ES8301219A1 - Procedimiento para la preparacion de 2-fenilamino-imidazoli-nas-(2) sustituidas - Google Patents

Procedimiento para la preparacion de 2-fenilamino-imidazoli-nas-(2) sustituidas

Info

Publication number
ES8301219A1
ES8301219A1 ES506103A ES506103A ES8301219A1 ES 8301219 A1 ES8301219 A1 ES 8301219A1 ES 506103 A ES506103 A ES 506103A ES 506103 A ES506103 A ES 506103A ES 8301219 A1 ES8301219 A1 ES 8301219A1
Authority
ES
Spain
Prior art keywords
acid addition
addition salts
imidazoline
derivatives
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES506103A
Other languages
English (en)
Other versions
ES506103A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CH Boehringer Sohn AG and Co KG
Original Assignee
CH Boehringer Sohn AG and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CH Boehringer Sohn AG and Co KG filed Critical CH Boehringer Sohn AG and Co KG
Publication of ES506103A0 publication Critical patent/ES506103A0/es
Publication of ES8301219A1 publication Critical patent/ES8301219A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/44—Nitrogen atoms not forming part of a nitro radical
    • C07D233/50—Nitrogen atoms not forming part of a nitro radical with carbocyclic radicals directly attached to said nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE 2-FENILAMINO-IMIDAZOLINAS-(2)SUSTITUIDAS Y DE SUS SALES DE ADICION DE ACIDO, DE FORMULA (I), EN LA QUE R -R PUEDEN SER VARIOS TIPOS DE RADICALES Y N VALE 0 O 1. CONSISTE EN LA REACCION DE UN DERIVADO DE IMIDAZOLINA DE FORMULA (II), O SU ANION, CON UN HALOGENURO DE FORMULA HAL-R , EN LAS QUE HAL ES CLORO, BROMO O YODO; Y R -R Y N TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). LA REACCION SE LLEVA A CABO EN UN DISOLVENTE ORGANICO, EN PRESENCIA DE UN AGENTE FIJADOR DE ACIDOS, A UNA TEMPERATURA ENTRE 40<025>C Y 120<025>C. >ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE ENFERMEDADES CORONARIAS.
ES506103A 1979-11-26 1981-10-08 Procedimiento para la preparacion de 2-fenilamino-imidazoli-nas-(2) sustituidas Expired ES8301219A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19792947563 DE2947563A1 (de) 1979-11-26 1979-11-26 Neue substituierte 2-phenylamino-imidazoline-(2), deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zur herstellung derselben

Publications (2)

Publication Number Publication Date
ES506103A0 ES506103A0 (es) 1982-11-16
ES8301219A1 true ES8301219A1 (es) 1982-11-16

Family

ID=6086893

Family Applications (2)

Application Number Title Priority Date Filing Date
ES497105A Expired ES8201140A1 (es) 1979-11-26 1980-11-25 Procedimiento para la preparacion de 2-fenilamino-imidazoli nas-(2)sustituidas.
ES506103A Expired ES8301219A1 (es) 1979-11-26 1981-10-08 Procedimiento para la preparacion de 2-fenilamino-imidazoli-nas-(2) sustituidas

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES497105A Expired ES8201140A1 (es) 1979-11-26 1980-11-25 Procedimiento para la preparacion de 2-fenilamino-imidazoli nas-(2)sustituidas.

Country Status (13)

Country Link
US (1) US4361575A (es)
EP (1) EP0029505B1 (es)
JP (1) JPS5687568A (es)
AT (1) ATE9333T1 (es)
AU (1) AU539870B2 (es)
DE (2) DE2947563A1 (es)
DK (1) DK146688C (es)
ES (2) ES8201140A1 (es)
FI (1) FI68616C (es)
IE (1) IE50570B1 (es)
IL (1) IL61560A (es)
NO (1) NO150436C (es)
ZA (1) ZA807337B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2499991A1 (fr) * 1981-02-19 1982-08-20 Sandoz Sa Nouveaux 2,1,3-benzothiadiazoles et 2,1,3-benzoxadiazoles, leur preparation et leur application comme medicaments
US4515800A (en) * 1981-11-20 1985-05-07 Icilio Cavero Method of lowering intraocular pressure using phenylimino-imidazoles
US4461904A (en) * 1981-11-20 1984-07-24 Alcon Laboratories, Inc. 2-(Trisubstituted phenylimino)-imidazolines
DE3514351A1 (de) * 1985-04-20 1986-11-06 Boehringer Ingelheim KG, 6507 Ingelheim Neue substituierte 2-(n-alkinyl-n-phenyl)amino)-imidazolinderivate, deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zu deren herstellung
WO1996004270A1 (en) 1994-08-04 1996-02-15 Synaptic Pharmaceutical Corporation Novel benzimidazole derivatives
US6495583B1 (en) 1997-03-25 2002-12-17 Synaptic Pharmaceutical Corporation Benzimidazole derivatives
EP1431292A1 (en) * 2002-12-16 2004-06-23 Laboratoire Theramex 1-N-phenylamino-1H-imidazole derivatives as aromatase inhibitors

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE759048A (fr) * 1969-11-17 1971-05-17 Boehringer Sohn Ingelheim Nouvelles n-aminoalcoyl-arylamino-imidazolines-(2) substituees et procedes pour les fabriquer
BE759125A (fr) * 1969-11-19 1971-05-18 Boehringer Sohn Ingelheim Nouvelles n-allyl-2-arylamino-imidazolines-(2) substituees et procedes pour les fabriquer
US3850926A (en) * 1971-01-21 1974-11-26 Boehringer Sohn Ingelheim 2-(n-substituted-phenylamino)-imidazolines-(2)
BE787683A (fr) * 1971-08-20 1973-02-19 Boehringer Sohn Ingelheim 2-phenylimino-imidazolidines, leurs sels d'addition avec des acides et procedes pour les fabriquer
DE2259160A1 (de) * 1972-12-02 1974-06-06 Boehringer Sohn Ingelheim Neue substituierte 2-phenylaminoimidazoline, deren saeureadditionssalze und verfahren zur herstellung derselben sowie ihre verwendung als arzneimittel
DE2457979A1 (de) * 1974-12-07 1976-06-16 Beiersdorf Ag 2-n-aryl-hydroxyamino-imidazoline-(2) und verfahren zu deren herstellung
DE2523103C3 (de) * 1975-05-24 1979-11-29 C.H. Boehringer Sohn, 6507 Ingelheim Substituierte 2-[N-Progargyl-N-(2-chlorphenyl)amino] -imidazoline-^), deren Säureadditionssalze, Verfahren zu ihrer Herstellung und deren Verwendung
DE2636732A1 (de) * 1976-08-14 1978-02-16 Boehringer Sohn Ingelheim Neue substituierte 2-phenylamino- imidazoline- (2), deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zur herstellung derselben
DE2830278A1 (de) * 1978-07-10 1980-01-31 Boehringer Sohn Ingelheim Neue substituierte 2-phenylamino-imidazoline-(2), deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zur herstellung derselben
DE2831234A1 (de) * 1978-07-15 1980-01-31 Boehringer Sohn Ingelheim Neue substituierte 2-phenylamino-imidazoline-(2) deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zur herstellung derselben
DE2831671A1 (de) * 1978-07-19 1980-02-07 Boehringer Sohn Ingelheim Neue substituierte 2-phenylamino-imidazoline-(2), deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zur herstellung derselben

Also Published As

Publication number Publication date
AU6469180A (en) 1981-06-04
ES497105A0 (es) 1981-12-01
ATE9333T1 (de) 1984-09-15
DE3069173D1 (en) 1984-10-18
IE802445L (en) 1981-05-26
FI803654L (fi) 1981-05-27
FI68616B (fi) 1985-06-28
ES506103A0 (es) 1982-11-16
NO150436B (no) 1984-07-09
JPS5687568A (en) 1981-07-16
IE50570B1 (en) 1986-05-14
AU539870B2 (en) 1984-10-18
DE2947563A1 (de) 1981-06-04
FI68616C (fi) 1985-10-10
DK146688B (da) 1983-12-05
ES8201140A1 (es) 1981-12-01
DK146688C (da) 1984-05-21
US4361575A (en) 1982-11-30
NO803547L (no) 1981-05-27
ZA807337B (en) 1982-08-25
EP0029505A1 (de) 1981-06-03
EP0029505B1 (de) 1984-09-12
IL61560A (en) 1984-09-30
IL61560A0 (en) 1980-12-31
NO150436C (no) 1984-10-17
DK501480A (da) 1981-05-27

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