MX2010009022A - Derivados 16 alfa, 17 alfa-acetal glucocorticoesteroideos y su uso. - Google Patents

Derivados 16 alfa, 17 alfa-acetal glucocorticoesteroideos y su uso.

Info

Publication number
MX2010009022A
MX2010009022A MX2010009022A MX2010009022A MX2010009022A MX 2010009022 A MX2010009022 A MX 2010009022A MX 2010009022 A MX2010009022 A MX 2010009022A MX 2010009022 A MX2010009022 A MX 2010009022A MX 2010009022 A MX2010009022 A MX 2010009022A
Authority
MX
Mexico
Prior art keywords
glucocorticosteroidal
alpa
acetal
alpha
derivatives
Prior art date
Application number
MX2010009022A
Other languages
English (en)
Inventor
Matti Lepistoe
Svetlana Ivanova
Haakan Bladh
Frank Burkamp
Tesfaledet Mussie
Sumita Bhattacharyya
Paul Andersson
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of MX2010009022A publication Critical patent/MX2010009022A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pulmonology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

La presente invención proporciona compuestos de la fórmula (I) en donde R1, R2, R3, R4, R5 y R6 son como se definieron en la especificación, a un proceso para su preparación, a las composiciones farmacéuticas que los contienen y a su uso en terapia. (ver fórmula (I)).
MX2010009022A 2008-02-27 2009-02-27 Derivados 16 alfa, 17 alfa-acetal glucocorticoesteroideos y su uso. MX2010009022A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3180108P 2008-02-27 2008-02-27
PCT/SE2009/050220 WO2009108118A1 (en) 2008-02-27 2009-02-27 16 alpha, 17 alpa-acetal glucocorticosteroidal derivatives and their use

Publications (1)

Publication Number Publication Date
MX2010009022A true MX2010009022A (es) 2010-09-07

Family

ID=41016344

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010009022A MX2010009022A (es) 2008-02-27 2009-02-27 Derivados 16 alfa, 17 alfa-acetal glucocorticoesteroideos y su uso.

Country Status (11)

Country Link
US (1) US20110294766A1 (es)
EP (1) EP2257568A1 (es)
JP (1) JP2011513303A (es)
KR (1) KR20110005236A (es)
CN (1) CN102015750A (es)
AU (1) AU2009217824A1 (es)
BR (1) BRPI0907789A2 (es)
CA (1) CA2716476A1 (es)
MX (1) MX2010009022A (es)
RU (1) RU2010133722A (es)
WO (1) WO2009108118A1 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ584160A (en) 2007-10-04 2011-05-27 Astrazeneca Ab Steroidal [3,2-c] pyrazole compounds, with glucocorticoid activity
UY32520A (es) 2009-04-03 2010-10-29 Astrazeneca Ab Compuestos que tienen actividad agonista del receptor de glucocorticoesteroides
JP2013504524A (ja) * 2009-09-11 2013-02-07 シエシー ファルマセウティチィ ソシエタ ペル アチオニ イソオキサゾリジン誘導体
US8470812B2 (en) 2009-12-30 2013-06-25 Arqule, Inc. Substituted benzo-pyrimido-tetrazolo-diazepine compounds
JP6053700B2 (ja) * 2011-03-15 2016-12-27 シエシー ファルマセウティチィ ソシエタ ペル アチオニ イソオキサゾリジン誘導体
US9155747B2 (en) * 2012-09-13 2015-10-13 Chiesi Farmaceutici S.P.A. Isoxazolidine derivatives
PL3464318T3 (pl) * 2016-06-02 2021-11-08 Abbvie Inc. Agonista receptora glukokortykoidowego i jego immunokoniugaty
CR20200239A (es) 2017-12-01 2020-09-21 Abbvie Inc Agonista del receptor de glucocorticoides e inmunoconjugados de este
CN109575095A (zh) * 2019-01-20 2019-04-05 湖南科瑞生物制药股份有限公司 一种16a-羟基醋酸泼尼松龙的制备方法
CN112851743A (zh) * 2019-11-27 2021-05-28 重庆华邦胜凯制药有限公司 一种氧化杂质的制备方法
EP4289857A1 (en) * 2021-02-04 2023-12-13 Shanghai Senhui Medicine Co., Ltd. Drug conjugate of glucocorticoid receptor agonist, and application thereof in medicine
AR125084A1 (es) * 2021-03-23 2023-06-07 Lilly Co Eli Agonistas del receptor de glucocorticoides novedosos
TW202304462A (zh) 2021-03-23 2023-02-01 美商美國禮來大藥廠 糖皮質素受體激動劑
AR125079A1 (es) 2021-03-23 2023-06-07 Lilly Co Eli Agonistas de receptores de glucocorticoides sustituidos con carboxi
TW202327620A (zh) * 2021-09-14 2023-07-16 大陸商映恩生物製藥（蘇州）有限公司 一種抗炎症的化合物及其用途
TW202421101A (zh) * 2022-09-15 2024-06-01 美商艾德森特克斯治療股份有限公司 新穎的糖皮質素受體促效劑及其免疫綴合物

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB933868A (en) * 1958-12-08 1963-08-14 American Cyanamid Co Process for fluorinating steroids
SE8306370D0 (sv) * 1983-11-18 1983-11-18 Draco Ab Novel androstane-17beta-carboxylic acid esters, a process and intermediates for their preparation, compositions and method for the treatment of inflammatory conditions
WO1994025478A1 (en) * 1993-04-29 1994-11-10 Instytut Farmaceutyczny 16α,17α-ACETAL GLUCOCORTICOSTEROIDAL DERIVATIVES
GB0110411D0 (en) * 2001-04-27 2001-06-20 Astrazeneca Ab Chemical process
WO2005028495A1 (en) * 2003-09-24 2005-03-31 Glaxo Group Limited Anti-inflammatory glucocorticoids
WO2007054974A2 (en) * 2005-09-28 2007-05-18 Arch Pharmalab Limited A green chemistry process for the preparation of pregnadiene esters

Also Published As

Publication number Publication date
US20110294766A1 (en) 2011-12-01
WO2009108118A9 (en) 2010-09-02
CN102015750A (zh) 2011-04-13
BRPI0907789A2 (pt) 2019-01-22
EP2257568A1 (en) 2010-12-08
WO2009108118A1 (en) 2009-09-03
RU2010133722A (ru) 2012-04-10
KR20110005236A (ko) 2011-01-17
JP2011513303A (ja) 2011-04-28
AU2009217824A1 (en) 2009-09-03
CA2716476A1 (en) 2009-09-03

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Legal Events

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