EA201590667A1 - Ациламинопиримидиновые производные для лечения вирусных инфекций и других заболеваний - Google Patents

Ациламинопиримидиновые производные для лечения вирусных инфекций и других заболеваний

Info

Publication number
EA201590667A1
EA201590667A1 EA201590667A EA201590667A EA201590667A1 EA 201590667 A1 EA201590667 A1 EA 201590667A1 EA 201590667 A EA201590667 A EA 201590667A EA 201590667 A EA201590667 A EA 201590667A EA 201590667 A1 EA201590667 A1 EA 201590667A1
Authority
EA
Eurasian Patent Office
Prior art keywords
diseases
treatment
viral infections
acylaminopyrimidine
derivatives
Prior art date
Application number
EA201590667A
Other languages
English (en)
Other versions
EA034650B1 (ru
Inventor
Дэвид Крейг Мак Гоуен
Серж Мария Алоисиус Питерс
Вернер Эмбрехтс
Стефан Жюльен Ласт
Тим Хьюго Мария Йонкерс
Пьер Жан-Мари Бернар Рабуассон
Original Assignee
Янссен Сайенсиз Айрлэнд Юси
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Янссен Сайенсиз Айрлэнд Юси filed Critical Янссен Сайенсиз Айрлэнд Юси
Publication of EA201590667A1 publication Critical patent/EA201590667A1/ru
Publication of EA034650B1 publication Critical patent/EA034650B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Настоящее изобретение относится к ациламинопиримидиновым производным, способам их получения, фармацевтическим композициям и их применению в терапии.
EA201590667A 2012-10-05 2013-10-03 Ациламинопиримидиновые производные для лечения вирусных инфекций и других заболеваний EA034650B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12187519 2012-10-05
PCT/EP2013/070619 WO2014053595A1 (en) 2012-10-05 2013-10-03 Acylaminopyrimidine derivatives for the treatment of viral infections and further diseases

Publications (2)

Publication Number Publication Date
EA201590667A1 true EA201590667A1 (ru) 2015-07-30
EA034650B1 EA034650B1 (ru) 2020-03-03

Family

ID=47049003

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201590667A EA034650B1 (ru) 2012-10-05 2013-10-03 Ациламинопиримидиновые производные для лечения вирусных инфекций и других заболеваний

Country Status (21)

Country Link
US (1) US9790191B2 (ru)
EP (1) EP2903967B3 (ru)
JP (1) JP6283033B2 (ru)
KR (2) KR102252649B1 (ru)
CN (2) CN104884434B (ru)
AU (1) AU2013326486B2 (ru)
BR (1) BR112015007366A2 (ru)
CA (1) CA2882786C (ru)
CL (1) CL2015000784A1 (ru)
DK (1) DK2903967T6 (ru)
EA (1) EA034650B1 (ru)
ES (1) ES2701098T7 (ru)
HK (1) HK1210463A1 (ru)
IL (1) IL237760B (ru)
MX (1) MX369803B (ru)
NZ (1) NZ705360A (ru)
PH (1) PH12015500713B1 (ru)
SG (1) SG11201502589YA (ru)
UA (1) UA118018C2 (ru)
WO (1) WO2014053595A1 (ru)
ZA (1) ZA201502238B (ru)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY170941A (en) 2011-04-08 2019-09-19 Janssen Sciences Ireland Uc Pyrimidine derivatives for the treatment of viral infections
BR112014011162A2 (pt) 2011-11-09 2017-05-09 Janssen R&D Ireland derivados purínicos para o tratamento de infecções virais
PL2872515T3 (pl) 2012-07-13 2017-05-31 Janssen Sciences Ireland Uc Puryny makrocykliczne do leczenia infekcji wirusowych
BR112015007366A2 (pt) 2012-10-05 2017-07-04 Janssen Sciences Ireland Uc derivados de acilaminopirimidina para o tratamento de infecções virais e outras doenças
MX365114B (es) 2012-10-10 2019-05-23 Janssen Sciences Ireland Uc Derivados pirrolo[3,2-d]pirimidinicos para el tratamiento de infecciones viricas y otras enfermedades.
SG11201503042QA (en) 2012-11-16 2015-06-29 Janssen Sciences Ireland Uc Heterocyclic substituted 2-amino-quinazoline derivatives for the treatment of viral infections
SG11201506639XA (en) 2013-02-21 2015-09-29 Janssen Sciences Ireland Uc 2-aminopyrimidine derivatives for the treatment of viral infections
AU2014242954B2 (en) 2013-03-29 2018-03-15 Janssen Sciences Ireland Uc Macrocyclic deaza-purinones for the treatment of viral infections
MY191923A (en) 2013-05-24 2022-07-18 Janssen Sciences Ireland Uc Pyridone derivatives for the treatment of viral infections and further diseases
NO3030563T3 (ru) 2013-06-27 2018-01-06
UA117253C2 (uk) 2013-07-30 2018-07-10 ЯНССЕН САЙЄНСЕЗ АЙРЛЕНД ЮСі ПОХІДНІ ТІЄНО[3,2-d]ПІРИМІДИНІВ ДЛЯ ЛІКУВАННЯ ВІРУСНИХ ІНФЕКЦІЙ
SG11201811448RA (en) 2016-07-01 2019-01-30 Janssen Sciences Ireland Unlimited Co Dihydropyranopyrimidines for the treatment of viral infections
EA038646B1 (ru) * 2016-09-29 2021-09-28 Янссен Сайенсиз Айрлэнд Анлимитед Компани Пиримидиновые пролекарства для лечения вирусных инфекций и других заболеваний
TW202415645A (zh) 2018-03-01 2024-04-16 愛爾蘭商健生科學愛爾蘭無限公司 ２，４－二胺基喹唑啉衍生物及其醫學用途
BR112021015577A2 (pt) 2019-02-08 2021-10-05 Research & Business Foundation Sungkyunkwan University Complexo-colesterol agonista do receptor toll-like 7 ou 8 e uso do mesmo
CN115666637A (zh) 2020-03-02 2023-01-31 蛋白科技先锋 基于病原体细胞壁骨架的模拟活病原体的纳米粒子及其制备方法
JP2023536953A (ja) 2020-08-04 2023-08-30 プロジェニア インコーポレイテッド 動力学的制御が可能なアジュバントを含むｍＲＮＡワクチン
JP2023536954A (ja) 2020-08-04 2023-08-30 プロジェニア インコーポレイテッド 活性化部位が一時的に不活性化したトール様受容体７または８作用薬と機能性薬物の結合体およびその用途
EP4194008A1 (en) 2020-08-04 2023-06-14 Progeneer Inc. Kinetically acting adjuvant ensemble

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5434157A (en) * 1979-03-19 1995-07-18 The Upjohn Company 6-aryl pyrimidine compounds and method for treating viral infections and inducing interferon production
ATE267175T1 (de) 1998-08-27 2004-06-15 Sumitomo Pharma Pyrimidin derivate
WO2006053109A1 (en) 2004-11-10 2006-05-18 Synta Pharmaceuticals Corp. Heteroaryl compounds
WO2008104472A1 (en) * 2007-02-28 2008-09-04 F. Hoffmann-La Roche Ag 2, 4 -diaminopyrimidine derivatives and their use as p2x antagonists or as prodrugs thereof
PE20091236A1 (es) 2007-11-22 2009-09-16 Astrazeneca Ab Derivados de pirimidina como immunomoduladores de tlr7
SG175796A1 (en) 2009-05-21 2011-12-29 Astrazeneca Ab Novel pyrimidine derivatives and their use in the treatment of cancer and further diseases
MY170941A (en) * 2011-04-08 2019-09-19 Janssen Sciences Ireland Uc Pyrimidine derivatives for the treatment of viral infections
BR112015007366A2 (pt) 2012-10-05 2017-07-04 Janssen Sciences Ireland Uc derivados de acilaminopirimidina para o tratamento de infecções virais e outras doenças

Also Published As

Publication number Publication date
JP2015534559A (ja) 2015-12-03
KR102252649B1 (ko) 2021-05-17
IL237760B (en) 2018-06-28
DK2903967T3 (da) 2019-01-02
CN111606861A (zh) 2020-09-01
PH12015500713A1 (en) 2015-05-18
CN104884434A (zh) 2015-09-02
MX2015004288A (es) 2015-08-06
NZ705360A (en) 2018-11-30
ES2701098T7 (es) 2021-02-03
AU2013326486B2 (en) 2017-09-14
BR112015007366A2 (pt) 2017-07-04
ES2701098T3 (es) 2019-02-20
MX369803B (es) 2019-11-21
DK2903967T6 (da) 2020-07-13
PH12015500713B1 (en) 2015-05-18
JP6283033B2 (ja) 2018-02-21
US20150274676A1 (en) 2015-10-01
AU2013326486A1 (en) 2015-03-19
CA2882786A1 (en) 2014-04-10
SG11201502589YA (en) 2015-04-29
CL2015000784A1 (es) 2015-06-12
EP2903967B3 (en) 2020-04-15
EA034650B1 (ru) 2020-03-03
KR102198128B1 (ko) 2021-01-05
KR20150064729A (ko) 2015-06-11
HK1210463A1 (en) 2016-04-22
WO2014053595A1 (en) 2014-04-10
ZA201502238B (en) 2017-01-25
CA2882786C (en) 2020-10-20
EP2903967B1 (en) 2018-09-12
EP2903967A1 (en) 2015-08-12
KR20210002129A (ko) 2021-01-06
CN104884434B (zh) 2020-05-12
UA118018C2 (uk) 2018-11-12
US9790191B2 (en) 2017-10-17

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