ES480827A1 - Procedimiento para la preparacion de acidos fenilaminotiofe-noaceticos. - Google Patents

Procedimiento para la preparacion de acidos fenilaminotiofe-noaceticos.

Info

Publication number
ES480827A1
ES480827A1 ES480827A ES480827A ES480827A1 ES 480827 A1 ES480827 A1 ES 480827A1 ES 480827 A ES480827 A ES 480827A ES 480827 A ES480827 A ES 480827A ES 480827 A1 ES480827 A1 ES 480827A1
Authority
ES
Spain
Prior art keywords
denotes
group
atom
phenylaminothiophene
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES480827A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda GmbH
Original Assignee
Byk Gulden Lomberg Chemische Fabrik GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Byk Gulden Lomberg Chemische Fabrik GmbH filed Critical Byk Gulden Lomberg Chemische Fabrik GmbH
Publication of ES480827A1 publication Critical patent/ES480827A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/36—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pain & Pain Management (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Procedimiento para la preparación de ácidos fenilaminotiofenoacéticos de la fórmula general I **(Fórmula)** en donde R1 significa un átomo de hidrógeno, un átomo de cloro, un átomo de bromo a o un grupo metilo, R2 significa un grupo -CH2-COOH o un grupo -CH2-COOR6 y R3 significa un átomo de hidrógeno un átomo de halógeno, un grupo alcohilo, un grupo alcoxi o un grupo trifluorometico, R4 tiene uno de los significados de R3, R5 significa un átomo de hidrógeno, un átomo de halógeno o un grupo alcohilo, R6 significa un grupo alcohilo con 1 a 5 átomos de carbono, eventualmente sustituido con grupos hidroxi, hidroxialcoxi o alcanoiloxi, o un grupo bencilo; y n significa 1 ó 2 y las sales de los ácidos.
ES480827A 1978-05-24 1979-05-23 Procedimiento para la preparacion de acidos fenilaminotiofe-noaceticos. Expired ES480827A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH568778 1978-05-24
CH341979 1979-04-10

Publications (1)

Publication Number Publication Date
ES480827A1 true ES480827A1 (es) 1979-12-01

Family

ID=25692954

Family Applications (1)

Application Number Title Priority Date Filing Date
ES480827A Expired ES480827A1 (es) 1978-05-24 1979-05-23 Procedimiento para la preparacion de acidos fenilaminotiofe-noaceticos.

Country Status (17)

Country Link
US (1) US4272507A (es)
EP (1) EP0005559B1 (es)
AU (1) AU522119B2 (es)
CA (1) CA1132585A (es)
DE (2) DE2961218D1 (es)
DK (1) DK157020C (es)
ES (1) ES480827A1 (es)
FR (1) FR2426686A1 (es)
GB (1) GB2021584B (es)
HU (1) HU181648B (es)
IE (1) IE48508B1 (es)
IL (1) IL57360A (es)
MY (1) MY8600270A (es)
NZ (1) NZ190521A (es)
PT (1) PT69655A (es)
SG (1) SG70185G (es)
YU (1) YU118379A (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH672888A5 (es) * 1986-11-07 1990-01-15 Mepha Ag
EP0338493B1 (de) * 1988-04-22 1996-10-16 Byk Gulden Lomberg Chemische Fabrik GmbH Tetrahydro-4-phenylimino-3-thiophenessigsäuren
ES2083961T3 (es) * 1988-04-22 1996-05-01 Byk Gulden Lomberg Chem Fab Acidos 3-anilino-2-hidroxicarbonil-4-tiofenoaceticos.
GR900100380A (el) * 1989-05-20 1991-10-10 Fisons Plc Μέ?οδος παρασκευής αντι-φλεγμονωδών παραγώγων αμινοφενόλης.
US5556863A (en) * 1993-06-11 1996-09-17 Astra Aktiebolag Compound for gastric acid secretion inhibition
IS4164A (is) * 1993-06-11 1994-12-12 Ab Astra Efnasambönd sem hindra flæði magasýru
US6858223B2 (en) * 1998-06-23 2005-02-22 Altana Pharma Ag Compositions comprising phenylaminothiophenacetic acid derivatives for the treatment of acute or adult respiratory distress syndrome (ARDS) and infant respiratory distress syndrome (IRDS)
DE19827907C2 (de) * 1998-06-23 2003-05-15 Altana Pharma Ag Neue pharmazeutische Zusammensetzungen zur Behandlung von IRDS und ARDS
US7524973B2 (en) * 2003-02-19 2009-04-28 Altana Pharma Ag Nitrate esters of phenylaminothiophenacetic acid derivatives
EP2508511A1 (en) * 2011-04-07 2012-10-10 Laboratoire Biodim Inhibitors of viral replication, their process of preparation and their therapeutical uses

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3445473A (en) * 1965-04-10 1969-05-20 Hoechst Ag 3-anilino-thiophene-4-carboxylic acids,esters,and amides

Also Published As

Publication number Publication date
AU4728579A (en) 1979-11-29
EP0005559A1 (de) 1979-11-28
DE2961218D1 (en) 1982-01-14
GB2021584B (en) 1982-09-22
FR2426686A1 (fr) 1979-12-21
DK157020B (da) 1989-10-30
DK157020C (da) 1990-03-26
CA1132585A (en) 1982-09-28
MY8600270A (en) 1986-12-31
IE48508B1 (en) 1985-02-20
YU118379A (en) 1983-02-28
AU522119B2 (en) 1982-05-20
SG70185G (en) 1989-09-29
EP0005559B1 (de) 1981-11-04
GB2021584A (en) 1979-12-05
DE2920861A1 (de) 1979-11-29
NZ190521A (en) 1980-10-08
IL57360A (en) 1982-08-31
IL57360A0 (en) 1979-09-30
IE790996L (en) 1979-11-24
DK215079A (da) 1979-11-25
HU181648B (en) 1983-10-28
FR2426686B1 (es) 1980-12-12
PT69655A (de) 1979-06-01
US4272507A (en) 1981-06-09

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19991202