IL72448A0 - Pyrimidone derivatives,process for their preparation,compositions containing them and their use as histamine h1-antagonists - Google Patents

Pyrimidone derivatives,process for their preparation,compositions containing them and their use as histamine h1-antagonists

Info

Publication number
IL72448A0
IL72448A0 IL72448A IL7244884A IL72448A0 IL 72448 A0 IL72448 A0 IL 72448A0 IL 72448 A IL72448 A IL 72448A IL 7244884 A IL7244884 A IL 7244884A IL 72448 A0 IL72448 A0 IL 72448A0
Authority
IL
Israel
Prior art keywords
pyridyl
oxo
methyl
histamine
antagonists
Prior art date
Application number
IL72448A
Other languages
English (en)
Original Assignee
Smith Kline French Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smith Kline French Lab filed Critical Smith Kline French Lab
Publication of IL72448A0 publication Critical patent/IL72448A0/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62Oxygen or sulfur atoms
    • C07D213/63One oxygen atom
    • C07D213/64One oxygen atom attached in position 2 or 6
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/08Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing alicyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61Halogen atoms or nitro radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72Nitrogen atoms
    • C07D213/73Unsubstituted amino or imino radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Impact Printers (AREA)
  • Luminescent Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)
  • Treating Waste Gases (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Steroid Compounds (AREA)
IL72448A 1983-07-23 1984-07-19 Pyrimidone derivatives,process for their preparation,compositions containing them and their use as histamine h1-antagonists IL72448A0 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB838319874A GB8319874D0 (en) 1983-07-23 1983-07-23 Compounds

Publications (1)

Publication Number Publication Date
IL72448A0 true IL72448A0 (en) 1984-11-30

Family

ID=10546171

Family Applications (1)

Application Number Title Priority Date Filing Date
IL72448A IL72448A0 (en) 1983-07-23 1984-07-19 Pyrimidone derivatives,process for their preparation,compositions containing them and their use as histamine h1-antagonists

Country Status (23)

Country Link
US (1) US4665078A (de)
EP (1) EP0134091B1 (de)
JP (1) JPS6048986A (de)
KR (1) KR850001194A (de)
AT (1) ATE27818T1 (de)
AU (1) AU3080984A (de)
CS (1) CS244446B2 (de)
DD (1) DD216463A5 (de)
DE (1) DE3464249D1 (de)
DK (1) DK359184A (de)
ES (1) ES8602761A1 (de)
FI (1) FI842907A (de)
GB (1) GB8319874D0 (de)
GR (1) GR79961B (de)
HU (1) HUT34745A (de)
IL (1) IL72448A0 (de)
JO (1) JO1326B1 (de)
NO (1) NO842963L (de)
NZ (1) NZ208956A (de)
PL (1) PL248859A1 (de)
PT (1) PT78961A (de)
RO (1) RO89219A (de)
ZA (1) ZA845622B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT78358B (en) * 1983-04-07 1986-05-30 Smith Kline French Lab Chemical process
US7045519B2 (en) * 1998-06-19 2006-05-16 Chiron Corporation Inhibitors of glycogen synthase kinase 3
EP1087963B1 (de) 1998-06-19 2004-08-25 Chiron Corporation Glycogen synthase kinase 3 inhibitoren
US10596401B2 (en) 2016-08-11 2020-03-24 Victaulic Company Modular valve assembly
US20180193681A1 (en) 2017-01-06 2018-07-12 Globe Fire Sprinkler Corporation Control valve assembly with test, drain and adjustable pressure relief valve
EP3775636B1 (de) 2018-03-29 2024-09-04 Victaulic Company Kombinierte steuer- und rückschlagventilanordnung für ein nassleitungssystem
CA3151291A1 (en) 2019-09-20 2021-03-25 Yoram Ringer Ball valve assembly

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4154834A (en) * 1975-12-29 1979-05-15 Smith Kline & French Laboratories Limited Substituted isocytosines having histamine H2 -antagonist activity
IN151188B (de) * 1978-02-13 1983-03-05 Smith Kline French Lab
ZW21281A1 (en) * 1980-10-01 1981-11-18 Smith Kline French Lab Amine derivatives
PT75074B (en) * 1981-06-27 1986-02-26 Smith Kline French Lab Process for preparing certain pyrimidone derivatives and compositions containing them

Also Published As

Publication number Publication date
GR79961B (de) 1984-10-31
DK359184A (da) 1985-01-24
GB8319874D0 (en) 1983-08-24
DD216463A5 (de) 1984-12-12
JO1326B1 (en) 1986-11-30
CS244446B2 (en) 1986-07-17
ZA845622B (en) 1985-07-31
PL248859A1 (en) 1985-07-16
HUT34745A (en) 1985-04-28
PT78961A (en) 1984-08-01
EP0134091A1 (de) 1985-03-13
DE3464249D1 (de) 1987-07-23
FI842907A0 (fi) 1984-07-19
ES534452A0 (es) 1985-12-01
ATE27818T1 (de) 1987-07-15
NZ208956A (en) 1987-03-06
US4665078A (en) 1987-05-12
ES8602761A1 (es) 1985-12-01
NO842963L (no) 1985-01-24
JPS6048986A (ja) 1985-03-16
CS557184A2 (en) 1985-08-15
KR850001194A (ko) 1985-03-16
FI842907A (fi) 1985-01-24
DK359184D0 (da) 1984-07-20
AU3080984A (en) 1985-01-24
RO89219A (ro) 1986-03-15
EP0134091B1 (de) 1987-06-16

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