DE69723846D1 - Verfahren zur Herstellung von Sildenafil - Google Patents

Verfahren zur Herstellung von Sildenafil

Info

Publication number
DE69723846D1
DE69723846D1 DE69723846T DE69723846T DE69723846D1 DE 69723846 D1 DE69723846 D1 DE 69723846D1 DE 69723846 T DE69723846 T DE 69723846T DE 69723846 T DE69723846 T DE 69723846T DE 69723846 D1 DE69723846 D1 DE 69723846D1
Authority
DE
Germany
Prior art keywords
sildenafil
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69723846T
Other languages
English (en)
Other versions
DE69723846T2 (de
Inventor
Peter James Dunn
Albert Shaw Wood
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Ireland Pharmaceuticals
Original Assignee
Pfizer Ltd
Pfizer Research and Development Co NV SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10795332&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69723846(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer Ltd, Pfizer Research and Development Co NV SA filed Critical Pfizer Ltd
Publication of DE69723846D1 publication Critical patent/DE69723846D1/de
Application granted granted Critical
Publication of DE69723846T2 publication Critical patent/DE69723846T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/26—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Urology & Nephrology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DE69723846T 1996-06-14 1997-06-04 Verfahren zur Herstellung von Sildenafil Expired - Lifetime DE69723846T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9612514.1A GB9612514D0 (en) 1996-06-14 1996-06-14 Novel process
GB9612514 1996-06-14

Publications (2)

Publication Number Publication Date
DE69723846D1 true DE69723846D1 (de) 2003-09-04
DE69723846T2 DE69723846T2 (de) 2004-03-04

Family

ID=10795332

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69723846T Expired - Lifetime DE69723846T2 (de) 1996-06-14 1997-06-04 Verfahren zur Herstellung von Sildenafil
DE69700321T Expired - Lifetime DE69700321T2 (de) 1996-06-14 1997-06-04 Verfahren zur Herstellung Sildenafil

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69700321T Expired - Lifetime DE69700321T2 (de) 1996-06-14 1997-06-04 Verfahren zur Herstellung Sildenafil

Country Status (48)

Country Link
US (2) US5955611A (de)
EP (2) EP0812845B1 (de)
JP (2) JP2866841B2 (de)
KR (1) KR100207352B1 (de)
CN (2) CN1106399C (de)
AP (1) AP717A (de)
AR (1) AR003401A1 (de)
AT (2) ATE246194T1 (de)
AU (1) AU697684B2 (de)
BG (1) BG62554B1 (de)
BR (1) BR9703580A (de)
CA (1) CA2207694C (de)
CO (1) CO4780028A1 (de)
CZ (1) CZ290942B6 (de)
DE (2) DE69723846T2 (de)
DK (2) DK0812845T3 (de)
DZ (1) DZ2247A1 (de)
EA (1) EA000102B1 (de)
EG (1) EG24123A (de)
ES (2) ES2134051T3 (de)
GB (1) GB9612514D0 (de)
GR (1) GR3031087T3 (de)
HK (1) HK1033459A1 (de)
HN (1) HN1997000072A (de)
HR (1) HRP970326B1 (de)
HU (1) HU224497B1 (de)
ID (1) ID18745A (de)
IL (3) IL121000A (de)
IN (5) IN187350B (de)
IS (2) IS1922B (de)
MA (1) MA24205A1 (de)
MX (1) MX9704433A (de)
NO (2) NO304551B1 (de)
NZ (1) NZ328084A (de)
OA (1) OA10426A (de)
PE (2) PE20011303A1 (de)
PL (1) PL189333B1 (de)
PT (1) PT916675E (de)
RS (2) RS49924B (de)
SA (1) SA97180124B1 (de)
SG (1) SG50024A1 (de)
SI (2) SI0812845T1 (de)
SK (5) SK283896B6 (de)
TN (1) TNSN97102A1 (de)
TR (1) TR199700470A2 (de)
UA (1) UA27085C2 (de)
UY (2) UY24585A1 (de)
ZA (1) ZA975259B (de)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060222647A1 (en) * 1993-05-27 2006-10-05 Beavo Joseph A Methods and compositions for modulating the activity of PDE5
RS50118B (sr) * 1997-04-25 2009-03-25 Pfizer Inc., Pirazolopirimidinoni koji inhibiraju tip 5 ciklične guanozin 3',5'-monofosfat fosfo-diesteraze (cgmp pde5) za tretman seksualne disfunkcije
CN1309561A (zh) * 1997-05-29 2001-08-22 持田制药株式会社 勃起机能障碍治疗剂
US6399618B1 (en) 1997-07-09 2002-06-04 Cardiome Pharma Corp Compositions and methods for modulating sexual activity
GB9722520D0 (en) 1997-10-24 1997-12-24 Pfizer Ltd Compounds
CH693954A5 (de) 1997-11-12 2004-05-14 Bayer Ag 2-Phenyl-substituierte Imidazotriazinone als Phosphodiesterase Inhibitoren.
JP3721077B2 (ja) 1998-04-20 2005-11-30 ファイザー・インク 性的不全を治療するためのピラゾロピリミジノンｃＧＭＰＰＤＥ５阻害剤
CA2235642C (en) 1998-05-15 2007-11-13 Torcan Chemical Ltd. Processes for preparing sildenafil
US6077841A (en) * 1998-09-04 2000-06-20 Janssen Pharmaceutica, N.V. 5-heterocyclyl pyrazolo[4,3-d]pyrimidin-7-ones for the treatment of male erectile dysfunction
GB9822238D0 (en) * 1998-10-12 1998-12-09 Pfizer Ltd Process for preparation of pyrazolo[4,3-D]pyrimidin-7-ones and intermediates thereof
GB9823102D0 (en) 1998-10-23 1998-12-16 Pfizer Ltd Pharmaceutically active compounds
GB9823103D0 (en) * 1998-10-23 1998-12-16 Pfizer Ltd Pharmaceutically active compounds
GB9823101D0 (en) 1998-10-23 1998-12-16 Pfizer Ltd Pharmaceutically active compounds
KR100353014B1 (ko) * 1998-11-11 2002-09-18 동아제약 주식회사 발기부전 치료에 효과를 갖는 피라졸로피리미디논 화합물
US6087362A (en) * 1999-03-16 2000-07-11 Pentech Pharmaceuticals, Inc. Apomorphine and sildenafil composition
AU5204800A (en) * 1999-06-21 2001-01-09 Biochemical Pharmaceutical Factory of Zhuhai Sez, The Process for preparing sildenafil, and troche which comprises sildenafil and apomorphine
CN1094492C (zh) * 1999-06-21 2002-11-20 杭州神鹰医药化工有限公司 西地那非的制备方法
CN1077108C (zh) * 1999-07-13 2002-01-02 成都地奥制药集团有限公司 用于制备药物昔多芬的前体化合物
WO2001019827A1 (en) * 1999-09-13 2001-03-22 Cipla Ltd. A novel process for the synthesis of sildenafil citrate
US6075028A (en) * 1999-09-23 2000-06-13 Graham; Richard Method of treating Tourette's syndrome and related CNS disorders
TWI265925B (en) 1999-10-11 2006-11-11 Pfizer Pyrazolo[4,3-d]pyrimidin-7-ones useful in inhibiting type 5 cyclic guanosine 3',5'-monophosphate phosphodiesterases(cGMP PDE5), process and intermediates for their preparation, their uses and composition comprising them
JP2003511452A (ja) 1999-10-11 2003-03-25 ファイザー・インク ホスホジエステラーゼ阻害剤としての５−（２−置換−５−ヘテロシクリルスルホニルピリド−３−イル）−ジヒドロピラゾロ［４，３−ｄ］ピリミジン−７−オン
CA2411957C (en) * 2000-06-22 2007-09-18 Pfizer Inc. Novel process for the preparation of pyrazolopyrimidinones
US6667398B2 (en) 2000-06-22 2003-12-23 Pfizer Inc Process for the preparation of pyrazolopyrimidinones
US6730786B2 (en) * 2000-06-22 2004-05-04 Pfizer Inc Process for the preparation of pyrazolopyrimidinones
GB0015462D0 (en) * 2000-06-22 2000-08-16 Pfizer Ltd Novel process for the preparation of pyrazolopyrimidinones
EP1176147A1 (de) * 2000-07-28 2002-01-30 Pfizer Limited Verfahren zur Herstellung von Pyrazolo[4,3-d]pyrimidin-7-onen und Zwischenprodukten davon
US6407259B1 (en) 2000-07-28 2002-06-18 Pfizer Inc. Process for the preparation of pyrazoles
EP1176142A1 (de) * 2000-07-28 2002-01-30 Pfizer Inc. Verfahren zur Herstellung von Pyrazolen
US6821978B2 (en) * 2000-09-19 2004-11-23 Schering Corporation Xanthine phosphodiesterase V inhibitors
CN1127506C (zh) * 2001-06-29 2003-11-12 刘宝顺 一种治疗阳痿的新化合物
CA2457944C (en) * 2001-08-28 2009-09-29 Schering Corporation Polycyclic guanine phosphodiesterase v inhibitors
EP1719772A1 (de) 2002-05-31 2006-11-08 Schering Corporation Verfahren zur Herstellung von Xanthin Phosphodiesterase v Inhibitoren und deren Vorstufen
DE10232113A1 (de) 2002-07-16 2004-01-29 Bayer Ag Vardenafil Hydrochlorid Trihydrat enthaltende Arzneimittel
CN100374441C (zh) 2003-06-06 2008-03-12 天津倍方科技发展有限公司 二氢吡咯[2，3-d]嘧啶-4-酮衍生物，其制备方法及其制药用途
CN100360531C (zh) * 2003-12-18 2008-01-09 中国人民解放军军事医学科学院放射与辐射医学研究所 用于预防或治疗阳萎和性冷淡的新吡唑并嘧啶类化合物
EP1779852A3 (de) * 2004-01-05 2007-05-09 Teva Pharmaceutical Industries Ltd. Prozesse zur herstellung von sildenafil-base und zitratsalz
DE602005004966T2 (de) * 2004-01-05 2009-03-12 Teva Pharmaceutical Industries Ltd. Prozesse zur herstellung von sildenafil-base und zitratsalz
DE102005009240A1 (de) 2005-03-01 2006-09-07 Bayer Healthcare Ag Arzneiformen mit verbesserten pharmakokinetischen Eigenschaften
CN101563348B (zh) * 2006-12-21 2011-08-24 上海特化医药科技有限公司 西地那非的制备方法及其中间体
ES2310144B1 (es) 2007-06-15 2010-01-12 Galenicum Health, S.L. Intermedios para la preparacion de un inhibidor de la fosfodiesterasa tipo 5.
BRPI0823356A2 (pt) 2008-12-12 2015-06-16 Rhein Siegfried Sa De Cv Composição de liberação pulsátil de sildenafil e processo para prepará-la
MX2010006227A (es) 2010-06-07 2011-12-14 World Trade Imp Exp Wtie Ag Nuevos derivados 1,4-diazepanos, inhibidores de pde-5.
CN102993205B (zh) * 2012-12-27 2015-04-15 华润赛科药业有限责任公司 一种高收率制备高纯度西地那非游离碱的纯化方法
CN103044330B (zh) * 2013-01-14 2018-11-13 常州亚邦制药有限公司 西地那非中间体4-氨基-1-甲基-3-正丙基吡唑-5-甲酰胺的绿色合成新工艺
CN105085526B (zh) * 2014-05-15 2017-08-01 重庆圣华曦药业股份有限公司 一种改进的西地那非制备方法
CN105753870B (zh) * 2016-04-01 2018-05-22 重庆康刻尔制药有限公司 一种西地那非杂质f及其制备方法和应用
WO2017168174A1 (en) 2016-04-02 2017-10-05 N4 Pharma Uk Limited New pharmaceutical forms of sildenafil
CN105837578A (zh) * 2016-04-05 2016-08-10 重庆康刻尔制药有限公司 一种西地那非杂质d的合成方法
WO2018069316A2 (en) 2016-10-10 2018-04-19 Transgene Sa Immunotherapeutic product and mdsc modulator combination therapy
CN113493459B (zh) * 2020-04-07 2022-12-13 广州白云山医药集团股份有限公司白云山制药总厂 Pde5抑制剂化合物及其制备方法和应用
CN112961160A (zh) * 2021-03-05 2021-06-15 遂成药业股份有限公司 一种西地那非的改良合成工艺
CN113754612B (zh) * 2021-10-26 2023-09-26 山东安舜制药有限公司 一种西地那非中间体的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4871843A (en) * 1983-10-18 1989-10-03 Dropic-Societe Civile De Gestion De Droits De Propriete Industrielle Cyclic benzenesulfonamides, process for their preparation and their use as active substance of pharmaceutical compositions
GB9013750D0 (en) * 1990-06-20 1990-08-08 Pfizer Ltd Therapeutic agents
GB9114760D0 (en) * 1991-07-09 1991-08-28 Pfizer Ltd Therapeutic agents
GB9311920D0 (en) * 1993-06-09 1993-07-28 Pfizer Ltd Therapeutic agents
RS50118B (sr) * 1997-04-25 2009-03-25 Pfizer Inc., Pirazolopirimidinoni koji inhibiraju tip 5 ciklične guanozin 3',5'-monofosfat fosfo-diesteraze (cgmp pde5) za tretman seksualne disfunkcije
US6087368A (en) * 1998-06-08 2000-07-11 Bristol-Myers Squibb Company Quinazolinone inhibitors of cGMP phosphodiesterase

Also Published As

Publication number Publication date
SK74397A3 (en) 1998-06-03
HRP970326A2 (en) 1998-06-30
SG50024A1 (en) 1998-06-15
EP0916675B1 (de) 2003-07-30
AP717A (en) 1999-01-04
DZ2247A1 (fr) 2002-12-18
ES2134051T3 (es) 1999-09-16
JP3058863B2 (ja) 2000-07-04
AU2487897A (en) 1997-12-18
US5955611A (en) 1999-09-21
ZA975259B (en) 1997-12-15
IL121000A0 (en) 1997-11-20
GB9612514D0 (en) 1996-08-14
EA000102B1 (ru) 1998-08-27
DE69723846T2 (de) 2004-03-04
RS49924B (sr) 2008-09-29
MA24205A1 (fr) 1997-12-31
EP0916675A3 (de) 1999-07-14
GR3031087T3 (en) 1999-12-31
IN187319B (de) 2002-03-23
IN187350B (de) 2002-03-30
AP9701009A0 (en) 1997-07-31
BG62554B1 (bg) 2000-02-29
IN187320B (de) 2002-03-23
SI0916675T1 (en) 2003-12-31
AU697684B2 (en) 1998-10-15
JP2866841B2 (ja) 1999-03-08
SK283896B6 (sk) 2004-04-06
KR100207352B1 (en) 1999-07-15
JPH11171879A (ja) 1999-06-29
EP0812845B1 (de) 1999-07-14
NO306115B1 (no) 1999-09-20
CZ181197A3 (cs) 1998-03-18
NO304551B1 (no) 1999-01-11
SA97180124A (ar) 2005-12-03
DE69700321D1 (de) 1999-08-19
HN1997000072A (es) 1997-12-26
PE20011303A1 (es) 2001-12-25
IN187318B (de) 2002-03-23
BR9703580A (pt) 1998-11-10
NO972481D0 (no) 1997-05-30
HK1033459A1 (en) 2001-08-31
ATE246194T1 (de) 2003-08-15
CN1282740A (zh) 2001-02-07
IS6634A (is) 2002-11-25
NO985064D0 (no) 1998-10-30
AR003401A1 (es) 1998-08-05
EP0812845A1 (de) 1997-12-17
BG101569A (en) 1998-01-30
ATE182150T1 (de) 1999-07-15
PT916675E (pt) 2003-11-28
IS4503A (is) 1997-12-15
UY24612A1 (es) 2000-09-29
KR980002051A (ko) 1998-03-30
SA97180124B1 (ar) 2006-02-08
HRP970326B1 (en) 2000-10-31
US6066735A (en) 2000-05-23
CO4780028A1 (es) 1999-05-26
HUP9701048A2 (hu) 1998-12-28
RS20060484A (en) 2007-04-10
DE69700321T2 (de) 1999-11-04
DK0812845T3 (da) 1999-11-29
PE1299A1 (es) 1999-01-13
IL125411A0 (en) 1999-03-12
CN1149206C (zh) 2004-05-12
NO972481L (no) 1997-12-15
SK283894B6 (sk) 2004-04-06
UY24585A1 (es) 1997-12-02
CZ290942B6 (cs) 2002-11-13
TNSN97102A1 (fr) 2005-03-15
IL121000A (en) 2000-02-29
UA27085C2 (uk) 2000-02-28
IS1922B (is) 2004-03-15
NZ328084A (en) 1998-08-26
DK0916675T3 (da) 2003-10-27
HU224497B1 (hu) 2005-10-28
PL320555A1 (en) 1997-12-22
PL189333B1 (pl) 2005-07-29
ES2201397T3 (es) 2004-03-16
JPH1081688A (ja) 1998-03-31
CN1168376A (zh) 1997-12-24
HU9701048D0 (en) 1997-08-28
MX9704433A (es) 1998-11-30
ID18745A (id) 1998-05-07
EP0916675A2 (de) 1999-05-19
YU25497A (sh) 1998-12-23
SI0812845T1 (en) 1999-12-31
IS1923B (is) 2004-03-15
TR199700470A2 (xx) 1998-01-21
CA2207694A1 (en) 1997-12-14
SK283893B6 (sk) 2004-04-06
IN187317B (de) 2002-03-23
HUP9701048A3 (en) 2000-10-30
RS49653B (sr) 2007-09-21
IL125411A (en) 2000-02-29
SK283897B6 (sk) 2004-04-06
CN1106399C (zh) 2003-04-23
EA199700061A1 (ru) 1997-12-30
NO985064L (no) 1997-12-15
OA10426A (en) 2001-12-07
SK283895B6 (sk) 2004-04-06
EG24123A (en) 2008-07-06
CA2207694C (en) 1999-11-23

Similar Documents

Publication Publication Date Title
DE69723846D1 (de) Verfahren zur Herstellung von Sildenafil
DE59509204D1 (de) Verfahren zur Herstellung von Hydrogenalkoxysilanen
DE59509333D1 (de) Verfahren zur Herstellung von 3-Acryloxypropylalkoxysilanen
DE69501412D1 (de) Verfahren zur Herstellung von Isocanaten
DE69702550D1 (de) Verfahren zur Herstellung von peroxiperfluoropolyxyalkylene
DE69734526D1 (de) Verfahren zur herstellung von thiazolederivaten
DE59702177D1 (de) Verfahren zur Herstellung von Hydroxymethylcyclopropan
DE59505473D1 (de) Verfahren zur Herstellung von Glykoloylaniliden
DE59610221D1 (de) Verfahren zur Herstellung von 2-Acetyl-gamma-butyrolacton
DE59501150D1 (de) Verfahren zur Herstellung von Polyisoolefinen
DE69703764D1 (de) Verfahren zur Herstellung von N-Acetonylbenzamide
DE69806876D1 (de) Verfahren zur Herstellung von 2-Chlorprop-1-en
DE59501307D1 (de) Verfahren zur Herstellung von Fluoranilinen
DE69705291D1 (de) Verfahren zur Herstellung von Distyrol-biphenylverbindungen
DE59500563D1 (de) Verfahren zur Herstellung von N-Alkenylcarbonsäureamiden
DE69703599D1 (de) Verfahren zur Herstellung von 2-H-Heptafluorpropan
DE69737685D1 (de) Verfahren zur herstellung von hexanitrohexaazawurtzitaneen
DE59500564D1 (de) Verfahren zur Herstellung von Benzthiazolylazoanilinen
DE59802385D1 (de) Verfahren zur Herstellung von N-Alkylcarbazolen
DE59505555D1 (de) Verfahren zur Herstellung von 1-Chlor-3-methyl-but-2-en
DE59705748D1 (de) Verfahren zur Herstellung von Cyclopentanolen
DE69711276D1 (de) Verfahren zur Herstellung von Acetonylbenzamiden
DE69705810D1 (de) Verfahren zur Herstellung von 2-Hydroxy-4-Alkyloxy-Benzophenon
DE69700508D1 (de) Verfahren zur Herstellung von Organodisilanen
DE59704518D1 (de) Verfahren zur Herstellung von Isocamphyl-cyclohexanolen

Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: PFIZER RESEARCH AND DEVELOPMENT CO., N.V./S.A., DU

8327 Change in the person/name/address of the patent owner

Owner name: PFIZER IRELAND PHARMACEUTICALS, DUN LAOGHAIRE, IE

8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: PFIZER IRELAND PHARMACEUTICALS, DUN LAOGHAIRE, COU