HUT45010A - Process for producing cyclopentyl-ether derivatives and pharmaceutical compositions containing them as active components - Google Patents
Process for producing cyclopentyl-ether derivatives and pharmaceutical compositions containing them as active componentsInfo
- Publication number
- HUT45010A HUT45010A HU864173A HU417386A HUT45010A HU T45010 A HUT45010 A HU T45010A HU 864173 A HU864173 A HU 864173A HU 417386 A HU417386 A HU 417386A HU T45010 A HUT45010 A HU T45010A
- Authority
- HU
- Hungary
- Prior art keywords
- alkyl
- pharmaceutical compositions
- compositions containing
- active components
- ether derivatives
- Prior art date
Links
- BOTLEXFFFSMRLQ-UHFFFAOYSA-N cyclopentyloxycyclopentane Chemical class C1CCCC1OC1CCCC1 BOTLEXFFFSMRLQ-UHFFFAOYSA-N 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 4
- SSUFGFDSOZQATQ-UHFFFAOYSA-N 7-[3-hydroxy-2-(2-hydroxy-3-phenoxypropoxy)-5-oxocyclopentyl]hept-5-enoic acid Chemical compound C=1C=CC=CC=1OCC(O)COC1C(O)CC(=O)C1CC=CCCCC(O)=O SSUFGFDSOZQATQ-UHFFFAOYSA-N 0.000 abstract 2
- -1 SOMe Chemical group 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000001622 2-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C([H])=C(*)C([H])=C([H])C2=C1[H] 0.000 abstract 1
- 125000004644 alkyl sulfinyl group Chemical group 0.000 abstract 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 229940006138 antiglaucoma drug and miotics prostaglandin analogues Drugs 0.000 abstract 1
- 125000000043 benzamido group Chemical group [H]N([*])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
- 125000001589 carboacyl group Chemical group 0.000 abstract 1
- 150000001768 cations Chemical class 0.000 abstract 1
- KXGVEGMKQFWNSR-LLQZFEROSA-N deoxycholic acid Chemical compound C([C@H]1CC2)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 KXGVEGMKQFWNSR-LLQZFEROSA-N 0.000 abstract 1
- 125000000816 ethylene group Chemical group [H]C([H])([*:1])C([H])([H])[*:2] 0.000 abstract 1
- 125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Prostaglandin analogues of formula (I) are new: n = 1 or 2; m = 2-5 and X = cis. or trans-CH=CH or CH2CH2, or m = 1-4 and X CH=C=CH; R1 = (a) phenyl opt. substd. by 1-4C alkyl, 1-4C alkoxy, 1-4C alkanoyl, SMe, SOMe, SO2Me, halogen, COOR2, NHCOR'2, CONR3R4, NHCONH2, CH2CH(CONH2)NHCOMe or 2-benzamido-2 -carbamoylethyl, or (b) 2-naphthyl; R2 = H, 1-4C alkyl, phenyl or a cation; R'2 = H, 1-4C alkyl or phenyl opt. substd. by OH, NHCOMe or benzamido; R3 and R4 = H or 1-4C alkyl; Y = CH2-CR5(OH)-CR6(OAr)-R7; R5-R7 = H or Me, at least one being H; Ar = phenyl opt. substd. by 1 or 2 of 1-4C alkyl, 1-4C alkoxy, 1-4C alkylthio, 1-4C alkylsulphinyl, 1-4C alkylsulphonyl, halogen and CF3. - (IR-(1alpha(Z), 2beta(R), 3alpha))-(-) -4-benzamidophenyl 7-(3-hydroxy-2-(2 -hydroxy-3-phenoxypropoxy) -5-oxocyclopentyl) -5-heptenoate (Ia) is specifically claimed.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB858510277A GB8510277D0 (en) | 1985-04-23 | 1985-04-23 | Carbocyclic compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUT45010A true HUT45010A (en) | 1988-05-30 |
| HU199411B HU199411B (en) | 1990-02-28 |
Family
ID=10578043
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU864173A HU199411B (en) | 1985-04-23 | 1986-10-03 | Process for producing cyclopentyl ether derivatives and pharmaceutical compositions containing them as active components |
Country Status (29)
| Country | Link |
|---|---|
| JP (1) | JPS61249951A (en) |
| KR (1) | KR860008132A (en) |
| CN (1) | CN1011783B (en) |
| AT (1) | AT395421B (en) |
| AU (1) | AU593797B2 (en) |
| BE (1) | BE904656A (en) |
| CA (1) | CA1275094A (en) |
| CH (1) | CH667265A5 (en) |
| DE (1) | DE3613573A1 (en) |
| DK (1) | DK183986A (en) |
| ES (3) | ES8802137A1 (en) |
| FI (1) | FI85368C (en) |
| FR (1) | FR2580632B1 (en) |
| GB (2) | GB8510277D0 (en) |
| GR (1) | GR861060B (en) |
| HK (1) | HK51691A (en) |
| HU (1) | HU199411B (en) |
| IL (1) | IL78552A (en) |
| IT (1) | IT1190277B (en) |
| LU (1) | LU86404A1 (en) |
| MY (1) | MY100829A (en) |
| NL (1) | NL8601025A (en) |
| NO (1) | NO165069C (en) |
| NZ (1) | NZ215910A (en) |
| PH (1) | PH23597A (en) |
| PT (1) | PT82440B (en) |
| SE (1) | SE460193B (en) |
| SG (1) | SG92990G (en) |
| ZA (1) | ZA863006B (en) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0265247B1 (en) * | 1986-10-22 | 1990-08-08 | Glaxo Group Limited | Cyclopentyl ethers and their preparation and pharmaceutical formulation |
| GB8625322D0 (en) * | 1986-10-22 | 1986-11-26 | Glaxo Group Ltd | Chemical compounds |
| GB8625321D0 (en) * | 1986-10-22 | 1986-11-26 | Glaxo Group Ltd | Chemical compounds |
| GB8625325D0 (en) * | 1986-10-22 | 1986-11-26 | Glaxo Group Ltd | Chemical compounds |
| GB8625326D0 (en) * | 1986-10-22 | 1986-11-26 | Glaxo Group Ltd | Medicaments |
| US5231208A (en) * | 1987-06-16 | 1993-07-27 | Nissan Chemical Industries, Ltd. | Substituted cyclic ketones, substituted cyclic enones, and process for producing the same |
| US5254708A (en) * | 1987-06-16 | 1993-10-19 | Nissan Chemical Industries, Ltd. | Substituted cyclic ketones, substituted cyclic enones, and process for producing the same |
| US5227505A (en) * | 1987-06-16 | 1993-07-13 | Nissan Chemical Industries, Ltd. | Substituted cyclic ketones, substituted cyclic enones, and process for producing the same |
| JP2696933B2 (en) * | 1987-06-16 | 1998-01-14 | 日産化学工業株式会社 | Substituted cyclic ketones and substituted cyclic enones and methods for their preparation |
| GB8822141D0 (en) * | 1988-09-21 | 1988-10-26 | Glaxo Group Ltd | Chemical compounds |
| AU1709699A (en) | 1997-12-22 | 1999-07-12 | Alcon Laboratories, Inc. | 13-oxa prostaglandins for the treatment of glaucoma and ocular hypertension |
| JP4666257B2 (en) | 2003-07-25 | 2011-04-06 | 小野薬品工業株式会社 | Cartilage-related disease treatment |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ197729A (en) * | 1980-08-12 | 1985-03-20 | Sanofi Sa | 13-oxaprostanoic acid derivatives and pharmaceutical compositions |
| GB2082176B (en) * | 1980-08-12 | 1984-07-11 | Sanofi Sa | Heteroprostaglandin derivatives and processes for preparing them |
| GB8410396D0 (en) * | 1984-04-24 | 1984-05-31 | Glaxo Group Ltd | Carbocyclic compounds |
-
1985
- 1985-04-23 GB GB858510277A patent/GB8510277D0/en active Pending
-
1986
- 1986-04-21 IL IL78552A patent/IL78552A/en not_active IP Right Cessation
- 1986-04-22 IT IT47919/86A patent/IT1190277B/en active
- 1986-04-22 AU AU56461/86A patent/AU593797B2/en not_active Ceased
- 1986-04-22 FI FI861687A patent/FI85368C/en not_active IP Right Cessation
- 1986-04-22 CN CN86102778A patent/CN1011783B/en not_active Expired
- 1986-04-22 NO NO861584A patent/NO165069C/en unknown
- 1986-04-22 ES ES554238A patent/ES8802137A1/en not_active Expired
- 1986-04-22 CA CA000507274A patent/CA1275094A/en not_active Expired - Fee Related
- 1986-04-22 BE BE0/216578A patent/BE904656A/en not_active IP Right Cessation
- 1986-04-22 GR GR861060A patent/GR861060B/en unknown
- 1986-04-22 CH CH1622/86A patent/CH667265A5/en not_active IP Right Cessation
- 1986-04-22 SE SE8601852A patent/SE460193B/en not_active IP Right Cessation
- 1986-04-22 LU LU86404A patent/LU86404A1/en unknown
- 1986-04-22 NL NL8601025A patent/NL8601025A/en not_active Application Discontinuation
- 1986-04-22 DK DK183986A patent/DK183986A/en not_active Application Discontinuation
- 1986-04-22 NZ NZ215910A patent/NZ215910A/en unknown
- 1986-04-22 KR KR1019860003086A patent/KR860008132A/en not_active Application Discontinuation
- 1986-04-22 ZA ZA863006A patent/ZA863006B/en unknown
- 1986-04-22 PH PH33693A patent/PH23597A/en unknown
- 1986-04-22 DE DE19863613573 patent/DE3613573A1/en not_active Withdrawn
- 1986-04-22 AT AT0106986A patent/AT395421B/en not_active IP Right Cessation
- 1986-04-22 GB GB08609821A patent/GB2174702B/en not_active Expired
- 1986-04-22 PT PT82440A patent/PT82440B/en not_active IP Right Cessation
- 1986-04-22 FR FR868605781A patent/FR2580632B1/en not_active Expired
- 1986-04-23 JP JP61092446A patent/JPS61249951A/en active Pending
- 1986-10-03 HU HU864173A patent/HU199411B/en not_active IP Right Cessation
- 1986-12-30 MY MYPI86000259A patent/MY100829A/en unknown
-
1987
- 1987-08-12 ES ES557659A patent/ES8900044A1/en not_active Expired
-
1988
- 1988-04-12 ES ES557828A patent/ES9000022A1/en not_active Expired - Fee Related
-
1990
- 1990-11-15 SG SG929/90A patent/SG92990G/en unknown
-
1991
- 1991-07-04 HK HK516/91A patent/HK51691A/en unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| HU90 | Patent valid on 900628 | ||
| HMM4 | Cancellation of final prot. due to non-payment of fee |