ES8202544A1 - Procedimiento para la preparacion de 2-fenilamino-imidazoli-nas -(2) sustituidas - Google Patents

Procedimiento para la preparacion de 2-fenilamino-imidazoli-nas -(2) sustituidas

Info

Publication number
ES8202544A1
ES8202544A1 ES497664A ES497664A ES8202544A1 ES 8202544 A1 ES8202544 A1 ES 8202544A1 ES 497664 A ES497664 A ES 497664A ES 497664 A ES497664 A ES 497664A ES 8202544 A1 ES8202544 A1 ES 8202544A1
Authority
ES
Spain
Prior art keywords
acid addition
addition salts
imidazolines
phenylamino
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES497664A
Other languages
English (en)
Other versions
ES497664A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CH Boehringer Sohn AG and Co KG
Original Assignee
CH Boehringer Sohn AG and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CH Boehringer Sohn AG and Co KG filed Critical CH Boehringer Sohn AG and Co KG
Publication of ES497664A0 publication Critical patent/ES497664A0/es
Publication of ES8202544A1 publication Critical patent/ES8202544A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/44—Nitrogen atoms not forming part of a nitro radical
    • C07D233/52—Nitrogen atoms not forming part of a nitro radical with hetero atoms directly attached to said nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE 2-FENILAMINO-IMIDZOLINAS-(2) SUSTITUIDAS, Y DE SUS SALES DE ACIDO, FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE R1 Y R2, SON FLUOR, CLORO, BROMO O UN RADICAL TRIBLUOROMETILO; Y R3 PUEDE SER UNO DE VARIOS TIPOS DE RADICALES. CONSISTE EN LA REACCION DE UNA 2-FENILAMINO-IMIDAZOLINA-(2) DE FORMULA (II) O SU SAL SODICA CON UN HALOGENURO DE FORMULA R3X, EN LAS QUE R1, R2 Y R3 TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I) Y X ES CLORO, BROMO O YODO. LA REACCION SE LLEVA A CABO EN UN DISOLVENTE ORGANICO POLAR O NO POLAR Y EN PRESENCIA DE UN AGENTE FIJADOR DE ACIDOS, O LA TEMPERATURA AMBIENTE.
ES497664A 1979-12-14 1980-12-12 Procedimiento para la preparacion de 2-fenilamino-imidazoli-nas -(2) sustituidas Expired ES8202544A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19792950345 DE2950345A1 (de) 1979-12-14 1979-12-14 Neue substituierte 2-phenylaminoimidazoline-(2), deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zur herstellung derselben

Publications (2)

Publication Number Publication Date
ES497664A0 ES497664A0 (es) 1982-02-01
ES8202544A1 true ES8202544A1 (es) 1982-02-01

Family

ID=6088485

Family Applications (1)

Application Number Title Priority Date Filing Date
ES497664A Expired ES8202544A1 (es) 1979-12-14 1980-12-12 Procedimiento para la preparacion de 2-fenilamino-imidazoli-nas -(2) sustituidas

Country Status (13)

Country Link
US (1) US4327106A (es)
EP (1) EP0030620B1 (es)
JP (1) JPS5692873A (es)
AT (1) ATE7913T1 (es)
AU (1) AU535927B2 (es)
DE (2) DE2950345A1 (es)
DK (1) DK531080A (es)
ES (1) ES8202544A1 (es)
FI (1) FI73414C (es)
IE (1) IE51062B1 (es)
IL (1) IL61695A (es)
NO (1) NO151587C (es)
ZA (1) ZA807790B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2499991A1 (fr) * 1981-02-19 1982-08-20 Sandoz Sa Nouveaux 2,1,3-benzothiadiazoles et 2,1,3-benzoxadiazoles, leur preparation et leur application comme medicaments
US4461904A (en) * 1981-11-20 1984-07-24 Alcon Laboratories, Inc. 2-(Trisubstituted phenylimino)-imidazolines
US8328017B2 (en) 2006-04-11 2012-12-11 Poppack, Llc User inflated breachable container, and method

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2016290A1 (de) * 1970-04-06 1971-11-04 C H Boehrmger Sohn, 6507 Ingel heim Substituierte N Hydroxylakyl 2 arylamine) imidazoline (2) und Verfahren zu deren Herstellung
DE2457979A1 (de) * 1974-12-07 1976-06-16 Beiersdorf Ag 2-n-aryl-hydroxyamino-imidazoline-(2) und verfahren zu deren herstellung
DE2830278A1 (de) * 1978-07-10 1980-01-31 Boehringer Sohn Ingelheim Neue substituierte 2-phenylamino-imidazoline-(2), deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zur herstellung derselben
DE2831671A1 (de) * 1978-07-19 1980-02-07 Boehringer Sohn Ingelheim Neue substituierte 2-phenylamino-imidazoline-(2), deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zur herstellung derselben
DE2855306A1 (de) * 1978-12-21 1980-07-10 Boehringer Sohn Ingelheim Mittel zur senkung der herzfrequenz

Also Published As

Publication number Publication date
NO151587C (no) 1985-05-08
EP0030620B1 (de) 1984-06-13
DE3068245D1 (en) 1984-07-19
DK531080A (da) 1981-06-15
FI803887L (fi) 1981-06-15
ZA807790B (en) 1982-07-28
IE51062B1 (en) 1986-09-17
DE2950345A1 (de) 1981-07-02
ATE7913T1 (de) 1984-06-15
FI73414C (fi) 1987-10-09
JPS5692873A (en) 1981-07-27
AU6537180A (en) 1981-06-18
EP0030620A2 (de) 1981-06-24
EP0030620A3 (en) 1981-09-02
ES497664A0 (es) 1982-02-01
IL61695A0 (en) 1981-01-30
AU535927B2 (en) 1984-04-12
IL61695A (en) 1984-10-31
NO151587B (no) 1985-01-21
FI73414B (fi) 1987-06-30
NO803748L (no) 1981-06-15
IE802602L (en) 1981-06-14
US4327106A (en) 1982-04-27

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