AR044320A1 - Derivados 3-decladinosilo de la clase de 9a - n-carbamoil - y 9a-ntiocarbamoil- 9 dihidro-9a aza- 9a - homoeritromicina a - Google Patents
Derivados 3-decladinosilo de la clase de 9a - n-carbamoil - y 9a-ntiocarbamoil- 9 dihidro-9a aza- 9a - homoeritromicina aInfo
- Publication number
- AR044320A1 AR044320A1 ARP040101631A ARP040101631A AR044320A1 AR 044320 A1 AR044320 A1 AR 044320A1 AR P040101631 A ARP040101631 A AR P040101631A AR P040101631 A ARP040101631 A AR P040101631A AR 044320 A1 AR044320 A1 AR 044320A1
- Authority
- AR
- Argentina
- Prior art keywords
- individually
- group
- individually represents
- halogen
- hydroxyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Cosmetics (AREA)
- Thermal Transfer Or Thermal Recording In General (AREA)
Abstract
La presente se refiere a nuevos derivados 3-decladinosilo de 9a-N-carbamoil- y 9a-N-tiocarbamoil-9-deoxo-9-dihidro-9a-aza-9a-homoeritromicina A, de fórmula general (1), a sus sales de adición farmacéuticamente aceptables con ácidos orgánicos o inorgánicos y a sus hidratos, donde: R1 representa individualmente hidrógeno o conjuntamente con R2 representan un enlace doble; R2 representa individualmente hidrógeno, hidroxilo o un grupo de fórmula (2), donde: Y representa individualmente un anillo aromático monocíclico no sustituido o sustituido por grupos que se seleccionan independientemente entre halógeno, OH, OMe, NO2, NH2; o R2 conjuntamente con R3 representan cetona o conjuntamente con R1 representan un enlace doble; R3 representa individualmente hidrógeno o conjuntamente con R2 representan cetona o conjuntamente con R4 representan éter; R4 representa individualmente hidroxilo, un grupo OCH3 o conjuntamente con R3 representan éter; R5 representa individualmente un grupo alquilo C1-4, un grupo alquenilo C2-4, -(CH2)m-Ar, donde Ar representa individualmente fenilo o fenilo sustituido por uno o dos grupos que se seleccionan independientemente entre halógeno o halógeno alquilo, y m oscila entre 0 y 3; R6 representa individualmente hidrógeno o un grupo protegido hidroxilo y X representa oxígeno o azufre, a intermediarios para la síntesis de otros compuestos macrólidos con actividad antibacteriana, al procedimiento para su preparación, a sus sales de adición farmacéuticamente aceptables con ácidos orgánicos o inorgánicos y sus hidratos, al procedimiento para la preparación de composiciones farmacéuticas, así como también al empleo de composiciones farmacéuticas para tratar infecciones bacterianas.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HR20030381A HRP20030381B1 (en) | 2003-05-14 | 2003-05-14 | 3-DECLADINOZYL 9a-N-CARBAMOYL AND 9a-N-THIOCARBAMOYL DERIVATIVES 9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERYTHROMICYNE A |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR044320A1 true AR044320A1 (es) | 2005-09-07 |
Family
ID=33446264
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP040101631A AR044320A1 (es) | 2003-05-14 | 2004-05-14 | Derivados 3-decladinosilo de la clase de 9a - n-carbamoil - y 9a-ntiocarbamoil- 9 dihidro-9a aza- 9a - homoeritromicina a |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US20070066544A1 (es) |
| EP (1) | EP1631575B1 (es) |
| JP (1) | JP2007501268A (es) |
| CN (1) | CN100345860C (es) |
| AR (1) | AR044320A1 (es) |
| AT (1) | ATE344270T1 (es) |
| CA (1) | CA2525143A1 (es) |
| CL (1) | CL2004001026A1 (es) |
| CY (1) | CY1107321T1 (es) |
| DE (1) | DE602004003054T2 (es) |
| DK (1) | DK1631575T3 (es) |
| ES (1) | ES2274453T3 (es) |
| HK (1) | HK1092156A1 (es) |
| HR (1) | HRP20030381B1 (es) |
| IS (1) | IS8109A (es) |
| PL (1) | PL1631575T3 (es) |
| PT (1) | PT1631575E (es) |
| RS (1) | RS20050837A (es) |
| SI (1) | SI1631575T1 (es) |
| WO (1) | WO2004101591A1 (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006087642A2 (en) * | 2005-01-14 | 2006-08-24 | Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. | 9a-carbamoyl and thiocarbamoyl azalides with antimalarial activity |
| US20080200403A1 (en) * | 2005-01-14 | 2008-08-21 | Glaxosmithkline | 9A-Carbamoyl and Thiocarbamoyl Azalides with Anti-Inflammatory Activity |
| KR102528984B1 (ko) | 2013-04-04 | 2023-05-08 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 매크롤라이드 그리고 그의 제조방법 및 용도 |
| CN104119413B (zh) * | 2014-07-29 | 2016-08-24 | 华中农业大学 | 一种土拉霉素残留标示物的合成方法 |
| CA2963815A1 (en) | 2014-10-08 | 2016-04-14 | President And Fellows Of Harvard College | 14-membered ketolides and methods of their preparation and use |
| EP3273969A4 (en) | 2015-03-25 | 2018-11-21 | President and Fellows of Harvard College | Macrolides with modified desosamine sugars and uses thereof |
| GB201608236D0 (en) | 2016-05-11 | 2016-06-22 | Fidelta D O O | Seco macrolide compounds |
| AU2019385333A1 (en) * | 2018-11-19 | 2021-07-01 | President And Fellows Of Harvard College | C10-alkylene substituted 13-membered macrolides and uses thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| YU43116B (en) * | 1979-04-02 | 1989-04-30 | Pliva Pharm & Chem Works | Process for preparing 11-aza-4-o-cladinosyl-6-o-desosaminyl-15-ethyl-7,13,14-trihydroxy-3,5,7,9,12,14-hexamethyl-oxacyclopentadecane-2-one(11-aza-10-deox |
| HRP931480B1 (en) * | 1993-12-08 | 1997-08-31 | Sour Pliva | 9a-N-(N'-CARBAMONYL) and 9a-N-(N'-THIOCARBAMONYL) DERIVATES OF 9-DEOXO-9a-HOMOERYTHROMYCIN A |
| HRP990130B1 (en) * | 1999-05-03 | 2004-06-30 | Pliva D D | HALOGEN DERIVATIVES 9a-N-(N'-ARYLCARBAMOYL)- AND 9a-N-(N'-ARYLTHIOCARBAMOYL)-9-DEOXO-9a-AZA-9a OF HOMOERYTHROMYCIN A |
| US20020115621A1 (en) * | 2000-08-07 | 2002-08-22 | Wei-Gu Su | Macrolide antibiotics |
| HRP20010146B1 (en) * | 2001-02-28 | 2005-10-31 | Pliva D.D. | 9a-N-(N'-(PHENYLSULFONYL)CARBAMOYL) DERIVATIVES OF 9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERYTHROMYCIN A AND OF 5-O-DESOSAMINYL-9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERYTHRONOLIDE A |
| US6933283B2 (en) * | 2002-04-25 | 2005-08-23 | Abbott Laboratories | 11-deoxy azalide antibacterials |
-
2003
- 2003-05-14 HR HR20030381A patent/HRP20030381B1/xx not_active IP Right Cessation
-
2004
- 2004-05-11 PT PT04732143T patent/PT1631575E/pt unknown
- 2004-05-11 CN CNB2004800130438A patent/CN100345860C/zh not_active Expired - Fee Related
- 2004-05-11 CA CA002525143A patent/CA2525143A1/en not_active Abandoned
- 2004-05-11 PL PL04732143T patent/PL1631575T3/pl unknown
- 2004-05-11 SI SI200430155T patent/SI1631575T1/sl unknown
- 2004-05-11 DK DK04732143T patent/DK1631575T3/da active
- 2004-05-11 EP EP04732143A patent/EP1631575B1/en not_active Expired - Lifetime
- 2004-05-11 AT AT04732143T patent/ATE344270T1/de not_active IP Right Cessation
- 2004-05-11 ES ES04732143T patent/ES2274453T3/es not_active Expired - Lifetime
- 2004-05-11 WO PCT/HR2004/000014 patent/WO2004101591A1/en active Application Filing
- 2004-05-11 US US10/557,025 patent/US20070066544A1/en not_active Abandoned
- 2004-05-11 DE DE602004003054T patent/DE602004003054T2/de not_active Expired - Lifetime
- 2004-05-11 JP JP2006530610A patent/JP2007501268A/ja active Pending
- 2004-05-11 RS YUP-2005/0837A patent/RS20050837A/sr unknown
- 2004-05-13 CL CL200401026A patent/CL2004001026A1/es unknown
- 2004-05-14 AR ARP040101631A patent/AR044320A1/es not_active Application Discontinuation
-
2005
- 2005-10-31 IS IS8109A patent/IS8109A/is unknown
-
2006
- 2006-11-17 HK HK06112660A patent/HK1092156A1/xx not_active IP Right Cessation
-
2007
- 2007-01-10 CY CY20071100033T patent/CY1107321T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CY1107321T1 (el) | 2012-11-21 |
| DE602004003054D1 (de) | 2006-12-14 |
| ES2274453T3 (es) | 2007-05-16 |
| PL1631575T3 (pl) | 2007-03-30 |
| CL2004001026A1 (es) | 2005-04-22 |
| WO2004101591A1 (en) | 2004-11-25 |
| HRP20030381B1 (en) | 2007-05-31 |
| HK1092156A1 (en) | 2007-02-02 |
| IS8109A (is) | 2005-10-31 |
| SI1631575T1 (sl) | 2007-04-30 |
| CA2525143A1 (en) | 2004-11-25 |
| CN1788013A (zh) | 2006-06-14 |
| DK1631575T3 (da) | 2007-02-26 |
| EP1631575A1 (en) | 2006-03-08 |
| EP1631575B1 (en) | 2006-11-02 |
| PT1631575E (pt) | 2007-01-31 |
| JP2007501268A (ja) | 2007-01-25 |
| HRP20030381A2 (en) | 2005-02-28 |
| ATE344270T1 (de) | 2006-11-15 |
| RS20050837A (en) | 2007-12-31 |
| US20070066544A1 (en) | 2007-03-22 |
| CN100345860C (zh) | 2007-10-31 |
| DE602004003054T2 (de) | 2007-06-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EA200701176A1 (ru) | Новые соединения нафталина, способ их получения и фармацевтические композиции, содержащие их | |
| CY1109331T1 (el) | Παραγωγα αμινοφαινυλιου ως νεοι αναστολεις της αποακετυλασης ιστονης | |
| BR0010555A (pt) | Inibidores de neuraminidases | |
| DE602004008098D1 (de) | Substituierte 2h-ä1,2,4ütriazoloä4,3-aüpyrazine als gsk-3-inhibitoren | |
| CL2004000917A1 (es) | Compuestos derivados de tiazol; procedimiento de preparacion; composicion farmaceutica; y su uso para el tratamiento de enfermedades mediadas por 3-cinasa de dosfatidilnositol tal como enfermedades respiratorias, alergias, artritis reumatoide, osteoa | |
| AR063988A1 (es) | Derivados heterociclicos, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen | |
| UY30804A1 (es) | Derivados de nicotinamida, sus sales y solvatos, composiciones farmacéuticas conteniendolas y aplicaciones | |
| UY27891A1 (es) | Nuevos derivados de glicosido de tiofeno, procedimientos para la preparación de los mismos, medicamentos que contienen estos compuestos, y el uso de los mismos. | |
| UY29886A1 (es) | Derivados de pirazol novedosos, composiciones farmaccuticas que los contienen, procedimientos para la preparacinn de los mismos y aplicaciones | |
| CY1113639T1 (el) | Παραγωγα βενζαμιδιου και ετεροαρενιου | |
| DOP2006000063A (es) | Derivados de ciclopropanocarboxamida | |
| AR058348A1 (es) | Derivados de 1-aza-biciclo-nonano y composiciones farmaceuticas que los comprenden | |
| RS51661B (en) | NEW DIOSMETHINE DERIVATIVES, THE PROCEDURE FOR THEIR MAKING AND THE PHARMACEUTICAL MIXTURES CONTAINING THEM | |
| AR049401A1 (es) | Aza-biciclononanos | |
| BRPI0408353A (pt) | composto, composição farmacêutica, métodos para o tratamento de neoplasias suscetìveis e para o tratamento de infecções virais, e, uso de um composto | |
| BRPI1010300B8 (pt) | processos para a preparação de um composto, de dronedarone, ou um sal do mesmo, de uma formulação farmacêutica, e de um intermediário de dronedarone, ou um sal do mesmo | |
| ATE501103T1 (de) | Organische verbindungen | |
| CU20090173A7 (es) | Nuevos compuestos heterocíclicos nitrogenados, su preparación y su utilización como medicamentos antibacterianos | |
| PA8573501A1 (es) | Derivados de benzoxazina y su empleo | |
| CY1107321T1 (el) | Νεα 3-δεκλαδινοσυλ-9α-ν-καρβaμοϋλικα και 9α-ν-θειοκαρβαμοϋλικα παραγωγα της 9-δεσοξο-9-διυδρο-9α-αζα-9α-ομοepυθρομυκινης | |
| HRP20050390A2 (en) | Substituted benzoxazinones and uses thereof | |
| PA8589801A1 (es) | Aminoalcoxiindoles | |
| TNSN07395A1 (en) | Novel phenyl-pyridinyl-piperazine derivatives, a method for the production thereof and pharmaceutical compositions containing said derivatives | |
| BR0208812A (pt) | Derivados fenil heterociclil éter como inibidores de recaptação de serotonina | |
| AR029001A1 (es) | Derivados de bencil-3,4-metilendioxicinamico y el uso de los mismos para la manufactura de un medicamento |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |