DK1265882T3 - Fremgangsmåde til fremstilling af citalopram - Google Patents

Fremgangsmåde til fremstilling af citalopram

Info

Publication number
DK1265882T3
DK1265882T3 DK01913738T DK01913738T DK1265882T3 DK 1265882 T3 DK1265882 T3 DK 1265882T3 DK 01913738 T DK01913738 T DK 01913738T DK 01913738 T DK01913738 T DK 01913738T DK 1265882 T3 DK1265882 T3 DK 1265882T3
Authority
DK
Denmark
Prior art keywords
group
citalopram
cyano
cor
hydrogen
Prior art date
Application number
DK01913738T
Other languages
English (en)
Inventor
Hans Petersen
Original Assignee
Lundbeck & Co As H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Application granted granted Critical
Publication of DK1265882T3 publication Critical patent/DK1265882T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Psychiatry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Cephalosporin Compounds (AREA)
DK01913738T 2000-03-14 2001-03-09 Fremgangsmåde til fremstilling af citalopram DK1265882T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200000415 2000-03-14
PCT/DK2001/000162 WO2001068630A1 (en) 2000-03-14 2001-03-09 Method for the preparation of citalopram

Publications (1)

Publication Number Publication Date
DK1265882T3 true DK1265882T3 (da) 2004-06-01

Family

ID=8159331

Family Applications (1)

Application Number Title Priority Date Filing Date
DK01913738T DK1265882T3 (da) 2000-03-14 2001-03-09 Fremgangsmåde til fremstilling af citalopram

Country Status (26)

Country Link
US (1) US6806376B2 (da)
EP (1) EP1265882B1 (da)
JP (1) JP2003527386A (da)
KR (1) KR20020080476A (da)
CN (1) CN1418205A (da)
AT (1) ATE257832T1 (da)
AU (1) AU2001239213A1 (da)
BG (1) BG107051A (da)
BR (1) BR0109268A (da)
CA (1) CA2402557A1 (da)
DE (1) DE60101786T2 (da)
DK (1) DK1265882T3 (da)
EA (1) EA005094B1 (da)
ES (1) ES2214400T3 (da)
HR (1) HRP20020740A2 (da)
HU (1) HUP0300178A2 (da)
IL (1) IL151488A0 (da)
IS (1) IS6527A (da)
MX (1) MXPA02008653A (da)
NO (1) NO20024198D0 (da)
PL (1) PL360107A1 (da)
PT (1) PT1265882E (da)
SK (1) SK14512002A3 (da)
TR (2) TR200400611T4 (da)
WO (1) WO2001068630A1 (da)
ZA (1) ZA200206897B (da)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE237604T1 (de) * 1999-04-14 2003-05-15 Lundbeck & Co As H Verfahren zur herstellung von citalopram
IES20010157A2 (en) 2000-03-03 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram
MXPA02008684A (es) 2000-03-13 2003-02-24 Lundbeck & Co As H Alquilacion gradual de 1-(4-fluorofenil)-1,3-dihidroisobenzofuranos 5-substituidos.
MXPA02008869A (es) 2000-03-13 2003-02-10 Lundbeck & Co As H Metodo para la preparacion de citalopram.
NL1017500C1 (nl) 2000-03-13 2001-04-26 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
AR032455A1 (es) 2000-05-12 2003-11-12 Lundbeck & Co As H Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
AR040970A1 (es) 2002-08-12 2005-04-27 Lundbeck & Co As H Metodo para la separacion de intermediarios que pueden ser utilizados para la preparacion de escitalopram
AU2003223105A1 (en) * 2003-03-24 2004-10-18 Hetero Drugs Limited Novel crystalline forms of (s)-citalopram oxalate
CN100569765C (zh) 2003-12-19 2009-12-16 杭州民生药业集团有限公司 西酞普兰中间体晶体碱
TWI339651B (en) 2004-02-12 2011-04-01 Lundbeck & Co As H Method for the separation of intermediates which may be used for the preparation of escitalopram

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1143703A (da) 1965-03-18
GB1526331A (en) 1976-01-14 1978-09-27 Kefalas As Phthalanes
GB8419963D0 (en) 1984-08-06 1984-09-12 Lundbeck & Co As H Intermediate compound and method
GB8814057D0 (en) 1988-06-14 1988-07-20 Lundbeck & Co As H New enantiomers & their isolation
US5296507A (en) 1990-09-06 1994-03-22 H.Lundbeck A/S Treatment of cerbrovascular disorders
DE19626659A1 (de) 1996-07-03 1998-01-08 Basf Ag Verfahren zur Herstellung von Phthaliden
DE19627697A1 (de) 1996-07-10 1998-01-15 Basf Ag Verfahren zur Herstellung von Phthaliden
SK283309B6 (sk) 1997-07-08 2003-05-02 H. Lundbeck A/S Spôsob výroby citalopramu a medziprodukty
UA62985C2 (en) 1997-11-10 2004-01-15 Lunnbeck As H A method for the preparation of citalopram
AU738359B2 (en) 1997-11-11 2001-09-13 H. Lundbeck A/S Method for the preparation of citalopram
DK1123284T3 (da) 1998-10-20 2003-04-28 Lundbeck & Co As H Fremgangsmåde til fremstilling af citalopram
ES2195644T3 (es) 1998-12-23 2003-12-01 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida.
AR022329A1 (es) 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
ATE237604T1 (de) 1999-04-14 2003-05-15 Lundbeck & Co As H Verfahren zur herstellung von citalopram
ITMI991579A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991581A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
CH692298A5 (de) 1999-10-25 2002-04-30 Lundbeck & Co As H Verfahren zur Herstellung von Zwischenstufen für die Citalopramsynthese sowie zur Herstellung von Escitalopram.
AR026063A1 (es) 1999-11-01 2002-12-26 Lundbeck & Co As H Metodo para la preparacion de 5-carboxiftalida.
US6310222B1 (en) 1999-11-01 2001-10-30 Sumika Fine Chemicals Co., Ltd. Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate
DK1246812T3 (da) 1999-12-28 2004-07-05 Lundbeck & Co As H Fremgangsmåde til fremstilling af citalopram
CZ20022627A3 (cs) 1999-12-30 2002-10-16 H. Lundbeck A/S Způsob výroby citalopramu
UA72569C2 (uk) 2000-01-14 2005-03-15 Х. Луннбек А/С Спосіб одержання 5-ціанофталіду
US6433196B1 (en) 2000-02-17 2002-08-13 Sumika Fine Chemicals Co., Ltd. Production method of citalopram, intermediate therefor and production method of the intermediate
IES20010143A2 (en) 2000-02-24 2001-07-25 Lundbeck & Co As H Method for the preparation of citalopram
NL1017415C1 (nl) 2000-02-24 2001-05-18 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
IES20010157A2 (en) 2000-03-03 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram
GB0005477D0 (en) 2000-03-07 2000-04-26 Resolution Chemicals Limited Process for the preparation of citalopram
NL1017500C1 (nl) 2000-03-13 2001-04-26 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
MXPA02008869A (es) 2000-03-13 2003-02-10 Lundbeck & Co As H Metodo para la preparacion de citalopram.
IL151487A0 (en) 2000-03-16 2003-04-10 Lundbeck & Co As H Method for the preparation of 5-cyano-1-(4-flourophenyl)-1,3-dihydroisobenzofurans
EA200200332A1 (ru) 2000-07-06 2002-06-27 Х.Лундбекк А/С Способ получения циталопрама
FI20011621A (fi) 2000-08-18 2002-02-19 Lundbeck & Co As H Menetelmä sitalopraamin valmistamiseksi
NL1017525C1 (nl) 2000-12-22 2001-04-26 Lundbeck & Co As H Werkwijze voor de bereiding van zuiver Citalopram
PT1181272E (pt) 2000-12-28 2003-01-31 Lundbeck & Co As H Processo para a preparacao de citalopram puro

Also Published As

Publication number Publication date
EA005094B1 (ru) 2004-10-28
HRP20020740A2 (en) 2004-12-31
EA200200970A1 (ru) 2003-02-27
US6806376B2 (en) 2004-10-19
PT1265882E (pt) 2004-06-30
CN1418205A (zh) 2003-05-14
MXPA02008653A (es) 2003-02-24
IS6527A (is) 2002-08-27
NO20024198L (no) 2002-09-03
KR20020080476A (ko) 2002-10-23
HUP0300178A2 (en) 2003-05-28
BR0109268A (pt) 2002-12-03
EP1265882A1 (en) 2002-12-18
AU2001239213A1 (en) 2001-09-24
IL151488A0 (en) 2003-04-10
EP1265882B1 (en) 2004-01-14
CA2402557A1 (en) 2001-09-20
US20030050484A1 (en) 2003-03-13
BG107051A (en) 2003-05-30
DE60101786T2 (de) 2004-07-15
TR200400611T4 (tr) 2004-04-21
ATE257832T1 (de) 2004-01-15
JP2003527386A (ja) 2003-09-16
NO20024198D0 (no) 2002-09-03
PL360107A1 (en) 2004-09-06
ZA200206897B (en) 2003-08-28
SK14512002A3 (sk) 2003-03-04
DE60101786D1 (de) 2004-02-19
TR200202155T2 (tr) 2002-12-23
WO2001068630A1 (en) 2001-09-20
ES2214400T3 (es) 2004-09-16

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