ES8605679A1 - Procedimiento para producir un preparado acuoso de insulina estabilizado frente a solicitaciones mecanicas - Google Patents

Procedimiento para producir un preparado acuoso de insulina estabilizado frente a solicitaciones mecanicas

Info

Publication number
ES8605679A1
ES8605679A1 ES543972A ES543972A ES8605679A1 ES 8605679 A1 ES8605679 A1 ES 8605679A1 ES 543972 A ES543972 A ES 543972A ES 543972 A ES543972 A ES 543972A ES 8605679 A1 ES8605679 A1 ES 8605679A1
Authority
ES
Spain
Prior art keywords
plunger pipe
plate
damper
sealing plate
pipe
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES543972A
Other languages
English (en)
Other versions
ES543972A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19843443877 external-priority patent/DE3443877A1/de
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of ES543972A0 publication Critical patent/ES543972A0/es
Publication of ES8605679A1 publication Critical patent/ES8605679A1/es
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Zoology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Luminescent Compositions (AREA)
  • Prostheses (AREA)
  • External Artificial Organs (AREA)
  • Steroid Compounds (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

Abstract

METODO DE PREPARACION DE COMPOSICIONES ACUOSAS DE INSULINA ESTABILIZADAS FRENTE A SOLICITACIONES MECANICAS. COMPRENDE LA ADICION DE 1 A 30% EN PESO DE UN AGENTE ESPESANTE QUE PUEDA ACTUAR COMO ADITIVO DE DEPOSITO, FISIOLOGICAMENTE COMPATIBLE Y UNA SUSTANCIA TENSIOACTIVA, TAMBIEN FISIOLOGICAMENTE COMPATIBLE, A UNA COMPOSICION ACUOSA DE INSULINA, QUE TIENE UNA CONCENTRACION DE INSULINA SUPERIOR A 1 U.I./ML. SE AJUSTA EL PH A UN VALOR ENTRE 2,5 Y 8,5, SE AÑADE UN TAMPON, UN AGENTE DE ISOTONIA, UN AGENTE CONSERVANTE Y HASTA 100 M07G DE IONES DE ZINC CON CADA 100 U.I., CON LO QUE SE PRODUCE UNA COMPOSICION ACUOSA QUE TIENE UNA VISCOSIDAD DE AL MENOS 1,75 MPAS, A 4JC. ESTAS COMPOSICIONES TIENEN APLICACIONES FARMACOLOGICAS PARA EMPLEAR EN APARATOS DOSIFICADORES AUTOMATICOS EN EL TRATAMIENTO DE LA DIABETES MELLITUS.
ES543972A 1984-06-09 1985-06-07 Procedimiento para producir un preparado acuoso de insulina estabilizado frente a solicitaciones mecanicas Expired ES8605679A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE3421615 1984-06-09
DE3421613 1984-06-09
DE19843443877 DE3443877A1 (de) 1984-06-09 1984-12-01 Insulinzubereitungen, verfahren zu deren herstellung und deren verwendung

Publications (2)

Publication Number Publication Date
ES543972A0 ES543972A0 (es) 1986-01-16
ES8605679A1 true ES8605679A1 (es) 1986-01-16

Family

ID=27192050

Family Applications (1)

Application Number Title Priority Date Filing Date
ES543972A Expired ES8605679A1 (es) 1984-06-09 1985-06-07 Procedimiento para producir un preparado acuoso de insulina estabilizado frente a solicitaciones mecanicas

Country Status (16)

Country Link
EP (1) EP0166971B1 (es)
AT (1) ATE50502T1 (es)
AU (1) AU575951B2 (es)
CA (1) CA1258427A (es)
DE (1) DE3576120D1 (es)
DK (1) DK162255C (es)
ES (1) ES8605679A1 (es)
FI (1) FI80596C (es)
GR (1) GR851393B (es)
HU (1) HU200102B (es)
IE (1) IE57998B1 (es)
IL (1) IL75448A (es)
NO (1) NO164277C (es)
NZ (1) NZ212338A (es)
PH (1) PH24118A (es)
PT (1) PT80620B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ228285A (en) * 1988-03-11 1991-08-27 Teikoku Seiyaku Kk Pharmaceutical composition comprising a polypeptide and adapted for intravaginal administration
DE10114178A1 (de) 2001-03-23 2002-10-10 Aventis Pharma Gmbh Zinkfreie und zinkarme Insulinzubereitungen mit verbesserter Stabilität
DE10227232A1 (de) * 2002-06-18 2004-01-15 Aventis Pharma Deutschland Gmbh Saure Insulinzubereitungen mit verbesserter Stabilität
CN102256618A (zh) 2008-10-17 2011-11-23 赛诺菲-安万特德国有限公司 胰岛素和glp-1激动剂的组合
JP5832439B2 (ja) 2009-11-13 2015-12-16 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング Ｇｌｐ−１アゴニスト、インスリン及びメチオニンを含む薬学的組成物
US9707176B2 (en) 2009-11-13 2017-07-18 Sanofi-Aventis Deutschland Gmbh Pharmaceutical composition comprising a GLP-1 agonist and methionine
ES2606554T3 (es) 2010-08-30 2017-03-24 Sanofi-Aventis Deutschland Gmbh Uso de AVE0010 para la fabricación de un medicamento para el tratamiento de la diabetes mellitus de tipo 2
US9821032B2 (en) 2011-05-13 2017-11-21 Sanofi-Aventis Deutschland Gmbh Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
TWI559929B (en) 2011-09-01 2016-12-01 Sanofi Aventis Deutschland Pharmaceutical composition for use in the treatment of a neurodegenerative disease
JP6457484B2 (ja) 2013-04-03 2019-01-23 サノフイＳａｎｏｆｉ インスリンの長時間作用型製剤による糖尿病の治療
AU2015359376B2 (en) 2014-12-12 2021-09-09 Sanofi-Aventis Deutschland Gmbh Insulin glargine/lixisenatide fixed ratio formulation
TWI748945B (zh) 2015-03-13 2021-12-11 德商賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患治療
TW201705975A (zh) 2015-03-18 2017-02-16 賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患之治療

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2474729A (en) * 1945-01-03 1949-06-28 Rhone Poulenc Sa Insulin preparations
US2574889A (en) * 1947-10-06 1951-11-13 Leo Ab Methylated gelatin-insulin preparation
SU1011126A1 (ru) * 1981-07-14 1983-04-15 Всесоюзный научно-исследовательский и испытательный институт медицинской техники Средство дл лечени сахарного диабета
CA1176160A (en) * 1981-08-27 1984-10-16 Ronald E. Chance Human proinsulin pharmaceutical formulations
FI78616C (fi) * 1982-02-05 1989-09-11 Novo Industri As Foerfarande foer framstaellning av en foer infusionsaendamaol avsedd stabiliserad insulinloesning, som har en foerhoejd zinkhalt.
AU4292585A (en) * 1984-04-30 1985-11-28 Trustees Of Columbia University In The City Of New York, The Topical treatment of diabetes with insulin and penetrant enhancer applied to the skin and covered by a patch

Also Published As

Publication number Publication date
IE851431L (en) 1985-12-09
HU200102B (en) 1990-04-28
FI80596C (fi) 1990-07-10
IE57998B1 (en) 1993-06-02
GR851393B (en) 1985-11-25
HUT37893A (en) 1986-03-28
NZ212338A (en) 1989-02-24
EP0166971B1 (de) 1990-02-28
FI852273L (fi) 1985-12-10
DK254585D0 (da) 1985-06-06
ES543972A0 (es) 1986-01-16
PT80620A (de) 1985-07-01
NO852314L (no) 1985-12-10
IL75448A0 (en) 1985-10-31
ATE50502T1 (de) 1990-03-15
DE3576120D1 (de) 1990-04-05
DK254585A (da) 1985-12-10
FI80596B (fi) 1990-03-30
FI852273A0 (fi) 1985-06-06
AU575951B2 (en) 1988-08-11
DK162255B (da) 1991-10-07
EP0166971A1 (de) 1986-01-08
PH24118A (en) 1990-03-05
PT80620B (pt) 1987-10-20
CA1258427A (en) 1989-08-15
IL75448A (en) 1989-07-31
NO164277C (no) 1990-09-19
AU4342485A (en) 1985-12-12
DK162255C (da) 1992-03-16
NO164277B (no) 1990-06-11

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20051102