ES2368594T3 - Derivados sustituidos de ciclohexilmetilo. - Google Patents

Derivados sustituidos de ciclohexilmetilo. Download PDF

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ES2368594T3
ES2368594T3 ES06841030T ES06841030T ES2368594T3 ES 2368594 T3 ES2368594 T3 ES 2368594T3 ES 06841030 T ES06841030 T ES 06841030T ES 06841030 T ES06841030 T ES 06841030T ES 2368594 T3 ES2368594 T3 ES 2368594T3
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cyclohexilmetilo
substituted derivatives
compounds
cyclohexylmethyl
preparing
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Stefan OBERBÖRSCH
Beatrix Merla
Bernd Sundermann
Werner Englberger
Hagen-Heinrich Hennies
Achim Kless
Petra Bloms-Funke
Babette-Yvonne Kögel
Heinz Graubaum
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Gruenenthal GmbH
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Abstract

Derivados sustituidos de ciclohexilmetilo de la fórmula general I en la que R 1 significa alquilo de C1-C8, en cada caso ramificado o sin ramificar, saturado o insaturado, sin sustituir o sustituido una vez o múltiples veces; arilo o heteroarilo, sin sustituir o sustituido una vez o múltiples veces; cicloalquilo de C3-10 saturado o insaturado, sin sustituir o sustituido una vez o múltiples veces; un radical arilo o heteroarilo unido a través de una cadena de alquilo de C1-4, en cada caso sin sustituir o sustituido una vez o múltiples veces; (CH2)mCHN-OH, (CH2)nNR 6 R 7 o (CH2)nOR 8 , representando n 0, 1, 2 ó 3 y m 0, 1 ó 2; o significa un grupo C(O)OR 9 ó CONR 10 R 11 unido a través de un grupo alquilo de C1-3, que puede ser saturado o insaturado; R 2 significa H u OH; ó R 1 y R 2 representan en común o =N-OH; R 3 significa arilo o heteroarilo, sin sustituir o sustituido una vez o múltiples veces; o significa un radical arilo unido a través de un grupo alquilo de C1-3, que puede estar sin sustituir o sustituido una vez o múltiples veces; R 4 y R 5 significan independientemente uno de otro H; alquilo de C1-3, sin sustituir, no significando R 4 y R 5 simultáneamente H, o los radicales R 4 y R 5 significan en común CH2CH2OCH2CH2, o (CH2)3-6; R 6 significa H; alquilo de C1-8, saturado o insaturado, ramificado o sin ramificar, sin sustituir o sustituido una vez o múltiples veces; arilo, heteroarilo o cicloalquilo de C3-10, en cada caso sin sustituir o sustituido una vez o múltiples veces; o un radical arilo o heteroarilo unido a través de una cadena de alquilo de C1-4, en cada caso sin sustituir o sustituido una vez o múltiples veces; R 7 significa H; alquilo de C1-8, saturado o insaturado, ramificado o sin ramificar, sin sustituir o sustituido una vez o múltiples veces; arilo, heteroarilo o cicloalquilo de C3-10, en cada caso sin sustituir o sustituido una vez o múltiples veces; o un radical arilo o heteroarilo unido a través de una cadena de alquilo de C1-4, en cada caso sin sustituir o sustituido una vez o múltiples veces; C(O)NR 10 R 11 , C(S)NR 10 R 11 , SO2R 12 o C(O)R 13 ; R 8 significa H; alquilo de C1-8, en cada caso ramificado o sin ramificar, saturado o insaturado, sin sustituir o sustituido una vez o múltiples veces; cicloalquilo de C3-10, saturado o insaturado, sin sustituir o sustituido una vez o múltiples veces; un radical arilo o heteroarilo unido a través de una cadena de alquilo de C1-4, sin sustituir o sustituido una vez o múltiples veces; R 9 significa H; alquilo de C1-8, saturado o insaturado, ramificado o sin ramificar, sin sustituir o sustituido una vez o múltiples veces; R 10 y R 11 significan independientemente uno de otro H; cicloalquilo de C3-10, saturado o insaturado, sin sustituir o sustituido una vez o múltiples veces; arilo o heteroarilo, en cada caso sin sustituir o sustituido una vez o múltiples veces; o un radical arilo o heteroarilo unido a través de una cadena de alquilo de C1-4, en cada caso sin sustituir o sustituido una vez o múltiples veces; R 12 significa arilo o heteroarilo, en cada caso sin sustituir o sustituido una vez o múltiples veces; alquilo de C1-8, en cada caso saturado o insaturado, ramificado o sin ramificar, sin sustituir o sustituido una vez o múltiples veces; cicloalquilo de C3-10, saturado o insaturado, sin sustituir o sustituido una vez o múltiples veces; o un radical arilo o heteroarilo unido a través de una cadena de alquilo de C1-3, en cada caso sin sustituir o sustituido una vez o múltiples veces; R 13 significa alquilo de C1-8, saturado o insaturado, ramificado o sin ramificar, sin sustituir o sustituido una vez o múltiples veces; cicloalquilo de C3-10, arilo o heteroarilo, en cada caso sin sustituir o sustituido una vez o múltiples veces; o un radical arilo o heteroarilo unido a través de una cadena de alquilo de C1-4, en cada caso sin sustituir o sustituido una vez o múltiples veces, pudiendo la cadena de alquilo ser ramificada o sin ramificar, y estar sin sustituir o sustituida una vez o múltiples veces; en forma del racemato; de los enantiómeros, de los diastereoisómeros, de mezclas de los enantiómeros o diastereoisómeros, o de un enantiómero o diastereoisómero individual; de las bases y/o de las sales de ácidos fisiológicamente compatibles.
ES06841030T 2005-12-22 2006-12-19 Derivados sustituidos de ciclohexilmetilo. Active ES2368594T3 (es)

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DE102005061428A DE102005061428A1 (de) 2005-12-22 2005-12-22 Substituierte Cyclohexylmethyl-Derivate
DE102005061428 2005-12-22

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CN101384544A (zh) 2009-03-11
AU2006334746A1 (en) 2007-07-19
CA2634567A1 (en) 2007-07-19
EP1989174A1 (de) 2008-11-12
US20090286833A1 (en) 2009-11-19
RU2008129644A (ru) 2010-01-27
WO2007079930A1 (de) 2007-07-19
PT1989174E (pt) 2011-09-20
JP4896157B2 (ja) 2012-03-14
RU2451009C2 (ru) 2012-05-20
IL192253A0 (en) 2008-12-29
SI1989174T1 (sl) 2011-10-28
AU2006334746B2 (en) 2012-02-23
IL192253A (en) 2015-01-29
CY1116885T1 (el) 2017-04-05
HK1125358A1 (en) 2009-08-07
DK1989174T3 (da) 2011-10-10
PL1989174T3 (pl) 2011-11-30
CA2634567C (en) 2014-03-25
EP1989174B1 (de) 2011-08-03
ATE518824T1 (de) 2011-08-15
US8058475B2 (en) 2011-11-15
JP2009520720A (ja) 2009-05-28
CN101384544B (zh) 2014-01-22

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