DK1361880T3 - 6-substituerede pyrido-pyrimidiner - Google Patents

6-substituerede pyrido-pyrimidiner

Info

Publication number: DK1361880T3
Authority: DK; Denmark
Prior art keywords: pyrimidines; substituted pyrido; pyrido; substituted
Prior art date: 2001-02-12

Application number

DK02726103T

Other languages

English (en)

Inventor

Jian Jeffrey Chen

James Patrick Dunn

David Michael Goldstein

Christoph Martin Stahl

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-02-12

Filing date

2002-02-04

Publication date

2006-01-23

2002-02-04 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2006-01-23 Application granted granted Critical

2006-01-23 Publication of DK1361880T3 publication Critical patent/DK1361880T3/da

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Rheumatology (AREA)
Immunology (AREA)
Dermatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Cardiology (AREA)
Hospice & Palliative Care (AREA)
Physical Education & Sports Medicine (AREA)
Heart & Thoracic Surgery (AREA)
Pulmonology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

DK02726103T 2001-02-12 2002-02-04 6-substituerede pyrido-pyrimidiner DK1361880T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US26837501P	2001-02-12	2001-02-12
US33465401P	2001-11-30	2001-11-30

Publications (1)

Publication Number	Publication Date
DK1361880T3 true DK1361880T3 (da)	2006-01-23

Family

ID=26953040

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK02726103T DK1361880T3 (da)	2001-02-12	2002-02-04	6-substituerede pyrido-pyrimidiner

Country Status (32)

Country	Link
US (3)	US6696566B2 (da)
EP (1)	EP1361880B1 (da)
JP (1)	JP4064818B2 (da)
KR (1)	KR100639772B1 (da)
CN (1)	CN100376571C (da)
AR (1)	AR035854A1 (da)
AT (1)	ATE305303T1 (da)
AU (1)	AU2002256615B2 (da)
BR (1)	BRPI0207172B8 (da)
CA (1)	CA2434834C (da)
CZ (1)	CZ20032416A3 (da)
DE (1)	DE60206363T2 (da)
DK (1)	DK1361880T3 (da)
ES (1)	ES2249574T3 (da)
HK (1)	HK1066170A1 (da)
HR (1)	HRP20030624B1 (da)
HU (1)	HU229604B1 (da)
IL (2)	IL156872A0 (da)
JO (1)	JO2410B1 (da)
MA (1)	MA26993A1 (da)
MX (1)	MXPA03007166A (da)
MY (1)	MY131518A (da)
NO (1)	NO326133B1 (da)
NZ (1)	NZ526961A (da)
PA (1)	PA8539201A1 (da)
PE (1)	PE20020976A1 (da)
PL (1)	PL366918A1 (da)
RU (1)	RU2269527C2 (da)
SK (1)	SK11322003A3 (da)
WO (1)	WO2002064594A2 (da)
YU (1)	YU63703A (da)
ZA (1)	ZA200305938B (da)

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US7053070B2 (en) *	2000-01-25	2006-05-30	Warner-Lambert Company	Pyrido[2,3-d]pyrimidine-2,7-diamine kinase inhibitors
WO2002064594A2 (en)	2001-02-12	2002-08-22	F. Hoffmann-La Roche Ag	6-substituted pyrido-pyrimidines
IL162721A0 (en)	2002-01-22	2005-11-20	Warner Lambert Co	2-(Pyridin-2-ylamino)-pyridoÄ2,3-dÜpyrimidin-7-ones
MXPA04009585A (es)	2002-04-03	2005-01-11	Hoffmann La Roche	Compuestos imidazo fusionados.
JP4252534B2 (ja)	2002-08-06	2009-04-08	エフ．ホフマン−ラロシュアーゲー	ｐ−３８ＭＡＰキナーゼインヒビターとしての６−アルコキシ−ピリド−ピリミジン類
WO2004060346A2 (en)	2002-12-30	2004-07-22	Angiotech International Ag	Drug delivery from rapid gelling polymer composition
JP4695588B2 (ja) *	2003-02-26	2011-06-08	スージェン，インク．	プロテインキナーゼ阻害剤としてのアミノヘテロアリール化合物
CA2520785A1 (en) *	2003-04-16	2004-10-28	F. Hoffmann-La Roche Ag	Substituted 7-aza-quinazoline compounds
DE602004005238T2 (de) *	2003-11-13	2007-11-08	F. Hoffmann-La Roche Ag	Hydroxyalkylsubstituierte pyrido-7-pyrimidin-7-one
US20090131430A1 (en) *	2004-11-23	2009-05-21	Palle Venkata P	Pyrido'2,3-dipyrimidines as anti-inflammatory agents
US20060142312A1 (en) *	2004-12-23	2006-06-29	Pfizer Inc	C6-aryl and heteroaryl substituted pyrido[2,3-D] pyrimidin-7-ones
EP1846403A1 (en) *	2005-02-02	2007-10-24	Ranbaxy Laboratories Limited	Azabicyclo derivatives as anti-inflammatory agents
WO2006119504A2 (en) *	2005-05-04	2006-11-09	Renovis, Inc.	Fused heterocyclic compounds, and compositions and uses thereof
DE602006010564D1 (de) *	2005-07-21	2009-12-31	Hoffmann La Roche	Pyridoä2,3-düpyrimidin-2,4-diamin-verbindungen als ptpib-hemmer
ES2351939T3 (es) *	2005-08-09	2011-02-14	Irm Llc	Compuestos y composiciones como inhibidores de proteínas cinasas.
US8686002B2 (en)	2005-08-21	2014-04-01	AbbVie Deutschland GmbH & Co. KG	Heterocyclic compounds and their use as binding partners for 5-HT5 receptors
JO2783B1 (en) *	2005-09-30	2014-03-15	نوفارتيس ايه جي	Compounds 2-Amino-7, 8-dihydro-6H-Bayredo (3,4-D) Pyrimidine-5-Ones
WO2008150260A1 (en) *	2007-06-06	2008-12-11	Gpc Biotech, Inc.	8-oxy-2-aminopyrido (2, 3-d) pyrimidin-7-one derivatives as kinase inhibitors and anticancer agents
WO2008078249A1 (en) *	2006-12-21	2008-07-03	Ranbaxy Laboratories Limited	Anti-inflammatory agents
AU2008248296B2 (en)	2007-05-07	2011-12-01	Amgen Inc.	Pyrazolo-pyridinone and pyrazolo-pyrazinone compounds as P38 modulators, process for their preparation, and their pharmaceutical use
JP2010529973A (ja)	2007-06-15	2010-09-02	エフ．ホフマン−ラロシュアーゲー	３−アミノ−ペンタン−１，５−ジオールの新規製造方法
US8367671B2 (en)	2008-03-21	2013-02-05	Amgen Inc.	Pyrazolo[3.4-B]pyrazine compounds as p38 modulators and methods of use as anti-inflamatory agents
EP2112150B1 (en)	2008-04-22	2013-10-16	Forma Therapeutics, Inc.	Improved raf inhibitors
WO2010046273A2 (en) *	2008-10-22	2010-04-29	F. Hoffmann-La Roche Ag	Pyrimidinyl pyridone inhibitors of jnk
WO2010071846A2 (en)	2008-12-19	2010-06-24	Afraxis, Inc.	Compounds for treating neuropsychiatric conditions
BR112012007935A2 (pt)	2009-10-09	2019-09-24	Afraxis Inc	8-etil-6(aril)pirido(2,3-d)pirimidin-7(8h) para tratamento de sindrome de snc
KR101754664B1 (ko)	2009-12-18	2017-07-06	템플 유니버시티-오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션	치환된 피리도〔2,3-ｄ〕피리미딘-7(8ｈ)-온스 및 이의 치료 용도
US9828373B2 (en)	2014-07-26	2017-11-28	Sunshine Lake Pharma Co., Ltd.	2-amino-pyrido[2,3-D]pyrimidin-7(8H)-one derivatives as CDK inhibitors and uses thereof
EP3468604B1 (en)	2016-06-08	2021-01-20	Support-Venture GmbH	Pharmaceutical combinations for treating cancer
CN109803968A (zh)	2016-08-15	2019-05-24	辉瑞公司	吡啶并嘧啶酮cdk2/4/6抑制剂
CN109562105A (zh)	2016-08-17	2019-04-02	企业支持有限责任公司	预防或治疗听力损失的方法
US11117858B2 (en)	2017-01-11	2021-09-14	The General Hospital Corporation	Voltage gated sodium channel imaging agents
SG11201908870PA (en)	2017-04-04	2019-10-30	Strekin Ag	Methods of preventing or treating ophthalmic diseases
AU2018325442B2 (en) *	2017-08-31	2023-04-13	Dana-Farber Cancer Institute, Inc.	Inhibitors of EGFR and/or HER2 and methods of use
KR20200067170A (ko)	2017-10-05	2020-06-11	풀크럼 쎄러퓨틱스, 인코포레이티드	FSHD의 치료를 위하여 DUX4 및 하류 유전자 발현을 저감시키는 p38 키나제 저해제
US10342786B2 (en)	2017-10-05	2019-07-09	Fulcrum Therapeutics, Inc.	P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD
US20210261547A1 (en) *	2018-06-27	2021-08-26	Tufts Medical Center, Inc.	Pyridopyrimidine compounds and methods of their use
CA3104371A1 (en)	2018-07-13	2020-01-16	Kinarus Ag	Combinations of ppar agonists and p38 kinase inhibitors for preventing or treating fibrotic diseases
TW202112368A (zh)	2019-06-13	2021-04-01	荷蘭商法西歐知識產權股份有限公司	用於治療有關dux4表現之疾病的抑制劑組合
US20230263803A1 (en)	2020-08-11	2023-08-24	Kinarus Ag	Methods of preventing or treating covid-19 and related viral diseases or disorders

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PL198640B1 (pl)	1998-06-19	2008-07-31	Pfizer Prod Inc	Związki pirolo[2,3-d]pirymidynowe, środek farmaceutyczny i zastosowanie tych związków
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US7053070B2 (en) *	2000-01-25	2006-05-30	Warner-Lambert Company	Pyrido[2,3-d]pyrimidine-2,7-diamine kinase inhibitors
EE200200506A (et) *	2000-03-06	2004-02-16	Warner-Lambert Company	5-alküülpürido[2,3-d]pürimidiinid kui türosiinkinaasi inhibiitorid
US6518276B2 (en) *	2000-08-31	2003-02-11	Syntex (U.S.A.) Llc	7-oxo-pyridopyrimidines (II)
WO2002064594A2 (en)	2001-02-12	2002-08-22	F. Hoffmann-La Roche Ag	6-substituted pyrido-pyrimidines
IL162721A0 (en) *	2002-01-22	2005-11-20	Warner Lambert Co	2-(Pyridin-2-ylamino)-pyridoÄ2,3-dÜpyrimidin-7-ones

2002
- 2002-02-04 WO PCT/EP2002/001106 patent/WO2002064594A2/en not_active Application Discontinuation
- 2002-02-04 SK SK11322003A patent/SK11322003A3/sk unknown
- 2002-02-04 CZ CZ20032416A patent/CZ20032416A3/cs unknown
- 2002-02-04 DE DE60206363T patent/DE60206363T2/de not_active Expired - Lifetime
- 2002-02-04 DK DK02726103T patent/DK1361880T3/da active
- 2002-02-04 NZ NZ526961A patent/NZ526961A/en unknown
- 2002-02-04 IL IL15687202A patent/IL156872A0/xx unknown
- 2002-02-04 JP JP2002564525A patent/JP4064818B2/ja not_active Expired - Lifetime
- 2002-02-04 KR KR1020037010562A patent/KR100639772B1/ko active IP Right Grant
- 2002-02-04 ES ES02726103T patent/ES2249574T3/es not_active Expired - Lifetime
- 2002-02-04 AU AU2002256615A patent/AU2002256615B2/en not_active Expired
- 2002-02-04 CN CNB028048342A patent/CN100376571C/zh not_active Expired - Lifetime
- 2002-02-04 AT AT02726103T patent/ATE305303T1/de active
- 2002-02-04 EP EP02726103A patent/EP1361880B1/en not_active Expired - Lifetime
- 2002-02-04 BR BR0207172-0 patent/BRPI0207172B8/pt not_active IP Right Cessation
- 2002-02-04 RU RU2003125887/04A patent/RU2269527C2/ru not_active IP Right Cessation
- 2002-02-04 YU YU63703A patent/YU63703A/sh unknown
- 2002-02-04 MX MXPA03007166A patent/MXPA03007166A/es active IP Right Grant
- 2002-02-04 HU HU0303458A patent/HU229604B1/hu unknown
- 2002-02-04 CA CA2434834A patent/CA2434834C/en not_active Expired - Lifetime
- 2002-02-04 PL PL02366918A patent/PL366918A1/xx not_active Application Discontinuation
- 2002-02-06 JO JO200212A patent/JO2410B1/en active
- 2002-02-08 PA PA20028539201A patent/PA8539201A1/es unknown
- 2002-02-08 PE PE2002000097A patent/PE20020976A1/es not_active Application Discontinuation
- 2002-02-11 AR ARP020100430A patent/AR035854A1/es unknown
- 2002-02-11 MY MYPI20020491A patent/MY131518A/en unknown
- 2002-02-11 US US10/073,845 patent/US6696566B2/en not_active Expired - Lifetime
2003
- 2003-07-10 IL IL156872A patent/IL156872A/en unknown
- 2003-07-31 ZA ZA2003/05938A patent/ZA200305938B/en unknown
- 2003-08-01 HR HR20030624A patent/HRP20030624B1/xx not_active IP Right Cessation
- 2003-08-11 MA MA27273A patent/MA26993A1/fr unknown
- 2003-08-11 NO NO20033540A patent/NO326133B1/no not_active IP Right Cessation
- 2003-11-25 US US10/722,703 patent/US7169794B2/en not_active Expired - Lifetime
2004
- 2004-11-19 HK HK04109141A patent/HK1066170A1/xx not_active IP Right Cessation
2007
- 2007-01-09 US US11/651,302 patent/US7449581B2/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
US7449581B2 (en)	2008-11-11
SK11322003A3 (en)	2004-10-05
MXPA03007166A (es)	2003-11-18
ZA200305938B (en)	2005-01-26
BRPI0207172B8 (pt)	2021-05-25
JP4064818B2 (ja)	2008-03-19
KR100639772B1 (ko)	2006-10-30
AU2002256615B2 (en)	2007-09-13
US6696566B2 (en)	2004-02-24
CN1503672A (zh)	2004-06-09
CZ20032416A3 (cs)	2004-07-14
NO20033540D0 (no)	2003-08-11
US20030171584A1 (en)	2003-09-11
US20070135458A1 (en)	2007-06-14
US20040116698A1 (en)	2004-06-17
CN100376571C (zh)	2008-03-26
EP1361880B1 (en)	2005-09-28
AR035854A1 (es)	2004-07-21
IL156872A0 (en)	2004-02-08
HRP20030624B1 (en)	2007-03-31
NZ526961A (en)	2005-03-24
KR20040018254A (ko)	2004-03-02
ATE305303T1 (de)	2005-10-15
ES2249574T3 (es)	2006-04-01
YU63703A (sh)	2006-05-25
WO2002064594A3 (en)	2003-01-09
HUP0303458A2 (hu)	2004-01-28
JO2410B1 (en)	2007-06-17
NO326133B1 (no)	2008-10-06
HUP0303458A3 (en)	2012-12-28
NO20033540L (no)	2003-08-11
DE60206363D1 (de)	2006-02-09
BRPI0207172B1 (pt)	2019-04-09
IL156872A (en)	2009-07-20
US7169794B2 (en)	2007-01-30
HK1066170A1 (en)	2005-03-18
BR0207172A (pt)	2004-03-30
CA2434834C (en)	2010-09-14
HU229604B1 (en)	2014-02-28
MY131518A (en)	2007-08-30
HRP20030624A2 (en)	2005-06-30
RU2269527C2 (ru)	2006-02-10
EP1361880A2 (en)	2003-11-19
PA8539201A1 (es)	2004-08-31
DE60206363T2 (de)	2006-07-06
RU2003125887A (ru)	2005-03-20
MA26993A1 (fr)	2004-12-20
PE20020976A1 (es)	2002-10-29
JP2004525896A (ja)	2004-08-26
WO2002064594A2 (en)	2002-08-22
CA2434834A1 (en)	2002-08-22
PL366918A1 (en)	2005-02-07

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DK1373228T3 (da)	2008-08-04	Substituerede fluoralkoxyphenylsulfonylurinstoffer
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DE50203984D1 (de)	2005-09-22	Kugelgelenk
DE50203412D1 (de)	2005-07-21	Schwenkkolbenverdränger
DE50208029D1 (de)	2006-10-12	Kugelgelenk
ATE355059T1 (de)	2006-03-15	Isoxazolopyridinone
DK1406858T3 (da)	2009-11-23	Substituerede 4-aminocyklohexanoler
DE50203093D1 (de)	2005-06-16	Losradlager
ATE319694T1 (de)	2006-03-15	Phenylalkyne
ATA18372001A (de)	2005-07-15	Gelenksbolzenbaueinheit
DE50209293D1 (de)	2007-03-08	Amidpolymermasse
DE50207815D1 (de)	2006-09-21	Kugelgelenk