HUP0302792A2 - Dipeptidil peptidáz ciklopropil-kondenzált pirrolidin-bázisú inhibitorai és eljárás előállításukra és a vegyületeket tartalmazó gyógyszerkészítmények - Google Patents

Dipeptidil peptidáz ciklopropil-kondenzált pirrolidin-bázisú inhibitorai és eljárás előállításukra és a vegyületeket tartalmazó gyógyszerkészítmények

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Publication number
HUP0302792A2
HUP0302792A2 HU0302792A HUP0302792A HUP0302792A2 HU P0302792 A2 HUP0302792 A2 HU P0302792A2 HU 0302792 A HU0302792 A HU 0302792A HU P0302792 A HUP0302792 A HU P0302792A HU P0302792 A2 HUP0302792 A2 HU P0302792A2
Authority
HU
Hungary
Prior art keywords
dipeptidyl peptidase
compounds
onhibitors
cyclopropyl
preparation
Prior art date
Application number
HU0302792A
Other languages
English (en)
Inventor
David J. Augeri
David A. Betebenner
Lawrence G. Hamann
David R. Magnin
Jeffrey A. Robl
Richard B. Sulsky
Original Assignee
Bristol-Myers Squibb Co.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22693638&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HUP0302792(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bristol-Myers Squibb Co. filed Critical Bristol-Myers Squibb Co.
Publication of HUP0302792A2 publication Critical patent/HUP0302792A2/hu
Publication of HUP0302792A3 publication Critical patent/HUP0302792A3/hu
Publication of HU228110B1 publication Critical patent/HU228110B1/hu
Priority to HUS1200030C priority Critical patent/HUS1200030I1/hu
Priority to HUS1200031C priority patent/HUS1200031I1/hu

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    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
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    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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Abstract

A találmány tárgyát az általános képletű - ahol x 0 vagy 1; és y 0vagy 1 (azzal a fenntartással, hogy x = 1, amikor y = 0, és x = 0,amikor y =1); n 0 vagy 1; X hidrogénatom vagy cianocsoport; és R1, R2,R3 és R4 azonos vagy különböző, a hidrogénatom és adott esetbenszubsztituált alkil-, cikloalkil-, aril-, heteroaril- vagy egyébösszetett szerves csoport - dipeptidil peptidáz IV (DP4) gátlóvegyületek, alkalmazásuk és ezeket önmagukban vagy kombinációbantartalmazó gyógyszerkészítmények képezik. Ó
HU0302792A 2000-03-10 2001-03-05 Cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase iv and method for their preparation and pharmaceutical compositions containing the compounds HU228110B1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
HUS1200030C HUS1200030I1 (hu) 2000-03-10 2012-12-14 Dipeptidil peptidáz IV ciklopropil-kondenzált pirrolidin-bázisú inhibitorai és eljárás elõállításukra és a vegyületeket tartalmazó gyógyszerkészítmények
HUS1200031C HUS1200031I1 (hu) 2000-03-10 2012-12-14 Dipeptidil peptidáz IV ciklopropil-kondenzált pirrolidin-bázisú inhibitorai és eljárás elõállításukra és a vegyületeket tartalmazó gyógyszerkészítmények

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18855500P 2000-03-10 2000-03-10
PCT/US2001/007151 WO2001068603A2 (en) 2000-03-10 2001-03-05 Cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl iv, processes for their preparation, and their use

Publications (3)

Publication Number Publication Date
HUP0302792A2 true HUP0302792A2 (hu) 2003-12-29
HUP0302792A3 HUP0302792A3 (en) 2007-03-28
HU228110B1 HU228110B1 (en) 2012-11-28

Family

ID=22693638

Family Applications (5)

Application Number Title Priority Date Filing Date
HU1200545A HU230347B1 (hu) 2000-03-10 2001-03-05 Dipeptidil peptidáz IV ciklopropil-kondenzált pirrolidin-bázisú inhibitorai, eljárás az előállításukra és alkalmazásuk
HU0302792A HU228110B1 (en) 2000-03-10 2001-03-05 Cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase iv and method for their preparation and pharmaceutical compositions containing the compounds
HU1200546A HU230380B1 (hu) 2000-03-10 2001-03-05 N-Védett amino-hidroxi-adamantán-karbonsav és eljárás az előálllítására
HUS1200030C HUS1200030I1 (hu) 2000-03-10 2012-12-14 Dipeptidil peptidáz IV ciklopropil-kondenzált pirrolidin-bázisú inhibitorai és eljárás elõállításukra és a vegyületeket tartalmazó gyógyszerkészítmények
HUS1200031C HUS1200031I1 (hu) 2000-03-10 2012-12-14 Dipeptidil peptidáz IV ciklopropil-kondenzált pirrolidin-bázisú inhibitorai és eljárás elõállításukra és a vegyületeket tartalmazó gyógyszerkészítmények

Family Applications Before (1)

Application Number Title Priority Date Filing Date
HU1200545A HU230347B1 (hu) 2000-03-10 2001-03-05 Dipeptidil peptidáz IV ciklopropil-kondenzált pirrolidin-bázisú inhibitorai, eljárás az előállításukra és alkalmazásuk

Family Applications After (3)

Application Number Title Priority Date Filing Date
HU1200546A HU230380B1 (hu) 2000-03-10 2001-03-05 N-Védett amino-hidroxi-adamantán-karbonsav és eljárás az előálllítására
HUS1200030C HUS1200030I1 (hu) 2000-03-10 2012-12-14 Dipeptidil peptidáz IV ciklopropil-kondenzált pirrolidin-bázisú inhibitorai és eljárás elõállításukra és a vegyületeket tartalmazó gyógyszerkészítmények
HUS1200031C HUS1200031I1 (hu) 2000-03-10 2012-12-14 Dipeptidil peptidáz IV ciklopropil-kondenzált pirrolidin-bázisú inhibitorai és eljárás elõállításukra és a vegyületeket tartalmazó gyógyszerkészítmények

Country Status (37)

Country Link
US (2) US6395767B2 (hu)
EP (4) EP1559710B1 (hu)
JP (5) JP4460205B2 (hu)
KR (2) KR100758407B1 (hu)
CN (2) CN1213028C (hu)
AR (1) AR027634A1 (hu)
AT (1) ATE396176T1 (hu)
AU (2) AU2001245466B2 (hu)
BE (2) BE2010C008I2 (hu)
BR (1) BRPI0109115B8 (hu)
CA (1) CA2402894C (hu)
CO (1) CO5280198A1 (hu)
CY (3) CY1108273T1 (hu)
CZ (3) CZ304355B6 (hu)
DE (3) DE122010000008I1 (hu)
DK (1) DK1261586T3 (hu)
EG (1) EG25854A (hu)
ES (4) ES2768961T3 (hu)
FR (1) FR10C0010I2 (hu)
HK (2) HK1049330B (hu)
HU (5) HU230347B1 (hu)
IL (4) IL151372A0 (hu)
LU (2) LU91650I2 (hu)
MX (1) MXPA02008837A (hu)
MY (1) MY124512A (hu)
NL (1) NL300436I1 (hu)
NO (3) NO324227B1 (hu)
NZ (1) NZ520821A (hu)
PE (1) PE20020771A1 (hu)
PL (1) PL207041B1 (hu)
PT (1) PT1261586E (hu)
RU (1) RU2286986C2 (hu)
SG (1) SG152030A1 (hu)
TW (2) TWI258468B (hu)
UY (2) UY26613A1 (hu)
WO (1) WO2001068603A2 (hu)
ZA (1) ZA200206816B (hu)

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