DE68918804D1 - Acyclische 6-substituierte pyrimidin nukleosid-abkömmlinge und antivirale mittel, die dieselben als aktive mittel enthalten. - Google Patents

Acyclische 6-substituierte pyrimidin nukleosid-abkömmlinge und antivirale mittel, die dieselben als aktive mittel enthalten.

Info

Publication number
DE68918804D1
DE68918804D1 DE68918804T DE68918804T DE68918804D1 DE 68918804 D1 DE68918804 D1 DE 68918804D1 DE 68918804 T DE68918804 T DE 68918804T DE 68918804 T DE68918804 T DE 68918804T DE 68918804 D1 DE68918804 D1 DE 68918804D1
Authority
DE
Germany
Prior art keywords
group
atom
scrubbers
acyclic
oxygen atom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE68918804T
Other languages
English (en)
Other versions
DE68918804T2 (de
Inventor
Tadashi Miyasaka
Hiromichi Tanaka
Clercq Erik De
Masanori Baba
Richard Walker
Masaru - Machida Coopu Ubasawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Kasei Corp
Original Assignee
Mitsubishi Kasei Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Kasei Corp filed Critical Mitsubishi Kasei Corp
Publication of DE68918804D1 publication Critical patent/DE68918804D1/de
Application granted granted Critical
Publication of DE68918804T2 publication Critical patent/DE68918804T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/60—Three or more oxygen or sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE68918804T 1988-03-31 1989-03-31 Acyclische 6-substituierte pyrimidin nukleosid-abkömmlinge und antivirale mittel, die dieselben als aktive mittel enthalten. Expired - Fee Related DE68918804T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP7667788 1988-03-31
PCT/JP1989/000347 WO1989009213A1 (en) 1988-03-31 1989-03-31 6-substituted acyclicpyrimidine nucleoside derivatives and antiviral agents containing same as active ingredients

Publications (2)

Publication Number Publication Date
DE68918804D1 true DE68918804D1 (de) 1994-11-17
DE68918804T2 DE68918804T2 (de) 1995-02-23

Family

ID=13612062

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68918804T Expired - Fee Related DE68918804T2 (de) 1988-03-31 1989-03-31 Acyclische 6-substituierte pyrimidin nukleosid-abkömmlinge und antivirale mittel, die dieselben als aktive mittel enthalten.

Country Status (12)

Country Link
US (1) US5112835A (de)
EP (1) EP0371139B1 (de)
KR (1) KR950006713B1 (de)
AT (1) ATE112767T1 (de)
CA (1) CA1334535C (de)
CH (1) CH676712A5 (de)
DD (1) DD283613A5 (de)
DE (1) DE68918804T2 (de)
ES (1) ES2013664A6 (de)
HU (1) HU206328B (de)
WO (1) WO1989009213A1 (de)
ZA (1) ZA892407B (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR0155168B1 (ko) * 1989-09-29 1998-11-16 미우라 아끼라 6-치환된 아시클로피리미딘 뉴클레오시드 유도체 및 이를 활성성분으로 함유하는 항비루스제
USRE37979E1 (en) 1989-09-29 2003-02-04 Mitsubishi Chemical Corporation Pyrimidine derivatives and anti-viral agent containing the same as active ingredient thereof
HU205917B (en) * 1989-09-29 1992-07-28 Mitsubishi Chem Ind Process for producing 6-substituted pyrimidine derivatives and antiviral pharmaceutical compositions containing them as active components
EP0449726B1 (de) * 1990-03-29 1997-06-11 Mitsubishi Chemical Corporation Pyrimidin-Nukleosid-Derivate und antivirale Mittel, die diese Derivate als aktiven Bestandteil enthalten
ATE161722T1 (de) * 1990-07-19 1998-01-15 Wellcome Found Enzyminaktivatoren
GB9020930D0 (en) 1990-09-26 1990-11-07 Wellcome Found Pharmaceutical combinations
AU1994492A (en) * 1991-07-22 1993-02-23 Baker Cummins Pharmaceuticals, Inc. Acyclic 6-phenylselenenyl pyrimidine nucleosides
US5792868A (en) * 1991-09-18 1998-08-11 Ajinomoto Co., Inc. Process for producing acyclic nucleosides and process for separating purine nucleosides
US5476855A (en) * 1993-11-02 1995-12-19 Mahmoud H. el Kouni Enzyme inhibitors, their synthesis and methods for use
US6051576A (en) * 1994-01-28 2000-04-18 University Of Kentucky Research Foundation Means to achieve sustained release of synergistic drugs by conjugation
AU693107B2 (en) * 1994-02-28 1998-06-25 Sunkyong Industries Co., Ltd. Pyrimidine acyclonucleoside derivatives
KR100219922B1 (ko) * 1996-05-16 1999-09-01 이서봉 신규한 항바이러스성 6-아릴옥시 및 6-아릴카르보닐 2,4-피리미딘디온 유도체 및 그의 제조 방법
US5998411A (en) * 1998-03-17 1999-12-07 Hughes Institute Heterocyclic nonnucleoside inhibitors of reverse transcriptase
EA004049B1 (ru) 1998-11-10 2003-12-25 Янссен Фармацевтика Н.В. Пиримидины, ингибирующие репликацию вич
US6136335A (en) 1998-12-31 2000-10-24 Hughes Institute Phenethyl-5-bromopyridylthiourea (PBT) and dihydroalkoxybenzyloxopyrimidine (DABO) derivatives exhibiting spermicidal activity
EE04991B1 (et) * 1999-09-24 2008-04-15 Janssen Pharmaceutica N.V. Osake, ravimvorm, nende valmistamismeetodid, osakeste kasutamine ning farmatseutiline pakend
GB0400290D0 (en) 2004-01-08 2004-02-11 Medivir Ab dUTPase inhibitors
KR20100041798A (ko) * 2007-06-29 2010-04-22 한국화학연구원 신규 ｈｉｖ 역전사효소 억제제
TW200918507A (en) * 2007-06-29 2009-05-01 Gilead Sciences Inc Novel HIV reverse transcriptase inhibitors
WO2009085797A1 (en) * 2007-12-21 2009-07-09 Gilead Sciences, Inc. Processes for preparing hiv reverse transcriptase inhibitors
HRPK20090508B3 (hr) 2009-09-25 2012-12-31 Sveučilište u Zagrebu Novi 6-supstituirani derivati pirimidina

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5434751B2 (de) * 1972-08-11 1979-10-29
US3947444A (en) * 1973-06-21 1976-03-30 Solomon Aronovich Giller Process for producing N1 -(Dihydroxyalkyl)-5-substituted uracils
JPS5032186A (de) * 1973-07-17 1975-03-28
JPS5188974A (de) * 1975-02-03 1976-08-04
JPS5738774A (en) * 1980-08-19 1982-03-03 Chugai Pharmaceut Co Ltd Uracil derivative and its preparation
US4347360A (en) * 1980-09-16 1982-08-31 Ens Bio Logicals Inc. Ring open nucleoside analogues
JP3245191B2 (ja) * 1991-07-30 2002-01-07 ヤマハ発動機株式会社 自動二輪車のメインスタンドロック装置
JPH05188974A (ja) * 1992-01-08 1993-07-30 Pioneer Electron Corp 多入力音量調整装置
JPH06156171A (ja) * 1992-11-18 1994-06-03 Mitsubishi Electric Corp 車載用レーダ装置

Also Published As

Publication number Publication date
AU3357589A (en) 1989-10-16
CH676712A5 (de) 1991-02-28
ATE112767T1 (de) 1994-10-15
KR950006713B1 (ko) 1995-06-21
US5112835A (en) 1992-05-12
EP0371139B1 (de) 1994-10-12
DD283613A5 (de) 1990-10-17
HU206328B (en) 1992-10-28
EP0371139A4 (en) 1991-08-28
DE68918804T2 (de) 1995-02-23
CA1334535C (en) 1995-02-21
ES2013664A6 (es) 1990-05-16
EP0371139A1 (de) 1990-06-06
KR900700463A (ko) 1990-08-13
WO1989009213A1 (en) 1989-10-05
ZA892407B (en) 1989-11-29
AU611284B2 (en) 1991-06-06

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee