ES2368594T3 - Derivados sustituidos de ciclohexilmetilo. - Google Patents
Derivados sustituidos de ciclohexilmetilo. Download PDFInfo
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- ES2368594T3 ES2368594T3 ES06841030T ES06841030T ES2368594T3 ES 2368594 T3 ES2368594 T3 ES 2368594T3 ES 06841030 T ES06841030 T ES 06841030T ES 06841030 T ES06841030 T ES 06841030T ES 2368594 T3 ES2368594 T3 ES 2368594T3
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- cyclohexilmetilo
- substituted derivatives
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- cyclohexylmethyl
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- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
- C07C211/29—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
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- C07C211/39—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton
- C07C211/40—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing only non-condensed rings
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- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
- C07C233/04—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C233/06—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
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- C07C233/12—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups
- C07C233/13—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
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- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/18—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
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- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/65—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
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- C07C233/66—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups
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- C07C233/67—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/68—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/73—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
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- C07C251/42—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atom of at least one of the oxyimino groups bound to a carbon atom of a ring other than a six-membered aromatic ring
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- C07C251/44—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atom of at least one of the oxyimino groups being part of a ring other than a six-membered aromatic ring
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- C07C275/26—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of rings other than six-membered aromatic rings
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- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/20—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
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- C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
- C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
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- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
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Abstract
Derivados sustituidos de ciclohexilmetilo de la fórmula general I en la que R 1 significa alquilo de C1-C8, en cada caso ramificado o sin ramificar, saturado o insaturado, sin sustituir o sustituido una vez o múltiples veces; arilo o heteroarilo, sin sustituir o sustituido una vez o múltiples veces; cicloalquilo de C3-10 saturado o insaturado, sin sustituir o sustituido una vez o múltiples veces; un radical arilo o heteroarilo unido a través de una cadena de alquilo de C1-4, en cada caso sin sustituir o sustituido una vez o múltiples veces; (CH2)mCHN-OH, (CH2)nNR 6 R 7 o (CH2)nOR 8 , representando n 0, 1, 2 ó 3 y m 0, 1 ó 2; o significa un grupo C(O)OR 9 ó CONR 10 R 11 unido a través de un grupo alquilo de C1-3, que puede ser saturado o insaturado; R 2 significa H u OH; ó R 1 y R 2 representan en común o =N-OH; R 3 significa arilo o heteroarilo, sin sustituir o sustituido una vez o múltiples veces; o significa un radical arilo unido a través de un grupo alquilo de C1-3, que puede estar sin sustituir o sustituido una vez o múltiples veces; R 4 y R 5 significan independientemente uno de otro H; alquilo de C1-3, sin sustituir, no significando R 4 y R 5 simultáneamente H, o los radicales R 4 y R 5 significan en común CH2CH2OCH2CH2, o (CH2)3-6; R 6 significa H; alquilo de C1-8, saturado o insaturado, ramificado o sin ramificar, sin sustituir o sustituido una vez o múltiples veces; arilo, heteroarilo o cicloalquilo de C3-10, en cada caso sin sustituir o sustituido una vez o múltiples veces; o un radical arilo o heteroarilo unido a través de una cadena de alquilo de C1-4, en cada caso sin sustituir o sustituido una vez o múltiples veces; R 7 significa H; alquilo de C1-8, saturado o insaturado, ramificado o sin ramificar, sin sustituir o sustituido una vez o múltiples veces; arilo, heteroarilo o cicloalquilo de C3-10, en cada caso sin sustituir o sustituido una vez o múltiples veces; o un radical arilo o heteroarilo unido a través de una cadena de alquilo de C1-4, en cada caso sin sustituir o sustituido una vez o múltiples veces; C(O)NR 10 R 11 , C(S)NR 10 R 11 , SO2R 12 o C(O)R 13 ; R 8 significa H; alquilo de C1-8, en cada caso ramificado o sin ramificar, saturado o insaturado, sin sustituir o sustituido una vez o múltiples veces; cicloalquilo de C3-10, saturado o insaturado, sin sustituir o sustituido una vez o múltiples veces; un radical arilo o heteroarilo unido a través de una cadena de alquilo de C1-4, sin sustituir o sustituido una vez o múltiples veces; R 9 significa H; alquilo de C1-8, saturado o insaturado, ramificado o sin ramificar, sin sustituir o sustituido una vez o múltiples veces; R 10 y R 11 significan independientemente uno de otro H; cicloalquilo de C3-10, saturado o insaturado, sin sustituir o sustituido una vez o múltiples veces; arilo o heteroarilo, en cada caso sin sustituir o sustituido una vez o múltiples veces; o un radical arilo o heteroarilo unido a través de una cadena de alquilo de C1-4, en cada caso sin sustituir o sustituido una vez o múltiples veces; R 12 significa arilo o heteroarilo, en cada caso sin sustituir o sustituido una vez o múltiples veces; alquilo de C1-8, en cada caso saturado o insaturado, ramificado o sin ramificar, sin sustituir o sustituido una vez o múltiples veces; cicloalquilo de C3-10, saturado o insaturado, sin sustituir o sustituido una vez o múltiples veces; o un radical arilo o heteroarilo unido a través de una cadena de alquilo de C1-3, en cada caso sin sustituir o sustituido una vez o múltiples veces; R 13 significa alquilo de C1-8, saturado o insaturado, ramificado o sin ramificar, sin sustituir o sustituido una vez o múltiples veces; cicloalquilo de C3-10, arilo o heteroarilo, en cada caso sin sustituir o sustituido una vez o múltiples veces; o un radical arilo o heteroarilo unido a través de una cadena de alquilo de C1-4, en cada caso sin sustituir o sustituido una vez o múltiples veces, pudiendo la cadena de alquilo ser ramificada o sin ramificar, y estar sin sustituir o sustituida una vez o múltiples veces; en forma del racemato; de los enantiómeros, de los diastereoisómeros, de mezclas de los enantiómeros o diastereoisómeros, o de un enantiómero o diastereoisómero individual; de las bases y/o de las sales de ácidos fisiológicamente compatibles.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102005061428A DE102005061428A1 (de) | 2005-12-22 | 2005-12-22 | Substituierte Cyclohexylmethyl-Derivate |
DE102005061428 | 2005-12-22 |
Publications (1)
Publication Number | Publication Date |
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ES2368594T3 true ES2368594T3 (es) | 2011-11-18 |
Family
ID=37909393
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES06841030T Active ES2368594T3 (es) | 2005-12-22 | 2006-12-19 | Derivados sustituidos de ciclohexilmetilo. |
Country Status (18)
Country | Link |
---|---|
US (1) | US8058475B2 (es) |
EP (1) | EP1989174B1 (es) |
JP (1) | JP4896157B2 (es) |
CN (1) | CN101384544B (es) |
AT (1) | ATE518824T1 (es) |
AU (1) | AU2006334746B2 (es) |
CA (1) | CA2634567C (es) |
CY (1) | CY1116885T1 (es) |
DE (1) | DE102005061428A1 (es) |
DK (1) | DK1989174T3 (es) |
ES (1) | ES2368594T3 (es) |
HK (1) | HK1125358A1 (es) |
IL (1) | IL192253A (es) |
PL (1) | PL1989174T3 (es) |
PT (1) | PT1989174E (es) |
RU (1) | RU2451009C2 (es) |
SI (1) | SI1989174T1 (es) |
WO (1) | WO2007079930A1 (es) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2477604A1 (en) | 2002-03-13 | 2003-09-25 | Signum Biosciences, Inc. | Modulation of protein methylation and phosphoprotein phosphate |
US7923041B2 (en) | 2005-02-03 | 2011-04-12 | Signum Biosciences, Inc. | Compositions and methods for enhancing cognitive function |
CA2601777A1 (en) | 2005-02-03 | 2006-08-10 | Signum Biosciences, Inc. | Compositions and methods for enhancing cognitive function |
DE102007020493A1 (de) * | 2007-04-30 | 2008-11-06 | Grünenthal GmbH | Substituierte Amid-Derivate |
EP2518052B1 (de) | 2008-03-27 | 2017-12-20 | Grünenthal GmbH | Substituierte 4-Aminocyclohexan-Derivate |
CA2718209A1 (en) | 2008-03-27 | 2009-10-01 | Gruenenthal Gmbh | (hetero)aryl cyclohexane derivatives |
SI2271613T1 (sl) | 2008-03-27 | 2014-08-29 | Grunenthal Gmbh | Hidroksimetilcikloheksilamini |
TWI466866B (zh) | 2008-03-27 | 2015-01-01 | 被取代之環己基二胺 | |
JP5542119B2 (ja) | 2008-03-27 | 2014-07-09 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | スピロ(5.5)ウンデカン誘導体 |
CA2719742C (en) | 2008-03-27 | 2016-11-08 | Gruenenthal Gmbh | Substituted spirocyclic cyclohexane derivatives |
AU2009239430B2 (en) | 2008-04-21 | 2015-01-22 | Signum Biosciences, Inc. | Compounds, compositions and methods for making the same |
US8273900B2 (en) | 2008-08-07 | 2012-09-25 | Novartis Ag | Organic compounds |
JPWO2013146754A1 (ja) * | 2012-03-27 | 2015-12-14 | 塩野義製薬株式会社 | Trpv4阻害活性を有する芳香族複素5員環誘導体 |
JP6509321B2 (ja) | 2014-07-15 | 2019-05-08 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | 置換アザスピロ(4.5)デカン誘導体 |
TW201607923A (zh) | 2014-07-15 | 2016-03-01 | 歌林達有限公司 | 被取代之氮螺環(4.5)癸烷衍生物 |
CN104402857B (zh) * | 2014-10-31 | 2017-04-12 | 嘉兴学院 | 一种环己二酮单缩酮的纯化方法 |
UY36390A (es) | 2014-11-05 | 2016-06-01 | Flexus Biosciences Inc | Compuestos moduladores de la enzima indolamina 2,3-dioxigenasa (ido), sus métodos de síntesis y composiciones farmacéuticas que los contienen |
CA2964276A1 (en) * | 2014-11-05 | 2016-05-12 | Flexus Biosciences, Inc. | Immunoregulatory agents |
CN107674029A (zh) * | 2016-08-02 | 2018-02-09 | 上海迪诺医药科技有限公司 | 多环化合物、其药物组合物及应用 |
SG11201901452UA (en) | 2016-09-01 | 2019-03-28 | Mebias Discovery Llc | Substituted ureas and methods of making and using same |
JP6571065B2 (ja) | 2016-12-08 | 2019-09-04 | 株式会社東芝 | 振動装置 |
CN113979922A (zh) * | 2020-07-27 | 2022-01-28 | 新发药业有限公司 | 一种n-苄基哌啶-4-甲醛及n-苄基哌啶-4-甲醇的制备方法 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1931927A1 (de) * | 1968-07-06 | 1970-01-15 | Yamanouchi Pharma Co Ltd | Neue Cyclohexylaminderivate |
SE9802208D0 (sv) * | 1998-06-22 | 1998-06-22 | Astra Pharma Inc | Novel compounds |
DE19915601A1 (de) * | 1999-04-07 | 2000-10-19 | Gruenenthal Gmbh | 3-Amino-3-arylpropan-1-ol-Derivate, deren Herstellung und Verwendung |
CN1240206A (zh) * | 1999-06-17 | 2000-01-05 | 华东理工大学 | 1-[2-(二甲氨基)-1-(4-甲氧基苯基)乙基]环已醇盐酸盐的制备方法 |
DE10000312A1 (de) * | 2000-01-05 | 2001-07-12 | Gruenenthal Gmbh | Substituierte Aminomethyl-Phenyl-Cyclohexanderivate |
DE10049481A1 (de) * | 2000-09-29 | 2002-05-02 | Gruenenthal Gmbh | Substituierte C-Cyclohexylmethylamin-Derivate |
DE10108307A1 (de) * | 2001-02-21 | 2002-08-29 | Gruenenthal Gmbh | Substituierte Propan-1,3-diamin-Derivate |
DE10123163A1 (de) * | 2001-05-09 | 2003-01-16 | Gruenenthal Gmbh | Substituierte Cyclohexan-1,4-diaminderivate |
DE10213051B4 (de) * | 2002-03-23 | 2013-03-07 | Grünenthal GmbH | Substituierte 4-Aminocyclohexanole |
DE10224107A1 (de) * | 2002-05-29 | 2003-12-11 | Gruenenthal Gmbh | Kombination ausgewählter Opioide mit anderen Wirkstoffen zur Therapie der Harninkontinenz |
DE10252665A1 (de) * | 2002-11-11 | 2004-06-03 | Grünenthal GmbH | 4-Aminomethyl-1-aryl-cyclohexylamin-Derivate |
DE10356362A1 (de) * | 2003-11-28 | 2005-06-23 | Grünenthal GmbH | Verwendung von 1-Phenyl-3-dimethylamino-propanverbindungen zur Therapie von Angststörungen |
DE102005061427A1 (de) * | 2005-12-22 | 2007-06-28 | Grünenthal GmbH | Substituierte Oxadiazol-Derivate |
-
2005
- 2005-12-22 DE DE102005061428A patent/DE102005061428A1/de not_active Withdrawn
-
2006
- 2006-12-19 PL PL06841030T patent/PL1989174T3/pl unknown
- 2006-12-19 JP JP2008546227A patent/JP4896157B2/ja not_active Expired - Fee Related
- 2006-12-19 EP EP06841030A patent/EP1989174B1/de not_active Not-in-force
- 2006-12-19 AU AU2006334746A patent/AU2006334746B2/en not_active Ceased
- 2006-12-19 CA CA2634567A patent/CA2634567C/en not_active Expired - Fee Related
- 2006-12-19 AT AT06841030T patent/ATE518824T1/de active
- 2006-12-19 CN CN200680053170.XA patent/CN101384544B/zh not_active Expired - Fee Related
- 2006-12-19 ES ES06841030T patent/ES2368594T3/es active Active
- 2006-12-19 RU RU2008129644/04A patent/RU2451009C2/ru not_active IP Right Cessation
- 2006-12-19 SI SI200631115T patent/SI1989174T1/sl unknown
- 2006-12-19 PT PT06841030T patent/PT1989174E/pt unknown
- 2006-12-19 DK DK06841030.7T patent/DK1989174T3/da active
- 2006-12-19 WO PCT/EP2006/012224 patent/WO2007079930A1/de active Application Filing
-
2008
- 2008-06-17 IL IL192253A patent/IL192253A/en not_active IP Right Cessation
- 2008-06-20 US US12/143,433 patent/US8058475B2/en not_active Expired - Fee Related
-
2009
- 2009-05-11 HK HK09104277.7A patent/HK1125358A1/xx not_active IP Right Cessation
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2011
- 2011-11-02 CY CY20111101052T patent/CY1116885T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
EP1989174B1 (de) | 2011-08-03 |
DK1989174T3 (da) | 2011-10-10 |
WO2007079930A1 (de) | 2007-07-19 |
PT1989174E (pt) | 2011-09-20 |
CN101384544A (zh) | 2009-03-11 |
IL192253A (en) | 2015-01-29 |
HK1125358A1 (en) | 2009-08-07 |
PL1989174T3 (pl) | 2011-11-30 |
CN101384544B (zh) | 2014-01-22 |
US8058475B2 (en) | 2011-11-15 |
SI1989174T1 (sl) | 2011-10-28 |
DE102005061428A1 (de) | 2007-08-16 |
JP2009520720A (ja) | 2009-05-28 |
CY1116885T1 (el) | 2017-04-05 |
CA2634567A1 (en) | 2007-07-19 |
AU2006334746A1 (en) | 2007-07-19 |
EP1989174A1 (de) | 2008-11-12 |
US20090286833A1 (en) | 2009-11-19 |
AU2006334746B2 (en) | 2012-02-23 |
RU2451009C2 (ru) | 2012-05-20 |
CA2634567C (en) | 2014-03-25 |
JP4896157B2 (ja) | 2012-03-14 |
RU2008129644A (ru) | 2010-01-27 |
ATE518824T1 (de) | 2011-08-15 |
IL192253A0 (en) | 2008-12-29 |
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