FR2385722A1 - Nouveaux derives de cephalosporine, leur procede de preparation et leur application en therapeutique - Google Patents

Nouveaux derives de cephalosporine, leur procede de preparation et leur application en therapeutique

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Publication number
FR2385722A1
FR2385722A1 FR7809661A FR7809661A FR2385722A1 FR 2385722 A1 FR2385722 A1 FR 2385722A1 FR 7809661 A FR7809661 A FR 7809661A FR 7809661 A FR7809661 A FR 7809661A FR 2385722 A1 FR2385722 A1 FR 2385722A1
Authority
FR
France
Prior art keywords
preparation process
therapeutic application
cephalosporin derivatives
new cephalosporin
new
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7809661A
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English (en)
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FR2385722B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
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Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of FR2385722A1 publication Critical patent/FR2385722A1/fr
Application granted granted Critical
Publication of FR2385722B1 publication Critical patent/FR2385722B1/fr
Expired legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/40—Unsubstituted amino or imino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/50—Nitrogen atoms bound to hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/587—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with aliphatic hydrocarbon radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms, said aliphatic radicals being substituted in the alpha-position to the ring by a hetero atom, e.g. with m >= 0, Z being a singly or a doubly bound hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D463/10—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D463/14—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hetero atoms directly attached in position 7
    • C07D463/16—Nitrogen atoms
    • C07D463/18—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof
    • C07D463/20—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D463/22—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen further substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D505/00—Heterocyclic compounds containing 5-oxa-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

L'invention concerne des dérivés de céphèmes, répondant à la formule générale I :
FR7809661A 1977-04-02 1978-03-31 Nouveaux derives de cephalosporine, leur procede de preparation et leur application en therapeutique Expired FR2385722B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19772714880 DE2714880A1 (de) 1977-04-02 1977-04-02 Cephemderivate und verfahren zu ihrer herstellung
DE19772716707 DE2716707A1 (de) 1977-04-02 1977-04-15 Cephemderivate und verfahren zu ihrer herstellung

Publications (2)

Publication Number Publication Date
FR2385722A1 true FR2385722A1 (fr) 1978-10-27
FR2385722B1 FR2385722B1 (fr) 1985-09-27

Family

ID=25771827

Family Applications (3)

Application Number Title Priority Date Filing Date
FR7809661A Expired FR2385722B1 (fr) 1977-04-02 1978-03-31 Nouveaux derives de cephalosporine, leur procede de preparation et leur application en therapeutique
FR8110233A Granted FR2485017A1 (fr) 1977-04-02 1981-05-22 Nouveaux derives de cephalosporine et leur application en therapeutique
FR8110234A Granted FR2485018A1 (fr) 1977-04-02 1981-05-22 Nouveaux derives de cephalosporine et leur application en therapeutique

Family Applications After (2)

Application Number Title Priority Date Filing Date
FR8110233A Granted FR2485017A1 (fr) 1977-04-02 1981-05-22 Nouveaux derives de cephalosporine et leur application en therapeutique
FR8110234A Granted FR2485018A1 (fr) 1977-04-02 1981-05-22 Nouveaux derives de cephalosporine et leur application en therapeutique

Country Status (28)

Country Link
US (4) US4758556A (fr)
JP (2) JPS5858354B2 (fr)
AT (1) AT367425B (fr)
AU (1) AU528277B2 (fr)
BE (1) BE865632A (fr)
CA (1) CA1259606A (fr)
CH (1) CH638810A5 (fr)
CS (1) CS208747B2 (fr)
DD (1) DD137231A5 (fr)
DE (2) DE2714880A1 (fr)
DK (1) DK165060C (fr)
ES (2) ES468475A1 (fr)
FI (1) FI70221C (fr)
FR (3) FR2385722B1 (fr)
GB (1) GB1604971A (fr)
GR (1) GR73632B (fr)
HK (1) HK39083A (fr)
IE (1) IE47211B1 (fr)
IL (1) IL54407A (fr)
IT (1) IT1093750B (fr)
LU (1) LU79350A1 (fr)
NL (1) NL7803486A (fr)
NO (1) NO160211C (fr)
NZ (1) NZ186842A (fr)
OA (1) OA05928A (fr)
PT (1) PT67856B (fr)
SE (2) SE448378B (fr)
YU (1) YU41827B (fr)

Cited By (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2399418A1 (fr) * 1977-03-14 1979-03-02 Fujisawa Pharmaceutical Co Procede de preparation d'acides iminoacetiques et nouveaux produits ainsi obtenus, utilises pour la synthese d'acides cepham- ou cephem-carboxyliques
FR2453161A1 (fr) * 1978-08-31 1980-10-31 Fujisawa Pharmaceutical Co Procede de preparation de derives d'acide thiazolylacetique et nouveaux produits ainsi obtenus
FR2476647A2 (fr) * 1980-02-26 1981-08-28 Roussel Uclaf Procede de preparation de derives de l'acide 2-(2-amino protege 4-thiazolyl) 2-alkoxyimino acetique isomere syn
FR2488258A1 (fr) * 1980-08-11 1982-02-12 American Cyanamid Co Acide 7-beta-(alpha-syn-methoxyimino-alpha - (2-aminothiazol-4-yl) - acetamino)-3-((1,2,3-thiadiazol-5-ylthio) methyl)-3-cepheme-4-carboxylique et derives alkyliques en c1-c6 de celui-ci, compositions contenant ces composes et leurs applications
EP0045937A2 (fr) * 1980-08-11 1982-02-17 Fujisawa Pharmaceutical Co., Ltd. Dérivés de céphalosporine et procédés pour leur préparation
EP0049119A2 (fr) * 1980-09-30 1982-04-07 Sankyo Company Limited Dérivés de céphalosporines, leur préparation et compositions pharmaceutiques les contenant
EP0049499A2 (fr) * 1980-10-06 1982-04-14 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Dérivés de céphalosporine, leur préparation, compositions pharmaceutiques les contenant et intermédiaires pour leur préparation
FR2494279A1 (fr) * 1980-11-20 1982-05-21 Rhone Poulenc Ind Nouvelles oxacephalosporines, leur preparation et les medicaments qui les contiennent
EP0064256A2 (fr) * 1981-05-02 1982-11-10 Hoechst Aktiengesellschaft Dérivés de céphalosporine et procédé pour leur préparation
FR2505339A1 (fr) * 1981-05-11 1982-11-12 Rhone Poulenc Sante Nouvelles oxacephalosporines et leur preparation
FR2505338A1 (fr) * 1981-05-11 1982-11-12 Rhone Poulenc Sante Nouvelles oxacephalosporines et leur preparation
EP0064740A2 (fr) * 1981-05-12 1982-11-17 Hoechst Aktiengesellschaft Dérivés de céphalosporine et procédé pour leur préparation
FR2505840A1 (fr) * 1981-05-13 1982-11-19 Roussel Uclaf Nouveaux produits derives de l'acide 2-amino thiazolyl 2-oxyimino acetamido bicyclo-octene carboxylique, leur procede de preparation et leur application comme medicaments
FR2508458A1 (fr) * 1981-06-29 1982-12-31 Sandoz Sa Nouveaux derives de l'acide cephalosporanique, leur preparation et leur application comme medicaments
FR2512449A1 (fr) * 1981-09-08 1983-03-11 Lilly Co Eli Quinoleinium-betaines de cephalosporine et leur application pharmacolique
FR2512448A1 (fr) * 1981-09-08 1983-03-11 Lilly Co Eli Isoquinoleinium-betaines de cephalosporine et son application pharmaceutique
EP0074268A2 (fr) * 1981-09-08 1983-03-16 Eli Lilly And Company Dérivés de céphalosporines thiéno- et furopyridinium substitués
EP0074645A2 (fr) * 1981-09-14 1983-03-23 Fujisawa Pharmaceutical Co., Ltd. Dérivés de céphalosporine, procédés pour leur préparation et compositions pharmaceutiques les contenant
EP0075600A1 (fr) * 1981-03-16 1983-04-06 MITSUI TOATSU CHEMICALS, Inc. Derives de 2-thiazolamines, leur procede de preparation et composition medicinale les contenant
FR2514004A1 (fr) * 1981-10-02 1983-04-08 Lilly Co Eli Antibiotiques de dioximino-cephalosporines
EP0076528A2 (fr) * 1980-02-18 1983-04-13 Roussel-Uclaf Nouvelles oximes dérivées de l'acide 3-alkyloxy ou 3-alkylthiométhyl 7-amino thiazolylacétamido céphalosporanique et leur préparation
EP0078532A2 (fr) * 1981-11-03 1983-05-11 Hoechst Aktiengesellschaft Sels cristallins de céfodizim et procédé pour leur préparation
EP0081971A2 (fr) * 1981-12-08 1983-06-22 Tanabe Seiyaku Co., Ltd. Dérivé de céphalosporine et procédé pour sa préparation
EP0095329A2 (fr) * 1982-05-20 1983-11-30 Glaxo Group Limited Céphalosporines antibiotiques
FR2529556A1 (fr) * 1982-06-30 1984-01-06 Glaxo Group Ltd Nouvelles cephalosporines a activite antibiotique, leur procede de preparation et leur application en therapeutique
FR2529555A1 (fr) * 1982-06-30 1984-01-06 Glaxo Group Ltd Cephalosporines a activite antibiotique, leur procede de preparation et leur application en therapeutique
FR2532936A1 (fr) * 1982-09-13 1984-03-16 Roussel Uclaf Nouveaux derives de l'acide 2-amino-thiazolyl-4-yl acetique comportant une fonction oxime substituee et leur procede de preparation
FR2536402A1 (fr) * 1982-11-24 1984-05-25 Glaxo Group Ltd Cephalosporines, leur procede de preparation et leur application en therapeutique
EP0112164A2 (fr) * 1982-12-13 1984-06-27 Yamanouchi Pharmaceutical Co. Ltd. Dérivés céphem, leur préparation et les médicaments les contenant
EP0111935A2 (fr) * 1982-12-23 1984-06-27 Hoechst Aktiengesellschaft Dérivés de céphalosporine et procédé pour leur préparation
EP0113243A2 (fr) * 1982-12-24 1984-07-11 Kureha Kagaku Kogyo Kabushiki Kaisha Dérivés de céphalosporine
EP0097961A3 (en) * 1982-06-28 1984-10-03 Bristol-Myers Company Cephalosporin derivatives, a process for the manufacture thereof and pharmaceutical compositions containing said derivatives
EP0132501A2 (fr) * 1983-03-31 1985-02-13 Ajinomoto Co., Inc. Dérivés de céphalosporine, préparation et compositions pharmaceutiques
FR2552089A2 (fr) * 1981-05-13 1985-03-22 Roussel Uclaf Nouveaux produits derives de l'acide 2-amino thiazolyl 2-oxyimino acetamido bicyclo-octene carboxylique, leur procede de preparation et leur application comme medicaments
EP0135142A2 (fr) * 1983-08-25 1985-03-27 Hoechst Aktiengesellschaft Dérivés de céphalosporine et procédé pour leur préparation
EP0145906A2 (fr) * 1983-10-31 1985-06-26 Fujisawa Pharmaceutical Co., Ltd. Dérivés de céphalosporine et procédés pour leur préparation
EP0150609A2 (fr) * 1983-12-30 1985-08-07 Glaxo Group Limited Antibiotiques de céphalosporine
US4603129A (en) * 1980-02-23 1986-07-29 Hoechst Aktiengesellschaft Cephalosporin derivatives
EP0193858A1 (fr) * 1985-03-01 1986-09-10 Merck & Co. Inc. Dérivés de 1-oxa-1-déthia-céphalosporine et agent antibactérien les contenant
EP0214462A2 (fr) * 1985-08-05 1987-03-18 Fujisawa Pharmaceutical Co., Ltd. Dérivés de 3-céphem 3,7-disubstitué et procédés pour leur préparation
EP0221719A2 (fr) * 1985-10-22 1987-05-13 Biogal Gyogyszergyar Dérivés de céphalosporine, leurs procédés de préparation et compositions pharmaceutiques les contenant
EP0226093A2 (fr) * 1985-12-03 1987-06-24 Hoechst Aktiengesellschaft Procédé pour la préparation de céfodizime
EP0241901A2 (fr) * 1986-04-14 1987-10-21 Banyu Pharmaceutical Co., Ltd. Dérivés de céphalosporine, leurs procédés de préparation et agents antibactériens
US4708956A (en) * 1985-12-12 1987-11-24 Kyowa Hakko Kogyo Co., Ltd. 3-position halogenated cephalosporin analogs and pharmaceutical compositions
EP0272827A2 (fr) * 1986-12-23 1988-06-29 ZENECA Pharma S.A. 3-Hétérocycliquethiométhyl céphalosporines
EP0304155A2 (fr) * 1987-07-23 1989-02-22 ZENECA Pharma S.A. Dérivés de céphalosporine, procédé pour leur préparation et leurs compositions pharmaceutiques
EP0336705A2 (fr) * 1988-04-05 1989-10-11 Ajinomoto Co., Inc. Composés céphem et procédé pour leur préparation
EP0390066A2 (fr) * 1989-03-29 1990-10-03 Hoechst Aktiengesellschaft Dérivés de céphalosporines et procédé pour leur préparation
US5412093A (en) * 1986-12-23 1995-05-02 Ici Pharma 3-heterocyclic thiomethyl cephalosporins

Families Citing this family (186)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
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GR73632B (fr) 1984-03-26
DD137231A5 (de) 1979-08-22
CH638810A5 (de) 1983-10-14
AU528277B2 (en) 1983-04-21
CA1259606A (fr) 1989-09-19
US4278793A (en) 1981-07-14
DK165060C (da) 1993-02-22
JPS549296A (en) 1979-01-24
FR2485018B1 (fr) 1985-04-12
NZ186842A (en) 1980-11-14
PT67856B (de) 1979-12-19
DE2714880A1 (de) 1978-10-26
JPS5716887A (en) 1982-01-28
SE448378B (sv) 1987-02-16
IT1093750B (it) 1985-07-26
FR2485018A1 (fr) 1981-12-24
ES468475A1 (es) 1979-08-16
JPS5858354B2 (ja) 1983-12-24
IT7821901A0 (it) 1978-03-31
US4758556A (en) 1988-07-19
NO160211B (no) 1988-12-12
FI70221B (fi) 1986-02-28
AT367425B (de) 1982-07-12
SE8306994L (sv) 1983-12-16
JPS6228153B2 (fr) 1987-06-18
FR2485017A1 (fr) 1981-12-24
GB1604971A (en) 1981-12-16
CS208747B2 (en) 1981-09-15
FR2385722B1 (fr) 1985-09-27
ES477591A1 (es) 1980-01-01
NO781130L (no) 1978-10-03
YU76578A (en) 1983-04-30
FI70221C (fi) 1986-09-15
IE780642L (en) 1978-10-02
YU41827B (en) 1988-02-29
PT67856A (de) 1978-04-01
USRE35754E (en) 1998-03-24
BE865632A (fr) 1978-10-03
IL54407A (en) 1985-09-29
DE2716707A1 (de) 1978-10-19
HK39083A (en) 1983-10-13
SE7803660L (sv) 1978-10-03
IL54407A0 (en) 1978-06-15
DK143378A (da) 1978-10-03
IE47211B1 (en) 1984-01-25
NL7803486A (nl) 1978-10-04
US5710146A (en) 1998-01-20
LU79350A1 (de) 1978-11-27
FI780966A (fi) 1978-10-03
OA05928A (fr) 1981-06-30
SE8306994D0 (sv) 1983-12-16
NO160211C (no) 1989-03-22
DK165060B (da) 1992-10-05
ATA229078A (de) 1981-11-15
FR2485017B1 (fr) 1985-04-12
AU3464878A (en) 1979-10-04

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