HRP20030381B1 - 3-DECLADINOZYL 9a-N-CARBAMOYL AND 9a-N-THIOCARBAMOYL DERIVATIVES 9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERYTHROMICYNE A - Google Patents

3-DECLADINOZYL 9a-N-CARBAMOYL AND 9a-N-THIOCARBAMOYL DERIVATIVES 9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERYTHROMICYNE A

Info

Publication number: HRP20030381B1
Authority: HR; Croatia
Prior art keywords: meaning; individual; group; hydrogen; aza
Prior art date: 2003-05-14

Application number

HR20030381A

Other languages

English (en)

Croatian (hr)

Inventor

Maru�i�-I�tuk Zorica

Kujund�i� Nedjeljko

Mutak Stjepan

Original Assignee

GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-05-14

Filing date

2003-05-14

Publication date

2007-05-31

2003-05-14 Application filed by GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. filed Critical GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o.

2003-05-14 Priority to HR20030381A priority Critical patent/HRP20030381B1/xx

2004-05-11 Priority to SI200430155T priority patent/SI1631575T1/sl

2004-05-11 Priority to PL04732143T priority patent/PL1631575T3/pl

2004-05-11 Priority to DK04732143T priority patent/DK1631575T3/da

2004-05-11 Priority to EP04732143A priority patent/EP1631575B1/en

2004-05-11 Priority to AT04732143T priority patent/ATE344270T1/de

2004-05-11 Priority to JP2006530610A priority patent/JP2007501268A/ja

2004-05-11 Priority to CNB2004800130438A priority patent/CN100345860C/zh

2004-05-11 Priority to PCT/HR2004/000014 priority patent/WO2004101591A1/en

2004-05-11 Priority to ES04732143T priority patent/ES2274453T3/es

2004-05-11 Priority to PT04732143T priority patent/PT1631575E/pt

2004-05-11 Priority to US10/557,025 priority patent/US20070066544A1/en

2004-05-11 Priority to YUP-2005/0837A priority patent/RS20050837A/sr

2004-05-11 Priority to DE602004003054T priority patent/DE602004003054T2/de

2004-05-11 Priority to CA002525143A priority patent/CA2525143A1/en

2004-05-13 Priority to CL200401026A priority patent/CL2004001026A1/es

2004-05-14 Priority to ARP040101631A priority patent/AR044320A1/es

2005-02-28 Publication of HRP20030381A2 publication Critical patent/HRP20030381A2/hr

2005-10-31 Priority to IS8109A priority patent/IS8109A/is

2006-11-17 Priority to HK06112660A priority patent/HK1092156A1/xx

2007-01-10 Priority to CY20071100033T priority patent/CY1107321T1/el

2007-05-31 Publication of HRP20030381B1 publication Critical patent/HRP20030381B1/xx

Links

229910052739 hydrogen Inorganic materials 0.000 abstract 4
239000001257 hydrogen Substances 0.000 abstract 4
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
125000001033 ether group Chemical group 0.000 abstract 2
229910052736 halogen Inorganic materials 0.000 abstract 2
150000002367 halogens Chemical class 0.000 abstract 2
150000002576 ketones Chemical class 0.000 abstract 2
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
125000006656 (C2-C4) alkenyl group Chemical group 0.000 abstract 1
JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical compound O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
MDFFNEOEWAXZRQ-UHFFFAOYSA-N aminyl Chemical compound [NH2] MDFFNEOEWAXZRQ-UHFFFAOYSA-N 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
125000001188 haloalkyl group Chemical group 0.000 abstract 1
150000004677 hydrates Chemical class 0.000 abstract 1
150000002431 hydrogen Chemical class 0.000 abstract 1
150000007522 mineralic acids Chemical class 0.000 abstract 1
125000002950 monocyclic group Chemical group 0.000 abstract 1
150000007524 organic acids Chemical class 0.000 abstract 1
235000005985 organic acids Nutrition 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
125000006239 protecting group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1
239000011593 sulfur Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Oncology (AREA)
Animal Behavior & Ethology (AREA)
Communicable Diseases (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Cosmetics (AREA)
Thermal Transfer Or Thermal Recording In General (AREA)

HR20030381A 2003-05-14 2003-05-14 3-DECLADINOZYL 9a-N-CARBAMOYL AND 9a-N-THIOCARBAMOYL DERIVATIVES 9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERYTHROMICYNE A HRP20030381B1 (en)

Priority Applications (20)

Application Number	Priority Date	Filing Date	Title
HR20030381A HRP20030381B1 (en)	2003-05-14	2003-05-14	3-DECLADINOZYL 9a-N-CARBAMOYL AND 9a-N-THIOCARBAMOYL DERIVATIVES 9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERYTHROMICYNE A
ES04732143T ES2274453T3 (es)	2003-05-14	2004-05-11	Nuevos derivados 3-decladinosil 9a-n-carbamoilicos y 9a-n-tiocarbamoilicos de 9-desoxo-9-dihidro-9a-aza-9a-homoeritromicina a.
YUP-2005/0837A RS20050837A (en)	2003-05-14	2004-05-11	NEW 3-DECLADINOSYL 9a-N-CARBAMOYL AND 9a-N-THIOCARBAMOYL DERIVATIVES OF 9-DEOX-9-DIHYDRO-9a-AZA-9A- HOMOERYTHROMYCIN A NEW 3- DECLADINOSYL 9A-N-CARBAMOYL AND -A- N-THIOCARBAMOYL DERIVATIVES OF 9- DEOX-9-DIHYDRO-9A-AZA-9A- HOMOERYTHROMYCIN A
DK04732143T DK1631575T3 (da)	2003-05-14	2004-05-11	Nye 3-decladinosyl-9a-N-carbamoyl- og 9a-N-thiocarbamoylderivater af 9-deox-9-dihydro-9a-AZA-9A-homoerythromycin A
EP04732143A EP1631575B1 (en)	2003-05-14	2004-05-11	NEW 3-DECLADINOSYL 9a-N -CARBAMOYL AND 9a-N -THIOCARBAMOYL DERIVATIVES OF 9-DEOX-9-DIHYDRO-9a-AZA-9A-HOMOERYTHROMYCIN A
AT04732143T ATE344270T1 (de)	2003-05-14	2004-05-11	Neue 3-decladinosyl-9a-n-carbamoyl- und 9a-n- thiocarbamoylderivate von 9-deoxo-9-dihydro-9a- aza-9a-homoerythromycin a
JP2006530610A JP2007501268A (ja)	2003-05-14	2004-05-11	新規な９−デオキソ−９−ジヒドロ−９ａ−アザ−９ａ−ホモエリスロマイシンＡの３−デクラジノシル９ａ−Ｎ−カルバモイル及び９ａ−Ｎ−チオカルバモイル誘導体
CNB2004800130438A CN100345860C (zh)	2003-05-14	2004-05-11	新的9－脱氧－9－二氢－9A－氮杂－9A－高红霉素A的3－去红霉糖基9a－N－氨基甲酰基和9a－N－硫代氨基甲酰基衍生物
PCT/HR2004/000014 WO2004101591A1 (en)	2003-05-14	2004-05-11	NEW 3-DECLADINOSYL 9a-N-CARBAMOYL AND 9a-N-THIOCARBAMOYL DERIVATIVES OF 9-DEOX-9-DIHYDRO-9a-AZA-9A-HOMOERYTHROMYCIN A
SI200430155T SI1631575T1 (sl)	2003-05-14	2004-05-11	NOVI 3-DEKLADINOZIL 9a-N-KARBAMOILNI IN 9a-N-TIOKARBAMOILNI DERIVATI 9-DEOKS-9-DIHIDRO-9a-AZA-9a-HOMOERITROMICINA A
PT04732143T PT1631575E (pt)	2003-05-14	2004-05-11	NOVOS DERIVADOS 3- DECLADINOSIL 9ª-N-CARBAMOIL E 9ª-N- TIOCARBAMOIL DE 9-DESOXI-9-DI-HIDRO-9ª-AZA-9ª-HOMOERITROMICINA
US10/557,025 US20070066544A1 (en)	2003-05-14	2004-05-11	3-Decladinosyl 9a-n-carbamoyl and 9a-n-thiocarbamoyl derivatives of 9-deoxo-9-dihydro-9a-aza-9a-homoerythromycin a
PL04732143T PL1631575T3 (pl)	2003-05-14	2004-05-11	Nowe 3-dekladinozylo-9a-N-karbamoilowe i 9a-N-tiokarbamoilowe pochodne 9-deokso-9-dihydro-9a-aza-9a homoerytromycyny A
DE602004003054T DE602004003054T2 (de)	2003-05-14	2004-05-11	Neue 3-decladinosyl-9a-n-carbamoyl- und 9a-n-thiocarbamoylderivate von 9-deoxo-9-dihydro-9a-aza-9a-homoerythromycin a
CA002525143A CA2525143A1 (en)	2003-05-14	2004-05-11	New 3-decladinosyl 9a-n-carbamoyl and 9a-n-thiocarbamoyl derivatives of 9-deoxo-9-dihydro-9a-aza-9a-homoerythromycin a
CL200401026A CL2004001026A1 (es)	2003-05-14	2004-05-13	COMPUESTOS DERIVADOS DE 3-DECLADINOSILO DE 9a-N-CARBAMOIL Y 9a-N-TIOCARBAMOIL-9-DEOXO-9-DIHIDRO-9a-AZA-9a-HOMOERITROMICINA A; Y PROCEDIMIENTO DE PREPARACION, UTILES COMO AGENTES ANTIBACTERIANOS.
ARP040101631A AR044320A1 (es)	2003-05-14	2004-05-14	Derivados 3-decladinosilo de la clase de 9a - n-carbamoil - y 9a-ntiocarbamoil- 9 dihidro-9a aza- 9a - homoeritromicina a
IS8109A IS8109A (is)	2003-05-14	2005-10-31	Nýjar 3-dekladínósýl 9a-N-karbamóýl og 9a-N-þíókarbamóýl afleiður af 9-deoxó-9-díhýdró-9a-asa-9a-hómóerýþrómýsíni A
HK06112660A HK1092156A1 (en)	2003-05-14	2006-11-17	New 3-decladinosyl 9A-N-carbamoyl and 9A-N-thiocarbamoyl derivatives of 9-deox-9-di-hydro-9A-aza-9A homoerythromycin a
CY20071100033T CY1107321T1 (el)	2003-05-14	2007-01-10	Νεα 3-δεκλαδινοσυλ-9α-ν-καρβaμοϋλικα και 9α-ν-θειοκαρβαμοϋλικα παραγωγα της 9-δεσοξο-9-διυδρο-9α-αζα-9α-ομοepυθρομυκινης

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
HR20030381A HRP20030381B1 (en)	2003-05-14	2003-05-14	3-DECLADINOZYL 9a-N-CARBAMOYL AND 9a-N-THIOCARBAMOYL DERIVATIVES 9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERYTHROMICYNE A

Publications (2)

Publication Number	Publication Date
HRP20030381A2 HRP20030381A2 (en)	2005-02-28
HRP20030381B1 true HRP20030381B1 (en)	2007-05-31

Family

ID=33446264

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HR20030381A HRP20030381B1 (en)	2003-05-14	2003-05-14	3-DECLADINOZYL 9a-N-CARBAMOYL AND 9a-N-THIOCARBAMOYL DERIVATIVES 9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERYTHROMICYNE A

Country Status (20)

Country	Link
US (1)	US20070066544A1 (es)
EP (1)	EP1631575B1 (es)
JP (1)	JP2007501268A (es)
CN (1)	CN100345860C (es)
AR (1)	AR044320A1 (es)
AT (1)	ATE344270T1 (es)
CA (1)	CA2525143A1 (es)
CL (1)	CL2004001026A1 (es)
CY (1)	CY1107321T1 (es)
DE (1)	DE602004003054T2 (es)
DK (1)	DK1631575T3 (es)
ES (1)	ES2274453T3 (es)
HK (1)	HK1092156A1 (es)
HR (1)	HRP20030381B1 (es)
IS (1)	IS8109A (es)
PL (1)	PL1631575T3 (es)
PT (1)	PT1631575E (es)
RS (1)	RS20050837A (es)
SI (1)	SI1631575T1 (es)
WO (1)	WO2004101591A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2006087642A2 (en) *	2005-01-14	2006-08-24	Glaxosmithkline Istrazivacki Centar Zagreb D.O.O.	9a-carbamoyl and thiocarbamoyl azalides with antimalarial activity
US20080200403A1 (en) *	2005-01-14	2008-08-21	Glaxosmithkline	9A-Carbamoyl and Thiocarbamoyl Azalides with Anti-Inflammatory Activity
KR102528984B1 (ko)	2013-04-04	2023-05-08	프레지던트 앤드 펠로우즈 오브 하바드 칼리지	매크롤라이드 그리고 그의 제조방법 및 용도
CN104119413B (zh) *	2014-07-29	2016-08-24	华中农业大学	一种土拉霉素残留标示物的合成方法
CA2963815A1 (en)	2014-10-08	2016-04-14	President And Fellows Of Harvard College	14-membered ketolides and methods of their preparation and use
EP3273969A4 (en)	2015-03-25	2018-11-21	President and Fellows of Harvard College	Macrolides with modified desosamine sugars and uses thereof
GB201608236D0 (en)	2016-05-11	2016-06-22	Fidelta D O O	Seco macrolide compounds
AU2019385333A1 (en) *	2018-11-19	2021-07-01	President And Fellows Of Harvard College	C10-alkylene substituted 13-membered macrolides and uses thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
YU43116B (en) *	1979-04-02	1989-04-30	Pliva Pharm & Chem Works	Process for preparing 11-aza-4-o-cladinosyl-6-o-desosaminyl-15-ethyl-7,13,14-trihydroxy-3,5,7,9,12,14-hexamethyl-oxacyclopentadecane-2-one(11-aza-10-deox
HRP931480B1 (en) *	1993-12-08	1997-08-31	Sour Pliva	9a-N-(N'-CARBAMONYL) and 9a-N-(N'-THIOCARBAMONYL) DERIVATES OF 9-DEOXO-9a-HOMOERYTHROMYCIN A
HRP990130B1 (en) *	1999-05-03	2004-06-30	Pliva D D	HALOGEN DERIVATIVES 9a-N-(N'-ARYLCARBAMOYL)- AND 9a-N-(N'-ARYLTHIOCARBAMOYL)-9-DEOXO-9a-AZA-9a OF HOMOERYTHROMYCIN A
US20020115621A1 (en) *	2000-08-07	2002-08-22	Wei-Gu Su	Macrolide antibiotics
HRP20010146B1 (en) *	2001-02-28	2005-10-31	Pliva D.D.	9a-N-(N'-(PHENYLSULFONYL)CARBAMOYL) DERIVATIVES OF 9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERYTHROMYCIN A AND OF 5-O-DESOSAMINYL-9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERYTHRONOLIDE A
US6933283B2 (en) *	2002-04-25	2005-08-23	Abbott Laboratories	11-deoxy azalide antibacterials

2003
- 2003-05-14 HR HR20030381A patent/HRP20030381B1/xx not_active IP Right Cessation
2004
- 2004-05-11 PT PT04732143T patent/PT1631575E/pt unknown
- 2004-05-11 CN CNB2004800130438A patent/CN100345860C/zh not_active Expired - Fee Related
- 2004-05-11 CA CA002525143A patent/CA2525143A1/en not_active Abandoned
- 2004-05-11 PL PL04732143T patent/PL1631575T3/pl unknown
- 2004-05-11 SI SI200430155T patent/SI1631575T1/sl unknown
- 2004-05-11 DK DK04732143T patent/DK1631575T3/da active
- 2004-05-11 EP EP04732143A patent/EP1631575B1/en not_active Expired - Lifetime
- 2004-05-11 AT AT04732143T patent/ATE344270T1/de not_active IP Right Cessation
- 2004-05-11 ES ES04732143T patent/ES2274453T3/es not_active Expired - Lifetime
- 2004-05-11 WO PCT/HR2004/000014 patent/WO2004101591A1/en active Application Filing
- 2004-05-11 US US10/557,025 patent/US20070066544A1/en not_active Abandoned
- 2004-05-11 DE DE602004003054T patent/DE602004003054T2/de not_active Expired - Lifetime
- 2004-05-11 JP JP2006530610A patent/JP2007501268A/ja active Pending
- 2004-05-11 RS YUP-2005/0837A patent/RS20050837A/sr unknown
- 2004-05-13 CL CL200401026A patent/CL2004001026A1/es unknown
- 2004-05-14 AR ARP040101631A patent/AR044320A1/es not_active Application Discontinuation
2005
- 2005-10-31 IS IS8109A patent/IS8109A/is unknown
2006
- 2006-11-17 HK HK06112660A patent/HK1092156A1/xx not_active IP Right Cessation
2007
- 2007-01-10 CY CY20071100033T patent/CY1107321T1/el unknown

Also Published As

Publication number	Publication date
CY1107321T1 (el)	2012-11-21
DE602004003054D1 (de)	2006-12-14
ES2274453T3 (es)	2007-05-16
PL1631575T3 (pl)	2007-03-30
CL2004001026A1 (es)	2005-04-22
WO2004101591A1 (en)	2004-11-25
HK1092156A1 (en)	2007-02-02
IS8109A (is)	2005-10-31
SI1631575T1 (sl)	2007-04-30
CA2525143A1 (en)	2004-11-25
CN1788013A (zh)	2006-06-14
DK1631575T3 (da)	2007-02-26
EP1631575A1 (en)	2006-03-08
EP1631575B1 (en)	2006-11-02
PT1631575E (pt)	2007-01-31
JP2007501268A (ja)	2007-01-25
HRP20030381A2 (en)	2005-02-28
ATE344270T1 (de)	2006-11-15
RS20050837A (en)	2007-12-31
US20070066544A1 (en)	2007-03-22
AR044320A1 (es)	2005-09-07
CN100345860C (zh)	2007-10-31
DE602004003054T2 (de)	2007-06-06

Legal Events

Date	Code	Title	Description
2005-02-28	A1OB	Publication of a patent application
2005-07-11	ARAI	Request for the grant of a patent on the basis of the submitted results of a substantive examination of a patent application
2007-01-05	PNAN	Change of the applicant name, address/residence	Owner name: GLAXOSMITHKLINE ISTRAZIVACKI CENTAR ZAGREB D.O.O.,
2007-05-31	B1PR	Patent granted
2008-04-21	ODRP	Renewal fee for the maintenance of a patent	Payment date: 20080421 Year of fee payment: 6
2009-11-15	PBON	Lapse due to non-payment of renewal fee	Effective date: 20090515

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