EA201190217A1 - Замещенные 2-ацетамидо-5-арил-1,2,4-триазолоны и их применение - Google Patents

Замещенные 2-ацетамидо-5-арил-1,2,4-триазолоны и их применение

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Publication number
EA201190217A1
EA201190217A1 EA201190217A EA201190217A EA201190217A1 EA 201190217 A1 EA201190217 A1 EA 201190217A1 EA 201190217 A EA201190217 A EA 201190217A EA 201190217 A EA201190217 A EA 201190217A EA 201190217 A1 EA201190217 A1 EA 201190217A1
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EA
Eurasian Patent Office
Prior art keywords
triazolones
acetamido
substituted
aril
application
Prior art date
Application number
EA201190217A
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English (en)
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EA023694B1 (ru
Inventor
Ульф Брюггемайер
Шанталь Фюрстнер
Фолькер Гайсс
Йорг Кельдених
Армин Керн
Мартина Дельбек
Петер Колькхоф
Аксель Кретшмер
Элизабет Пок
Карстен Шмек
Хуберт Трюбель
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Байер Фарма Акциенгезельшафт
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Application filed by Байер Фарма Акциенгезельшафт filed Critical Байер Фарма Акциенгезельшафт
Publication of EA201190217A1 publication Critical patent/EA201190217A1/ru
Publication of EA023694B1 publication Critical patent/EA023694B1/ru

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    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/70One oxygen atom
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • A61K31/41661,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
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    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41961,2,4-Triazoles
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    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K9/2022Organic macromolecular compounds
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
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Abstract

Данное изобретение относится к новым замещенным 2-ацетамидо-5-арил-1,2,4-триазолонам общей формулы (I)к способу их получения, к применению их самих или в комбинации для лечения и/или предупреждения болезней, а также к их применению для получения лекарств для лечения и/или предупреждения болезней, в частности для лечения и/или предупреждения сердечно-сосудистых (кардиоваскулярных) заболеваний.
EA201190217A 2009-03-18 2010-03-12 Замещенные 2-ацетамидо-5-арил-1,2,4-триазолоны и их применение EA023694B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102009013640 2009-03-18
DE102010001064A DE102010001064A1 (de) 2009-03-18 2010-01-20 Substituierte 2-Acetamido-5-Aryl-1,2,4-triazolone und deren Verwendung
PCT/EP2010/001565 WO2010105770A1 (de) 2009-03-18 2010-03-12 Substituierte 2-acetamido-5-aryl-1,2,4-triazolone und deren verwendung

Publications (2)

Publication Number Publication Date
EA201190217A1 true EA201190217A1 (ru) 2012-04-30
EA023694B1 EA023694B1 (ru) 2016-07-29

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EA201190217A EA023694B1 (ru) 2009-03-18 2010-03-12 Замещенные 2-ацетамидо-5-арил-1,2,4-триазолоны и их применение

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US (2) US8202895B2 (ru)
EP (1) EP2408751B1 (ru)
JP (1) JP5849043B2 (ru)
KR (1) KR20110128206A (ru)
CN (2) CN103864704A (ru)
AR (1) AR075868A1 (ru)
AU (1) AU2010225170B2 (ru)
BR (1) BRPI1009481A2 (ru)
CA (1) CA2755641C (ru)
CL (1) CL2011002255A1 (ru)
CO (1) CO6440531A2 (ru)
CR (1) CR20110485A (ru)
CU (2) CU24085B1 (ru)
DE (1) DE102010001064A1 (ru)
DO (1) DOP2011000285A (ru)
EA (1) EA023694B1 (ru)
EC (1) ECSP11011320A (ru)
ES (1) ES2648871T3 (ru)
GT (1) GT201100239A (ru)
HK (2) HK1167864A1 (ru)
HN (1) HN2011002406A (ru)
IL (2) IL214614A0 (ru)
MA (1) MA33123B1 (ru)
MX (1) MX2011009539A (ru)
MY (1) MY156777A (ru)
NZ (1) NZ595207A (ru)
PE (1) PE20120656A1 (ru)
SG (2) SG10201401415QA (ru)
SV (1) SV2011004019A (ru)
TN (1) TN2011000466A1 (ru)
TW (1) TW201100392A (ru)
UA (1) UA108198C2 (ru)
UY (1) UY32497A (ru)
WO (1) WO2010105770A1 (ru)

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DE102008060967A1 (de) 2008-12-06 2010-06-10 Bayer Schering Pharma Aktiengesellschaft Substituierte Phenylsulfonyltriazolone und ihre Verwendung
DE102010001064A1 (de) 2009-03-18 2010-09-23 Bayer Schering Pharma Aktiengesellschaft Substituierte 2-Acetamido-5-Aryl-1,2,4-triazolone und deren Verwendung
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BR112012021498B8 (pt) 2010-02-27 2020-04-14 Bayer Ip Gmbh ariltriazolonas ligadas a bisaril e seu uso
DE102010040187A1 (de) * 2010-09-02 2012-03-08 Bayer Schering Pharma Aktiengesellschaft Substituierte N-Phenethyl-triazolonacetamide und ihre Verwendung
DE102010040924A1 (de) 2010-09-16 2012-03-22 Bayer Schering Pharma Aktiengesellschaft Substituierte Phenylacet- und Phenylpropanamide und ihre Verwendung
EP3197891B1 (de) 2014-09-24 2018-11-21 Bayer Pharma Aktiengesellschaft Faktor xia hemmende pyridobenzazepin- und pyridobenzazocin-derivate
TWI694072B (zh) 2014-11-03 2020-05-21 德商拜耳製藥股份有限公司 經羥烷基取代之苯基三唑衍生物及其用途
EP3452472A1 (en) 2016-05-03 2019-03-13 Bayer Aktiengesellschaft Hydroxyalkyl-substituted heteroaryltriazole derivatives and uses thereof
WO2017191105A1 (en) 2016-05-03 2017-11-09 Bayer Pharma Aktiengesellschaft Amide-substituted aryltriazole derivatives and uses thereof
EP3452469A1 (en) 2016-05-03 2019-03-13 Bayer Pharma Aktiengesellschaft Fluoroalkyl-substituted aryltriazole derivatives and uses thereof
WO2017191117A1 (en) 2016-05-03 2017-11-09 Bayer Pharma Aktiengesellschaft V1a receptor antagonists for use in the treatment of renal diseases
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US10800746B2 (en) 2016-05-03 2020-10-13 Bayer Pharma Aktiengesellschaft Oxoalkyl-substituted phenyltriazole derivatives and uses thereof
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