HU229604B1 - 6-substituted pyrido-pyrimidines, process for their preparation and pharmaceutical compositions containing them - Google Patents

6-substituted pyrido-pyrimidines, process for their preparation and pharmaceutical compositions containing them

Info

Publication number
HU229604B1
HU229604B1 HU0303458A HUP0303458A HU229604B1 HU 229604 B1 HU229604 B1 HU 229604B1 HU 0303458 A HU0303458 A HU 0303458A HU P0303458 A HUP0303458 A HU P0303458A HU 229604 B1 HU229604 B1 HU 229604B1
Authority
HU
Hungary
Prior art keywords
pyrimidines
preparation
pharmaceutical compositions
compositions containing
substituted pyrido
Prior art date
Application number
HU0303458A
Other languages
English (en)
Inventor
Jian Jeffrey Chen
James Patrick Dunn
David Michael Goldstein
Christoph Martin Stahl
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of HUP0303458A2 publication Critical patent/HUP0303458A2/hu
Publication of HUP0303458A3 publication Critical patent/HUP0303458A3/hu
Publication of HU229604B1 publication Critical patent/HU229604B1/hu

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
HU0303458A 2001-02-12 2002-02-04 6-substituted pyrido-pyrimidines, process for their preparation and pharmaceutical compositions containing them HU229604B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US26837501P 2001-02-12 2001-02-12
US33465401P 2001-11-30 2001-11-30
PCT/EP2002/001106 WO2002064594A2 (en) 2001-02-12 2002-02-04 6-substituted pyrido-pyrimidines

Publications (3)

Publication Number Publication Date
HUP0303458A2 HUP0303458A2 (hu) 2004-01-28
HUP0303458A3 HUP0303458A3 (en) 2012-12-28
HU229604B1 true HU229604B1 (en) 2014-02-28

Family

ID=26953040

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0303458A HU229604B1 (en) 2001-02-12 2002-02-04 6-substituted pyrido-pyrimidines, process for their preparation and pharmaceutical compositions containing them

Country Status (32)

Country Link
US (3) US6696566B2 (hu)
EP (1) EP1361880B1 (hu)
JP (1) JP4064818B2 (hu)
KR (1) KR100639772B1 (hu)
CN (1) CN100376571C (hu)
AR (1) AR035854A1 (hu)
AT (1) ATE305303T1 (hu)
AU (1) AU2002256615B2 (hu)
BR (1) BRPI0207172B8 (hu)
CA (1) CA2434834C (hu)
CZ (1) CZ20032416A3 (hu)
DE (1) DE60206363T2 (hu)
DK (1) DK1361880T3 (hu)
ES (1) ES2249574T3 (hu)
HK (1) HK1066170A1 (hu)
HR (1) HRP20030624B1 (hu)
HU (1) HU229604B1 (hu)
IL (2) IL156872A0 (hu)
JO (1) JO2410B1 (hu)
MA (1) MA26993A1 (hu)
MX (1) MXPA03007166A (hu)
MY (1) MY131518A (hu)
NO (1) NO326133B1 (hu)
NZ (1) NZ526961A (hu)
PA (1) PA8539201A1 (hu)
PE (1) PE20020976A1 (hu)
PL (1) PL366918A1 (hu)
RU (1) RU2269527C2 (hu)
SK (1) SK11322003A3 (hu)
WO (1) WO2002064594A2 (hu)
YU (1) YU63703A (hu)
ZA (1) ZA200305938B (hu)

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IL162721A0 (en) 2002-01-22 2005-11-20 Warner Lambert Co 2-(Pyridin-2-ylamino)-pyridoÄ2,3-dÜpyrimidin-7-ones
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JP4252534B2 (ja) 2002-08-06 2009-04-08 エフ.ホフマン−ラ ロシュ アーゲー p−38MAPキナーゼインヒビターとしての6−アルコキシ−ピリド−ピリミジン類
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JP4695588B2 (ja) * 2003-02-26 2011-06-08 スージェン, インク. プロテインキナーゼ阻害剤としてのアミノヘテロアリール化合物
CA2520785A1 (en) * 2003-04-16 2004-10-28 F. Hoffmann-La Roche Ag Substituted 7-aza-quinazoline compounds
DE602004005238T2 (de) * 2003-11-13 2007-11-08 F. Hoffmann-La Roche Ag Hydroxyalkylsubstituierte pyrido-7-pyrimidin-7-one
US20090131430A1 (en) * 2004-11-23 2009-05-21 Palle Venkata P Pyrido'2,3-dipyrimidines as anti-inflammatory agents
US20060142312A1 (en) * 2004-12-23 2006-06-29 Pfizer Inc C6-aryl and heteroaryl substituted pyrido[2,3-D] pyrimidin-7-ones
EP1846403A1 (en) * 2005-02-02 2007-10-24 Ranbaxy Laboratories Limited Azabicyclo derivatives as anti-inflammatory agents
WO2006119504A2 (en) * 2005-05-04 2006-11-09 Renovis, Inc. Fused heterocyclic compounds, and compositions and uses thereof
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JO2783B1 (en) * 2005-09-30 2014-03-15 نوفارتيس ايه جي Compounds 2-Amino-7, 8-dihydro-6H-Bayredo (3,4-D) Pyrimidine-5-Ones
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BR112012007935A2 (pt) 2009-10-09 2019-09-24 Afraxis Inc 8-etil-6(aril)pirido(2,3-d)pirimidin-7(8h) para tratamento de sindrome de snc
KR101754664B1 (ko) 2009-12-18 2017-07-06 템플 유니버시티-오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션 치환된 피리도〔2,3-d〕피리미딘-7(8h)-온스 및 이의 치료 용도
US9828373B2 (en) 2014-07-26 2017-11-28 Sunshine Lake Pharma Co., Ltd. 2-amino-pyrido[2,3-D]pyrimidin-7(8H)-one derivatives as CDK inhibitors and uses thereof
EP3468604B1 (en) 2016-06-08 2021-01-20 Support-Venture GmbH Pharmaceutical combinations for treating cancer
CN109803968A (zh) 2016-08-15 2019-05-24 辉瑞公司 吡啶并嘧啶酮cdk2/4/6抑制剂
CN109562105A (zh) 2016-08-17 2019-04-02 企业支持有限责任公司 预防或治疗听力损失的方法
US11117858B2 (en) 2017-01-11 2021-09-14 The General Hospital Corporation Voltage gated sodium channel imaging agents
SG11201908870PA (en) 2017-04-04 2019-10-30 Strekin Ag Methods of preventing or treating ophthalmic diseases
AU2018325442B2 (en) * 2017-08-31 2023-04-13 Dana-Farber Cancer Institute, Inc. Inhibitors of EGFR and/or HER2 and methods of use
KR20200067170A (ko) 2017-10-05 2020-06-11 풀크럼 쎄러퓨틱스, 인코포레이티드 FSHD의 치료를 위하여 DUX4 및 하류 유전자 발현을 저감시키는 p38 키나제 저해제
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TW202112368A (zh) 2019-06-13 2021-04-01 荷蘭商法西歐知識產權股份有限公司 用於治療有關dux4表現之疾病的抑制劑組合
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IL162721A0 (en) * 2002-01-22 2005-11-20 Warner Lambert Co 2-(Pyridin-2-ylamino)-pyridoÄ2,3-dÜpyrimidin-7-ones

Also Published As

Publication number Publication date
US7449581B2 (en) 2008-11-11
SK11322003A3 (en) 2004-10-05
MXPA03007166A (es) 2003-11-18
ZA200305938B (en) 2005-01-26
BRPI0207172B8 (pt) 2021-05-25
JP4064818B2 (ja) 2008-03-19
KR100639772B1 (ko) 2006-10-30
AU2002256615B2 (en) 2007-09-13
US6696566B2 (en) 2004-02-24
CN1503672A (zh) 2004-06-09
CZ20032416A3 (cs) 2004-07-14
NO20033540D0 (no) 2003-08-11
US20030171584A1 (en) 2003-09-11
US20070135458A1 (en) 2007-06-14
US20040116698A1 (en) 2004-06-17
CN100376571C (zh) 2008-03-26
EP1361880B1 (en) 2005-09-28
AR035854A1 (es) 2004-07-21
IL156872A0 (en) 2004-02-08
HRP20030624B1 (en) 2007-03-31
NZ526961A (en) 2005-03-24
KR20040018254A (ko) 2004-03-02
ATE305303T1 (de) 2005-10-15
ES2249574T3 (es) 2006-04-01
YU63703A (sh) 2006-05-25
WO2002064594A3 (en) 2003-01-09
HUP0303458A2 (hu) 2004-01-28
JO2410B1 (en) 2007-06-17
NO326133B1 (no) 2008-10-06
HUP0303458A3 (en) 2012-12-28
NO20033540L (no) 2003-08-11
DE60206363D1 (de) 2006-02-09
BRPI0207172B1 (pt) 2019-04-09
IL156872A (en) 2009-07-20
US7169794B2 (en) 2007-01-30
HK1066170A1 (en) 2005-03-18
BR0207172A (pt) 2004-03-30
DK1361880T3 (da) 2006-01-23
CA2434834C (en) 2010-09-14
MY131518A (en) 2007-08-30
HRP20030624A2 (en) 2005-06-30
RU2269527C2 (ru) 2006-02-10
EP1361880A2 (en) 2003-11-19
PA8539201A1 (es) 2004-08-31
DE60206363T2 (de) 2006-07-06
RU2003125887A (ru) 2005-03-20
MA26993A1 (fr) 2004-12-20
PE20020976A1 (es) 2002-10-29
JP2004525896A (ja) 2004-08-26
WO2002064594A2 (en) 2002-08-22
CA2434834A1 (en) 2002-08-22
PL366918A1 (en) 2005-02-07

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