor, a strawberry flavor, a milk flavor, and an onion flavor; and a colorant such as yellow No. 4 and red No. 2 may be contained. Its content is usually 0.001 to 5% by weight.
[0014]
The present poison bait may optionally contain other insecticidally active ingredients as active ingredients in addition to the present compound. Examples of such insecticidal active ingredients include azamethifos, boric acid, N-phenylpyrazole compounds, and neonicotinoid compounds such as imidacloprid.
[0015]
The present poison bait can take various forms such as powder, granule, block, tablet, liquid, semi-milled, and gel.
[0016]
When the present poison bait is in powder form, it can be obtained by mixing the present compound, an ingestion inducer and other components as necessary, water, acetone and other solvents, and drying as necessary. The powdery poisonous bait can be made into a granular or massive poisonous bait by further adding water to the poisonous bait, and then formed into a tablet by adding water to the powdery poisonous bait and tableting. Of the present poison bait. Further, by diluting and dispersing the present compound, an ingestion-inducing substance and, if necessary, other components with water, alcohol, or the like, a liquid or semi-milled poisonous bait can be obtained. In addition, the present gelled poison bait is further mixed with a gelling agent such as carrageenan, pectin, agar, gelatin, gelatin gum, sodium alginate, guar gum, gellan gum, and locust bean gum. It can be obtained by mixing.
[0017]
In using the present compound in the present poison bait, the present compound may be used as it is, or a preparation containing the present compound, such as a powder, a wettable powder, an emulsion, and an oil, may be used.
[0018]
The flies which can be effectively controlled by the present poison bait include, for example, a house fly ( Musca domestica ), a house fly ( Musca corvina ), a house fly ( Muscina stabulans ), and a house fly ( Fannia es franc esca ulica ). Fleas ( Scuttle flies ) such as flea fly (Megaselia spiracularis), Spiny-flies (Spiny-legged flies), Drosophila melanogaster ( Drosophila frogs, etc., Drosophila melanogaster ) Fresh flies).
[0019]
As a method of applying the present poison bait, when the present poison bait is a solid such as powder, granule, block, tablet, etc., the poison bait is applied to flies in a livestock barn, a house floor, or around a garbage disposal plant. A method of dispersing the present poison bait in a place where flies are generated or fly, that is, a place where flies are generated or fly, or a surrounding area, or placing the poison bait in an open container, and the like can be mentioned.
[0020]
1 m ² per in terms of application rates the compound in that case is usually 0.1-100 mg.
[0021]
If the poison bait is liquid, 1 m ² per in terms of the compound, the amount of the poison bait comprising a normally 0.1-100 mg, barn, a house, flies such as landfills around occurs or Examples of the method include application to floors, walls, pillars, cage frames, and the like at the place where the birds fly, and a method of installing an open container filled with the present poison bait at or around these places.
[0022]
When the poison bait is in the form of a gel or semi-pulverized, the amount of the poison bait, which is usually 0.1 to 100 mg / m ² in terms of the present compound, is put in an open container, and then the animal In addition to the method of installation at or near the place where flies occur or fly, such as inside a house, around a garbage disposal site, etc., the wall or floor of the place where this poison bait filled in a syringe is applied using a bait gun And the like.
[0023]
【Example】
Formulation Example 1
(1) 250 ml of Tornado Flowable (trade name of Kumiai Chemical Co., Ltd., a flowable preparation containing 10% by weight of indoxacarb) was concentrated under reduced pressure using an evaporator. The residue was washed three times with 200 ml of acetone, and then filtered with a glass filter. The filtrate was concentrated under reduced pressure using an evaporator, and the obtained concentrate was purified by silica gel column chromatography (hexane: ethyl acetate = 10: 1 by volume) to obtain 18.0 g of a raw material of indoxacarb.
[0024]
(2) 0.5 part by weight of indoxacarb obtained in (1), 50 parts by weight of granulated sugar and 49.5 parts by weight of dextrin are mixed, an appropriate amount of water is added thereto, kneaded, extruded, and dried. To obtain a granular poison bait.
[0025]
Formulation Example 2
0.1 part by weight of indoxacarb obtained in Formulation Example 1 (1), 20 parts by weight of diethylene glycol monoethyl ether, 5 parts by weight of granulated sugar and 74.9 parts by weight of distilled water are mixed to obtain a liquid poison bait. .
[0026]
Test example 1
(1) A predetermined amount of a drug solution obtained by dissolving indoxacarb obtained in Formulation Example 1 (1) in acetone is mixed with 2 g of a mixture consisting of skim milk powder and granulated sugar (2: 1 by weight) and air-dried. And a poison bait containing indoxacarb at the concentrations shown in Table 1.
[0027]
(2) In a nylon net cage (22 × 22 × 22 cm), an aluminum dish (diameter 3.8 cm) containing 2 g of untreated food (mixture of skim milk powder and granulated sugar, weight ratio 2: 1) and water were placed. A plastic cup was placed therein, into which 20 housefly adults (10 males and 10 females) were released. Subsequently, an aluminum dish (3.8 cm in diameter) containing 2 g of the poison bait obtained in (1) was placed in the cage. One day after the installation, the number of house fly mortality was observed, and the mortality was determined. Each triplicate was performed. Table 1 shows the results.
[0028]
For comparison, a predetermined amount of a poison bait obtained by treating in the same manner as in (1) except that the active ingredient is d-phenothrin or a 10% azamethifos powder (manufactured by Nippon Ciba Geigy, trade name: Alphacron Plus) was similarly used. The same test was performed three times for each of the poison baits obtained by the treatment. Table 1 shows the results.
[0029]
[Table 1]

[0030]
Reference test example 1
(1) A 10% by weight indoxacarb flowable agent (trade name: Tornado Flowable, manufactured by Kumiai Chemical Co., Ltd.) was diluted 200 times with water to prepare a drug solution containing 0.05% by weight of indoxacarb.
[0031]
(2) Twenty adult houseflies (10 males and 10 females) were released into a glass box (70 × 70 × 70 cm), and 2.1 ml of the above-mentioned drug solution was sprayed into the mice with a spray gun. After 10 minutes of exposure, all house flies were collected in clean plastic containers and fed food and water, and one day later, mortality was observed to determine mortality. Each triplicate was performed. Table 2 shows the results.
[0032]
In addition, a 5% by weight d-phenothrin emulsion (composition: d-phenothrin: xylene: sorbol SM200 (Emulsifier manufactured by Toho Chemical Co., Ltd.) = 5: 85: 10% by weight) was diluted 100-fold with water, and d-phenothrin 0.1% was diluted with water. A drug solution containing 05% by weight was prepared, and the same test as in (2) was performed. Each triplicate was performed. Table 2 shows the results.
[0033]
[Table 2]

[0034]
【The invention's effect】
The poison bait for controlling flies of the present invention exhibits excellent effect in controlling flies.

Claims (3)

Equation (1)

A poison bait for controlling flies, which comprises an oxadiazine compound represented by the formula (1) and a feed-inducing substance. The poison bait according to claim 1, wherein the feed-inducing substance is at least one selected from saccharides, starch, cereal flour, dairy products, animal flour, insect flour, trichocene and acetal. A method for controlling flies, comprising treating the poison bait according to claim 1 or 2 at or near a place where flies are generated or fly.