EA201291336A1 - Замещенные 5-фтор-1н-пиразолопиридины и их применение - Google Patents

Замещенные 5-фтор-1н-пиразолопиридины и их применение

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Publication number
EA201291336A1
EA201291336A1 EA201291336A EA201291336A EA201291336A1 EA 201291336 A1 EA201291336 A1 EA 201291336A1 EA 201291336 A EA201291336 A EA 201291336A EA 201291336 A EA201291336 A EA 201291336A EA 201291336 A1 EA201291336 A1 EA 201291336A1
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EA
Eurasian Patent Office
Prior art keywords
substituted
pyrazolopiridine
fluor
application
prevention
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EA201291336A
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English (en)
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EA023631B1 (ru
EA023631B9 (ru
Inventor
Маркус Фольманн
Йоханнес-Петер Сташ
Горден Редлих
Енс Аккерштафф
Нильс Грибенов
Вальтер Кро
Андреас Кнорр
Ева-Мария Беккер
Франк Вундер
Фолькхарт Мин-Джиан Ли
Эльке Хартманн
Ёахим Миттендорф
Карл-Хайнц Шлеммер
Рольф Яутелат
Дональд Бирер
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Байер Интеллектуэль Проперти Гмбх
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Publication of EA201291336A1 publication Critical patent/EA201291336A1/ru
Publication of EA023631B1 publication Critical patent/EA023631B1/ru
Publication of EA023631B9 publication Critical patent/EA023631B9/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C309/04—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing only one sulfo group
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
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    • C07C309/01—Sulfonic acids
    • C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
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    • C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C07C57/13—Dicarboxylic acids
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
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  • General Health & Medical Sciences (AREA)
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  • Medicinal Chemistry (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Изобретение относится к новым замещенным 5-фтор-1Н-пиразолопиридинам, способам их получения, к их применению самих или в комбинации для лечения и/или профилактики заболеваний, а также к их применению для получения лекарств для лечения и профилактики заболеваний, в частности для лечения и профилактики сердечно-сосудистых заболеваний.
EA201291336A 2010-05-26 2011-05-24 Замещенные 5-фтор-1h-пиразолопиридины и их применение EA023631B9 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102010021637A DE102010021637A1 (de) 2010-05-26 2010-05-26 Substituierte 5-Fluor-1H-Pyrazolopyridine und ihre Verwendung
PCT/EP2011/058431 WO2011147809A1 (de) 2010-05-26 2011-05-24 Substituierte 5-fluor-1h-pyrazolopyridine und ihre verwendung

Publications (3)

Publication Number Publication Date
EA201291336A1 true EA201291336A1 (ru) 2013-04-30
EA023631B1 EA023631B1 (ru) 2016-06-30
EA023631B9 EA023631B9 (ru) 2017-04-28

Family

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Family Applications (1)

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EA201291336A EA023631B9 (ru) 2010-05-26 2011-05-24 Замещенные 5-фтор-1h-пиразолопиридины и их применение

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US (8) US8420656B2 (ru)
EP (1) EP2576547B1 (ru)
JP (1) JP5896991B2 (ru)
KR (1) KR101862420B1 (ru)
CN (1) CN102939289B (ru)
AR (1) AR081628A1 (ru)
AU (1) AU2011257335B2 (ru)
BR (2) BR112012030010A2 (ru)
CA (1) CA2800697C (ru)
CL (1) CL2012003226A1 (ru)
CO (1) CO6640226A2 (ru)
CR (1) CR20120596A (ru)
CU (1) CU24086B1 (ru)
CY (2) CY1117372T1 (ru)
DE (1) DE102010021637A1 (ru)
DK (1) DK2576547T3 (ru)
DO (1) DOP2012000299A (ru)
EA (1) EA023631B9 (ru)
EC (1) ECSP12012310A (ru)
ES (1) ES2567795T3 (ru)
FR (1) FR21C1038I2 (ru)
GT (1) GT201200313A (ru)
HK (1) HK1182112A1 (ru)
HR (1) HRP20160370T1 (ru)
HU (2) HUE026912T2 (ru)
IL (2) IL223050A (ru)
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ME (1) ME02393B (ru)
MX (1) MX2012013324A (ru)
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NL (1) NL301146I2 (ru)
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NZ (1) NZ603800A (ru)
PE (1) PE20130402A1 (ru)
PL (1) PL2576547T3 (ru)
RS (1) RS54704B1 (ru)
SG (1) SG185460A1 (ru)
SI (1) SI2576547T1 (ru)
TN (1) TN2012000549A1 (ru)
TW (1) TWI516263B (ru)
UA (1) UA109660C2 (ru)
UY (1) UY33396A (ru)
WO (1) WO2011147809A1 (ru)

Cited By (1)

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RU2818488C2 (ru) * 2018-12-17 2024-05-02 Адверио Фарма Гмбх Продукт активного соединения метил { 4,6-диамино-2-[5-фтор-1-(2-фторбензил)-1H-пиразоло[3,4-b]пиридин-3-ил]пиримидин-5-ил} карбамата, имеющий улучшенные свойства, его получение и состав

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