ES8802137A1 - Un precedimiento para preparar derivados de ciclopentil-eter - Google Patents
Un precedimiento para preparar derivados de ciclopentil-eterInfo
- Publication number
- ES8802137A1 ES8802137A1 ES554238A ES554238A ES8802137A1 ES 8802137 A1 ES8802137 A1 ES 8802137A1 ES 554238 A ES554238 A ES 554238A ES 554238 A ES554238 A ES 554238A ES 8802137 A1 ES8802137 A1 ES 8802137A1
- Authority
- ES
- Spain
- Prior art keywords
- ethes
- cyclopentyl
- preparation
- pharmaceutical formulation
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- -1 3-phenoxy-2-hydroxypropyl Chemical group 0.000 abstract 1
- 208000025865 Ulcer Diseases 0.000 abstract 1
- 230000027119 gastric acid secretion Effects 0.000 abstract 1
- 230000002496 gastric effect Effects 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 231100000397 ulcer Toxicity 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
DERIVADOS DEL CICLOPENTIL-ETER (I), DONDE NO EXCLUSIVAMENTE N ES 1 O 2, M 2-5, X CHFCH CIS O TRANS, R1 FENILO, Y UN GRUPO (II), CON R5, R6 Y R7 HIDROGENO O METILO; SE OBTIENEN OXIDANDO UN COMPUESTO (III), CON R8 UN GRUPO PROTECTOR DE HIDROXILO, CON CLOROCROMATO DE PIRIDINO Y OTROS, EN UN DISOLVENTE COMO EL DICLOROMETANO, ENTRE C10JC Y TEMPERATURA AMBIENTE, ELIMINANDO LOS GRUPOS PROTECTORES DE HIDROXILO Y OPCIONALMENTE ESOMERIZAR X DE CIS A TRANS O REDUCIRLO A CH2-CH2. POSEEN ACTIVIDAD TIPO PGE2 Y COMO LA PROSTAGLANDINA INHIBEN LA SECRECION DE JUGO ACIDO GASTRICO Y PROPORCIONAN CITOPROTECCION GASTROINTESTINAL.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB858510277A GB8510277D0 (en) | 1985-04-23 | 1985-04-23 | Carbocyclic compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES554238A0 ES554238A0 (es) | 1988-04-01 |
| ES8802137A1 true ES8802137A1 (es) | 1988-04-01 |
Family
ID=10578043
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES554238A Expired ES8802137A1 (es) | 1985-04-23 | 1986-04-22 | Un precedimiento para preparar derivados de ciclopentil-eter |
| ES557659A Expired ES8900044A1 (es) | 1985-04-23 | 1987-08-12 | Un procedimiento para preparar derivados de ciclopentil-eter. |
| ES557828A Expired - Fee Related ES9000022A1 (es) | 1985-04-23 | 1988-04-12 | Un procedimiento para preparar derivados de ciclopentil-eter. |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES557659A Expired ES8900044A1 (es) | 1985-04-23 | 1987-08-12 | Un procedimiento para preparar derivados de ciclopentil-eter. |
| ES557828A Expired - Fee Related ES9000022A1 (es) | 1985-04-23 | 1988-04-12 | Un procedimiento para preparar derivados de ciclopentil-eter. |
Country Status (29)
| Country | Link |
|---|---|
| JP (1) | JPS61249951A (es) |
| KR (1) | KR860008132A (es) |
| CN (1) | CN1011783B (es) |
| AT (1) | AT395421B (es) |
| AU (1) | AU593797B2 (es) |
| BE (1) | BE904656A (es) |
| CA (1) | CA1275094A (es) |
| CH (1) | CH667265A5 (es) |
| DE (1) | DE3613573A1 (es) |
| DK (1) | DK183986A (es) |
| ES (3) | ES8802137A1 (es) |
| FI (1) | FI85368C (es) |
| FR (1) | FR2580632B1 (es) |
| GB (2) | GB8510277D0 (es) |
| GR (1) | GR861060B (es) |
| HK (1) | HK51691A (es) |
| HU (1) | HU199411B (es) |
| IL (1) | IL78552A (es) |
| IT (1) | IT1190277B (es) |
| LU (1) | LU86404A1 (es) |
| MY (1) | MY100829A (es) |
| NL (1) | NL8601025A (es) |
| NO (1) | NO165069C (es) |
| NZ (1) | NZ215910A (es) |
| PH (1) | PH23597A (es) |
| PT (1) | PT82440B (es) |
| SE (1) | SE460193B (es) |
| SG (1) | SG92990G (es) |
| ZA (1) | ZA863006B (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0265247B1 (en) * | 1986-10-22 | 1990-08-08 | Glaxo Group Limited | Cyclopentyl ethers and their preparation and pharmaceutical formulation |
| GB8625322D0 (en) * | 1986-10-22 | 1986-11-26 | Glaxo Group Ltd | Chemical compounds |
| GB8625321D0 (en) * | 1986-10-22 | 1986-11-26 | Glaxo Group Ltd | Chemical compounds |
| GB8625325D0 (en) * | 1986-10-22 | 1986-11-26 | Glaxo Group Ltd | Chemical compounds |
| GB8625326D0 (en) * | 1986-10-22 | 1986-11-26 | Glaxo Group Ltd | Medicaments |
| US5231208A (en) * | 1987-06-16 | 1993-07-27 | Nissan Chemical Industries, Ltd. | Substituted cyclic ketones, substituted cyclic enones, and process for producing the same |
| US5254708A (en) * | 1987-06-16 | 1993-10-19 | Nissan Chemical Industries, Ltd. | Substituted cyclic ketones, substituted cyclic enones, and process for producing the same |
| US5227505A (en) * | 1987-06-16 | 1993-07-13 | Nissan Chemical Industries, Ltd. | Substituted cyclic ketones, substituted cyclic enones, and process for producing the same |
| JP2696933B2 (ja) * | 1987-06-16 | 1998-01-14 | 日産化学工業株式会社 | 置換環状ケトン及び置換環状エノン並びにそれらの製造法 |
| GB8822141D0 (en) * | 1988-09-21 | 1988-10-26 | Glaxo Group Ltd | Chemical compounds |
| AU1709699A (en) | 1997-12-22 | 1999-07-12 | Alcon Laboratories, Inc. | 13-oxa prostaglandins for the treatment of glaucoma and ocular hypertension |
| JP4666257B2 (ja) | 2003-07-25 | 2011-04-06 | 小野薬品工業株式会社 | 軟骨関連疾患治療剤 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ197729A (en) * | 1980-08-12 | 1985-03-20 | Sanofi Sa | 13-oxaprostanoic acid derivatives and pharmaceutical compositions |
| GB2082176B (en) * | 1980-08-12 | 1984-07-11 | Sanofi Sa | Heteroprostaglandin derivatives and processes for preparing them |
| GB8410396D0 (en) * | 1984-04-24 | 1984-05-31 | Glaxo Group Ltd | Carbocyclic compounds |
-
1985
- 1985-04-23 GB GB858510277A patent/GB8510277D0/en active Pending
-
1986
- 1986-04-21 IL IL78552A patent/IL78552A/xx not_active IP Right Cessation
- 1986-04-22 IT IT47919/86A patent/IT1190277B/it active
- 1986-04-22 AU AU56461/86A patent/AU593797B2/en not_active Ceased
- 1986-04-22 FI FI861687A patent/FI85368C/fi not_active IP Right Cessation
- 1986-04-22 CN CN86102778A patent/CN1011783B/zh not_active Expired
- 1986-04-22 NO NO861584A patent/NO165069C/no unknown
- 1986-04-22 ES ES554238A patent/ES8802137A1/es not_active Expired
- 1986-04-22 CA CA000507274A patent/CA1275094A/en not_active Expired - Fee Related
- 1986-04-22 BE BE0/216578A patent/BE904656A/fr not_active IP Right Cessation
- 1986-04-22 GR GR861060A patent/GR861060B/el unknown
- 1986-04-22 CH CH1622/86A patent/CH667265A5/de not_active IP Right Cessation
- 1986-04-22 SE SE8601852A patent/SE460193B/sv not_active IP Right Cessation
- 1986-04-22 LU LU86404A patent/LU86404A1/fr unknown
- 1986-04-22 NL NL8601025A patent/NL8601025A/nl not_active Application Discontinuation
- 1986-04-22 DK DK183986A patent/DK183986A/da not_active Application Discontinuation
- 1986-04-22 NZ NZ215910A patent/NZ215910A/xx unknown
- 1986-04-22 KR KR1019860003086A patent/KR860008132A/ko not_active Application Discontinuation
- 1986-04-22 ZA ZA863006A patent/ZA863006B/xx unknown
- 1986-04-22 PH PH33693A patent/PH23597A/en unknown
- 1986-04-22 DE DE19863613573 patent/DE3613573A1/de not_active Withdrawn
- 1986-04-22 AT AT0106986A patent/AT395421B/de not_active IP Right Cessation
- 1986-04-22 GB GB08609821A patent/GB2174702B/en not_active Expired
- 1986-04-22 PT PT82440A patent/PT82440B/pt not_active IP Right Cessation
- 1986-04-22 FR FR868605781A patent/FR2580632B1/fr not_active Expired
- 1986-04-23 JP JP61092446A patent/JPS61249951A/ja active Pending
- 1986-10-03 HU HU864173A patent/HU199411B/hu not_active IP Right Cessation
- 1986-12-30 MY MYPI86000259A patent/MY100829A/en unknown
-
1987
- 1987-08-12 ES ES557659A patent/ES8900044A1/es not_active Expired
-
1988
- 1988-04-12 ES ES557828A patent/ES9000022A1/es not_active Expired - Fee Related
-
1990
- 1990-11-15 SG SG929/90A patent/SG92990G/en unknown
-
1991
- 1991-07-04 HK HK516/91A patent/HK51691A/xx unknown
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19970401 |