DK146017C - ANALOGY PROCEDURE FOR PREPARING 17ALFA-ACYLOXY-9ALFA, 21-DIHALOGEN-11BETA-HYDROXY-6ALFA-FLUOR-16BETA-METHYL-PREGNA-1,4-DIEN-3,20-DION COMPOUNDS - Google Patents

ANALOGY PROCEDURE FOR PREPARING 17ALFA-ACYLOXY-9ALFA, 21-DIHALOGEN-11BETA-HYDROXY-6ALFA-FLUOR-16BETA-METHYL-PREGNA-1,4-DIEN-3,20-DION COMPOUNDS

Info

Publication number: DK146017C
Authority: DK; Denmark
Prior art keywords: 9alfa; 6alfa; 17alfa; 16beta; 11beta
Prior art date: 1976-09-29

Application number

DK256977A

Other languages

Danish (da)

Other versions

DK256977A (en

DK146017B (en

Inventor

Jaroslav Kalvoda

Georg Anner

Original Assignee

Ciba Geigy Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1976-09-29

Filing date

1977-06-09

Publication date

1983-10-24

1977-06-09 Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag

1978-03-30 Publication of DK256977A publication Critical patent/DK256977A/en

1983-05-24 Publication of DK146017B publication Critical patent/DK146017B/en

1983-10-24 Application granted granted Critical

1983-10-24 Publication of DK146017C publication Critical patent/DK146017C/en

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C07J7/008—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
- C07J7/0085—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21 by an halogen atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
- C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
- C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
- C07J5/0069—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
- C07J5/0076—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group by an alkyl group
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes
- C07J71/0015—Oxiranes at position 9(11)

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Pain & Pain Management (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Rheumatology (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Steroid Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

DK256977A 1976-09-29 1977-06-09 ANALOGY PROCEDURE FOR PREPARING 17ALFA-ACYLOXY-9ALFA, 21-DIHALOGEN-11BETA-HYDROXY-6ALFA-FLUOR-16BETA-METHYL-PREGNA-1,4-DIEN-3,20-DION COMPOUNDS DK146017C (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
LU75903		1976-09-29
LU75903A LU75903A1 (en)	1976-09-29	1976-09-29

Publications (3)

Publication Number	Publication Date
DK256977A DK256977A (en)	1978-03-30
DK146017B DK146017B (en)	1983-05-24
DK146017C true DK146017C (en)	1983-10-24

Family

ID=19728370

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK256977A DK146017C (en)	1976-09-29	1977-06-09	ANALOGY PROCEDURE FOR PREPARING 17ALFA-ACYLOXY-9ALFA, 21-DIHALOGEN-11BETA-HYDROXY-6ALFA-FLUOR-16BETA-METHYL-PREGNA-1,4-DIEN-3,20-DION COMPOUNDS

Country Status (24)

Country	Link
JP (1)	JPS5356652A (en)
AT (3)	AT363197B (en)
AU (1)	AU514200B2 (en)
BE (1)	BE859120A (en)
CA (1)	CA1101410A (en)
CH (9)	CH624967A5 (en)
CY (1)	CY1178A (en)
DD (1)	DD133150A5 (en)
DE (1)	DE2743069C2 (en)
DK (1)	DK146017C (en)
ES (1)	ES462763A1 (en)
FR (1)	FR2366311A1 (en)
GB (1)	GB1563638A (en)
HK (1)	HK16683A (en)
HU (1)	HU175218B (en)
IE (1)	IE46047B1 (en)
IL (1)	IL53012A (en)
KE (1)	KE3258A (en)
LU (1)	LU75903A1 (en)
MY (1)	MY8400092A (en)
NL (1)	NL7710089A (en)
SE (1)	SE436751B (en)
SG (1)	SG3383G (en)
ZA (1)	ZA775800B (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NL187577C (en) *	1978-04-05	1991-11-18	Sibla Srl	3-ACETOXY-9BETA, 11BETA-EPOXY-PREGNA-1,3,5-TRIEN, PROCESS FOR THE PREPARATION THEREOF, AND PROCESS FOR THE PREPARATION OF 6-alpha-halogen-1,4-diene-3-ones.
DE3227312A1 (en) *	1982-07-19	1984-01-19	Schering AG, 1000 Berlin und 4709 Bergkamen	NEW 6.16 DIMETHYL CORTICOIDS, THEIR PRODUCTION AND USE
AU7556291A (en) *	1990-03-27	1991-10-21	Schering Corporation	Process for 9alpha-hydroxy steroid dehydration
US5972922A (en) *	1990-06-11	1999-10-26	Alcon Laboratories, Inc.	Steroids which inhibit angiogenesis
US7098328B2 (en)	2001-11-29	2006-08-29	Taro Pharmaceutical Industries Limited	Method for the preparation of 6α-fluoro corticosteroids
US8809307B2 (en)	2010-11-22	2014-08-19	Dow Pharmaceutical Sciences, Inc.	Pharmaceutical formulations containing corticosteroids for topical administration
US11957753B2 (en)	2010-11-22	2024-04-16	Bausch Health Ireland Limited	Pharmaceutical formulations containing corticosteroids for topical administration
HUE050603T2 (en)	2015-06-18	2020-12-28	Bausch Health Ireland Ltd	Topical compositions comprising a corticosteroid and a retinoid for treating psoriasis
US11311482B2 (en)	2017-05-12	2022-04-26	Bausch Health Us, Llc	Topical compositions and methods for treating skin diseases

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB898292A (en) *	1959-03-18	1962-06-06	Upjohn Co	Improvements in or relating to steroids and the manufacture thereof
US3644340A (en) *	1970-03-19	1972-02-22	Syntex Corp	Preparation of 21-chloro steroids
US3992422A (en) *	1975-08-14	1976-11-16	Schering Corporation	Process for the preparation of 21-halogeno-21-desoxy-17α-acyloxy-20-keto-pregnenes

1976
- 1976-09-29 LU LU75903A patent/LU75903A1/xx unknown
- 1976-12-09 CH CH1549976A patent/CH624967A5/en not_active IP Right Cessation
1977
- 1977-06-08 SE SE7706673A patent/SE436751B/en not_active IP Right Cessation
- 1977-06-09 DK DK256977A patent/DK146017C/en not_active IP Right Cessation
- 1977-09-14 NL NL7710089A patent/NL7710089A/en not_active Application Discontinuation
- 1977-09-24 DE DE2743069A patent/DE2743069C2/en not_active Expired
- 1977-09-26 CH CH1172177A patent/CH632279A5/en not_active IP Right Cessation
- 1977-09-27 DD DD7700201226A patent/DD133150A5/en unknown
- 1977-09-27 AU AU29148/77A patent/AU514200B2/en not_active Expired
- 1977-09-27 GB GB40131/77A patent/GB1563638A/en not_active Expired
- 1977-09-27 FR FR7729043A patent/FR2366311A1/en active Granted
- 1977-09-27 CY CY1178A patent/CY1178A/en unknown
- 1977-09-27 CA CA287,560A patent/CA1101410A/en not_active Expired
- 1977-09-28 ZA ZA00775800A patent/ZA775800B/en unknown
- 1977-09-28 IE IE1979/77A patent/IE46047B1/en not_active IP Right Cessation
- 1977-09-28 HU HU77CI1774A patent/HU175218B/en unknown
- 1977-09-28 IL IL53012A patent/IL53012A/en unknown
- 1977-09-28 AT AT0691077A patent/AT363197B/en not_active IP Right Cessation
- 1977-09-28 BE BE181243A patent/BE859120A/en not_active IP Right Cessation
- 1977-09-29 ES ES462763A patent/ES462763A1/en not_active Expired
- 1977-09-29 JP JP11619377A patent/JPS5356652A/en active Granted
1979
- 1979-02-28 AT AT0151279A patent/AT363202B/en not_active IP Right Cessation
- 1979-02-28 AT AT0151379A patent/AT363203B/en not_active IP Right Cessation
1980
- 1980-11-18 CH CH853780A patent/CH625808A5/en not_active IP Right Cessation
- 1980-11-18 CH CH853980A patent/CH625810A5/en not_active IP Right Cessation
- 1980-11-18 CH CH853880A patent/CH625809A5/en not_active IP Right Cessation
1981
- 1981-10-26 CH CH683281A patent/CH632000A5/en not_active IP Right Cessation
- 1981-10-26 CH CH683181A patent/CH631999A5/en not_active IP Right Cessation
- 1981-10-26 CH CH683081A patent/CH631998A5/en not_active IP Right Cessation
1982
- 1982-01-06 CH CH4682A patent/CH632521A5/en not_active IP Right Cessation
1983
- 1983-01-20 SG SG33/83A patent/SG3383G/en unknown
- 1983-01-21 KE KE3258A patent/KE3258A/en unknown
- 1983-05-19 HK HK166/83A patent/HK16683A/en not_active IP Right Cessation
1984
- 1984-12-30 MY MY92/84A patent/MY8400092A/en unknown

Also Published As

Publication number	Publication date
ES462763A1 (en)	1978-05-16
CH631998A5 (en)	1982-09-15
JPS5356652A (en)	1978-05-23
ATA151379A (en)	1980-12-15
SG3383G (en)	1983-09-09
FR2366311A1 (en)	1978-04-28
BE859120A (en)	1978-03-28
ATA691077A (en)	1980-12-15
IE46047B1 (en)	1983-02-09
CA1101410A (en)	1981-05-19
CY1178A (en)	1983-06-10
CH632279A5 (en)	1982-09-30
CH625810A5 (en)	1981-10-15
JPS6214557B2 (en)	1987-04-02
GB1563638A (en)	1980-03-26
SE7706673L (en)	1978-03-30
HU175218B (en)	1980-06-28
IE46047L (en)	1978-03-29
KE3258A (en)	1983-03-04
SE436751B (en)	1985-01-21
DD133150A5 (en)	1978-12-13
DK256977A (en)	1978-03-30
AU514200B2 (en)	1981-01-29
IL53012A0 (en)	1977-11-30
CH625808A5 (en)	1981-10-15
ZA775800B (en)	1978-08-30
IL53012A (en)	1982-05-31
AU2914877A (en)	1979-04-05
NL7710089A (en)	1978-03-31
MY8400092A (en)	1984-12-31
DE2743069C2 (en)	1987-03-05
CH624967A5 (en)	1981-08-31
AT363197B (en)	1981-07-10
AT363202B (en)	1981-07-27
LU75903A1 (en)	1978-05-16
ATA151279A (en)	1980-12-15
CH632521A5 (en)	1982-10-15
CH631999A5 (en)	1982-09-15
HK16683A (en)	1983-05-27
CH632000A5 (en)	1982-09-15
CH625809A5 (en)	1981-10-15
AT363203B (en)	1981-07-27
DE2743069A1 (en)	1978-03-30
FR2366311B1 (en)	1982-12-03
DK146017B (en)	1983-05-24

Legal Events

Date	Code	Title	Description
1997-07-14	PUP	Patent expired

Publication	Publication Date	Title
DK149749C (en)	1987-03-02	ANALOGY PROCEDURE FOR PREPARING N-ALKYL-2-HYDROXY-METHYL-3,4,5-TRIHYDROXY-PIPERIDE INGREDIATES
DK13177A (en)	1977-07-15	PROCEDURE FOR PREPARING PHTHALANES
DK157487C (en)	1990-06-11	ANALOGY PROCEDURE FOR THE PREPARATION OF PROLINE DERIVATIVES.
DK81277A (en)	1977-08-26	PROCEDURE FOR MAKING BIS-PYRIDINIUM COMPOUNDS
DK143708C (en)	1982-03-15	ANALOGY PROCEDURE FOR PREPARING 17ALFA-ACYLOXY-9ALFA, 21-DIHALOGEN-11BETA-HYDROXY-6ALFA-FLUOR-16ALFA-METHYL-PREGNA-1,4-DIEN-3,20-DION COMPOUNDS
DK145644C (en)	1983-07-04	ANALOGY PROCEDURE FOR PREPARING IMIDAZOLE COMPOUNDS
DK301077A (en)	1978-01-07	PROCEDURE FOR PREPARING 6A, 10A-TRANSHEXAHYDRODIBENZO (B, D) PYRAN-9-ONERS
DK147068C (en)	1984-09-10	ANALOGY PROCEDURE FOR PREPARING 1-NAPHTHYLMETHYL-CINNAMYL-AMINE DERIVATIVES
DK144702C (en)	1982-10-11	ANALOGY PROCEDURE FOR PREPARING 2,3-DIHYDRO-IMIDAZO (2,1-B) -THIAZOLD DERIVATIVES
DK148059C (en)	1985-07-29	ANALOGY PROCEDURE FOR PREPARING ANTHRACYCLING LYCOSIDE COMPOUNDS
DK146017C (en)	1983-10-24	ANALOGY PROCEDURE FOR PREPARING 17ALFA-ACYLOXY-9ALFA, 21-DIHALOGEN-11BETA-HYDROXY-6ALFA-FLUOR-16BETA-METHYL-PREGNA-1,4-DIEN-3,20-DION COMPOUNDS
DK123277A (en)	1977-09-23	PROCEDURE FOR MAKING 3-HALOGENMETHYL-3-CEPHEM COMPOUNDS
DK153489C (en)	1988-11-21	ANALOGY PROCEDURE FOR PREPARING 7-AMINOTHIAZOLYLACETAMIDOCEPHALOSPORANIC ACID DERIVATIVES
DK566977A (en)	1978-06-21	PROCEDURE FOR PREPARING POLYEN COMPOUNDS
DK233377A (en)	1977-12-02	PROCEDURE FOR THE PREPARATION OF OMEGA-NORAROMATIC-13,14-DEHYDRO-PROSTAGLANDINS
DK38577A (en)	1977-08-01	PROCEDURE FOR PREPARING BETALACTA CONTAINING COMPOUNDS
DK150484C (en)	1987-10-05	ANALOGY PROCEDURE FOR PREPARING 4-AMINO-3-THIOPHENCARBOXYLIC ACID DERIVATIVES
DK301277A (en)	1978-01-07	PROCEDURE FOR PREPARING SUBSTITUTED 2,6-METHANO-2H-1-BENZOXOCINES
DK247877A (en)	1977-12-05	PROCEDURE FOR PREPARING KLAVAM COMPOUNDS
DK142848C (en)	1981-08-24	ANALOGY PROCEDURE FOR PREPARING 2-ACYLAMIDO-4-AMINO-5-BENZYLPYRIMIDINE COMPOUNDS
DK395877A (en)	1978-03-21	PROCEDURE FOR MAKING 2- (4-AROYLPIPERAZIN-1-YL) -4-AMINO-6,7-DIMETHOXYQUINAZOLINES
DK73077A (en)	1977-08-22	PROCEDURE FOR PREPARING 2,9-DIOXATRICYCLO (4,3,1,03,7) DECANER
DK150299C (en)	1987-10-26	ANALOGY PROCEDURE FOR PREPARING 8-AMINOALKYL-TETRACYCLO (4,3,0,02,4,03,7) NONANDER DERIVATIVES
DK310777A (en)	1978-01-10	PROCEDURE FOR PREPARING GUAIACOL-P-ISOBUTYL HYDRATROPATE
DK146624C (en)	1984-05-07	ANALOGY PROCEDURE FOR PREPARING 1-AMINOALKYL-3,4-DIPHENYL-1H-PYRAZOLES