GB1030259A - Improvements in the production of n-acetyl-l-cysteine - Google Patents

Improvements in the production of n-acetyl-l-cysteine

Info

Publication number
GB1030259A
GB1030259A GB44256/64A GB4425664A GB1030259A GB 1030259 A GB1030259 A GB 1030259A GB 44256/64 A GB44256/64 A GB 44256/64A GB 4425664 A GB4425664 A GB 4425664A GB 1030259 A GB1030259 A GB 1030259A
Authority
GB
United Kingdom
Prior art keywords
cysteine
acetyl
cystine
barium
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB44256/64A
Inventor
Satoru Ishii
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Senju Pharmaceutical Co Ltd
Original Assignee
Senju Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Senju Pharmaceutical Co Ltd filed Critical Senju Pharmaceutical Co Ltd
Priority to GB44256/64A priority Critical patent/GB1030259A/en
Publication of GB1030259A publication Critical patent/GB1030259A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
    • C07C323/59—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton with acylated amino groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Electrolytic Production Of Non-Metals, Compounds, Apparatuses Therefor (AREA)

Abstract

N-acetyl-L-cysteine, is made by acetylating L-cystine in the presence of barium hydrate solution with ketene or acetic anhydride, to form N.N1 diacetyl-L-cysteine which is treated with sulphuric acid to remove barium as a precipitate of barium sulphate, and is then electrolytically reduced to N-acetyl-L-cysteine. Preferably a diaphragm cell is used with sulphuric acid as anolyte and the acid solution of the acetylated cysteine as catholyte. A carbon anode, and a cathode of tin, lead, mercury, or nickel which may be coated with platinum. Power at 12V, 5 Amps is applied, and the product solution is neutralised, concentrated and crystallized.ALSO:N: N1 - diacetyl-L-cystine is made by acetylating L-cystine in the presence of barium hydrate solution with ketene or acetic an-hydride.
GB44256/64A 1964-10-29 1964-10-29 Improvements in the production of n-acetyl-l-cysteine Expired GB1030259A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB44256/64A GB1030259A (en) 1964-10-29 1964-10-29 Improvements in the production of n-acetyl-l-cysteine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB44256/64A GB1030259A (en) 1964-10-29 1964-10-29 Improvements in the production of n-acetyl-l-cysteine

Publications (1)

Publication Number Publication Date
GB1030259A true GB1030259A (en) 1966-05-18

Family

ID=10432469

Family Applications (1)

Application Number Title Priority Date Filing Date
GB44256/64A Expired GB1030259A (en) 1964-10-29 1964-10-29 Improvements in the production of n-acetyl-l-cysteine

Country Status (1)

Country Link
GB (1) GB1030259A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997042358A1 (en) * 1996-05-07 1997-11-13 Universidad De Alicante Process for the electrochemical synthesis of n-acetylcysteine from cystine
CN110615749A (en) * 2018-06-19 2019-12-27 武汉远大弘元股份有限公司 Method for treating waste liquid from production of N-acetylcysteine
CN115772104A (en) * 2022-11-15 2023-03-10 广东百澳药业有限公司 Preparation method of N-acetyl-L-cysteine

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997042358A1 (en) * 1996-05-07 1997-11-13 Universidad De Alicante Process for the electrochemical synthesis of n-acetylcysteine from cystine
ES2108654A1 (en) * 1996-05-07 1997-12-16 Univ Alicante Process for the electrochemical synthesis of n-acetylcysteine from cystine
AU714021B2 (en) * 1996-05-07 1999-12-16 Universidad De Alicante Process for the electrochemical synthesis of N-acetylcysteine from cystine
US6159352A (en) * 1996-05-07 2000-12-12 Universidad De Alicante Process for the electrochemical synthesis of N-acetylcysteine from cystine
CN110615749A (en) * 2018-06-19 2019-12-27 武汉远大弘元股份有限公司 Method for treating waste liquid from production of N-acetylcysteine
CN110615749B (en) * 2018-06-19 2022-06-17 武汉远大弘元股份有限公司 Method for treating waste liquid from production of N-acetylcysteine
CN115772104A (en) * 2022-11-15 2023-03-10 广东百澳药业有限公司 Preparation method of N-acetyl-L-cysteine

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